LOCUS       NM_005065               7919 bp    mRNA    linear   PRI 03-FEB-2025
DEFINITION  Homo sapiens SEL1L adaptor subunit of SYVN1 ubiquitin ligase
            (SEL1L), transcript variant 1, mRNA.
ACCESSION   NM_005065
VERSION     NM_005065.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7919)
  AUTHORS   Song,Z., Thepsuwan,P., Hur,W.S., Torres,M., Wu,S.A., Wei,X.,
            Tushi,N.J., Wei,J., Ferraresso,F., Paton,A.W., Paton,J.C.,
            Zheng,Z., Zhang,K., Fang,D., Kastrup,C.J., Jaiman,S., Flick,M.J.
            and Sun,S.
  TITLE     Regulation of hepatic inclusions and fibrinogen biogenesis by
            SEL1L-HRD1 ERAD
  JOURNAL   Nat Commun 15 (1), 9244 (2024)
   PUBMED   39455574
  REMARK    GeneRIF: Regulation of hepatic inclusions and fibrinogen biogenesis
            by SEL1L-HRD1 ERAD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7919)
  AUTHORS   Correa-Medero,L.O., Jankowski,S.E., Hong,H.S., Armas,N.D.,
            Vijendra,A.I., Reynolds,M.B., Fogo,G.M., Awad,D., Dils,A.T.,
            Inoki,K.A., Williams,R.G., Ye,A.M., Svezhova,N., Gomez-Rivera,F.,
            Collins,K.L., O'Riordan,M.X., Sanderson,T.H., Lyssiotis,C.A. and
            Carty,S.A.
  TITLE     ER-associated degradation adapter Sel1L is required for CD8+ T cell
            function and memory formation following acute viral infection
  JOURNAL   Cell Rep 43 (5), 114156 (2024)
   PUBMED   38687642
  REMARK    GeneRIF: ER-associated degradation adapter Sel1L is required for
            CD8[+] T cell function and memory formation following acute viral
            infection.
REFERENCE   3  (bases 1 to 7919)
  AUTHORS   Podolsky,M.J., Kheyfets,B., Pandey,M., Beigh,A.H., Yang,C.D.,
            Lizama,C.O., Datta,R., Lin,L.L., Wang,Z., Wolters,P.J.,
            McManus,M.T., Qi,L. and Atabai,K.
  TITLE     Genome-wide screens identify SEL1L as an intracellular rheostat
            controlling collagen turnover
  JOURNAL   Nat Commun 15 (1), 1531 (2024)
   PUBMED   38378719
  REMARK    GeneRIF: Genome-wide screens identify SEL1L as an intracellular
            rheostat controlling collagen turnover.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7919)
  AUTHORS   Umphred-Wilson,K. and Adoro,S.
  TITLE     Hypomorphic human SEL1L and HRD1 variants uncouple multilayered
            ER-associated degradation machinery
  JOURNAL   J Clin Invest 134 (2), e175448 (2024)
   PUBMED   38226624
  REMARK    GeneRIF: Hypomorphic human SEL1L and HRD1 variants uncouple
            multilayered ER-associated degradation machinery.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7919)
  AUTHORS   Wang,H.H., Lin,L.L., Li,Z.J., Wei,X., Askander,O., Cappuccio,G.,
            Hashem,M.O., Hubert,L., Munnich,A., Alqahtani,M., Pang,Q.,
            Burmeister,M., Lu,Y., Poirier,K., Besmond,C., Sun,S.,
            Brunetti-Pierri,N., Alkuraya,F.S. and Qi,L.
  TITLE     Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are
            associated with neurodevelopmental disorders
  JOURNAL   J Clin Invest 134 (2), e170054 (2024)
   PUBMED   37943610
  REMARK    GeneRIF: Hypomorphic variants of SEL1L-HRD1 ER-associated
            degradation are associated with neurodevelopmental disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7919)
  AUTHORS   Donoviel,D.B. and Bernstein,A.
