LOCUS       NM_003004               2003 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens secreted and transmembrane 1 (SECTM1), mRNA.
ACCESSION   NM_003004
VERSION     NM_003004.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Yao,Z., Zhang,F., Qi,C., Wang,C., Mao,M., Zhao,C., Qi,M., Wang,Z.,
            Zhou,G., Jiang,X. and Xia,H.
  TITLE     SECTM1 promotes the development of glioblastoma and mesenchymal
            transition by regulating the TGFbeta1/Smad signaling pathway
  JOURNAL   Int J Biol Sci 20 (1), 78-93 (2024)
   PUBMED   38164182
  REMARK    GeneRIF: SECTM1 promotes the development of glioblastoma and
            mesenchymal transition by regulating the TGFbeta1/Smad signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Wang,T., Ge,Y., Xiao,M., Lopez-Coral,A., Li,L., Roesch,A.,
            Huang,C., Alexander,P., Vogt,T., Xu,X., Hwang,W.T., Lieu,M.,
            Belser,E., Liu,R., Somasundaram,R., Herlyn,M. and Kaufman,R.E.
  TITLE     SECTM1 produced by tumor cells attracts human monocytes via
            CD7-mediated activation of the PI3K pathway
  JOURNAL   J Invest Dermatol 134 (4), 1108-1118 (2014)
   PUBMED   24157461
  REMARK    GeneRIF: CD7 is present on monocytes and tumor macrophages and its
            ligand, SECTM1, is frequently expressed in corresponding melanoma
            tissues
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Bade-Doding,C., Gottmann,W., Baigger,A., Farren,M., Lee,K.P.,
            Blasczyk,R. and Huyton,T.
  TITLE     Autocrine GM-CSF transcription in the leukemic progenitor cell line
            KG1a is mediated by the transcription factor ETS1 and is negatively
            regulated through SECTM1 mediated ligation of CD7
  JOURNAL   Biochim Biophys Acta 1840 (3), 1004-1013 (2014)
   PUBMED   24211252
  REMARK    GeneRIF: SECTM1 secreted from bone marrow stromal cells may
            interact with CD7 to influence GM-CSF expression in leukemic cells.
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Wang,T., Huang,C., Lopez-Coral,A., Slentz-Kesler,K.A., Xiao,M.,
            Wherry,E.J. and Kaufman,R.E.
  TITLE     K12/SECTM1, an interferon-gamma regulated molecule, synergizes with
            CD28 to costimulate human T cell proliferation
  JOURNAL   J Leukoc Biol 91 (3), 449-459 (2012)
   PUBMED   22184754
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Lyman,S.D., Escobar,S., Rousseau,A.M., Armstrong,A. and
            Fanslow,W.C.
  TITLE     Identification of CD7 as a cognate of the human K12 (SECTM1)
            protein
  JOURNAL   J Biol Chem 275 (5), 3431-3437 (2000)
   PUBMED   10652336
REFERENCE   10 (bases 1 to 2003)
  AUTHORS   Slentz-Kesler,K.A., Hale,L.P. and Kaufman,R.E.
  TITLE     Identification and characterization of K12 (SECTM1), a novel human
            gene that encodes a Golgi-associated protein with transmembrane and
            secreted isoforms
  JOURNAL   Genomics 47 (3), 327-340 (1998)
   PUBMED   9480746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA589733.1, U77643.1,
            BI861812.1 and AC132872.17.
            
            On May 17, 2019 this sequence version replaced NM_003004.2.
