LOCUS       NM_001400165            4146 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens SEC31 homolog A, COPII coat complex component
            (SEC31A), transcript variant 22, mRNA.
ACCESSION   NM_001400165
VERSION     NM_001400165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4146)
  AUTHORS   Tobias,E.S., Lucas-Herald,A.K., Sagar,D., Montezano,A.C.,
            Rios,F.J., De Lucca Camargo,L., Hamilton,G., Gazdagh,G.,
            Diver,L.A., Williams,N., Herzyk,P., Touyz,R.M., Greenfield,A.,
            McGowan,R. and Ahmed,S.F.
  TITLE     SEC31A may be associated with pituitary hormone deficiency and
            gonadal dysgenesis
  JOURNAL   Endocrine 84 (2), 345-349 (2024)
   PUBMED   38400880
  REMARK    GeneRIF: SEC31A may be associated with pituitary hormone deficiency
            and gonadal dysgenesis.
REFERENCE   2  (bases 1 to 4146)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4146)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 4146)
  AUTHORS   Jin,L., Pahuja,K.B., Wickliffe,K.E., Gorur,A., Baumgartel,C.,
            Schekman,R. and Rape,M.
  TITLE     Ubiquitin-dependent regulation of COPII coat size and function
  JOURNAL   Nature 482 (7386), 495-500 (2012)
   PUBMED   22358839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4146)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4146)
  AUTHORS   Kim,J.H., Hong,J.A., Pih,K.T. and Hwang,I.
  TITLE     Identification and isolation of differentially expressed genes in
            osmotically stressed human oral keratinocytes
  JOURNAL   Arch Oral Biol 46 (4), 335-341 (2001)
   PUBMED   11269867
REFERENCE   8  (bases 1 to 4146)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   9  (bases 1 to 4146)
  AUTHORS   Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
  TITLE     Mammalian homologues of yeast sec31p. An ubiquitously expressed
            form is localized to endoplasmic reticulum (ER) exit sites and is
            essential for ER-Golgi transport
  JOURNAL   J Biol Chem 275 (18), 13597-13604 (2000)
   PUBMED   10788476
REFERENCE   10 (bases 1 to 4146)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021105.13 and AC108469.5.
            
            Summary: The protein encoded by this gene shares similarity with
            the yeast Sec31 protein, and is a component of the outer layer of
            the coat protein complex II (COPII). The encoded protein is
            involved in vesicle budding from the endoplasmic reticulum (ER) and
            contains multiple WD repeats near the N-terminus and a proline-rich
            region in the C-terminal half. It associates with the protein
            encoded by the SEC13 homolog, nuclear pore and COPII coat complex
            component (SEC13), and is required for ER-Golgi transport.
            Monoubiquitylation of this protein by CUL3-KLHL12 was found to
            regulate the size of COPII coats to accommodate unusually shaped
            cargo. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.22406.1,
                                           SRR1660805.151339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC021105.13        158813-158878
            67-149              AC021105.13        168026-168108
            150-273             AC021105.13        169044-169167
            274-472             AC021105.13        171038-171236
            473-568             AC021105.13        174144-174239
            569-709             AC021105.13        175215-175355
            710-852             AC021105.13        177880-178022
            853-952             AC021105.13        179542-179641
            953-1114            AC021105.13        182650-182811
            1115-1267           AC021105.13        183006-183158
            1268-1504           AC021105.13        185368-185604
            1505-1579           AC021105.13        186574-186648
            1580-1657           AC108469.5         59064-59141         c
            1658-1733           AC108469.5         55122-55197         c
            1734-1912           AC108469.5         54385-54563         c
            1913-2039           AC108469.5         52336-52462         c
            2040-2185           AC108469.5         51003-51148         c
            2186-2359           AC108469.5         48864-49037         c
            2360-2533           AC108469.5         46237-46410         c
            2534-2657           AC108469.5         41819-41942         c
            2658-2999           AC108469.5         39573-39914         c
            3000-3038           AC108469.5         28370-28408         c
            3039-3097           AC108469.5         26433-26491         c
            3098-3361           AC108469.5         24802-25065         c
            3362-3481           AC108469.5         21988-22107         c