  TITLE     SEL-1L maps to human chromosome 14, near the insulin-dependent
            diabetes mellitus locus 11
  JOURNAL   Genomics 56 (2), 232-233 (1999)
   PUBMED   10051412
REFERENCE   7  (bases 1 to 7919)
  AUTHORS   Harada,Y., Ozaki,K., Suzuki,M., Fujiwara,T., Takahashi,E.,
            Nakamura,Y. and Tanigami,A.
  TITLE     Complete cDNA sequence and genomic organization of a human
            pancreas-specific gene homologous to Caenorhabditis elegans sel-1
  JOURNAL   J Hum Genet 44 (5), 330-336 (1999)
   PUBMED   10496078
REFERENCE   8  (bases 1 to 7919)
  AUTHORS   Donoviel,D.B., Donoviel,M.S., Fan,E., Hadjantonakis,A. and
            Bernstein,A.
  TITLE     Cloning and characterization of Sel-1l, a murine homolog of the C.
            elegans sel-1 gene
  JOURNAL   Mech Dev 78 (1-2), 203-207 (1998)
   PUBMED   9858735
REFERENCE   9  (bases 1 to 7919)
  AUTHORS   Biunno,I., Appierto,V., Cattaneo,M., Leone,B.E., Balzano,G.,
            Socci,C., Saccone,S., Letizia,A., Della Valle,G. and Sgaramella,V.
  TITLE     Isolation of a pancreas-specific gene located on human chromosome
            14q31: expression analysis in human pancreatic ductal carcinomas
  JOURNAL   Genomics 46 (2), 284-286 (1997)
   PUBMED   9417916
REFERENCE   10 (bases 1 to 7919)
  AUTHORS   Ahmed,M., Khan,A.H., Mansoor,A., Khan,M.A. and Saeed,S.
  TITLE     Burkitt's lymphoma--a study of 50 consecutive cases
  JOURNAL   J Pak Med Assoc 43 (8), 151-153 (1993)
   PUBMED   8264092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP358857.1, AB020335.1,
            AF052059.1, BC040498.1, ES313707.1, DA833312.1, DA351814.1,
            CB986742.1 and CA447094.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005065.5.
            
            Summary: The protein encoded by this gene is part of a protein
            complex required for the retrotranslocation or dislocation of
            misfolded proteins from the endoplasmic reticulum lumen to the
            cytosol, where they are degraded by the proteasome in a
            ubiquitin-dependent manner. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.251455.1,
                                           SRR1803614.1215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336735.9/ ENSP00000337053.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BP358857.1         9-72
            65-2716             AB020335.1         1-2652
            2717-3436           AF052059.1         2701-3420
            3437-3966           BC040498.1         1533-2062
            3967-4396           AB020335.1         3911-4340
            4397-4661           ES313707.1         233-497
            4662-5142           DA833312.1         108-588
            5143-6571           BC040498.1         3237-4665
            6572-6846           DA351814.1         277-551
            6847-7326           CB986742.1         86-565
            7327-7917           AB020335.1         7295-7885
            7918-7919           CA447094.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..7919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.1"
     gene            1..7919
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="SEL1L adaptor subunit of SYVN1 ubiquitin ligase"
                     /db_xref="GeneID:6400"
                     /db_xref="HGNC:HGNC:10717"
                     /db_xref="MIM:602329"
     exon            1..179
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2494
