LOCUS       NM_000450               3875 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens selectin E (SELE), mRNA.
ACCESSION   NM_000450
VERSION     NM_000450.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Sibiya,S., Mlambo,Z.P., Mthembu,M.H., Mkhwanazi,N.P. and Naicker,T.
  TITLE     Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin
            rs1805193 Polymorphisms in African Women Living with HIV and
            Preeclampsia
  JOURNAL   Int J Mol Sci 25 (19), 10860 (2024)
   PUBMED   39409189
  REMARK    GeneRIF: Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and
            E-Selectin rs1805193 Polymorphisms in African Women Living with HIV
            and Preeclampsia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3875)
  AUTHORS   Uy,G.L., DeAngelo,D.J., Lozier,J.N., Fisher,D.M., Jonas,B.A.,
            Magnani,J.L., Becker,P.S., Lazarus,H.M. and Winkler,I.G.
  TITLE     Targeting hematologic malignancies by inhibiting E-selectin: A
            sweet spot for AML therapy?
  JOURNAL   Blood Rev 65, 101184 (2024)
   PUBMED   38493006
  REMARK    GeneRIF: Targeting hematologic malignancies by inhibiting
            E-selectin: A sweet spot for AML therapy?
            Review article
REFERENCE   3  (bases 1 to 3875)
  AUTHORS   Zheng,H., An,M., Luo,Y., Diao,X., Zhong,W., Pang,M., Lin,Y.,
            Chen,J., Li,Y., Kong,Y., Zhao,Y., Yin,Y., Ai,L., Huang,J., Chen,C.
            and Lin,T.
  TITLE     PDGFRalpha+ITGA11+ fibroblasts foster early-stage cancer
            lymphovascular invasion and lymphatic metastasis via ITGA11-SELE
            interplay
  JOURNAL   Cancer Cell 42 (4), 682-700 (2024)
   PUBMED   38428409
  REMARK    GeneRIF: PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage
            cancer lymphovascular invasion and lymphatic metastasis via
            ITGA11-SELE interplay.
REFERENCE   4  (bases 1 to 3875)
  AUTHORS   Qasim Rahman,L. and Muhammad Ghareeb,R.
  TITLE     E-selectin is associated with stable angina and myocardial
            infarction in a sample of Kurdish population
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (3), 1-6 (2024)
   PUBMED   38650162
  REMARK    GeneRIF: E-selectin is associated with stable angina and myocardial
            infarction in a sample of Kurdish population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3875)
  AUTHORS   O'Dwyer,M., Kirkham-McCarthy,L., Cerreto,M., Foa,R. and Natoni,A.
  TITLE     PSGL-1 decorated with sialyl Lewisa/x promotes high affinity
            binding of myeloma cells to P-selectin but is dispensable for
            E-selectin engagement
  JOURNAL   Sci Rep 14 (1), 1756 (2024)
   PUBMED   38243063
  REMARK    GeneRIF: PSGL-1 decorated with sialyl Lewis[a/x] promotes high
            affinity binding of myeloma cells to P-selectin but is dispensable
            for E-selectin engagement.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3875)
  AUTHORS   Ryan,U.S. and Worthington,R.E.
  TITLE     Cell-cell contact mechanisms
  JOURNAL   Curr Opin Immunol 4 (1), 33-37 (1992)
   PUBMED   1375831
  REMARK    Review article
REFERENCE   7  (bases 1 to 3875)
  AUTHORS   Collins,T., Williams,A., Johnston,G.I., Kim,J., Eddy,R., Shows,T.,
            Gimbrone,M.A. Jr. and Bevilacqua,M.P.
  TITLE     Structure and chromosomal location of the gene for
            endothelial-leukocyte adhesion molecule 1
  JOURNAL   J Biol Chem 266 (4), 2466-2473 (1991)
   PUBMED   1703529
REFERENCE   8  (bases 1 to 3875)
  AUTHORS   Phillips,M.L., Nudelman,E., Gaeta,F.C., Perez,M., Singhal,A.K.,
            Hakomori,S. and Paulson,J.C.
  TITLE     ELAM-1 mediates cell adhesion by recognition of a carbohydrate
            ligand, sialyl-Lex
  JOURNAL   Science 250 (4984), 1130-1132 (1990)
   PUBMED   1701274
REFERENCE   9  (bases 1 to 3875)
  AUTHORS   Watson,M.L., Kingsmore,S.F., Johnston,G.I., Siegelman,M.H., Le
            Beau,M.M., Lemons,R.S., Bora,N.S., Howard,T.A., Weissman,I.L.,
            McEver,R.P. et al.
  TITLE     Genomic organization of the selectin family of leukocyte adhesion
            molecules on human and mouse chromosome 1
  JOURNAL   J Exp Med 172 (1), 263-272 (1990)
   PUBMED   1694218
REFERENCE   10 (bases 1 to 3875)
  AUTHORS   Hession,C., Osborn,L., Goff,D., Chi-Rosso,G., Vassallo,C.,
            Pasek,M., Pittack,C., Tizard,R., Goelz,S., McCarthy,K. et al.
