LOCUS       NM_006808                564 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC61 translocon subunit beta (SEC61B), mRNA.
ACCESSION   NM_006808
VERSION     NM_006808.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 564)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 564)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 564)
  AUTHORS   Stukalov,A., Girault,V., Grass,V., Karayel,O., Bergant,V.,
            Urban,C., Haas,D.A., Huang,Y., Oubraham,L., Wang,A., Hamad,M.S.,
            Piras,A., Hansen,F.M., Tanzer,M.C., Paron,I., Zinzula,L.,
            Engleitner,T., Reinecke,M., Lavacca,T.M., Ehmann,R., Wolfel,R.,
            Jores,J., Kuster,B., Protzer,U., Rad,R., Ziebuhr,J., Thiel,V.,
            Scaturro,P., Mann,M. and Pichlmair,A.
  TITLE     Multilevel proteomics reveals host perturbations by SARS-CoV-2 and
            SARS-CoV
  JOURNAL   Nature 594 (7862), 246-252 (2021)
   PUBMED   33845483
REFERENCE   4  (bases 1 to 564)
  AUTHORS   McGilvray,P.T., Anghel,S.A., Sundaram,A., Zhong,F., Trnka,M.J.,
            Fuller,J.R., Hu,H., Burlingame,A.L. and Keenan,R.J.
  TITLE     An ER translocon for multi-pass membrane protein biogenesis
  JOURNAL   Elife 9, e56889 (2020)
   PUBMED   32820719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 564)
  AUTHORS   Liu,T.W., Liu,F. and Kang,J.
  TITLE     Let-7b-5p is involved in the response of endoplasmic reticulum
            stress in acute pulmonary embolism through upregulating the
            expression of stress-associated endoplasmic reticulum protein 1
  JOURNAL   IUBMB Life 72 (8), 1725-1736 (2020)
   PUBMED   32534478
  REMARK    GeneRIF: Let-7b-5p is involved in the response of endoplasmic
            reticulum stress in acute pulmonary embolism through upregulating
            the expression of stress-associated endoplasmic reticulum protein
            1.
REFERENCE   6  (bases 1 to 564)
  AUTHORS   Kalies,K.U., Rapoport,T.A. and Hartmann,E.
  TITLE     The beta subunit of the Sec61 complex facilitates cotranslational
            protein transport and interacts with the signal peptidase during
            translocation
  JOURNAL   J Cell Biol 141 (4), 887-894 (1998)
   PUBMED   9585408
REFERENCE   7  (bases 1 to 564)
  AUTHORS   Chen,Y., Le Caherec,F. and Chuck,S.L.
  TITLE     Calnexin and other factors that alter translocation affect the
            rapid binding of ubiquitin to apoB in the Sec61 complex
  JOURNAL   J Biol Chem 273 (19), 11887-11894 (1998)
   PUBMED   9565615
REFERENCE   8  (bases 1 to 564)
  AUTHORS   Knight,B.C. and High,S.
  TITLE     Membrane integration of Sec61alpha: a core component of the
            endoplasmic reticulum translocation complex
  JOURNAL   Biochem J 331 (Pt 1) (Pt 1), 161-167 (1998)
   PUBMED   9512475
REFERENCE   9  (bases 1 to 564)
  AUTHORS   Wiertz,E.J., Tortorella,D., Bogyo,M., Yu,J., Mothes,W., Jones,T.R.,
            Rapoport,T.A. and Ploegh,H.L.
  TITLE     Sec61-mediated transfer of a membrane protein from the endoplasmic
            reticulum to the proteasome for destruction
  JOURNAL   Nature 384 (6608), 432-438 (1996)
   PUBMED   8945469
REFERENCE   10 (bases 1 to 564)
  AUTHORS   Hartmann,E., Sommer,T., Prehn,S., Gorlich,D., Jentsch,S. and
            Rapoport,T.A.
  TITLE     Evolutionary conservation of components of the protein
            translocation complex
  JOURNAL   Nature 367 (6464), 654-657 (1994)
   PUBMED   8107851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137067.7 and BC001734.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006808.2.
            
            Summary: The Sec61 complex is the central component of the protein
            translocation apparatus of the endoplasmic reticulum (ER) membrane.
            Oligomers of the Sec61 complex form a transmembrane channel where
            proteins are translocated across and integrated into the ER
            membrane. This complex consists of three membrane proteins- alpha,
            beta, and gamma. This gene encodes the beta-subunit protein. The
            Sec61 subunits are also observed in the post-ER compartment,
            suggesting that these proteins can escape the ER and recycle back.
            There is evidence for multiple polyadenylated sites for this
            transcript. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279854.286.1, SRR1660807.58439.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223641.5/ ENSP00000223641.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL137067.7         30920-30925
            7-564               BC001734.1         1-558
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..564
                     /gene="SEC61B"
                     /note="SEC61 translocon subunit beta"
                     /db_xref="GeneID:10952"
                     /db_xref="HGNC:HGNC:16993"
                     /db_xref="MIM:609214"
     exon            1..85
                     /gene="SEC61B"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..373
                     /gene="SEC61B"
                     /note="protein translocation complex beta; protein
                     transport protein SEC61 beta subunit; Sec61 complex, beta
                     subunit; Sec61 beta subunit; SEC61 translocon beta
                     subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit beta"
                     /protein_id="NP_006799.1"
                     /db_xref="CCDS:CCDS6741.1"
                     /db_xref="GeneID:10952"
                     /db_xref="HGNC:HGNC:16993"
                     /db_xref="MIM:609214"
                     /translation="MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSA
                     GRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS"
     exon            86..183
                     /gene="SEC61B"
                     /inference="alignment:Splign:2.1.0"
     exon            184..285
                     /gene="SEC61B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..564
                     /gene="SEC61B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      541..546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC61B"
                     /note="hexamer: AATAAA"
     polyA_site      564
                     /gene="SEC61B"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgcca gctgccggtc tttcgggggc tccgtaactt tctatccgtc cgcgtcagcg
       61 ccttgccacc ctcatctcca atatgcctgg tccgaccccc agtggcacta acgtgggatc
      121 ctcagggcgc tctcccagca aagcagtggc cgcccgggcg gcgggatcca ctgtccggca
      181 gaggaaaaat gccagctgtg ggacaaggag tgcaggccgc acaacctcgg caggcaccgg
      241 ggggatgtgg cgattctaca cagaagattc acctgggctc aaagttggcc ctgttccagt
      301 attggttatg agtcttctgt tcatcgcttc tgtatttatg ttgcacattt ggggcaagta
      361 cactcgttcg tagattcagt tacatccatc tgtcatctga agaaggagga aaaaacccaa
      421 catttcttgg accaaaagta tagtgactat ctgttcatga gagaaatttt ctgtaagctt
      481 gctgttttac aggggattta tcaataattg attttgagga atcagttttt ttctatggct
      541 aataaacttt ttaattcact tata
//
