LOCUS       NM_024077               3481 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens SECIS binding protein 2 (SECISBP2), transcript variant
            1, mRNA.
ACCESSION   NM_024077
VERSION     NM_024077.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Hilal,T., Killam,B.Y., Grozdanovic,M., Dobosz-Bartoszek,M.,
            Loerke,J., Burger,J., Mielke,T., Copeland,P.R., Simonovic,M. and
            Spahn,C.M.T.
  TITLE     Structure of the mammalian ribosome as it decodes the
            selenocysteine UGA codon
  JOURNAL   Science 376 (6599), 1338-1343 (2022)
   PUBMED   35709277
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Schoenmakers,E. and Chatterjee,K.
  TITLE     Human Genetic Disorders Resulting in Systemic Selenoprotein
            Deficiency
  JOURNAL   Int J Mol Sci 22 (23), 12927 (2021)
   PUBMED   34884733
  REMARK    GeneRIF: Human Genetic Disorders Resulting in Systemic
            Selenoprotein Deficiency.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Taguchi,T., Kurata,M., Onishi,I., Kinowaki,Y., Sato,Y., Shiono,S.,
            Ishibashi,S., Ikeda,M., Yamamoto,M., Kitagawa,M. and Yamamoto,K.
  TITLE     SECISBP2 is a novel prognostic predictor that regulates
            selenoproteins in diffuse large B-cell lymphoma
  JOURNAL   Lab Invest 101 (2), 218-227 (2021)
   PUBMED   33077808
  REMARK    GeneRIF: SECISBP2 is a novel prognostic predictor that regulates
            selenoproteins in diffuse large B-cell lymphoma.
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Papp,L.V., Wang,J., Kennedy,D., Boucher,D., Zhang,Y.,
            Gladyshev,V.N., Singh,R.N. and Khanna,K.K.
  TITLE     Functional characterization of alternatively spliced human SECISBP2
            transcript variants
  JOURNAL   Nucleic Acids Res 36 (22), 7192-7206 (2008)
   PUBMED   19004874
  REMARK    GeneRIF: A report of a complex splicing pattern in the 5'-region of
            human SECISBP2, wherein at least eight splice variants encode five
            isoforms with varying N-terminal sequence.
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   Dumitrescu,A.M., Liao,X.H., Abdullah,M.S., Lado-Abeal,J.,
            Majed,F.A., Moeller,L.C., Boran,G., Schomburg,L., Weiss,R.E. and
            Refetoff,S.
  TITLE     Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
  JOURNAL   Nat Genet 37 (11), 1247-1252 (2005)
   PUBMED   16228000
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Allmang,C., Carbon,P. and Krol,A.
  TITLE     The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding
            domain: identification of SBP2 amino acids important to SECIS RNA
            binding
  JOURNAL   RNA 8 (10), 1308-1318 (2002)
   PUBMED   12403468
  REMARK    GeneRIF: In addition to identifying key amino acids for SECIS
            recognition by SBP2, our findings led to the proposal that some of
            the recognition principles governing the 15.5 kD-U4 snRNA
            interaction must be similar in the SBP2-SECIS RNA complex
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Lescure,A., Allmang,C., Yamada,K., Carbon,P. and Krol,A.
  TITLE     cDNA cloning, expression pattern and RNA binding analysis of human
            selenocysteine insertion sequence (SECIS) binding protein 2
  JOURNAL   Gene 291 (1-2), 279-285 (2002)
   PUBMED   12095701
REFERENCE   9  (bases 1 to 3481)
  AUTHORS   Low,S.C., Grundner-Culemann,E., Harney,J.W. and Berry,M.J.
  TITLE     SECIS-SBP2 interactions dictate selenocysteine incorporation
            efficiency and selenoprotein hierarchy
  JOURNAL   EMBO J 19 (24), 6882-6890 (2000)
   PUBMED   11118223
REFERENCE   10 (bases 1 to 3481)
  AUTHORS   Copeland,P.R., Fletcher,J.E., Carlson,B.A., Hatfield,D.L. and
            Driscoll,D.M.
  TITLE     A novel RNA binding protein, SBP2, is required for the translation
            of mammalian selenoprotein mRNAs
  JOURNAL   EMBO J 19 (2), 306-314 (2000)
   PUBMED   10637234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP219148.1, BC068466.1 and
            BG572344.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_024077.4.
