LOCUS       NM_003944               1722 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens selenium binding protein 1 (SELENBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_003944
VERSION     NM_003944.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Zhao,W., Nikolic-Paterson,D.J., Li,K., Li,Y., Wang,Y., Chen,X.,
            Duan,Z., Zhang,Y., Liu,P., Lu,S., Fu,R. and Tian,L.
  TITLE     Selenium binding protein 1 protects renal tubular epithelial cells
            from ferroptosis by upregulating glutathione peroxidase 4
  JOURNAL   Chem Biol Interact 393, 110944 (2024)
   PUBMED   38518851
  REMARK    GeneRIF: Selenium binding protein 1 protects renal tubular
            epithelial cells from ferroptosis by upregulating glutathione
            peroxidase 4.
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Ma,J., Huang,X., Xu,J., Li,Z., Lai,J., Shen,Y., Zhao,J., Sun,X. and
            Ma,L.
  TITLE     SBP1 promotes tumorigenesis of thyroid cancer through TXN/NIS
            pathway
  JOURNAL   Mol Med 29 (1), 121 (2023)
   PUBMED   37684566
  REMARK    GeneRIF: SBP1 promotes tumorigenesis of thyroid cancer through
            TXN/NIS pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Philipp,T.M., Gernoth,L., Will,A., Schwarz,M., Ohse,V.A.,
            Kipp,A.P., Steinbrenner,H. and Klotz,L.O.
  TITLE     Selenium-binding protein 1 (SELENBP1) is a copper-dependent thiol
            oxidase
  JOURNAL   Redox Biol 65, 102807 (2023)
   PUBMED   37437449
  REMARK    GeneRIF: Selenium-binding protein 1 (SELENBP1) is a
            copper-dependent thiol oxidase.
REFERENCE   4  (bases 1 to 1722)
  AUTHORS   Zhu,Y., Pu,Q., Zhang,Q., Liu,Y., Ma,Y., Yuan,Y., Liu,L. and Zhu,W.
  TITLE     Selenium-binding protein 1 inhibits malignant progression and
            induces apoptosis via distinct mechanisms in non-small cell lung
            cancer
  JOURNAL   Cancer Med 12 (16), 17149-17170 (2023)
   PUBMED   37606338
  REMARK    GeneRIF: Selenium-binding protein 1 inhibits malignant progression
            and induces apoptosis via distinct mechanisms in non-small cell
            lung cancer.
REFERENCE   5  (bases 1 to 1722)
  AUTHORS   Kim,S., Kim,S.W., Bui,M.A.T., Kim,Y., Kim,M., Park,J.C., Kim,N.H.,
            Pyeon,G.H., Jo,Y.S., Jang,J., Koh,H.Y., Jeong,C.H., Kang,M.,
            Kang,H.J., Lee,Y.W., Stockmeier,C.A., Seong,J.K., Woo,D.H.,
            Han,J.S. and Kim,Y.S.
  TITLE     SELENBP1 overexpression in the prefrontal cortex underlies negative
            symptoms of schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 119 (51), e2203711119 (2022)
   PUBMED   36512497
  REMARK    GeneRIF: SELENBP1 overexpression in the prefrontal cortex underlies
            negative symptoms of schizophrenia.
REFERENCE   6  (bases 1 to 1722)
  AUTHORS   Porat,A., Sagiv,Y. and Elazar,Z.
  TITLE     A 56-kDa selenium-binding protein participates in intra-Golgi
            protein transport
  JOURNAL   J Biol Chem 275 (19), 14457-14465 (2000)
   PUBMED   10799528
REFERENCE   7  (bases 1 to 1722)
  AUTHORS   Chang,P.W., Tsui,S.K., Liew,C., Lee,C.C., Waye,M.M. and Fung,K.P.
  TITLE     Isolation, characterization, and chromosomal mapping of a novel
            cDNA clone encoding human selenium binding protein
  JOURNAL   J Cell Biochem 64 (2), 217-224 (1997)
   PUBMED   9027582
REFERENCE   8  (bases 1 to 1722)
  AUTHORS   Czar,M.J., Owens-Grillo,J.K., Dittmar,K.D., Hutchison,K.A.,
            Zacharek,A.M., Leach,K.L., Deibel,M.R. Jr. and Pratt,W.B.
  TITLE     Characterization of the protein-protein interactions determining
            the heat shock protein (hsp90.hsp70.hsp56) heterocomplex
  JOURNAL   J Biol Chem 269 (15), 11155-11161 (1994)
   PUBMED   8157642
REFERENCE   9  (bases 1 to 1722)
  AUTHORS   Lanfear,J., Fleming,J., Walker,M. and Harrison,P.
  TITLE     Different patterns of regulation of the genes encoding the closely
            related 56 kDa selenium- and acetaminophen-binding proteins in
            normal tissues and during carcinogenesis
  JOURNAL   Carcinogenesis 14 (3), 335-340 (1993)
   PUBMED   8453708
REFERENCE   10 (bases 1 to 1722)
  AUTHORS   Bartolone,J.B., Birge,R.B., Bulera,S.J., Bruno,M.K.,
            Nishanian,E.V., Cohen,S.D. and Khairallah,E.A.
  TITLE     Purification, antibody production, and partial amino acid sequence
            of the 58-kDa acetaminophen-binding liver proteins
  JOURNAL   Toxicol Appl Pharmacol 113 (1), 19-29 (1992)
   PUBMED   1553752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB288439.1 and BC009084.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003944.3.