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Suppressor of lin 12 (sel-1), C. elegans,
                     homolog of; sel-1 suppressor of lin-12-like 1; suppressor
                     of lin-12-like protein 1; SEL1L, ERAD E3 ligase adaptor
                     subunit; SEL1L adaptor subunit of ERAD E3 ubiquitin
                     ligase"
                     /codon_start=1
                     /product="protein sel-1 homolog 1 isoform 1 precursor"
                     /protein_id="NP_005056.3"
                     /db_xref="CCDS:CCDS9876.1"
                     /db_xref="GeneID:6400"
                     /db_xref="HGNC:HGNC:10717"
                     /db_xref="MIM:602329"
                     /translation="MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDES
                     VKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENK
                     DYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYK
                     ADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNH
                     TKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQA
                     KALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGG
                     SVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQ
                     NHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQ
                     SGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALK
                     YFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSY
                     KDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQ
                     GYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQ
                     DIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQLDMDQLLG
                     PEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPAPPQQEGPPEQQPPQ"
     exon            180..217
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..449
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..617
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..723
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..886
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..940
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1000
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1082
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1237
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1294
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1363
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1441
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1504
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1592
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1741
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1907
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1982
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2155
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2284
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..7919
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6524..6529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="hexamer: AATAAA"
     polyA_site      6546
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="major polyA site"
     regulatory      6560..6565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="hexamer: AATATA"
     polyA_site      6575
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
     regulatory      7810..7815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="hexamer: ATTAAA"
