LOCUS       NM_001191049            4328 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC31 homolog A, COPII coat complex component
            (SEC31A), transcript variant 6, mRNA.
ACCESSION   NM_001191049
VERSION     NM_001191049.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4328)
  AUTHORS   Tobias,E.S., Lucas-Herald,A.K., Sagar,D., Montezano,A.C.,
            Rios,F.J., De Lucca Camargo,L., Hamilton,G., Gazdagh,G.,
            Diver,L.A., Williams,N., Herzyk,P., Touyz,R.M., Greenfield,A.,
            McGowan,R. and Ahmed,S.F.
  TITLE     SEC31A may be associated with pituitary hormone deficiency and
            gonadal dysgenesis
  JOURNAL   Endocrine 84 (2), 345-349 (2024)
   PUBMED   38400880
  REMARK    GeneRIF: SEC31A may be associated with pituitary hormone deficiency
            and gonadal dysgenesis.
REFERENCE   2  (bases 1 to 4328)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4328)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4328)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 4328)
  AUTHORS   Jin,L., Pahuja,K.B., Wickliffe,K.E., Gorur,A., Baumgartel,C.,
            Schekman,R. and Rape,M.
  TITLE     Ubiquitin-dependent regulation of COPII coat size and function
  JOURNAL   Nature 482 (7386), 495-500 (2012)
   PUBMED   22358839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4328)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4328)
  AUTHORS   Kim,J.H., Hong,J.A., Pih,K.T. and Hwang,I.
  TITLE     Identification and isolation of differentially expressed genes in
            osmotically stressed human oral keratinocytes
  JOURNAL   Arch Oral Biol 46 (4), 335-341 (2001)
   PUBMED   11269867
REFERENCE   8  (bases 1 to 4328)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   9  (bases 1 to 4328)
  AUTHORS   Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
  TITLE     Mammalian homologues of yeast sec31p. An ubiquitously expressed
            form is localized to endoplasmic reticulum (ER) exit sites and is
            essential for ER-Golgi transport
  JOURNAL   J Biol Chem 275 (18), 13597-13604 (2000)
   PUBMED   10788476
REFERENCE   10 (bases 1 to 4328)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA218900.1, DC342364.1,
            BC039834.1, AK295810.1, BE710081.1 and AI802473.1.
            
            On Dec 24, 2015 this sequence version replaced NM_001191049.1.
            
            Summary: The protein encoded by this gene shares similarity with
            the yeast Sec31 protein, and is a component of the outer layer of
            the coat protein complex II (COPII). The encoded protein is
            involved in vesicle budding from the endoplasmic reticulum (ER) and
            contains multiple WD repeats near the N-terminus and a proline-rich
            region in the C-terminal half. It associates with the protein
            encoded by the SEC13 homolog, nuclear pore and COPII coat complex
            component (SEC13), and is required for ER-Golgi transport.
            Monoubiquitylation of this protein by CUL3-KLHL12 was found to
            regulate the size of COPII coats to accommodate unusually shaped
            cargo. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (6) lacks an exon in the 5'
            region, resulting in a distinct 5' UTR , use of an upstream
            in-frame start codon, and also uses an alternate in-frame splice
            site in the 3' coding region, compared to variant 5. The encoded
            isoform (5) is shorter, has a distinct N-terminus, and lacks an
            internal region, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295810.1, SRR1803614.258122.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DA218900.1         1-59
            60-98               DA218900.1         61-99
            99-230              DC342364.1         1-132
            231-3387            BC039834.1         237-3393
            3388-4144           AK295810.1         3286-4042
            4145-4292           BE710081.1         205-352             c
            4293-4328           AI802473.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..4328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..4328
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="SEC31 homolog A, COPII coat complex component"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
     exon            1..193
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3732
