LOCUS       NM_007214               6430 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens SEC63 homolog, protein translocation regulator
            (SEC63), mRNA.
ACCESSION   NM_007214
VERSION     NM_007214.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6430)
  AUTHORS   Hu,C., Xin,Z., Sun,X., Hu,Y., Zhang,C., Yan,R., Wang,Y., Lu,M.,
            Huang,J., Du,X., Xing,B. and Liu,X.
  TITLE     Activation of ACLY by SEC63 deploys metabolic reprogramming to
            facilitate hepatocellular carcinoma metastasis upon endoplasmic
            reticulum stress
  JOURNAL   J Exp Clin Cancer Res 42 (1), 108 (2023)
   PUBMED   37122003
  REMARK    GeneRIF: Activation of ACLY by SEC63 deploys metabolic
            reprogramming to facilitate hepatocellular carcinoma metastasis
            upon endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6430)
  AUTHORS   Huusko,J.M., Tiensuu,H., Haapalainen,A.M., Pasanen,A.,
            Tissarinen,P., Karjalainen,M.K., Zhang,G., Christensen,K.,
            Ryckman,K.K., Jacobsson,B., Murray,J.C., Kingsmore,S.F.,
            Hallman,M., Muglia,L.J. and Ramet,M.
  TITLE     Integrative genetic, genomic and transcriptomic analysis of heat
            shock protein and nuclear hormone receptor gene associations with
            spontaneous preterm birth
  JOURNAL   Sci Rep 11 (1), 17115 (2021)
   PUBMED   34429451
  REMARK    GeneRIF: Integrative genetic, genomic and transcriptomic analysis
            of heat shock protein and nuclear hormone receptor gene
            associations with spontaneous preterm birth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6430)
  AUTHORS   Li,X., Sun,S., Appathurai,S., Sundaram,A., Plumb,R. and
            Mariappan,M.
  TITLE     A Molecular Mechanism for Turning Off IRE1alpha Signaling during
            Endoplasmic Reticulum Stress
  JOURNAL   Cell Rep 33 (13), 108563 (2020)
   PUBMED   33378667
  REMARK    GeneRIF: A Molecular Mechanism for Turning Off IRE1alpha Signaling
            during Endoplasmic Reticulum Stress.
REFERENCE   4  (bases 1 to 6430)
  AUTHORS   Schorr,S., Nguyen,D., Hassdenteufel,S., Nagaraj,N., Cavalie,A.,
            Greiner,M., Weissgerber,P., Loi,M., Paton,A.W., Paton,J.C.,
            Molinari,M., Forster,F., Dudek,J., Lang,S., Helms,V. and
            Zimmermann,R.
  TITLE     Identification of signal peptide features for substrate specificity
            in human Sec62/Sec63-dependent ER protein import
  JOURNAL   FEBS J 287 (21), 4612-4640 (2020)
   PUBMED   32133789
  REMARK    GeneRIF: Identification of signal peptide features for substrate
            specificity in human Sec62/Sec63-dependent ER protein import.
REFERENCE   5  (bases 1 to 6430)
  AUTHORS   Hassdenteufel,S., Johnson,N., Paton,A.W., Paton,J.C., High,S. and
            Zimmermann,R.
  TITLE     Chaperone-Mediated Sec61 Channel Gating during ER Import of Small
            Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy
            Barrier
  JOURNAL   Cell Rep 23 (5), 1373-1386 (2018)
   PUBMED   29719251
REFERENCE   6  (bases 1 to 6430)
  AUTHORS   Davila,S., Furu,L., Gharavi,A.G., Tian,X., Onoe,T., Qian,Q., Li,A.,
            Cai,Y., Kamath,P.S., King,B.F., Azurmendi,P.J., Tahvanainen,P.,
            Kaariainen,H., Hockerstedt,K., Devuyst,O., Pirson,Y., Martin,R.S.,
            Lifton,R.P., Tahvanainen,E., Torres,V.E. and Somlo,S.
