LOCUS       NP_009145                760 aa            linear   PRI 16-JUN-2024
DEFINITION  translocation protein SEC63 homolog [Homo sapiens].
ACCESSION   NP_009145
VERSION     NP_009145.1
DBSOURCE    REFSEQ: accession NM_007214.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 760)
  AUTHORS   Hu,C., Xin,Z., Sun,X., Hu,Y., Zhang,C., Yan,R., Wang,Y., Lu,M.,
            Huang,J., Du,X., Xing,B. and Liu,X.
  TITLE     Activation of ACLY by SEC63 deploys metabolic reprogramming to
            facilitate hepatocellular carcinoma metastasis upon endoplasmic
            reticulum stress
  JOURNAL   J Exp Clin Cancer Res 42 (1), 108 (2023)
   PUBMED   37122003
  REMARK    GeneRIF: Activation of ACLY by SEC63 deploys metabolic
            reprogramming to facilitate hepatocellular carcinoma metastasis
            upon endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 760)
  AUTHORS   Huusko,J.M., Tiensuu,H., Haapalainen,A.M., Pasanen,A.,
            Tissarinen,P., Karjalainen,M.K., Zhang,G., Christensen,K.,
            Ryckman,K.K., Jacobsson,B., Murray,J.C., Kingsmore,S.F.,
            Hallman,M., Muglia,L.J. and Ramet,M.
  TITLE     Integrative genetic, genomic and transcriptomic analysis of heat
            shock protein and nuclear hormone receptor gene associations with
            spontaneous preterm birth
  JOURNAL   Sci Rep 11 (1), 17115 (2021)
   PUBMED   34429451
  REMARK    GeneRIF: Integrative genetic, genomic and transcriptomic analysis
            of heat shock protein and nuclear hormone receptor gene
            associations with spontaneous preterm birth.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 760)
  AUTHORS   Li,X., Sun,S., Appathurai,S., Sundaram,A., Plumb,R. and
            Mariappan,M.
  TITLE     A Molecular Mechanism for Turning Off IRE1alpha Signaling during
            Endoplasmic Reticulum Stress
  JOURNAL   Cell Rep 33 (13), 108563 (2020)
   PUBMED   33378667
  REMARK    GeneRIF: A Molecular Mechanism for Turning Off IRE1alpha Signaling
            during Endoplasmic Reticulum Stress.
REFERENCE   4  (residues 1 to 760)
  AUTHORS   Schorr,S., Nguyen,D., Hassdenteufel,S., Nagaraj,N., Cavalie,A.,
            Greiner,M., Weissgerber,P., Loi,M., Paton,A.W., Paton,J.C.,
            Molinari,M., Forster,F., Dudek,J., Lang,S., Helms,V. and
            Zimmermann,R.
  TITLE     Identification of signal peptide features for substrate specificity
            in human Sec62/Sec63-dependent ER protein import
  JOURNAL   FEBS J 287 (21), 4612-4640 (2020)
   PUBMED   32133789
  REMARK    GeneRIF: Identification of signal peptide features for substrate
            specificity in human Sec62/Sec63-dependent ER protein import.
REFERENCE   5  (residues 1 to 760)
  AUTHORS   Hassdenteufel,S., Johnson,N., Paton,A.W., Paton,J.C., High,S. and
            Zimmermann,R.
  TITLE     Chaperone-Mediated Sec61 Channel Gating during ER Import of Small
            Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy
            Barrier
  JOURNAL   Cell Rep 23 (5), 1373-1386 (2018)
   PUBMED   29719251
REFERENCE   6  (residues 1 to 760)
  AUTHORS   Davila,S., Furu,L., Gharavi,A.G., Tian,X., Onoe,T., Qian,Q., Li,A.,
            Cai,Y., Kamath,P.S., King,B.F., Azurmendi,P.J., Tahvanainen,P.,
            Kaariainen,H., Hockerstedt,K., Devuyst,O., Pirson,Y., Martin,R.S.,
            Lifton,R.P., Tahvanainen,E., Torres,V.E. and Somlo,S.
  TITLE     Mutations in SEC63 cause autosomal dominant polycystic liver
            disease
  JOURNAL   Nat Genet 36 (6), 575-577 (2004)
   PUBMED   15133510
  REMARK    GeneRIF: Mutations in SEC63 cause autosomal dominant polycystic
            liver disease, suggesting a role for cotranslational
            protein-processing pathways in maintaining epithelial luminal
            structure and implicating noncilial ER proteins in human polycystic
            disease.
REFERENCE   7  (residues 1 to 760)
  AUTHORS   Ponting,C.P.
