LOCUS       NM_015490               4634 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SEC31 homolog B, COPII coat complex component
            (SEC31B), mRNA.
ACCESSION   NM_015490
VERSION     NM_015490.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4634)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   2  (bases 1 to 4634)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   3  (bases 1 to 4634)
  AUTHORS   Fusco,C., Micale,L., Egorov,M., Monti,M., D'Addetta,E.V.,
            Augello,B., Cozzolino,F., Calcagni,A., Fontana,A., Polishchuk,R.S.,
            Didelot,G., Reymond,A., Pucci,P. and Merla,G.
  TITLE     The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and
            promotes the sequestration and clearance of ubiquitinated proteins
            into the aggresome
  JOURNAL   PLoS One 7 (7), e40440 (2012)
   PUBMED   22792322
REFERENCE   4  (bases 1 to 4634)
  AUTHORS   Stankewich,M.C., Stabach,P.R. and Morrow,J.S.
  TITLE     Human Sec31B: a family of new mammalian orthologues of yeast Sec31p
            that associate with the COPII coat
  JOURNAL   J Cell Sci 119 (Pt 5), 958-969 (2006)
   PUBMED   16495487
  REMARK    GeneRIF: The SEC31B protein is an orthologue of Saccharomyces
            cerevisiae Sec31p, a component of the COPII vesicle coat that
            mediates vesicular traffic from the endoplasmic reticulum.
REFERENCE   5  (bases 1 to 4634)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4634)
  AUTHORS   Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
  TITLE     Mammalian homologues of yeast sec31p. An ubiquitously expressed
            form is localized to endoplasmic reticulum (ER) exit sites and is
            essential for ER-Golgi transport
  JOURNAL   J Biol Chem 275 (18), 13597-13604 (2000)
   PUBMED   10788476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133352.12, BC034946.1,
            AF274863.1 and BM719543.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015490.3.
            
            Summary: This gene encodes a protein of unknown function. The
            protein has moderate similarity to rat VAP1 protein which is an
            endosomal membrane-associated protein, containing a putative
            Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF274863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370345.8/ ENSP00000359370.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL133352.12        56769-56791         c
            24-80               BC034946.1         6-62
            81-4602             AF274863.1         54-4575
            4603-4634           BM719543.1         388-419
FEATURES             Location/Qualifiers
     source          1..4634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..4634
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /note="SEC31 homolog B, COPII coat complex component"
                     /db_xref="GeneID:25956"
                     /db_xref="HGNC:HGNC:23197"
                     /db_xref="MIM:610258"
     exon            1..80
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..204
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..3665
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /note="secretory pathway component Sec31B-1; SEC31-related
                     protein B; SEC31-like protein 2; SEC31-like 2; SEC31
                     homolog B, COPII coating complex component"
                     /codon_start=1
                     /product="protein transport protein Sec31B"
                     /protein_id="NP_056305.1"
                     /db_xref="CCDS:CCDS7495.1"
                     /db_xref="GeneID:25956"
                     /db_xref="HGNC:HGNC:23197"
                     /db_xref="MIM:610258"
                     /translation="MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLE
                     IFEVDFRDPSLDLKHRGVLSALSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNV
                     THILSSGKEPVIAQKQKHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTL
                     GSKSQQPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSG
                     LAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELL
                     LTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSAASFNGWISLYSVM
                     GRSWEVQHMRQADKISSSFSKGQPLPPLQVPEQVAQAPLIPPLKKPPKWIRRPTGVSF
