LOCUS       NM_014302                425 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens SEC61 translocon subunit gamma (SEC61G), transcript
            variant 1, mRNA.
ACCESSION   NM_014302
VERSION     NM_014302.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Yuan,S., Liu,J., Yang,L., Zhang,X., Zhuang,K. and He,S.
  TITLE     Knockdown of circ_0044226 promotes endoplasmic reticulum
            stress-mediated autophagy and apoptosis in hepatic stellate cells
            via miR-4677-3p/SEC61G axis
  JOURNAL   J Bioenerg Biomembr 56 (3), 261-271 (2024)
   PUBMED   38421527
  REMARK    GeneRIF: Knockdown of circ_0044226 promotes endoplasmic reticulum
            stress-mediated autophagy and apoptosis in hepatic stellate cells
            via miR-4677-3p/SEC61G axis.
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Fan,Y., Wang,Y., Liu,F., Wang,H. and Li,Q.
  TITLE     SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK
            Signaling Pathway
  JOURNAL   Dis Markers 2022, 7016079 (2022)
   PUBMED   36092956
  REMARK    GeneRIF: SEC61G Promotes Cervical Cancer Proliferation by
            Activating MAPK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 425)
  AUTHORS   Shi,Y., Liang,Y., Wang,W. and Zhang,G.
  TITLE     SEC61G identified as a prognostic biomarker of head and neck
            squamous cell carcinoma
  JOURNAL   Eur Arch Otorhinolaryngol 279 (4), 2039-2048 (2022)
   PUBMED   34173014
  REMARK    GeneRIF: SEC61G identified as a prognostic biomarker of head and
            neck squamous cell carcinoma.
REFERENCE   4  (bases 1 to 425)
  AUTHORS   Zheng,Q., Wang,Z., Zhang,M., Yu,Y., Chen,R., Lu,T., Liu,L., Ma,J.,
            Liu,T., Zheng,H., Li,H. and Li,J.
  TITLE     Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive
            study based on bioinformatics and in vitro validation
  JOURNAL   BMC Cancer 21 (1), 1216 (2021)
   PUBMED   34774014
  REMARK    GeneRIF: Prognostic value of SEC61G in lung adenocarcinoma: a
            comprehensive study based on bioinformatics and in vitro
            validation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 425)
  AUTHORS   Lu,T., Chen,Y., Gong,X., Guo,Q., Lin,C., Luo,Q., Tu,Z., Pan,J. and
            Li,J.
  TITLE     SEC61G overexpression and DNA amplification correlates with
            prognosis and immune cell infiltration in head and neck squamous
            cell carcinoma
  JOURNAL   Cancer Med 10 (21), 7847-7862 (2021)
   PUBMED   34590792
  REMARK    GeneRIF: SEC61G overexpression and DNA amplification correlates
            with prognosis and immune cell infiltration in head and neck
            squamous cell carcinoma.
REFERENCE   6  (bases 1 to 425)
  AUTHORS   Greenfield,J.J. and High,S.
  TITLE     The Sec61 complex is located in both the ER and the ER-Golgi
            intermediate compartment
  JOURNAL   J Cell Sci 112 (Pt 10), 1477-1486 (1999)
   PUBMED   10212142
REFERENCE   7  (bases 1 to 425)
  AUTHORS   Chen,Y., Le Caherec,F. and Chuck,S.L.
  TITLE     Calnexin and other factors that alter translocation affect the
            rapid binding of ubiquitin to apoB in the Sec61 complex
  JOURNAL   J Biol Chem 273 (19), 11887-11894 (1998)
   PUBMED   9565615
REFERENCE   8  (bases 1 to 425)
  AUTHORS   Dodson,G. and Steiner,D.
  TITLE     The role of assembly in insulin's biosynthesis
  JOURNAL   Curr Opin Struct Biol 8 (2), 189-194 (1998)
   PUBMED   9631292
  REMARK    Review article
REFERENCE   9  (bases 1 to 425)
  AUTHORS   Wiertz,E.J., Tortorella,D., Bogyo,M., Yu,J., Mothes,W., Jones,T.R.,
            Rapoport,T.A. and Ploegh,H.L.
  TITLE     Sec61-mediated transfer of a membrane protein from the endoplasmic
            reticulum to the proteasome for destruction
  JOURNAL   Nature 384 (6608), 432-438 (1996)
   PUBMED   8945469
REFERENCE   10 (bases 1 to 425)
  AUTHORS   Hartmann,E., Sommer,T., Prehn,S., Gorlich,D., Jentsch,S. and
            Rapoport,T.A.
  TITLE     Evolutionary conservation of components of the protein
            translocation complex
  JOURNAL   Nature 367 (6464), 654-657 (1994)
   PUBMED   8107851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU932672.1, AF086539.1 and
            CD385140.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014302.3.
            
            Summary: The Sec61 complex is the central component of the protein
            translocation apparatus of the endoplasmic reticulum (ER) membrane.
            Oligomers of the Sec61 complex form a transmembrane channel where
            proteins are translocated across and integrated into the ER
            membrane. This complex consists of three membrane proteins- alpha,
            beta, and gamma. This gene encodes the gamma-subunit protein.
            Alternatively spliced transcript variants encoding the same protein
            have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB107787.1, HY068417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352861.9/ ENSP00000341538.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BU932672.1         39-88
            51-422              AF086539.1         42-413
            423-425             CD385140.1         431-433
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..425
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /note="SEC61 translocon subunit gamma"
                     /db_xref="GeneID:23480"
                     /db_xref="HGNC:HGNC:18277"
                     /db_xref="MIM:609215"
     exon            1..54
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            55..154
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..267
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /note="protein transport protein SEC61 gamma subunit;
                     Sec61 gamma subunit; SEC61 translocon gamma subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit gamma"
                     /protein_id="NP_055117.1"
                     /db_xref="CCDS:CCDS5513.1"
                     /db_xref="GeneID:23480"
                     /db_xref="HGNC:HGNC:18277"
                     /db_xref="MIM:609215"
                     /translation="MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGF
                     AIMGFIGFFVKLIHIPINNIIVGG"
     exon            155..257
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..425
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      404..409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /note="hexamer: ATTAAA"
     polyA_site      425
                     /gene="SEC61G"
                     /gene_synonym="SSS1"
                     /note="major polyA site"
ORIGIN      
        1 atcagcaagc tccagtgcta cgtgtccctg gcattttagg tgtcggttgg gtaggcagtc
       61 atggatcagg taatgcagtt tgttgagcca agtcggcagt ttgtaaagga ctccattcgg
      121 ctggttaaaa gatgcactaa acctgataga aaagaattcc agaagattgc catggcaaca
      181 gcaataggat ttgctataat gggattcatt ggcttctttg tgaaattgat ccatattcct
      241 attaataaca tcattgttgg tggctgaata cattttggaa gagagttttt catcttagag
      301 attggtgaac aagtgtgagg gtgtgagaaa ctcacagaat acaaatttgc ctgtatgttt
      361 tgtgggtttt tttttttcct ttcaagatgt tttctatttc taaattaaag taatttcaaa
      421 gtaaa
//