            
            Summary: This gene encodes a member of the selenium-binding protein
            family. Selenium is an essential nutrient that exhibits potent
            anticarcinogenic properties, and deficiency of selenium may cause
            certain neurologic diseases. The effects of selenium in preventing
            cancer and neurologic diseases may be mediated by selenium-binding
            proteins, and decreased expression of this gene may be associated
            with several types of cancer. The encoded protein may play a
            selenium-dependent role in ubiquitination/deubiquitination-mediated
            protein degradation. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.229394.1,
                                           SRR5189661.190547.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368868.10/ ENSP00000357861.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DB288439.1         30-46
            18-1722             BC009084.1         1-1705
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1722
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /note="selenium binding protein 1"
                     /db_xref="GeneID:8991"
                     /db_xref="HGNC:HGNC:10719"
                     /db_xref="MIM:604188"
     exon            1..68
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1483
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /EC_number="1.8.3.4"
                     /note="isoform 1 is encoded by transcript variant 1; 56
                     kDa selenium-binding protein; epididymis secretory sperm
                     binding protein Li 134P; methanethiol oxidase"
                     /codon_start=1
                     /product="methanethiol oxidase isoform 1"
                     /protein_id="NP_003935.2"
                     /db_xref="CCDS:CCDS995.1"
                     /db_xref="GeneID:8991"
                     /db_xref="HGNC:HGNC:10719"
                     /db_xref="MIM:604188"
                     /translation="MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYL
                     ATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISS
                     RIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGK
                     GGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPAD
                     VEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQR
                     FYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQ
                     YDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQL
                     SLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEP
                     LGPALAHELRYPGGDCSSDIWI"
     exon            69..125
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            126..238
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            239..424
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            425..545
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            546..728
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            729..907
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            908..986
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1108
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1320
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1722
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1698..1703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /note="hexamer: AATAAA"
     polyA_site      1722
                     /gene="SELENBP1"
                     /gene_synonym="EHMTO; HEL-S-134P; hSBP; LPSB; MTO; SBP56;
                     SP56"
                     /note="major polyA site"
ORIGIN      
        1 ggaacagcgg cctctgacac cagcacagca aacccgccgg gatcaaagtg taccagtcgg
       61 cagcatggct acgaaatgtg ggaattgtgg acccggctac tccacccctc tggaggccat
      121 gaaaggaccc agggaagaga tcgtctacct gccctgcatt taccgaaaca caggcactga
      181 ggccccagat tatctggcca ctgtggatgt tgaccccaag tctccccagt attgccaggt
      241 catccaccgg ctgcccatgc ccaacctgaa ggacgagctg catcactcag gatggaacac
      301 ctgcagcagc tgcttcggtg atagcaccaa gtcgcgcacc aagctggtgc tgcccagtct
      361 catctcctct cgcatctatg tggtggacgt gggctctgag ccccgggccc caaagctgca
      421 caaggtcatt gagcccaagg acatccatgc caagtgcgaa ctggcctttc tccacaccag
      481 ccactgcctg gccagcgggg aagtgatgat cagctccctg ggagacgtca agggcaatgg
      541 caaagggggt tttgtgctgc tggatgggga gacgttcgag gtgaagggga catgggagag
      601 acctgggggt gctgcaccgt tgggctatga cttctggtac cagcctcgac acaatgtcat
      661 gatcagcact gagtgggcag ctcccaatgt cttacgagat ggcttcaacc ccgctgatgt
      721 ggaggctgga ctgtacggga gccacttata tgtatgggac tggcagcgcc atgagattgt
      781 gcagaccctg tctctaaaag atgggcttat tcccttggag atccgcttcc tgcacaaccc
      841 agacgctgcc caaggctttg tgggctgcgc actcagctcc accatccagc gcttctacaa
      901 gaacgaggga ggtacatggt cagtggagaa ggtgatccag gtgcccccca agaaagtgaa
      961 gggctggctg ctgcccgaaa tgccaggcct gatcaccgac atcctgctct ccctggacga
     1021 ccgcttcctc tacttcagca actggctgca tggggacctg aggcagtatg acatctctga
     1081 cccacagaga ccccgcctca caggacagct cttcctcgga ggcagcattg ttaagggagg
     1141 ccctgtgcaa gtgctggagg acgaggaact aaagtcccag ccagagcccc tagtggtcaa
     1201 gggaaaacgg gtggctggag gccctcagat gatccagctc agcctggatg ggaagcgcct
     1261 ctacatcacc acgtcgctgt acagtgcctg ggacaagcag ttttaccctg atctcatcag
     1321 ggaaggctct gtgatgctgc aggttgatgt agacacagta aaaggagggc tgaagttgaa
     1381 ccccaacttc ctggtggact tcgggaagga gccccttggc ccagcccttg cccatgagct
     1441 ccgctaccct gggggcgatt gtagctctga catctggatt tgaactccac cctcatcacc
     1501 cacactccct attttgggcc ctcacttcct tggggacctg gcttcattct gctctctctt
     1561 ggcacccgac ccttggcagc atgtaccaca cagccaagct gagactgtgg caatgtgttg
     1621 agtcatatac atttactgac cactgttgct tgttgctcac tgtgctgctt ttccatgagc
     1681 tcttggaggc accaagaaat aaactcgtaa ccctgtcctt ca
//