  TITLE     Endothelial leukocyte adhesion molecule 1: direct expression
            cloning and functional interactions
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1673-1677 (1990)
   PUBMED   1689848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB209354.1 and BC142711.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 13, 2008 this sequence version replaced NM_000450.1.
            
            Summary: The protein encoded by this gene is found in
            cytokine-stimulated endothelial cells and is thought to be
            responsible for the accumulation of blood leukocytes at sites of
            inflammation by mediating the adhesion of cells to the vascular
            lining. It exhibits structural features such as the presence of
            lectin- and EGF-like domains followed by short consensus repeat
            (SCR) domains that contain 6 conserved cysteine residues. These
            proteins are part of the selectin family of cell adhesion
            molecules. Adhesion molecules participate in the interaction
            between leukocytes and the endothelium and appear to be involved in
            the pathogenesis of atherosclerosis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142677.1, M30640.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333360.12/ ENSP00000331736.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB209354.1         1-13
            14-3875             BC142711.1         1-3862
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..3875
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /note="selectin E"
                     /db_xref="GeneID:6401"
                     /db_xref="HGNC:HGNC:10718"
                     /db_xref="MIM:131210"
     exon            1..109
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            110..194
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1990
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /note="leukocyte endothelial cell adhesion molecule 2;
                     endothelial adhesion molecule 1; E-selectin; ELAM-1; CD62
                     antigen-like family member E; endothelial leukocyte
                     adhesion molecule 1"
                     /codon_start=1
                     /product="E-selectin precursor"
                     /protein_id="NP_000441.2"
                     /db_xref="CCDS:CCDS1283.1"
                     /db_xref="GeneID:6401"
                     /db_xref="HGNC:HGNC:10718"
                     /db_xref="MIM:131210"
                     /translation="MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRY
                     THLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEP
                     NNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINN
                     YTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS
                     METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF
                     ELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFT
                     CEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGS
                     SCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE
                     FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSG
                     EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGL
                     SLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL"
     exon            195..578
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            579..686
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            687..872
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1058
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1247
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1436
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1625
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1802
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1910
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1932
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2005
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..3875
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="SELE"
                     /gene_synonym="CD62E; ELAM; ELAM1; ESEL; LECAM2;
                     selectin-e"
                     /note="major polyA site"
ORIGIN      
        1 agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag
       61 tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg aaagtatttc
      121 aagcctaaac ctttgggtga aaagaactct tgaagtcatg attgcttcac agtttctctc
      181 agctctcact ttggtgcttc tcattaaaga gagtggagcc tggtcttaca acacctccac