                     AFGGKLVTFGLPSTPAHLVPQPCPRLVFISQVTTESEFLMRSAELQEALGSGNLLNYC
                     QNKSQQALLQSEKMLWQFLKVTLEQDSRMKFLKLLGYSKDELQKKVATWLKSDVGLGE
                     SPQPKGNDLNSDRQQAFCSQASKHTTKEASASSAFFDELVPQNMTPWEIPITKDIDGL
                     LSQALLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYLAKKKTKISSLLA
                     CVVQKNWKDVVCTCSLKNWREALALLLTYSGTEKFPELCDMLGTRMEQEGSRALTSEA
                     RLCYVCSGSVERLVECWAKCHQALSPMALQDLMEKVMVLNRSLEQLRGPHGVSPGPAT
                     TYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRLFHAQGSAVLGQQSPPFPF
                     PRIVVGATLHSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGP
                     RTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNPVGFPGTWPLPGSP
                     LPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGA
                     PCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPPAPITAPVMSLTPEL
                     QGILPSQPPVSSVSHAPPGVPGELSLQLQHLPPEKMERKELPPEHQSLKSSFEALLQR
                     CSLSATDLKTKRKLEEAAQRLEYLYEKLCEGTLSPHVVAGLHEVARCVDAGSFEQGLA
                     VHAQVAGCSSFSEVSSFMPILKAVLIIAHKLLV"
     exon            205..328
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..524
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..620
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..764
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..907
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1007
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1169
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1304
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1535
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1610
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1709
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1809
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1988
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2115
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2261
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2435
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2597
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2775
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..3090
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3149
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3296
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3413
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..3485
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..4634
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4614..4619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /note="hexamer: AATAAA"
     polyA_site      4634
                     /gene="SEC31B"
                     /gene_synonym="SEC31B-1; SEC31L2"
                     /note="major polyA site"
ORIGIN      
        1 gcccggctcc gcgcgagagc cctgccagag gagcggctcc ggccgccgcg cctgaccctt
       61 gtccggggtc ttccgcacag tgggctgagg gccatgtcag ttttctgcca cctacaggat
      121 agaccatgaa gctgaaggaa cttgagcggc cagctgtcca ggcatggagc ccagccagcc
      181 aatacccttt gtatctggcc acaggaacat ctgcccaaca gctagattcc tccttcagca
      241 caaatggcac attggaaata tttgaggttg atttcaggga cccttctctg gacttgaaac
      301 acagaggagt cctttctgcc ttgagcaggt ttcacaagct ggtctggggg agctttggca
      361 gtgggcttct ggaaagctcc ggggttattg ttggcggcgg ggacaatggc atgcttattc
      421 tatacaatgt gacccacatc ctgtcttcgg ggaaggagcc tgtgattgct cagaaacaga
      481 agcacacggg ggctgtcaga gccctcgact tgaatccttt ccagggcaac ctcctggctt
      541 caggggccag cgattctgaa atcttcattt gggatctgaa taacttgaat gtgccaatga
      601 ccctgggatc caagtcacag cagcctccag aggacatcaa ggcactgtct tggaaccggc
      661 aagcccaaca cattctgtct tctgctcacc ccagtggcaa ggcagttgtg tgggatctca
      721 ggaagaatga acctatcatc aaagtcagtg atcacagcaa caggatgcac tgctcaggcc
      781 tggcctggca tcctgacata gccacccagt tagtgctgtg ctcagaggat gatcgacttc
      841 ccgtgattca gctgtgggac ttgcgctttg cctcctcgcc cttgaaggtg ctggagagcc
      901 acagcagggg gatcttgtca gtgtcatgga gccaggctga tgctgagctg ctgctcacta
      961 gtgctaagga cagccagatc ttgtgccgga acctggggag cagtgaggtg gtatataagc
     1021 taccaacaca gagcagctgg tgctttgatg tgcagtggtg ccctcgggac ccttcagtgt
     1081 tctctgctgc ctccttcaac ggctggatca gtttgtactc tgtgatgggt aggagctggg
     1141 aagtccagca tatgagacag gctgacaaga tctcctcttc cttcagcaaa ggccagcctc