  TITLE     Mutations in SEC63 cause autosomal dominant polycystic liver
            disease
  JOURNAL   Nat Genet 36 (6), 575-577 (2004)
   PUBMED   15133510
  REMARK    GeneRIF: Mutations in SEC63 cause autosomal dominant polycystic
            liver disease, suggesting a role for cotranslational
            protein-processing pathways in maintaining epithelial luminal
            structure and implicating noncilial ER proteins in human polycystic
            disease.
REFERENCE   7  (bases 1 to 6430)
  AUTHORS   Ponting,C.P.
  TITLE     Proteins of the endoplasmic-reticulum-associated degradation
            pathway: domain detection and function prediction
  JOURNAL   Biochem J 351 Pt 2 (Pt 2), 527-535 (2000)
   PUBMED   11023840
REFERENCE   8  (bases 1 to 6430)
  AUTHORS   Meyer,H.A., Grau,H., Kraft,R., Kostka,S., Prehn,S., Kalies,K.U. and
            Hartmann,E.
  TITLE     Mammalian Sec61 is associated with Sec62 and Sec63
  JOURNAL   J Biol Chem 275 (19), 14550-14557 (2000)
   PUBMED   10799540
REFERENCE   9  (bases 1 to 6430)
  AUTHORS   Skowronek,M.H., Rotter,M. and Haas,I.G.
  TITLE     Molecular characterization of a novel mammalian DnaJ-like Sec63p
            homolog
  JOURNAL   Biol Chem 380 (9), 1133-1138 (1999)
   PUBMED   10543453
REFERENCE   10 (bases 1 to 6430)
  AUTHORS   Woollatt,E., Pine,K.A., Shine,J., Sutherland,G.R. and Iismaa,T.P.
  TITLE     Human Sec63 endoplasmic reticulum membrane protein, map position
            6q21
  JOURNAL   Chromosome Res 7 (1), 77 (1999)
   PUBMED   10219736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB049187.1, BM764168.1,
            BC047221.1, AJ011779.1 and AL024507.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007214.4.
            
            Summary: The Sec61 complex is the central component of the protein
            translocation apparatus of the endoplasmic reticulum (ER) membrane.
            The protein encoded by this gene and SEC62 protein are found to be
            associated with ribosome-free SEC61 complex. It is speculated that
            Sec61-Sec62-Sec63 may perform post-translational protein
            translocation into the ER. The Sec61-Sec62-Sec63 complex might also
            perform the backward transport of ER proteins that are subject to
            the ubiquitin-proteasome-dependent degradation pathway. The encoded
            protein is an integral membrane protein located in the rough ER.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2242919.1,
                                           SRR14038192.691772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369002.9/ ENSP00000357998.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               DB049187.1         93-214
            123-579             BM764168.1         69-525
            580-1449            BC047221.1         519-1388
            1450-2539           AJ011779.1         1349-2438
            2540-6430           AL024507.7         127918-131808
FEATURES             Location/Qualifiers
     source          1..6430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6430
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="SEC63 homolog, protein translocation regulator"
                     /db_xref="GeneID:11231"
                     /db_xref="HGNC:HGNC:21082"
                     /db_xref="MIM:608648"
     exon            1..323
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2482
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="SEC63 protein translocation regulator; SEC63-like
                     protein; dnaJ homolog subfamily C member 23"
                     /codon_start=1
                     /product="translocation protein SEC63 homolog"
                     /protein_id="NP_009145.1"