     polyA_site      7833
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
     regulatory      7900..7905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /note="hexamer: AATAAT"
     polyA_site      7919
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
ORIGIN      
        1 aggagactag agcaggaaga gcagcggcga ggcggcggtg gtggctgagt ccgtggtggc
       61 agaggcgaag gcgacagctc taggggttgg caccggcccc gagaggagga tgcgggtccg
      121 gatagggctg acgctgctgc tgtgtgcggt gctgctgagc ttggcctcgg cgtcctcgga
      181 tgaagaaggc agccaggatg aatccttaga ttccaagact actttgacat cagatgagtc
      241 agtaaaggac catactactg caggcagagt agttgctggt caaatatttc ttgattcaga
      301 agaatctgaa ttagaatcct ctattcaaga agaggaagac agcctcaaga gccaagaggg
      361 ggaaagtgtc acagaagata tcagctttct agagtctcca aatccagaaa acaaggacta
      421 tgaagagcca aagaaagtac ggaaaccagc tttgaccgcc attgaaggca cagcacatgg
      481 ggagccctgc cacttccctt ttcttttcct agataaggag tatgatgaat gtacatcaga
      541 tgggagggaa gatggcagac tgtggtgtgc tacaacctat gactacaaag cagatgaaaa
      601 gtggggcttt tgtgaaactg aagaagaggc tgctaagaga cggcagatgc aggaagcaga
      661 aatgatgtat caaactggaa tgaaaatcct taatggaagc aataagaaaa gccaaaaaag
      721 agaagcatat cggtatctcc aaaaggcagc aagcatgaac cataccaaag ccctggagag
      781 agtgtcatat gctcttttat ttggtgatta cttgccacag aatatccagg cagcgagaga
      841 gatgtttgag aagctgactg aggaaggctc tcccaaggga cagactgctc ttggctttct
      901 gtatgcctct ggacttggtg ttaattcaag tcaggcaaag gctcttgtat attatacatt
      961 tggagctctt gggggcaatc taatagccca catggttttg ggttacagat actgggctgg
     1021 catcggcgtc ctccagagtt gtgaatctgc cctgactcac tatcgtcttg ttgccaatca
     1081 tgttgctagt gatatctcgc taacaggagg ctcagtagta cagagaatac ggctgcctga
     1141 tgaagtggaa aatccaggaa tgaacagtgg aatgctagaa gaagatttga ttcaatatta
     1201 ccagttccta gctgaaaaag gtgatgtaca agcacaggtt ggtcttggac aactgcacct
     1261 gcacggaggg cgtggagtag aacagaatca tcagagagca tttgactact tcaatttagc
     1321 agcaaatgct ggcaattcac atgccatggc ctttttggga aagatgtatt cggaaggaag
     1381 tgacattgta cctcagagta atgagacagc tctccactac tttaagaaag ctgctgacat
     1441 gggcaaccca gttggacaga gtgggcttgg aatggcctac ctctatggga gaggagttca
     1501 agttaattat gatctagccc ttaagtattt ccagaaagct gctgaacaag gctgggtgga
     1561 tgggcagcta cagcttggtt ccatgtacta taatggcatt ggagtcaaga gagattataa
     1621 acaggccttg aagtatttta atttagcttc tcagggaggc catatcttgg ctttctataa
     1681 cctagctcag atgcatgcca gtggcaccgg cgtgatgcga tcatgtcaca ctgcagtgga
     1741 gttgtttaag aatgtatgtg aacgaggccg ttggtctgaa aggcttatga ctgcctataa
     1801 cagctataaa gatggcgatt acaatgctgc agtgatccag tacctcctcc tggctgaaca
     1861 gggctatgaa gtggcacaaa gcaatgcagc ctttattctt gatcagagag aagcaagcat
     1921 tgtaggtgag aatgaaactt atcccagagc tttgctacat tggaacaggg ccgcctctca
     1981 aggctatact gtggctagaa ttaagctcgg agactaccat ttctatgggt ttggcaccga
     2041 tgtagattat gaaactgcat ttattcatta ccgtctggct tctgagcagc aacacagtgc
     2101 acaagctatg tttaatctgg gatatatgca tgagaaagga ctgggcatta aacaggatat
     2161 tcaccttgcg aaacgttttt atgacatggc agctgaagcc agcccagatg cacaagttcc
     2221 agtcttccta gccctctgca aattgggcgt cgtctatttc ttgcagtaca tacgggaaac
     2281 aaacattcga gatatgttca cccaacttga tatggaccag cttttgggac ctgagtggga
     2341 cctttacctc atgaccatca ttgcgctgct gttgggaaca gtcatagctt acaggcaaag
     2401 gcagcaccaa gacatgcctg cacccaggcc tccagggcca cggccagctc caccccagca
