LOCUS       NM_015187               4543 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SEL1L family member 3 (SEL1L3), transcript variant 1,
            mRNA.
ACCESSION   NM_015187 XM_045277
VERSION     NM_015187.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4543)
  AUTHORS   Wang,H., Ma,X., Li,S. and Ni,X.
  TITLE     SEL1L3 as a link molecular between renal cell carcinoma and
            atherosclerosis based on bioinformatics analysis and experimental
            verification
  JOURNAL   Aging (Albany NY) 15 (22), 13150-13162 (2023)
   PUBMED   37993256
  REMARK    GeneRIF: SEL1L3 as a link molecular between renal cell carcinoma
            and atherosclerosis based on bioinformatics analysis and
            experimental verification.
REFERENCE   2  (bases 1 to 4543)
  AUTHORS   Shen,C.Y., Chang,W.H., Chen,Y.J., Weng,C.W., Regmi,P., Kier,M.K.K.,
            Su,K.Y., Chang,G.C., Chen,J.S., Chen,Y.J. and Yu,S.L.
  TITLE     Tissue Proteogenomic Landscape Reveals the Role of Uncharacterized
            SEL1L3 in Progression and Immunotherapy Response in Lung
            Adenocarcinoma
  JOURNAL   J Proteome Res 22 (4), 1056-1070 (2023)
   PUBMED   36349894
  REMARK    GeneRIF: Tissue Proteogenomic Landscape Reveals the Role of
            Uncharacterized SEL1L3 in Progression and Immunotherapy Response in
            Lung Adenocarcinoma.
REFERENCE   3  (bases 1 to 4543)
  AUTHORS   Chalasani,N., Guo,X., Loomba,R., Goodarzi,M.O., Haritunians,T.,
            Kwon,S., Cui,J., Taylor,K.D., Wilson,L., Cummings,O.W., Chen,Y.D.
            and Rotter,J.I.
  CONSRTM   Nonalcoholic Steatohepatitis Clinical Research Network
  TITLE     Genome-wide association study identifies variants associated with
            histologic features of nonalcoholic Fatty liver disease
  JOURNAL   Gastroenterology 139 (5), 1567-1576 (2010)
   PUBMED   20708005
REFERENCE   4  (bases 1 to 4543)
  AUTHORS   Christoforou,A., Le Hellard,S., Thomson,P.A., Morris,S.W.,
            Tenesa,A., Pickard,B.S., Wray,N.R., Muir,W.J., Blackwood,D.H.,
            Porteous,D.J. and Evans,K.L.
  TITLE     Association analysis of the chromosome 4p15-p16 candidate region
            for bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 12 (11), 1011-1025 (2007)
   PUBMED   17457313
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY152163.1, DB479874.1, BC060867.1, AK289687.1 and CR749817.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015187.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060867.1, SRR1803617.258886.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399878.8/ ENSP00000382767.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                HY152163.1         46-64
            20-166              DB479874.1         20-166
            167-345             BC060867.1         2-180
            346-3710            AK289687.1         137-3501
            3711-4398           CR749817.1         3537-4224
            4399-4543           BC060867.1         4235-4379
FEATURES             Location/Qualifiers
     source          1..4543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..4543
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="SEL1L family member 3"
                     /db_xref="GeneID:23231"
                     /db_xref="HGNC:HGNC:29108"
                     /db_xref="MIM:619914"
     exon            1..314
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..3551
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein sel-1 homolog 3; suppressor of lin-12-like protein
                     3; sel-1 suppressor of lin-12-like 3"
                     /codon_start=1
                     /product="protein sel-1 homolog 3 isoform 1"
                     /protein_id="NP_056002.2"
                     /db_xref="CCDS:CCDS47037.1"
                     /db_xref="GeneID:23231"
                     /db_xref="HGNC:HGNC:29108"
                     /db_xref="MIM:619914"
                     /translation="MQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRS
                     ACALLLLCYLNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVE
                     YLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDY
                     FIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDH
                     QVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELE
                     ATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQM
                     HLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFH
                     YNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYER
                     CAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHP
                     SLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSC
                     CGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYP
                     LDWELSYAYYSNIATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKH
                     EATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKG
                     QGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDA
                     SYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGNLETFPRD
                     PEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAH
                     ICEERPDLARRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSV
                     QMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLHSNNISILQELYERCW
                     SHSNEESFSPCSLAWLYLHLRLLWGAILHSALIYFLGTFLLSILIAWTVQYFQSVSAS
                     DPPPRPSQASPDTATSTASPAVTPAADASDQDQPTVTNNPEPRG"
     exon            315..885
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1012
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1134
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1250
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1309
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1442
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1575
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1716
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1928
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2108
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2228
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2369
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2432
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2609
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2737
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2821
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2912
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2997
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3107
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3235
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3338
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3411
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..4543
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="hexamer: GATAAA"
     polyA_site      3664
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="major polyA site"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="hexamer: AATAAA"
     polyA_site      4543
                     /gene="SEL1L3"
                     /gene_synonym="Sel-1L3"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggcg gcggcgggtc cggaggtggc ggcaggtggc cccgcgcgcg gcggccggcc
       61 cggccggggg cgggcgggaa ggtggcgcct cgggcggggg ccggtccctg caccaggtga
      121 cctgttccgg cccggatccg ggcggcctcg ccatgcagcg gcgcggcgcg gggctcgggt
      181 ggccgcggca gcagcagcag caacccccgc cgctcgcggt cggcccccgg gccgcagcca
      241 tggtcccgag tggcggcgtc ccccagggcc tcggcggccg ctctgcctgc gcgctgctcc
      301 tgctctgcta cctgaatgtt gtaccatctt tgggtaggca gacttccctg acgacatcag
      361 tgatacccaa agctgagcag agcgtggctt acaaagactt tatttatttt actgtctttg
      421 aaggaaacgt tcgcaacgtt tctgaagtct cggttgagta tttatgctct cagccttgtg
      481 ttgtcaattt ggaagcagtt gtttcatctg agttcagaag tagcattccc gtgtacaaaa
      541 aaaggtggaa gaatgagaaa catcttcaca ccagcaggac acaaatagta catgtgaaat
      601 ttccaagcat tatggtttac agagatgatt atttcatcag acattccatc tctgtatctg
      661 cagtgatagt acgcgcctgg attactcaca aatacagtgg cagagactgg aatgttaaat
      721 gggaggaaaa cttgctccat gctgtagcaa agaattatac cctcctgcag accatcccgc
      781 cttttgaacg ccctttcaaa gatcatcaag tgtgccttga gtggaacatg ggttatattt
      841 ggaaccttcg ggcaaacagg attccacagt gtcctctgga aaatgatgtg gttgccctgc
      901 ttggctttcc ttatgcctcc agtggagaaa acacaggcat tgtcaagaag ttcccgaggt
      961 ttcggaaccg agagctggag gccactcgac gccagaggat ggattaccca gtgtttactg
     1021 tttcattgtg gctttattta ctccattatt gcaaggccaa cctctgtggg attctgtact
     1081 ttgttgactc taatgagatg tacggcacac cttctgtatt tcttacggaa gagggctatt