                     /db_xref="CCDS:CCDS5061.1"
                     /db_xref="GeneID:11231"
                     /db_xref="HGNC:HGNC:21082"
                     /db_xref="MIM:608648"
                     /translation="MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQI
                     RLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQE
                     YNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKN
                     WEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRY
                     SGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQ
                     LIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQ
                     EMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEE
                     DNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIK
                     SQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNR
                     TKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDE
                     EEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKE
                     RALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELK
                     FPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQE
                     DSEGFEDSFEEEEEEEEDDD"
     exon            324..423
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            424..538
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            539..651
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            652..713
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            714..772
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            773..823
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            824..932
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1027
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1160
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1253
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1408
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1556
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1639
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1699
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1873
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2032
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2134
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2233
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2338
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..6430
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="hexamer: AATAAA"
     polyA_site      2750
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="hexamer: AATAAA"
     polyA_site      3420
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="major polyA site"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="hexamer: AATAAA"
     polyA_site      3874
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
     regulatory      6407..6412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /note="hexamer: AATAAA"
     polyA_site      6430
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
ORIGIN      
        1 ctctcgcgag agctggcgac ggcggcggca gcggcagagg tggcggcggc gtgtccgtga
       61 gagtggcgtg ggggcgggga ggagaggcgg cggcggcagt gtccaagcta cgccactcgg
      121 gccggggcgt tgggagcggg agtgcagagc gtggtcgtgg cggcggcggt gagaagagcg
      181 aggcggagga gggggtgcca tggccgggca gcagttccag tacgatgaca gtgggaacac
      241 cttcttctac ttcctcacct ccttcgtggg gctcatcgtg atcccggcga catactacct
      301 ctggccccga gatcagaatg ccgagcaaat tcgattaaag aatatcagaa aagtatatgg
      361 aaggtgtatg tggtatcgtt tacggttatt aaaaccccag ccaaatatta ttcctacagt
      421 aaagaaaata gttctgcttg caggatgggc attgttctta ttccttgcat ataaagtttc