     2461 ggaggggcca ccagagcagc agccaccaca gtaataggca ctgggtccag ccttgatcag
     2521 tgacagcgaa ggaagttatc tgctgggaac acttgcattt gatttaggac cttggatcag
     2581 tggtcacctc ccagaagagg cacggcacaa ggaagcattg aattcctaaa gctgcttaga
     2641 atctgatgcc tttattttca gggataagta actcttacct aaactgagct gaatgtttgt
     2701 ttcagtgcca tatggaataa caactttcag tggctttttt ttttcttttc tggaaacata
     2761 tgtgagacac tcagagtaat gtctactgta tccagctatc tttcttggat ccttttggtc
     2821 attatttcag tgtgcataag ttcttaatgt caaccatctt taaggtattg tgcatcgaca
     2881 ctaaaaactg atcagtgtaa aaaggaaaac ccagttgcaa gtttaaacgt gttcgaaagt
     2941 ctgaaaatag aacttgcctt ttaagttaaa aaaaaaaaaa gctatcttga aaatgttttg
     3001 gaactgcgat aactgagaaa ctcttaccag tccacatgca attagacata ttcagcatat
     3061 ttgttatttt aaaagggagg gttgggaggt ttcttattgg tgattgtcac acggtatacc
     3121 atactcctct ccttcaaaga atgaaaggcc ttgttaagga gttttttgtg agctttactt
     3181 ctttggaatg gaatatactt atgcaaaacc ttgtgaactg actccttgca ctaacgcgag
     3241 tttgccccac ctactctgta atttgcttgt ttgttttgaa tatacagagc cttgatccag
     3301 aagccagagg atggactaag tgggagaaat tagaaaacaa aacgaactct ggttggggta
     3361 ctacgatcac agacacagac atacttttcc taaagttgaa gcatttgttc ccaggattta
     3421 ttttactttg catttctttt tgcacaaaga acacatcacc ttcctgaatt ctttaaatat
     3481 gaaatatcat tgccagggta tggcttacag tgactactat tataatacta aaactcagag
     3541 aatcaaagat ggattaaact cagtggttga tgaaagccaa aacctgtttg tactgttcta
     3601 tactattcag gtatcttttt atttctgata gttttatatt ataatagaaa gccagccact
     3661 gcttagctat catagtcacc attttctcac tgttaacatt aggaaaatca aggctactat
     3721 gcttcaggat tgtctggtta aatagtatgg gaaaaaaact gaagagtttc acataattac
     3781 acacgtgaaa taattaaagc ttaaactgaa tttgtatttc attttattgt cagatggtgg
     3841 tgttcaccag cctgtatctt gtctgagact gcattcgtat ctgagcaggt tttctatgcc
     3901 tactgatgtc agtatgttta tactaacctt catgcttttt tcccagaatc cctcatctgc
     3961 cagaaaactt gaaaagttta ttgcttgtag agttgtactg ctttgatttt tgaagttggg
     4021 gtagtagtta gaactagatt taactagtct ataatgaaca tgaaggcttt tatatatgaa
     4081 gttgtatacc tttttgtgtt tagagaatta tgggaaacct ggtaagcaaa actttcctcc
     4141 cagataattg cttccaaatt cgaagagtta gtcaccaaga gagccatatg tatgaaagcg
     4201 tatctgtgaa aggtaggaaa cttacccccc ctaagtgtaa tgttgcttta ggcaactctt
     4261 gtaaatagtg agacttgttt ggtctcttac atgtagagat ttgagtgcag ttggtacagt
     4321 actttggtgt ctccaccact gtcccttctc cccgcttcaa aataagtgta atccacggta
     4381 gcagccacac ttcctttaga aggaactgtt ataatttatt taaaagttga aaaaccaccc
     4441 aagatgacta ccaactttca cttttttctt ctgccatcca ccctcatttt tcctttagca
     4501 agatttttat atctaacttt ccttccctcc attgagtacg tgctttgaga aaacatttct
     4561 taaaacagtg tgtgccacct aaggctggat gggaaagtgc agtcttgttg ttcatataaa
     4621 aacacacttc ttattagttt accacttgcc tttttctatt gttaatgttc tgaatttcct
     4681 tttcttggct tgtttctact tcattttacc ctgggtcact tgctgccagc agtttgtgaa
     4741 tggtgtcttt caaataactt agttcttatg gcttcactta aagactgtct caaaaatact
     4801 ttgctctctt cttctttttt gttcatggga catggtacct aagcaaatag gagttgggtt
     4861 tggtttttct cctaaaataa tgctcaatac ttacctaatc aaatggcatc catttgaata
     4921 aaatgacaat aactaaagct agttaatgtc agtgacatta aactaactcc aggattcagg
     4981 agttttaatg ttagaattta gatttaacag atagagtgtg gcttcatttg tccatggtag
     5041 cccatctctc ctaagacctt ttctagtctg tcttcctgcc ttcgaacttg atgacagtaa
     5101 aaccctgttt agtattctct tgtgcatttg gtttgttggt tagccgactg tcttgaaact
     5161 attcattttg cttctagttt tattttacag aggtagcatt ggtgggtttt tttttttttt