            3482-3553           AC108469.5         18470-18541         c
            3554-4146           AC108469.5         16094-16686         c
FEATURES             Location/Qualifiers
     source          1..4146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..4146
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="SEC31 homolog A, COPII coat complex component"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
     exon            1..66
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..149
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3733
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="isoform 14 is encoded by transcript variant 22;
                     yeast Sec31p homolog; protein transport protein Sec31A;
                     web1-like protein; SEC31-related protein A; SEC31-like
                     protein 1; SEC31 homolog A, COPII coating complex
                     component"
                     /codon_start=1
                     /product="protein transport protein Sec31A isoform 14"
                     /protein_id="NP_001387094.1"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
                     /translation="MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLE
                     IFELDLSDPSLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYD
                     PSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMT
                     PGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSG
                     LAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELL
                     LSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIM
                     GGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRR
                     PVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQ
                     SQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKALKDS
                     DQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTFNISVSGDIDGLITQALLT
                     GNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNW
                     KEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICA
                     GNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQY
                     ANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGHESPKIPYEKQQLPK
                     GRPGPVAGHHQMPRVQTQQYYPHGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVP
                     PYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYA
                     AQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPA
                     SQRTENQSIQDQAPMLEGPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
                     PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAP
                     GAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDA
                     SKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAF
                     MPVLKVVLTQANKLGV"
     exon            150..273
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..472
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..568
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..709
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..852
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..952
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1114
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1267
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1504
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1579
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1657
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1733
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1912
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2039
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2185
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2359
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2533
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2657
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2999
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3038
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3097
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3361
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3481
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3553
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..4146
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4146
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="major polyA site"
ORIGIN      
        1 gaatgctggg agagtccgac gagcgctgca ctaacgcagg atccggctgc cgaaggtcct
       61 cgccagcagg atgaagttaa aggaagtaga tcgtacagcc atgcaggcat ggagccctgc
      121 ccagaatcac cccatttacc tagcaacagg aacatctgct cagcaattgg atgcaacatt
      181 tagtacgaat gcttcccttg agatatttga attagacctc tctgatccat ccttggatat
      241 gaaatcttgt gccacattct cctcttctca caggtaccac aagttgattt gggggcctta