      481 caaaacagac cgagaatacc aagaatacaa tccttatgaa gtattaaatt tggatcctgg
      541 agccacagta gcagaaatta aaaaacaata tcgtttgctg tcacttaaat atcatccaga
      601 taaaggaggt gatgaggtta tgttcatgag gatagcaaaa gcttatgctg ctttaacgga
      661 tgaagagtcc cggaaaaatt gggaagaatt tggaaatcca gatgggcctc aagccacaag
      721 ctttggaatt gccctgccag cttggatagt tgaccagaaa aactcaattc tggttttact
      781 tgtatatgga ttggcattta tggttatcct tccagttgtt gtgggctctt ggtggtatcg
      841 ctcaatacgc tatagtggag accagattct aatacgcaca acacagattt atacatactt
      901 tgtttataaa acccgaaata tggatatgaa acgtcttatc atggttttgg ctggagcttc
      961 tgaatttgat cctcagtata ataaagatgc cacaagcaga ccaacggata atattctaat
     1021 accacagcta atcagagaaa ttggcagcat taatttaaag aagaatgagc ctccacttac
     1081 ctgcccatat agcctgaagg ccagagttct tttactgtct catcttgcta gaatgaaaat
     1141 tcctgagacc cttgaagaag atcagcaatt catgctaaaa aagtgtcctg ccctacttca
     1201 agaaatggtt aatgtaatct gccaactaat agtaatggcc cggaaccgtg aagaaaggga
     1261 gtttcgtgct ccaactttgg catccctaga aaactgcatg aagctttctc agatggccgt
     1321 tcagggactt cagcaattta agtctcccct tctgcagctc cctcatattg aagaggacaa
     1381 tcttagacgg gtttctaatc ataagaagta taaaattaaa actatccagg atttggtgag
     1441 tttaaaagaa tcagatcgtc acactctact gcacttcctt gaagatgaaa aatatgaaga
     1501 ggttatggct gtccttggga gttttccata tgtgaccatg gatataaaat cacaggtgtt
     1561 agatgatgaa gatagcaaca acatcacagt aggatcctta gttacagtgt tggttaagtt
     1621 gacaaggcaa acaatggctg aagtatttga aaaggagcag tccatctgtg ctgcagagga
     1681 acagccagca gaagatgggc agggtgaaac taacaagaac aggacaaaag gaggatggca
     1741 acagaagagt aaaggaccca agaaaactgc taaatcaaaa aaaaagaaac ctttaaaaaa
     1801 aaaacctaca cctgtgctat taccacagtc aaagcaacag aaacaaaagc aggcaaatgg
     1861 agtcgttggg aatgaagctg cagtaaagga agatgaagaa gaagtttcag ataagggcag
     1921 tgattctgaa gaagaagaaa ccaatagaga ttcccaaagt gagaaagatg atggtagtga
     1981 cagagactct gatagagagc aagatgaaaa acaaaacaaa gatgatgaag cagagtggca
     2041 agaattacaa caaagcatac agcgaaaaga gagagctcta ttggaaacca aatcaaaaat
     2101 aacacatcct gtgtatagcc tttactttcc tgaggaaaaa caagaatggt ggtggcttta
     2161 cattgcagat aggaaggagc agacattaat atccatgcca tatcatgtgt gtacgctgaa
     2221 agatacagag gaggtagagc tgaagtttcc tgcaccaggc aagcctggaa attatcagta
     2281 tactgtgttt ctgagatcag actcctatat gggtttggat cagattaaac cattgaagtt
     2341 ggaagttcat gaggctaagc ctgtgccaga aaatcaccca cagtgggata cagcaataga
     2401 gggggatgaa gaccaggagg acagtgaggg ctttgaagat agctttgagg aagaagagga
     2461 ggaagaagaa gatgatgact aagcagtact ctgaatggac cacagtgttt gcacatattt
     2521 gcaatttttt gctgttttgg aagtgtatca taaaccagaa acagtacaga actgatgttg
     2581 agggaggtgt agttttttta ctcttgaaat gggtgcataa tataactagg cagtggcggt
     2641 gccttggtac aacctgaaaa atgttaaggc ttattgaaac ctttcaagta ggggatggta
     2701 catttatttc atctgcaaat gataataaat cctttgttat tataactgtc cagaagtgtg
     2761 ggctatgtat tatctgatca gtctatggtc ccagtaaaag taaagatgca ggaaacacag
     2821 tctgtaaatg agcgactttt ctttgttcag ctttagtttt agcaaacacc acaaatatgt
     2881 tttaagtaac atcgctcaag tttaagtaac atcgctcaag ttgataatct cttgataagc
     2941 tctgttgttg acattttgca gtgatacaac agctccactc atagatttaa acttttattt
     3001 ttacttatct tggtcataag ttggcattct ctcacattcc acatgatata gagggctacg
     3061 ttttggaatt ttccttttct taattgccca gagttatcag acagattata aaaatggctt
     3121 ttaatggctt aaaccatttc taaacctcta tcttagcaga tcaatgcagg atctaattct
     3181 tttgataagt tctagctcta aaagtgatag tgggactgta tgttttctga tactggtggc
     3241 ttatgttatt aaaccttttt taaaaaaggt tcactctaaa agctgaacta catccttagt
     3301 tttcagtcta cttgactcta tcaggagctt tttaaggaaa gtaagtataa catgcaaagg
     3361 aagctttttt tgtattcatt ttggactcct gtcaataaaa atagaagttt gttgactcgt
     3421 tttatgtttc aatggtgtgt gtctttttac tatcaggaca taaatagggc aatccacttc