     5221 tctgtctctg tgtttgaagt ttcagtttct gttttctagg taaggcttat ttttgattag
     5281 cagtcaatgg caaagaaaaa gtaaatcaaa gatgacttct tttcaaaatg tattgtttag
     5341 cacttaactc agatgaattt ataaattatt aatcttgata ctaaggattt gttacttttt
     5401 tgcatattag gttaattttt accttacatg tgagagtctt accactaagc cattctgtct
     5461 ctgtactgtt gggaagtttt ggaaacccct gccagtgatc tggtgatgat ctgatgattt
     5521 atttaaagag ccgttgatgc ctccaggaaa cttaagtatt ttattaatat atatatagga
     5581 attttttttt attttgcttt gtctttctct cccttctttt atcctcatgt tcattcttca
     5641 aaccagtgtt ttggaagtat gcatgcaggc ctataaatga aaaacacaat tctttatgtg
     5701 tatagcatgt gtattaatgt ctaactacat acgcaaaaac ttcctttaca gaggttcgga
     5761 ctaacatttc acatgcacat ttcaaaacaa gatgtgtcat gaaaacagcc cctttacctg
     5821 ccaagacaag cagggctata tttcagtgac agctgatatt tgttttgaaa gtgaatctca
     5881 taatatatat atgtattaca cattattatg actagaagta tgtaagaaat gatcagaaca
     5941 aaagaaaatt tctattttca tgcaaatatt tttcatcagt catcactctc aaatataaat
     6001 taaaatataa cactcctgaa tgcctgaggc acgatctgga ttttaaatgt gtggtattca
     6061 ttgaaaagaa gctctccacc cacttggtat ttcaagaaaa tttaaaacga tcccaaggaa
     6121 agatgatttg tatgttaaag tgactgcaca agtaaaagtc caatgttgtg tgcatgaaaa
     6181 ggattccttg gttatgtgca gggaatcatc tcacatgctg tttttcctat ttggtttgag
     6241 aaacaggctg acactattct ctttgattag aaaataaact cataaaactc ataatgttga
     6301 tataatcaag atgtaaccac tataaatatg tagaagagga agttttaaaa gaccttaagc
     6361 tggcattgtg aaggaacacc atggtagact ctttttgtaa atgtattttg tatttaatga
     6421 aatgcagtat aaaggttggt gaagtgtaat ataattgtgt aaacaaatcc tgttaataga
     6481 gagatgtaca gaatcgtttt gtactgtatc ttgaaacttg tgaaataaag attccacctc
     6541 tggttatcct gtatgctgta atataccaca accaagcacc tttccagaca gacttttttt
     6601 aagctgaatg attcaatttt ttaatgtttt ttggaaattc agaagcttct gaaaacattc
     6661 acttgtggca atttgaattt atctttcatt ttaaactcct gaaattcaga tttttacaag
     6721 tccaatattg ccctagggag aacatgaatt tgctaagaaa tgttatcttt taaatctctg
     6781 atatctttgt cttgaagcag ccttgatatg tagtaagcgt gattcacttt agcctgatta
     6841 taatattatt tatctaaagt ttgtttatgc attgccttgt cccaggaatt ttttaagagg
     6901 acttgcagag acacgtacca cacagtaaca tttagactaa atatgctctg agtaaaggag
     6961 aaatgaaaaa atattaaatc aagagtgaac atgtacacaa agtgcaattg gaagtgggct
     7021 acaaatttgg cccccagctt cccagcaggc aactcaaaga ggtaactgag gtaaaatgtt
     7081 ccagctcaga agcattggat cttggataaa aagcctacat gatgcaaact gtggcaactg
     7141 agatgtcaga tctcaagatc tcaaattgta cttgtgggag cacagtcagt gaccccagat
     7201 gaccttgact gacctaaaag ttgtggggga agtcggatgt cagagcctta acaccagcag
     7261 gtgaccatcc aacctggggc aatgcctgcc tgttcaccac ttagcctctt tctggcaagt
     7321 cattagaatg tcctccatct tcattggctg caacttgatg agctacagcc tctttcctaa
     7381 cttcctttat gatgctagtt taggttggtt ataccagctt ggaagtatgc ttagattaag
     7441 ttacagcaga tacacaaatt agatgcaagt aaaaaaaatc agaatttctg tagtagaaac
     7501 tacgaaaaat aaaaaggaaa gtttttactt tttgggtatt tttttacgaa taagaaaaag
     7561 tgagcgttaa tcagttcaaa aggaggtact gctgtgtaat gggctttgta cgttccttct
     7621 catgtcactt acgtcactac ttcgccatca aattgaacaa gcttttaatt agatcctgaa
     7681 aattcactat gctagtagtt tattggtagt attatatttt gagtagaact ctgattttcc
     7741 ctagaggcca aattcttttt atctgggtta atttctttta aacataacaa tgttaatgct
     7801 gaattgtata ttaaatccca tttctaaaaa ccacacaatt ttttctcatg taagttgagt
     7861 ggaatgtggt tagttaactg aatttggaat gttcatataa ataatttgtt gctgctcaa
//