  TITLE     Proteins of the endoplasmic-reticulum-associated degradation
            pathway: domain detection and function prediction
  JOURNAL   Biochem J 351 Pt 2 (Pt 2), 527-535 (2000)
   PUBMED   11023840
REFERENCE   8  (residues 1 to 760)
  AUTHORS   Meyer,H.A., Grau,H., Kraft,R., Kostka,S., Prehn,S., Kalies,K.U. and
            Hartmann,E.
  TITLE     Mammalian Sec61 is associated with Sec62 and Sec63
  JOURNAL   J Biol Chem 275 (19), 14550-14557 (2000)
   PUBMED   10799540
REFERENCE   9  (residues 1 to 760)
  AUTHORS   Skowronek,M.H., Rotter,M. and Haas,I.G.
  TITLE     Molecular characterization of a novel mammalian DnaJ-like Sec63p
            homolog
  JOURNAL   Biol Chem 380 (9), 1133-1138 (1999)
   PUBMED   10543453
REFERENCE   10 (residues 1 to 760)
  AUTHORS   Woollatt,E., Pine,K.A., Shine,J., Sutherland,G.R. and Iismaa,T.P.
  TITLE     Human Sec63 endoplasmic reticulum membrane protein, map position
            6q21
  JOURNAL   Chromosome Res 7 (1), 77 (1999)
   PUBMED   10219736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB049187.1, BM764168.1,
            BC047221.1, AJ011779.1 and AL024507.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The Sec61 complex is the central component of the protein
            translocation apparatus of the endoplasmic reticulum (ER) membrane.
            The protein encoded by this gene and SEC62 protein are found to be
            associated with ribosome-free SEC61 complex. It is speculated that
            Sec61-Sec62-Sec63 may perform post-translational protein
            translocation into the ER. The Sec61-Sec62-Sec63 complex might also
            perform the backward transport of ER proteins that are subject to
            the ubiquitin-proteasome-dependent degradation pathway. The encoded
            protein is an integral membrane protein located in the rough ER.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2242919.1,
                                           SRR14038192.691772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369002.9/ ENSP00000357998.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..760
                     /product="translocation protein SEC63 homolog"
                     /note="SEC63 protein translocation regulator; SEC63-like
                     protein; dnaJ homolog subfamily C member 23"
                     /calculated_mol_wt=87866
     Site            15..35
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Site            70..90
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Region          104..162
                     /region_name="DnaJ"
                     /note="DnaJ domain; pfam00226"
                     /db_xref="CDD:395170"
     Site            order(132..134,139,142..143,146..147)
                     /site_type="other"
                     /note="HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:99751"
     Site            189..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Region          209..715
                     /region_name="SEC63"
                     /note="Domain of unknown function in Sec63p, Brr2p and
                     other proteins; smart00611"
                     /db_xref="CDD:214744"
     Region          492..617
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Region          720..760
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9UGP8.2)"
     Site            748
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9UGP8.2)"
     CDS             1..760
                     /gene="SEC63"
                     /gene_synonym="DNAJC23; ERdj2; PCLD2; PRO2507; SEC63L"
                     /coded_by="NM_007214.5:200..2482"
                     /db_xref="CCDS:CCDS5061.1"
                     /db_xref="GeneID:11231"
                     /db_xref="HGNC:HGNC:21082"
                     /db_xref="MIM:608648"
ORIGIN      
        1 magqqfqydd sgntffyflt sfvglivipa tyylwprdqn aeqirlknir kvygrcmwyr
       61 lrllkpqpni iptvkkivll agwalflfla ykvsktdrey qeynpyevln ldpgatvaei
      121 kkqyrllslk yhpdkggdev mfmriakaya altdeesrkn weefgnpdgp qatsfgialp
      181 awivdqknsi lvllvyglaf mvilpvvvgs wwyrsirysg dqilirttqi ytyfvyktrn
      241 mdmkrlimvl agasefdpqy nkdatsrptd nilipqlire igsinlkkne ppltcpyslk
      301 arvlllshla rmkipetlee dqqfmlkkcp allqemvnvi cqlivmarnr eerefraptl
      361 aslencmkls qmavqglqqf kspllqlphi eednlrrvsn hkkykiktiq dlvslkesdr
      421 htllhflede kyeevmavlg sfpyvtmdik sqvlddedsn nitvgslvtv lvkltrqtma
      481 evfekeqsic aaeeqpaedg qgetnknrtk ggwqqkskgp kktakskkkk plkkkptpvl
      541 lpqskqqkqk qangvvgnea avkedeeevs dkgsdseeee tnrdsqsekd dgsdrdsdre
      601 qdekqnkdde aewqelqqsi qrkerallet kskithpvys lyfpeekqew wwlyiadrke
      661 qtlismpyhv ctlkdteeve lkfpapgkpg nyqytvflrs dsymgldqik plklevheak
      721 pvpenhpqwd taiegdedqe dsegfedsfe eeeeeeeddd
//