            
            Summary: The protein encoded by this gene is one of the essential
            components of the machinery involved in co-translational insertion
            of selenocysteine (Sec) into selenoproteins. Sec is encoded by the
            UGA codon, which normally signals translation termination. The
            recoding of UGA as Sec codon requires a Sec insertion sequence
            (SECIS) element; present in the 3' untranslated regions of
            eukaryotic selenoprotein mRNAs. This protein specifically binds to
            the SECIS element, which is stimulated by a Sec-specific
            translation elongation factor. Mutations in this gene have been
            associated with reduction in enzymatic activity of type II
            iodothyronine deiodinase (a selenoprotein) and abnormal thyroid
            hormone metabolism. Alternatively spliced transcript variants have
            been found for this gene. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068466.1, SRR1660803.97246.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375807.8/ ENSP00000364965.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BP219148.1         28-65
            39-3460             BC068466.1         1-3422
            3461-3481           BG572344.1         400-420
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.2"
     gene            1..3481
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /note="SECIS binding protein 2"
                     /db_xref="GeneID:79048"
                     /db_xref="HGNC:HGNC:30972"
                     /db_xref="MIM:607693"
     exon            1..113
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2642
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     selenocysteine insertion sequence-binding protein 2; Sec
                     insertion sequence-binding protein 2"
                     /codon_start=1
                     /product="selenocysteine insertion sequence-binding
                     protein 2 isoform 1"
                     /protein_id="NP_076982.3"
                     /db_xref="CCDS:CCDS6683.1"
                     /db_xref="GeneID:79048"
                     /db_xref="HGNC:HGNC:30972"
                     /db_xref="MIM:607693"
                     /translation="MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFP
                     SSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQN
                     VYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFD
                     SERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEF
                     TTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNP
                     NESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADP
                     KNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKY
                     EVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQL
                     DLGGMLTALEKKQHSQHAKQSSKPVVVSVGAVPVLSKECASGERGRRMSQMKTPHNPL
                     DSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERKQRLQENAVSPAFTSDDTQDGES
                     GGDDQFPEQAELSGPEGMDELISTPSVEDKSEEPPGTELQRDTEASHLAPNHTTFPKI
                     HSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLK
                     HLKLKKLKCVIISPNCEKIQSKGGLDDTLHTIIDYACEQNIPFVFALNRKALGRSLNK
                     AVPVSVVGIFSYDGAQDQFHKMVELTVAARQAYKTMLENVQQELVGEPRPQAPPSLPT
                     QGPSCPAEDGPPALKEKEEPHYIEIWKKHLEAYSGCTLELEESLEASTSQMMNLNL"
     exon            114..259
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..509
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..651
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..878
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..957
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1166
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1289
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1379
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1512
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1679
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1815
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1969
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2190
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2345
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2538
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..3481
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /note="hexamer: AATAAA"
     polyA_site      3460
                     /gene="SECISBP2"