      241 ggaagctatg acttatgatg aggccagtgc ttattgtcag caaaggtaca cacacctggt
      301 tgcaattcaa aacaaagaag agattgagta cctaaactcc atattgagct attcaccaag
      361 ttattactgg attggaatca gaaaagtcaa caatgtgtgg gtctgggtag gaacccagaa
      421 acctctgaca gaagaagcca agaactgggc tccaggtgaa cccaacaata ggcaaaaaga
      481 tgaggactgc gtggagatct acatcaagag agaaaaagat gtgggcatgt ggaatgatga
      541 gaggtgcagc aagaagaagc ttgccctatg ctacacagct gcctgtacca atacatcctg
      601 cagtggccac ggtgaatgtg tagagaccat caataattac acttgcaagt gtgaccctgg
      661 cttcagtgga ctcaagtgtg agcaaattgt gaactgtaca gccctggaat cccctgagca
      721 tggaagcctg gtttgcagtc acccactggg aaacttcagc tacaattctt cctgctctat
      781 cagctgtgat aggggttacc tgccaagcag catggagacc atgcagtgta tgtcctctgg
      841 agaatggagt gctcctattc cagcctgcaa tgtggttgag tgtgatgctg tgacaaatcc
      901 agccaatggg ttcgtggaat gtttccaaaa ccctggaagc ttcccatgga acacaacctg
      961 tacatttgac tgtgaagaag gatttgaact aatgggagcc cagagccttc agtgtacctc
     1021 atctgggaat tgggacaacg agaagccaac gtgtaaagct gtgacatgca gggccgtccg
     1081 ccagcctcag aatggctctg tgaggtgcag ccattcccct gctggagagt tcaccttcaa
     1141 atcatcctgc aacttcacct gtgaggaagg cttcatgttg cagggaccag cccaggttga
     1201 atgcaccact caagggcagt ggacacagca aatcccagtt tgtgaagctt tccagtgcac
     1261 agccttgtcc aaccccgagc gaggctacat gaattgtctt cctagtgctt ctggcagttt
     1321 ccgttatggg tccagctgtg agttctcctg tgagcagggt tttgtgttga agggatccaa
     1381 aaggctccaa tgtggcccca caggggagtg ggacaacgag aagcccacat gtgaagctgt
     1441 gagatgcgat gctgtccacc agcccccgaa gggtttggtg aggtgtgctc attcccctat
     1501 tggagaattc acctacaagt cctcttgtgc cttcagctgt gaggagggat ttgaattaca
     1561 tggatcaact caacttgagt gcacatctca gggacaatgg acagaagagg ttccttcctg
     1621 ccaagtggta aaatgttcaa gcctggcagt tccgggaaag atcaacatga gctgcagtgg
     1681 ggagcccgtg tttggcactg tgtgcaagtt cgcctgtcct gaaggatgga cgctcaatgg
     1741 ctctgcagct cggacatgtg gagccacagg acactggtct ggcctgctac ctacctgtga
     1801 agctcccact gagtccaaca ttcccttggt agctggactt tctgctgctg gactctccct
     1861 cctgacatta gcaccatttc tcctctggct tcggaaatgc ttacggaaag caaagaaatt
     1921 tgttcctgcc agcagctgcc aaagccttga atcagatgga agctaccaaa agccttctta
     1981 catcctttaa gttcaaaaga atcagaaaca ggtgcatctg gggaactaga gggatacact
     2041 gaagttaaca gagacagata actctcctcg ggtctctggc ccttcttgcc tactatgcca
     2101 gatgccttta tggctgaaac cgcaacaccc atcaccactt caatagatca aagtccagca
     2161 ggcaaggacg gccttcaact gaaaagactc agtgttccct ttcctactct caggatcaag
     2221 aaagtgttgg ctaatgaagg gaaaggatat tttcttccaa gcaaaggtga agagaccaag
     2281 actctgaaat ctcagaattc cttttctaac tctcccttgc tcgctgtaaa atcttggcac
     2341 agaaacacaa tattttgtgg ctttctttct tttgcccttc acagtgtttc gacagctgat
     2401 tacacagttg ctgtcataag aatgaataat aattatccag agtttagagg aaaaaaatga
     2461 ctaaaaatat tataacttaa aaaaatgaca gatgttgaat gcccacaggc aaatgcatgg
     2521 agggttgtta atggtgcaaa tcctactgaa tgctctgtgc gagggttact atgcacaatt
     2581 taatcacttt catccctatg ggattcagtg cttcttaaag agttcttaag gattgtgata
     2641 tttttacttg cattgaatat attataatct tccatacttc ttcattcaat acaagtgtgg
     2701 tagggactta aaaaacttgt aaatgctgtc aactatgata tggtaaaagt tacttattct
     2761 agattacccc ctcattgttt attaacaaat tatgttacat ctgttttaaa tttatttcaa
     2821 aaagggaaac tattgtcccc tagcaaggca tgatgttaac cagaataaag ttctgagtgt
     2881 ttttactaca gttgtttttt gaaaacatgg tagaattgga gagtaaaaac tgaatggaag
     2941 gtttgtatat tgtcagatat tttttcagaa atatgtggtt tccacgatga aaaacttcca
     3001 tgaggccaaa cgttttgaac taataaaagc ataaatgcaa acacacaaag gtataatttt
     3061 atgaatgtct ttgttggaaa agaatacaga aagatggatg tgctttgcat tcctacaaag
     3121 atgtttgtca gatatgatat gtaaacataa ttcttgtata ttatggaaga ttttaaattc
     3181 acaatagaaa ctcaccatgt aaaagagtca tctggtagat ttttaacgaa tgaagatgtc
     3241 taatagttat tccctatttg ttttcttctg tatgttaggg tgctctggaa gagaggaatg
     3301 cctgtgtgag caagcattta tgtttattta taagcagatt taacaattcc aaaggaatct
     3361 ccagttttca gttgatcact ggcaatgaaa aattctcagt cagtaattgc caaagctgct
     3421 ctagccttga ggagtgtgag aatcaaaact ctcctacact tccattaact tagcatgtgt
     3481 tgaaaaaaaa gtttcagaga agttctggct gaacactggc aacaacaaag ccaacagtca
     3541 aaacagagat gtgataagga tcagaacagc agaggttctt ttaaaggggc agaaaaactc
     3601 tgggaaataa gagagaacaa ctactgtgat caggctatgt atggaataca gtgttatttt
     3661 ctttgaaatt gtttaagtgt tgtaaatatt tatgtaaact gcattagaaa ttagctgtgt
     3721 gaaataccag tgtggtttgt gtttgagttt tattgagaat tttaaattat aacttaaaat
     3781 attttataat ttttaaagta tatatttatt taagcttatg tcagacctat ttgacataac
     3841 actataaagg ttgacaataa atgtgcttat gttta
//