     1201 tcccaccact gcaggtgcca gagcaagtgg cacaagcacc actgatacct cccctgaaaa
     1261 aaccccccaa atggattaga agaccaacag gtgtttcatt tgcttttgga gggaagctgg
     1321 ttacttttgg cctccccagc acccctgccc atctggtgcc acagccttgc ccccgcctag
     1381 tcttcatcag tcaagtcacc acagaatctg aattcctgat gcgatcagct gagctgcagg
     1441 aggccttggg atcaggaaat ctactgaatt actgtcagaa caagagccag caagctttac
     1501 tgcaaagtga aaagatgctg tggcagttcc tgaaggtgac cttagagcaa gactccagaa
     1561 tgaaattcct aaagctttta ggatacagta aagatgagct tcagaagaag gtggccacat
     1621 ggttgaagag tgacgtgggg ctaggtgaga gtcctcagcc caagggaaat gacctcaaca
     1681 gtgacagaca acaggccttc tgcagccagg cctccaaaca caccacaaag gaagcctctg
     1741 cttcctcagc cttctttgat gagctggtcc ctcagaacat gactccttgg gagatcccca
     1801 tcacaaaaga tattgatgga ctcctaagcc aggctctcct gcttggggaa ctgggtccgg
     1861 ccgtggagct gtgtctgaag gaggagcgct ttgctgatgc cattatcctg gcccaggctg
     1921 ggggtacaga tctgctgaag caaacacagg agcgctactt ggccaagaag aaaaccaaaa
     1981 tctcctcgct tctagcctgt gttgtgcaaa agaattggaa ggatgtggtg tgtacctgta
     2041 gcctgaagaa ctggagagag gcactggctt tgctactgac atactcaggc acagagaaat
     2101 ttcccgagct ctgtgacatg ctgggaactc gcatggaaca ggagggcagc agggcactaa
     2161 cctccgaagc cagactctgt tatgtgtgct cagggagtgt ggagcggctg gtggagtgct
     2221 gggcaaaatg ccaccaggct ttgtccccca tggctctgca ggacctgatg gagaaggtga
     2281 tggttcttaa caggagcttg gagcaactgc ggggtcctca tggggtgagc ccaggccctg
     2341 ccacaaccta cagggtcact cagtatgcca acctcctggc agcccagggc agcctggcca
     2401 ctgccatgag ctttctaccc agggactgtg ctcagccacc agttcagcag ctaagagatc
     2461 ggctttttca tgctcaaggt tctgctgtct tgggccaaca gtctccccct ttccccttcc
     2521 cccggattgt tgtgggagct accctccact ctaaagagac atcatcttac agattgggat
     2581 cccagccttc tcaccaggtc ccaactccat ctccaaggcc aagggttttc acccctcagt
     2641 catcaccagc gatgcccttg gcaccttccc atcctagccc ttatcagggt cccaggacac
     2701 agaatataag tgactacagg gcacctgggc cccaggccat ccagcctttg cctttgagcc
     2761 ctggggtaag gcctgcttca tctcagccac agctattagg agggcaaagg gtgcaagttc
     2821 ctaacccggt gggattccct gggacatggc ctcttcctgg ttcccctcta cccatggcat
     2881 gcccaggcat catgcgacct ggctctacct ccctgcctga gactcctaga ctgttccctc
     2941 tgcttcctct gagaccacta ggtcccggcc gcatggtctc ccacacccca gcccctcctg
     3001 caagcttccc tgtgccatac cttccagggg acccaggtgc cccatgctct agtgtcctcc
     3061 caaccactgg catcttgact cctcacccag gacctcaaga ttcctggaaa gaagccccag
     3121 cccccagggg aaacctccag aggaacaagc tgccagagac atttatgccc ccagcaccaa
     3181 ttactgctcc agttatgagc ctcacccctg agctacaagg gattcttccc tcacagcccc
     3241 ctgtctccag tgtgagtcat gctcccccag gagttccagg agaactcagc ctgcagcttc
     3301 agcacctgcc acctgagaag atggaaagga aggagctgcc cccagagcat cagtccttga
     3361 agagcagctt tgaggcgctt ctccaacgct gctccctgtc tgcaactgac ttaaagacaa
     3421 aaaggaagct ggaagaggca gcccagcgtc tggagtatct atatgagaag ctctgtgagg
     3481 ggacactctc acctcatgtc gtggctgggc tccatgaggt tgcccgatgt gtggatgcag
     3541 gaagctttga gcagggcctt gcagtgcatg cccaggtggc gggctgtagc agcttcagcg
     3601 aggtgtccag cttcatgcct atcctgaagg ctgtcctcat catcgctcat aagctgctgg
     3661 tctaaaccag gcagcctctc ttgctaggag gccacttctg ctgttacata actcctccct
     3721 gcagaagagg ggacttctgc aacagattct gtttcttttt cccgactctt ttccttgctg
     3781 ccaggtatgt gatgctgtag gcttggctcc aaaccagctg agtgcctgct ttttactcct
     3841 ttatgtctgg ccttctagga tctgtccaag acactctcag gcctggaggc agggcataga
     3901 atcagttctt cactctccct aatactacac tctgtaagga cctggggcag gatatcttct
     3961 cccccaggga tcttctattt aagtggcttc tgagagggtg aacaggattg ttacttttaa
     4021 gcctacctct gctgtgaccc atcatgtggg tcttttgttt ctcccttctg tggtttatga
     4081 gcctgccctt accttttccc tgcctctgac ttggtatttc caggtccgta tttctctgta
     4141 gcccagggtc tggggtagag ctgactgctg ttcacccttt gaacaactca tggacgtgag
     4201 ggatgggtgc tgagcagaac caagagagga aactttggcg ctgttaaaat ggaatttctc
     4261 atctgccggc attattaagg gtgggctagg ttggatggaa ggtgaaaggg atgaactgcc
     4321 ttttgctgga agctgtctta ggctgtgaga caggagcagg ggaaccacag cctatgggga
     4381 actgcccttg actccaccta tgttggagcc ttagcccaag gccattcctt ctgtgatgat
     4441 aaagcccagt tctggaattg gagccatatt aaggaatgat tctcttccag cgctgctcct
     4501 caagggttgg gggtccttct ccctcgcagc caccacatgt ctcagggcta ccttctccga
     4561 ttggatttgc atttgtggca ctgtctttga tgcagtgatg tacttaatgg tgcaataaag
     4621 ctgcttcgat ttgg
//