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="isoform 5 is encoded by transcript variant 6; yeast
                     Sec31p homolog; protein transport protein Sec31A;
                     web1-like protein; SEC31-related protein A; SEC31-like
                     protein 1; SEC31 homolog A, COPII coating complex
                     component"
                     /codon_start=1
                     /product="protein transport protein Sec31A isoform 5"
                     /protein_id="NP_001177978.1"
                     /db_xref="CCDS:CCDS54773.1"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
                     /translation="MLGESDERCTNAGSGCRRSSPGTSAQQLDATFSTNASLEIFELD
                     LSDPSLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKII
                     AGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKT
                     QPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSGLAWHP
                     DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK
                     DAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTD
                     GLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGAS
                     FSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFI
                     NYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDG
                     ANVALKDSDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTFNISVSGDIDG
                     LITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLI
                     TAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQ
                     ACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVL
                     LAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGHESPKIP
                     YEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHGENPPPPGFIMHGNVNPNAAGQLPTSP
                     GHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSY
                     TGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQ
                     NGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQS
                     SFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKIT
                     KKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTI
                     TSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKLGV"
     exon            194..317
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..516
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..612
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..753
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..896
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..996
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1158
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1311
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1548
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1623
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1662
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1740
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1816
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1995
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2122
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2268
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2442
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2616
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2740
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..3037
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3096
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3360
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3480
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3552
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..4297
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4145
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="major polyA site"
     regulatory      4267..4272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="hexamer: AATAAA"
     polyA_site      4297
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
ORIGIN      
        1 gtgcgtcggg tgggcgggga aagatgtcgc tcccggaagt gttgggcgca gggcgtggct
       61 gcggctgcgg ctgccacgtt ggaacggaac gtggaggtgg ccctggccgg ggaggagggg
      121 cggcggcgaa tgctgggaga gtccgacgag cgctgcacta acgcaggatc cggctgccga
      181 aggtcctcgc caggaacatc tgctcagcaa ttggatgcaa catttagtac gaatgcttcc