     1141 tgcatattca gatgcatctt gtcaaagggg aagaccttgc tgtaaaaact aaattcatca
     1201 tacctttgaa ggagtggttt cgactggata tctcttttaa cggaggccag atagtagtaa
     1261 ccactagcat tggacaggat ttgaaaagct accacaatca gaccattagc ttccgggagg
     1321 atttccatta taatgacaca gctgggtact tcattattgg agggagcagg tatgtggctg
     1381 gcattgaagg gttttttgga cccctgaagt actatcgcct tcgcagtctg caccccgccc
     1441 agatttttaa tcccctcctt gagaagcaac ttgctgaaca aatcaagtta tattatgaaa
     1501 ggtgtgctga ggttcaagaa atagtatctg tgtatgcatc tgcagcaaag cacgggggcg
     1561 agagacaaga agcatgccac ctccacaact cctacctgga cctccagcgc aggtatggga
     1621 gaccctcgat gtgcagagcc ttcccctggg agaaggagct gaaagacaaa caccccagct
     1681 tgttccaggc attgctggag atggatctgc tgaccgtgcc aaggaaccaa aatgaatctg
     1741 tatcagaaat cggtgggaag atatttgaga aggctgtaaa gagactctct agcattgatg
     1801 gtcttcacca aattagctct atcgtcccct ttctgacgga ttccagctgc tgtggatacc
     1861 ataaagcatc ctactacctt gcagtctttt atgagactgg attaaatgtt cctcgggatc
     1921 agctgcaggg catgttgtat agtttggttg gaggccaggg gagtgagagg ctgtcttcaa
     1981 tgaatcttgg gtataaacac taccagggta ttgacaacta ccccctggac tgggaactgt
     2041 cgtatgccta ctacagcaac attgccacca agacacccct tgaccagcac acactgcaag
     2101 gagatcaggc atatgttgaa acaattagac taaaagatga tgaaatactc aaggtacaaa
     2161 ccaaagaaga tggagatgtc tttatgtggt tgaagcatga agctacccga ggcaatgcag
     2221 cagctcagca acgattggcc cagatgctgt tctgggggca gcaaggtgtg gccaagaatc
     2281 ccgaagcagc aattgagtgg tacgccaagg gcgccctgga gacggaggat cctgcgttaa
     2341 tctatgacta tgccattgtg ctattcaagg gtcaaggagt aaaaaagaac agacggcttg
     2401 ccttagagct gatgaagaaa gcagcttcca agggattgca tcaggcagtc aatggcctgg
     2461 gatggtatta ccacaaattc aagaaaaatt acgccaaagc agcaaagtac tggttaaaag
     2521 cagaagaaat ggggaaccca gatgcgtcat acaatcttgg agtcctgcat ttggatggca
     2581 tcttccctgg agttcctgga aggaatcaaa ctttagctgg tgaatatttc cataaggctg
     2641 cgcaaggtgg acacatggaa gggaccttgt ggtgttctct ctactatatc acaggcaacc
     2701 tggagacatt ccctagagat cctgagaaag ctgttgtatg ggcaaaacat gtagctgaga
     2761 aaaatggcta cttgggccat gtcatccgca aaggcctcaa tgcctacctg gaaggttcat
     2821 ggcatgaagc tttgctgtat tatgttttag cagcagaaac tggaattgaa gtgtcacaga
     2881 caaatttagc acacatctgt gaggagaggc cagacctggc caggagatac ttgggtgtta
     2941 actgtgtttg gagatactat aatttctctg tttttcaaat cgatgctcct tcctttgcat
     3001 atttgaagat gggagacctt tactactatg gccaccaaaa ccagtcacaa gacctggagt
     3061 tgtctgtgca gatgtacgcc caagccgccc tggatggaga ctcccaggga ttttttaacc
     3121 tggccctgct aatcgaggaa ggtacgataa tcccacacca tatcttggat ttcttggaaa
     3181 ttgactcaac tctccattct aataacatct ccattctcca ggaactgtac gaaaggtgct
     3241 ggagccacag taacgaggag tccttcagcc cctgctcctt ggcctggctt tacctgcact
     3301 tgcggcttct ctggggtgct atcctgcact cagccctgat ctactttctg ggaacctttc
     3361 tgctatccat attgatcgcc tggactgtgc agtatttcca gtctgtctca gcaagcgatc
     3421 cccctccaag accatcccag gcctccccag acactgccac gtccactgca agtccagctg
     3481 tgactccagc tgcagatgcc tctgaccaag accagcccac agtaactaat aacccggagc
     3541 cacgtgggtg aactgtgcac tccagttctc tccagatgag agagaatctt ttcaacagct
     3601 ggtattggga agctggggcc agggcatgat cctgataaac accttaaatg tcttgtcaac
     3661 tggatgcaaa ttttgcaatt ggtgtcattt tttttaaagt caaattacaa ggaagtaccc
     3721 agatcaggca gtggtaatac caaaggtcat caaacacata caaggaacat cttgatcata
     3781 gggcatgtgg ggaagtttac tgggccatca cagacttttg ttctagtgat tgtatgtatt
     3841 aggagtcata gcatgcccta cggcagatct ggattcttat acactaagat gtgtcttaag
     3901 aatcacagtg cgtgcttcat ccctttattg aagaacagaa aattatgact actctacaag
     3961 gtggataata ttttggtacc tgtgcttgcc acagccctgt tcctcaaagc tgaattgata
     4021 gatttctctt tgacttccaa gacctagcag ttataaggca ccttgaaata aattgtttgt
     4081 gcctggaaat gcagggaggg caatagcttt gtaaattggt ttacattttt ctccttgaat
     4141 ttttctaggg tcctagtgct tccgaatcat ttaatggcat tgtcggatat cttttacatt
     4201 tcaattgcaa tccatgaaat tacatttaga agattcttag tacttaactg tagtcttctc
     4261 catgaattac acgttagaat agactggcag caacggaata tgcagcaagt aagcctctag
     4321 cttatagttt catccctacc cctcatgcct gcgtgagtct gtacagggat atgtgtgtgt
     4381 gtgtgtgtgt gtgtgtgtta gagaggaaga ggaagagcag aatgtctgta tactacatgc
     4441 tgctaaggta gtgaataaat cagtaatgca atattgtggg tccaaactac tctttgcact
     4501 actttattta cagtagtaaa taaaattatt tttatacaat tga
//