            
            Summary: This gene encodes a transmembrane and secreted protein
            with characteristics of a type 1a transmembrane protein. It is
            found in a perinuclear Golgi-like pattern and thought to be
            involved in hematopoietic and/or immune system processes. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77643.1, SRR3476690.965940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269389.8/ ENSP00000269389.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA589733.1         280-280
            2-522               U77643.1           1-521
            523-998             BI861812.1         223-698
            999-2003            AC132872.17        24049-25053
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2003
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="secreted and transmembrane 1"
                     /db_xref="GeneID:6398"
                     /db_xref="HGNC:HGNC:10707"
                     /db_xref="MIM:602602"
     exon            1..67
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /inference="alignment:Splign:2.1.0"
     exon            68..213
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..866
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="type 1a transmembrane protein; secreted and
                     transmembrane protein 1"
                     /codon_start=1
                     /product="secreted and transmembrane protein 1 precursor"
                     /protein_id="NP_002995.1"
                     /db_xref="CCDS:CCDS11808.1"
                     /db_xref="GeneID:6398"
                     /db_xref="HGNC:HGNC:10707"
                     /db_xref="MIM:602602"
                     /translation="MQTCPLAFPGHVSQALGTLLFLAASLSAQNEGWDSPICTEGVVS
                     VSWGENTVMSCNISNAFSHVNIKLRAHGQESAIFNEVAPGYFSRDGWQLQVQGGVAQL
                     VIKGARDSHAGLYMWHLVGHQRNNRQVTLEVSGAEPQSAPDTGFWPVPAVVTAVFILL
                     VALVMFAWYRCRCSQQRREKKFFLLEPQMKVAALRAGAQQGLSRASAELWTPDSEPTP
                     RPLALVFKPSPLGALELLSPQPLFPYAADP"
     exon            214..522
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /inference="alignment:Splign:2.1.0"
     exon            523..656
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2003
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="hexamer: AACAAA"
     polyA_site      1731
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="major polyA site"
     regulatory      1762..1767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="hexamer: AACAAA"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
                     /note="hexamer: AAGAAA"
     polyA_site      1776
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
     polyA_site      1780
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
     polyA_site      1811
                     /gene="SECTM1"
                     /gene_synonym="K12; SECTM"
ORIGIN      
        1 cattttcctg gggctccggg gcgcggagaa gctgcatccc agaggagcgc gtccaggagc
       61 ggacccggga gtgtttcaag agccagtgac aaggaccagg ggcccaagtc ccaccagcca
      121 tgcagacctg ccccctggca ttccctggcc acgtttccca ggcccttggg accctcctgt
      181 ttttggctgc ctccttgagt gctcagaatg aaggctggga cagccccatc tgcacagagg
      241 gggtagtctc tgtgtcttgg ggcgagaaca ccgtcatgtc ctgcaacatc tccaacgcct
      301 tctcccatgt caacatcaag ctgcgtgccc acgggcagga gagcgccatc ttcaatgagg
      361 tggctccagg ctacttctcc cgggacggct ggcagctcca ggttcaggga ggcgtggcac
      421 agctggtgat caaaggcgcc cgggactccc atgctgggct gtacatgtgg cacctcgtgg
      481 gacaccagag aaataacaga caagtcacgc tggaggtttc aggtgcagaa ccccagtccg
      541 cccccgacac tgggttctgg cctgtgccag cggtggtcac tgctgtcttc atcctcttgg
      601 tcgctctggt catgttcgcc tggtacaggt gccgctgttc ccagcaacgc cgggagaaga
      661 agttcttcct cctagaaccc cagatgaagg tcgcagccct cagagcggga gcccagcagg
      721 gcctgagcag agcctccgct gaactgtgga ccccagactc cgagcccacc ccaaggccgc
      781 tggcactggt gttcaaaccc tcaccacttg gagccctgga gctgctgtcc ccccaaccct
      841 tgtttccata tgccgcagac ccatagccgc ctgcaaggca gagaggacac aggagagcca
      901 gccctgagtg ccgaccttgg gtggcggggc ctgggtctct cgtcccaccc ggagggcaca
      961 gacaccggct tgcttggcag gctgggcctc tgtgtcaccc actcctgggt gcgtgcagac
     1021 ccttcccctc caccccccag gtcttccaag ctctgcttcc tcagtttcca aaatggaacc
     1081 acctcacctc cgcagcaccc gacttaccag gacgcatgcc cctccctctg ccctcatcaa
     1141 acccacagac ccggactccc tttctgccac cccaggctgg tccggcccca ggtgtggggt
     1201 ccgctctctc cactcccagg gctccgcgcc caagtgaggg ggcccctgcc ggagcctcag
     1261 acacactcca gttcagggct gtggggggcc ttggccacat acctgtccct tggctatgag
     1321 caggctttgg gggcccttcc gcggcagccc cgggggccga ggtagggtcg ggggcttaga
     1381 ggctgggatg gctcctggcc ccaccgccag ggggcagcgc aggccgggct gggaggcggc
     1441 ggcggcggct cgggctgggg ggtcaggtgg acgccgccct ccggggctgg acgcgcatcc
     1501 ctcagtccct cggccacccg ggggtcgctc cctcgtgccc accgcacctg ccgagcctct
     1561 ttggacccag atctgttcat gcttttgtct tcgtcactgc ggcggggccc tttgatgtct
     1621 tcatctgtat ggggtggaaa aatcaccggg aatccccctt cagttctttg aaaaagttcc
     1681 atgactcgaa tatctgaaat gaagaaaaca aaccgactca caaacctcca agtagctcca
     1741 aatgcaattt ttaaaatgga aaacaaaaat ctgaaagaaa cgtctttagt ggctttaagc
     1801 cccaaaacgt ccctaaggcg tcctcgagat gaagacgggg gggagccccc agccaggtgg
     1861 agaccccgca gggacgcggc ggcgcccggt gaccgaggcc tcgcacagcc ggccgccctg
     1921 agggtcgggc cggagccagg gtccaagagg ggcgcgtttg tgtctcgggt taaaataagg
     1981 ttccgtccgc gtgctgggtc aga
//