                     /gene_synonym="SBP2; THMA1"
                     /note="major polyA site"
ORIGIN      
        1 ggaaacgctt tgtctgtccg gcaagccgac ggcccgctgc tggcctccgt gacgcggcct
       61 cctccgcgcc tcgcggcatg gcgtcggagg ggccgcggga gcccgaaagc gagggcatca
      121 agttatcagc agatgtcaaa ccatttgtcc ccagatttgc cgggctcaat gtggcatggt
      181 tagagtcctc agaagcatgt gtcttcccca gctctgcagc cacatactat ccgtttgttc
      241 aggaaccacc agtgacagag cagaaaatat atactgaaga catggccttt ggagcttcaa
      301 cttttccacc tcagtattta tcttctgaga taactcttca tccatatgcc tattctcctt
      361 atacccttga ctccacacag aatgtttact cagtgcctgg ctcccagtat ctttataacc
      421 aacccagttg ttaccgaggt tttcaaacag tgaagcatcg aaatgagaac acatgccctc
      481 tcccacaaga aatgaaagct ctgtttaaga agaaaaccta tgatgagaaa aaaacgtatg
      541 atcagcaaaa gtttgacagt gaaagggctg atggaactat atcatctgag ataaaatcag
      601 ctagaggttc acatcatttg tccatttacg ctgagaatag tttgaaatca gatggttacc
      661 ataagcgaac agacaggaaa tccagaatca ttgcaaaaaa tgtatctacc tccaaacctg
      721 agtttgaatt taccacactg gactttcctg aactgcaagg tgcagagaac aatatgtcag
      781 agatacagaa gcaacccaag tggggacctg tccactctgt ctctaccgac atttctcttc
      841 taagagaagt agtaaaacca gctgcagtgt tatcaaaggg tgaaatagtg gtgaaaaata
      901 acccaaatga atctgtaact gctaatgccg ctaccaattc tccttcatgt acaagagagt
      961 tatcttggac accaatgggt tatgttgttc gacagacatt atctacagaa ctgtcagcag
     1021 cccctaaaaa tgttacttct atgataaact taaagaccat tgcttcatca gcagatccta
     1081 aaaatgttag tataccatct tctgaagctt tatcttcgga tccttcctac aacaaagaaa
     1141 aacacattat tcatcctacc caaaagtcta aagcatcaca aggtagtgac cttgaacaaa
     1201 atgaagcctc aagaaagaat aagaaaaaga aagaaaaatc tacatcaaaa tatgaagtcc
     1261 tgacagttca agagcctcca aggattgaag atgccgagga atttcccaac ctggcagttg
     1321 catctgaaag aagagacaga atagagacac cgaaatttca atctaagcag cagccacagg
     1381 ataattttaa aaataatgta aagaagagcc agcttccagt gcagttggac ttggggggca
     1441 tgctgacagc cctggagaag aagcagcact ctcagcatgc aaagcagtcc tccaaaccag
     1501 tggtagtctc agttggagca gtgccagtcc tttccaaaga atgtgcatca ggggagagag
     1561 gccgccgcat gagtcaaatg aagaccccgc acaatccctt ggactccagc gccccactga
     1621 tgaagaaagg gaagcagagg gagatcccca aggccaagaa gccaacctca ctgaagaaga
     1681 ttattttgaa agaacggcaa gagagaaagc agcgtctcca agaaaatgct gtgagtccag
     1741 cttttaccag tgatgacaca caagatggag agagtggtgg tgatgaccag tttcccgagc
     1801 aggcagagct gtcagggcca gaggggatgg acgaactgat ctccactcct tcggttgagg
     1861 acaagtctga agagccacca ggcacagagc tccagaggga cacagaggcc tcccaccttg
     1921 ctcccaatca caccaccttc cctaagatcc acagccgcag attcagggat tactgcagcc
     1981 agatgcttag taaagaagtg gatgcttgtg ttaccgacct actcaaagaa ctggtccgtt
     2041 tccaagaccg tatgtaccag aaagatccag tcaaggccaa gactaaacgt cgacttgtgt
     2101 tggggttgag ggaggttctc aaacacctga agctcaaaaa actgaaatgt gtcattattt
     2161 ctcccaactg tgagaagata cagtcaaaag gtgggctgga tgacactttg cacacaatta
     2221 ttgattatgc ctgtgagcag aacattccct ttgtgtttgc tctcaaccgc aaagctctgg
     2281 ggcgcagttt gaataaggca gttcctgtca gtgtggtggg gatcttcagc tatgatgggg
     2341 cccaggatca gttccacaag atggttgagc tgacagtggc ggcccgacag gcgtacaaga
     2401 ccatgctgga gaatgtgcag caggagctgg tgggagagcc caggcctcag gcacctccca
     2461 gcctacccac acagggcccc agctgccctg cagaagatgg ccccccagcc ctgaaagaaa
     2521 aagaagagcc acactacatt gaaatctgga aaaaacatct ggaagcatac agtggatgta
     2581 ccctggagct agaagaatcc ttggaggctt caacctctca aatgatgaat ttgaatttat
     2641 gagagttctt gcctgtgtgt ctgtattttg ggtaaggagg ggaggtctga aaaagacttt
     2701 ggggcttttt cttctgtttt tcatgacaat gtaatttgtg taactgttga atctggaaat
     2761 tgatcagcat taaagggcac atgaagcagt gtctgcaggc gttcagtgct gcggagcctg
     2821 ttaaaggtca ctcagatgtg caggtgttaa tcttctctaa aagcctggtg atacagctct
     2881 ggctttctga gcacactacg gatctggaaa atactggaaa atgtgatact tagaatactt
     2941 tggctgctaa ggaaacttcc tctccattgc agaatagctg agccaagtga gtgagtttgc
     3001 agaaagcagg tggtgagctc ctgcctgctg gaggttgcca tggagggcca ttcctgcccg
     3061 gcaacagcac cgtcctgcag ggagccactt ggcagaaggg tgcagggctg ctggtgtcag
     3121 agcaagaggg ctacagggaa agggcccttt ctcaggggat gtagcttttt taaaagattt
     3181 gggaacactt ggaggatttg ctaaaatgag cctcagaagg aaaattggtt ttctaacctg
     3241 tgactttttg aaatgaatta ttcctttcag tctttatttt tcaaagaaac aatgtgtatt
     3301 gaagtaccta gatttgtttg ataatcaaca aatctttcct ttttcaatga acatattctg
     3361 aatgtggttt ctgtcttaga ccaggaggac agagtttgct ttcatatttt ccctgtaagt
     3421 aagagggctt atttatttta aataaagagt aattattaaa ttttgtttca gactctggtg
     3481 a
//