      301 taaaatggat tccaaaggag atgtctctgg agttctgatt gcaggtggtg aaaatggaaa
      361 tattattctc tatgatcctt ctaaaattat agctggagac aaggaagttg tgattgccca
      421 gaatgacaag catactggcc cagtgagagc cttggatgtg aacattttcc agactaatct
      481 ggtagcttct ggtgctaatg aatctgaaat ctacatatgg gatctaaata attttgcaac
      541 cccaatgaca ccaggagcca aaacacagcc gccagaagat atcagctgca ttgcatggaa
      601 cagacaagtt cagcatattt tagcatcagc cagtcccagt ggccgggcca ctgtatggga
      661 tcttagaaaa aatgagccaa tcatcaaagt cagtgaccat agtaacagaa tgcattgttc
      721 tgggttggca tggcatcctg atgttgctac tcagatggtc cttgcctccg aggatgaccg
      781 gttaccagtg atccagatgt gggatcttcg atttgcttcc tctccacttc gtgtcctgga
      841 aaaccatgcc agggggattt tggcaattgc ttggagcatg gcagatcctg aattgttact
      901 gagctgtgga aaagatgcta agattctctg ctccaatcca aacacaggag aggtgttata
      961 tgaacttccc accaacacac agtggtgctt cgatattcag tggtgtcccc gaaatcctgc
     1021 tgtcttatca gctgcttcgt ttgatgggcg tatcagtgtt tattctatca tgggaggtag
     1081 cacagatggt ttaagacaga aacaagttga caagctttca tcatcttttg ggaatcttga
     1141 tccctttggc acaggacagc cccttcctcc gttacaaatt ccacagcaga ctgctcagca
     1201 tagtatagtg ctgcctctga agaagccgcc caagtggatt cgaaggcctg ttggtgcttc
     1261 tttttcattt ggaggcaaac tggttacgtt tgagaatgtc agaatgcctt ctcatcaggg
     1321 agctgagcag cagcagcagc agcaccatgt gttcattagt caggttgtaa cagaaaagga
     1381 gttcctcagc cgatcagacc aacttcagca ggctgtgcag tcacaaggat ttatcaatta
     1441 ttgccaaaaa aaaattgatg cttctcagac tgaatttgag aaaaatgtgt ggtccttttt
     1501 gaaggtaaac tttgaggatg attctcgtgg aaaatacctt gaacttctag gatacagaaa
     1561 agaagatcta ggaaagaagg ctcttaaaga ctctgaccaa gtagcacaga gtgatgggga
     1621 ggagagccct gctgctgaag agcagctctt gggagagcac attaaagagg aaaaagaaga
     1681 atctgaattt ctaccctcat ctggaggaac atttaatatc tctgtcagtg gggacattga
     1741 tggtttaatt actcaggctt tgctgacggg caattttgag agtgctgttg acctttgttt
     1801 acatgataac cgcatggccg atgccattat attggccata gcaggtggac aagaactctt
     1861 ggctcgaacc cagaaaaaat acttcgcaaa atcccaaagc aaaattacca ggctcatcac
     1921 tgcagtggtg atgaagaact ggaaagagat tgttgagtct tgtgatctta aaaattggag
     1981 agaggcttta gctgcagtat tgacttatgc aaagccggat gaattttcag ccctttgtga
     2041 tcttttggga accaggcttg aaaatgaagg agatagcctc ctgcagactc aagcatgtct
     2101 ctgctatatt tgtgcaggga atgtagagaa attagttgca tgttggacta aagctcaaga
     2161 tggaagccac cctttgtcac ttcaggatct gattgagaaa gttgtcatcc tgcgaaaagc
     2221 tgtgcaactc actcaagcca tggacactag tactgtagga gttctcttgg ctgcgaagat
     2281 gagtcagtat gccaatttgt tggcagctca gggcagtatt gctgcagcct tggcttttct
     2341 tcctgacaac accaaccagc caaatatcat gcagcttcgt gacagacttt gtagagcaca
     2401 aggagagcct gtagcaggac atgaatcacc taaaattccg tacgagaaac agcagctccc
     2461 caagggcagg cctggaccag ttgctggcca ccaccagatg ccaagagttc aaactcaaca
     2521 atattatccc catggagaaa atcctccacc tccgggtttc ataatgcatg gaaatgttaa
     2581 tccaaatgct gctggtcagc ttcccacatc tccaggtcat atgcacaccc aggtaccacc
     2641 ttatccacag ccacagcctt atcaaccagc ccagccgtat cccttcggaa caggggggtc
     2701 agcaatgtat cgacctcagc agcctgttgc tcctcctact tcaaacgctt accctaacac
     2761 cccttacata tcttctgctt cttcctatac tgggcagtct cagctgtacg cagcacagca
     2821 ccaggcctct tcacctacct ccagccctgc tacttctttc cctcctcccc cttcctctgg
     2881 agcatccttc cagcatggcg gaccaggagc tccaccatca tcttcagctt atgcactgcc
     2941 tcctggaaca acaggtacac tgcctgctgc cagtgagctg cctgcgtccc aaagaacaga
     3001 aaaccagtct atccaagacc aggcacctat gttggaaggt cctcagaatg gttggaatga
     3061 ccctccagct ttgaacagag tacccaaaaa gaagaagatg cctgaaaact tcatgcctcc
     3121 tgttcccatc acatcaccaa tcatgaaccc gttgggtgac ccccagtcac aaatgctgca
     3181 gcaacagcct tcagctccag taccactgtc aagccagtct tcattcccac agccacatct
     3241 tccaggtggc cagcccttcc atggcgtaca gcaacctctt ggtcaaacag gcatgccacc
     3301 atctttttca aagcccaata ttgaaggtgc cccaggggct cctattggaa ataccttcca
     3361 gcatgtgcag tctttgccaa caaaaaaaat taccaagaaa cctattccag atgagcacct
     3421 cattctaaag accacatttg aggatcttat tcagcgctgc ctttcttcag caacagaccc
     3481 tcaaaccaag aggaagctag atgatgccag caaacgtttg gagtttctgt atgataaact
     3541 tagggaacag acactttcac caacaatcac cagtggttta cacaacattg caaggagcat
     3601 tgaaactcga aactactcag aaggattgac catgcatacc cacatagtta gcaccagcaa
     3661 cttcagtgag acctctgctt tcatgccagt tctcaaagtt gttctcaccc aggccaataa
     3721 gctgggtgtc taaaaggaca gcttctcttc cactcaatat tgccattttt ccaaagaaac
     3781 atgttaaaaa aaaaaattat aagacatgga ctagtcctca ttagcatgtt tgcatagcaa
     3841 ccagtcaaga gcatttacac tatttctgct gatatactca ccttagaact gctcagaacc
     3901 ctggtgcttt atttttgttt taatcttttg ttgccagtga tgattttcct attctgcaaa
     3961 tagtgtattt cctggattac acatagtatg gtttcctgaa gtattctgat aaatgtgttt
     4021 tttaaaacct caatatactt tttagaaaag gagcatctgg ttatgcataa agcagagcta
     4081 aaactaaatt tctttcatgt cctccctact tcctcagtgt caatcagatt aaagtgtgta
     4141 atccta
//