     3481 tttatttttc aactaaagat tgaatagtat tgtacattac tgctaaagtg actgctattt
     3541 ctgtatactg tagaaaaacc caggagtgag agggatttcc cctcatagta caactggaag
     3601 gatagtgctt gtaaagagta gagatgtgta catgatgaat cattgaggga gggtggatat
     3661 ttttattcct agatatggag gaaacataag tctgtagtat tataaaactg attgtaataa
     3721 ttctttccta tcaaaatctc cataggtcaa aatattgttg gaatactaaa atttgcaacc
     3781 ttgtttactt taaaaggttg ccactttcag tgcagaatac taccggcatc ttgttactgc
     3841 aatagttgga aataaaatgt gaaaattagc aaaaccatga atggtttttt tggttctaaa
     3901 tttaagatgt aatatttcct ataaaagggt gaaagcagtt tctttctcta taacctcaat
     3961 caccagttta gtgagagcct ttcttggcag gcaggaggca gtgtcactga ggattttttt
     4021 catttacttc attgtacaag taggagggtg ggtttaattt tcaaatcagg ttctgctgtg
     4081 aagcaccagt gtcttgaggc agctactgat tacctaagtg tggtggcagg gggtaagcca
     4141 gctggtgtca agtgaaagga gggattagag aaaacaggtg tggcacgaag gcaaggaaac
     4201 tgagcagaca agacagaaca atgtgtagaa tgcatatttc ctagttttct tgaaagattt
     4261 caagaaaagt tgtttttttt tttctagtgg ctactttgcc ttaaagaggc tttataagtt
     4321 cattcacaca gctggcttct ctggttttaa gattctggag aggatgataa cctagtaaca
     4381 ccacagtgct taaaaaaaaa aaaaaaaaaa aaactaccat caccagaaaa ttccaccagt
     4441 ttgttttcct tttctctttg tgtgatgtgt atgtacttcc caactaagta aaataaaatt
     4501 tcctctagtg agtgctttag gtaacctctt tccatatggc agtagtgaaa gaactgagcc
     4561 ttcagttgat agttcttctc tctccagcaa gtcgctaaac tccacatccc ttcgtttttc
     4621 ctctggaatg agaataacaa actatcctag tttgcattta atctaatgga aacttgagca
     4681 aagtttcaat tttcttccta taaagaaact gacattttgt caacaattga tgagcctata
     4741 gatcatacag tgtataggaa gtgaaattga aacagttaaa ttatgtgata tttttctcta
     4801 attggtaaag tacctattaa aatacagctg ttcatgagga gacttaccac aattcaaagt
     4861 gtagcagttg tgtattttag cattataata tttgattgag gccctgaggt gttaatatct
     4921 caatctcaga gttagatgtt catgtccttt ttgaattttt taaacatttt tcataatttt
     4981 ttttttaagt tagggagcac attgagtgaa gttctctgtg tagaacaata ccttctgctc
     5041 tgcttctccc agctttcact gagggctgga aaaggacagg cctgtccagc tgtactgtcc
     5101 cactgtgtat ggggaagctc aggctctggt ggaagcaggg ggcgtggatg tcaaacaact
     5161 gatgtggaaa cagggaggga gagatataat gaggctctct aggcatgtta tttttgacca
     5221 caagttttgt tcagtttgct tcagccaatc caaaccatat actagagtgt tctgtagtca
     5281 caattcttat ttcaaatgta attcagcacc ttacataatt tttgagaggt tgtcattcat
     5341 cacatattta ctgagtttct atgtgccagg ctctgtgact ggatactgga gctatcaaaa
     5401 tgaaaaaaat agtgttaaga actcactcgc tggtgttaga gcaggtagat gagtggcaat
     5461 ccatttaaat ccatttgcct tggctattat ttggaatgcc tttttttttt tttagtctat
     5521 ctactgtagg cagaagaatt atttctttag gggctagctg tttattttgc tggccttttt
     5581 ttctctcttt ctctttttct tcttaagacg gagtctcgct ctgtcctcca ggctggagga
     5641 gtgcagtggc acgatctcag ctcactgcaa cctccgcctc ccagcttcaa gcgattcttc
     5701 tgcctcagcc tcctgagtag ctgggactgc aggtgcatgc caccacaccc agctaatttt
     5761 ttaattttta gtagagatgg gattttgcca cgttgtccag cctggtctcg aactcctggc
     5821 ctcaagtgat cagccctcct cagcctccca aagtgctggc attacaggca tgagccactg
     5881 cgcccagcct gttgggtttt tttggaaaaa aaacaaaaac aacaaatcat catcctttcc
     5941 tttaaaatgt tttttttttt ttaagaaaca attttcccac aaacggtctg atttaactcc
     6001 atgaaatcct ctatttagac tgccttaaag tgaaataact gttggtgaac cataacattt
     6061 tgccagctgt gtagtgatta gtccaaatat gtctcaagaa gttagcacca agcattctca
     6121 tccatttaaa cttgatgcta gggctatttt gcaaaactta aaaagatgcg atcttgtaca
     6181 tatttctgta acctgagctg aaaacccaaa taacaatcat tgacatactt tagggctatt
     6241 gtttcaggtg ggggtgtata catcccaggg gcgtggagat gatcaatcca ttgaggaagt
     6301 attaagatga ttatttgtat ttaatctcat ccttttaaat ttctattttt gtgtgtttta
     6361 taatgtacat aatatattgt acaattgtac acttctatta tttataaata aacatttatt
     6421 ggtgcattaa
//