      241 cttgagatat ttgaattaga cctctctgat ccatccttgg atatgaaatc ttgtgccaca
      301 ttctcctctt ctcacaggta ccacaagttg atttgggggc cttataaaat ggattccaaa
      361 ggagatgtct ctggagttct gattgcaggt ggtgaaaatg gaaatattat tctctatgat
      421 ccttctaaaa ttatagctgg agacaaggaa gttgtgattg cccagaatga caagcatact
      481 ggcccagtga gagccttgga tgtgaacatt ttccagacta atctggtagc ttctggtgct
      541 aatgaatctg aaatctacat atgggatcta aataattttg caaccccaat gacaccagga
      601 gccaaaacac agccgccaga agatatcagc tgcattgcat ggaacagaca agttcagcat
      661 attttagcat cagccagtcc cagtggccgg gccactgtat gggatcttag aaaaaatgag
      721 ccaatcatca aagtcagtga ccatagtaac agaatgcatt gttctgggtt ggcatggcat
      781 cctgatgttg ctactcagat ggtccttgcc tccgaggatg accggttacc agtgatccag
      841 atgtgggatc ttcgatttgc ttcctctcca cttcgtgtcc tggaaaacca tgccaggggg
      901 attttggcaa ttgcttggag catggcagat cctgaattgt tactgagctg tggaaaagat
      961 gctaagattc tctgctccaa tccaaacaca ggagaggtgt tatatgaact tcccaccaac
     1021 acacagtggt gcttcgatat tcagtggtgt ccccgaaatc ctgctgtctt atcagctgct
     1081 tcgtttgatg ggcgtatcag tgtttattct atcatgggag gaagcacaga tggtttaaga
     1141 cagaaacaag ttgacaagct ttcatcatct tttgggaatc ttgatccctt tggcacagga
     1201 cagccccttc ctccgttaca aattccacag cagactgctc agcatagtat agtgctgcct
     1261 ctgaagaagc cgcccaagtg gattcgaagg cctgttggtg cttctttttc atttggaggc
     1321 aaactggtta cgtttgagaa tgtcagaatg ccttctcatc agggagctga gcagcagcag
     1381 cagcagcacc atgtgttcat tagtcaggtt gtaacagaaa aggagttcct cagccgatca
     1441 gaccaacttc agcaggctgt gcagtcacaa ggatttatca attattgcca aaaaaaaatt
     1501 gatgcttctc agactgaatt tgagaaaaat gtgtggtcct ttttgaaggt aaactttgag
     1561 gatgattctc gtggaaaata ccttgaactt ctaggataca gaaaagaaga tctaggaaag
     1621 aagattgctt tggccttgaa caaagtggat ggagccaatg tggctcttaa agactctgac
     1681 caagtagcac agagtgatgg ggaggagagc cctgctgctg aagagcagct cttgggagag
     1741 cacattaaag aggaaaaaga agaatctgaa tttctaccct catctggagg aacatttaat
     1801 atctctgtca gtggggacat tgatggttta attactcagg ctttgctgac gggcaatttt
     1861 gagagtgctg ttgacctttg tttacatgat aaccgcatgg ccgatgccat tatattggcc
     1921 atagcaggtg gacaagaact cttggctcga acccagaaaa aatacttcgc aaaatcccaa
     1981 agcaaaatta ccaggctcat cactgcagtg gtgatgaaga actggaaaga gattgttgag
     2041 tcttgtgatc ttaaaaattg gagagaggct ttagctgcag tattgactta tgcaaagccg
     2101 gatgaatttt cagccctttg tgatcttttg ggaaccaggc ttgaaaatga aggagatagc
     2161 ctcctgcaga ctcaagcatg tctctgctat atttgtgcag ggaatgtaga gaaattagtt
     2221 gcatgttgga ctaaagctca agatggaagc caccctttgt cacttcagga tctgattgag
     2281 aaagttgtca tcctgcgaaa agctgtgcaa ctcactcaag ccatggacac tagtactgta
     2341 ggagttctct tggctgcgaa gatgagtcag tatgccaatt tgttggcagc tcagggcagt
     2401 attgctgcag ccttggcttt tcttcctgac aacaccaacc agccaaatat catgcagctt
     2461 cgtgacagac tttgtagagc acaaggagag cctgtagcag gacatgaatc acctaaaatt
     2521 ccgtacgaga aacagcagct ccccaagggc aggcctggac cagttgctgg ccaccaccag
     2581 atgccaagag ttcaaactca acaatattat ccccatggag aaaatcctcc acctccgggt
     2641 ttcataatgc atggaaatgt taatccaaat gctgctggtc agcttcccac atctccaggt
     2701 catatgcaca cccaggtacc accttatcca cagccacagc cttatcaacc agcccagccg
     2761 tatcccttcg gaacaggggg gtcagcaatg tatcgacctc agcagcctgt tgctcctcct
     2821 acttcaaacg cttaccctaa caccccttac atatcttctg cttcttccta tactgggcag
     2881 tctcagctgt acgcagcaca gcaccaggcc tcttcaccta cctccagccc tgctacttct
     2941 ttccctcctc ccccttcctc tggagcatcc ttccagcatg gcggaccagg agctccacca
     3001 tcatcttcag cttatgcact gcctcctgga acaacaggtc ctcagaatgg ttggaatgac
     3061 cctccagctt tgaacagagt acccaaaaag aagaagatgc ctgaaaactt catgcctcct
     3121 gttcccatca catcaccaat catgaacccg ttgggtgacc cccagtcaca aatgctgcag
     3181 caacagcctt cagctccagt accactgtca agccagtctt cattcccaca gccacatctt
     3241 ccaggtggcc agcccttcca tggcgtacag caacctcttg gtcaaacagg catgccacca
     3301 tctttttcaa agcccaatat tgaaggtgcc ccaggggctc ctattggaaa taccttccag
     3361 catgtgcagt ctttgccaac aaaaaaaatt accaagaaac ctattccaga tgagcacctc
     3421 attctaaaga ccacatttga ggatcttatt cagcgctgcc tttcttcagc aacagaccct
     3481 caaaccaaga ggaagctaga tgatgccagc aaacgtttgg agtttctgta tgataaactt
     3541 agggaacaga cactttcacc aacaatcacc agtggtttac acaacattgc aaggagcatt
     3601 gaaactcgaa actactcaga aggattgacc atgcataccc acatagttag caccagcaac
     3661 ttcagtgaga cctctgcttt catgccagtt ctcaaagttg ttctcaccca ggccaataag
     3721 ctgggtgtct aaaaggacag cttctcttcc actcaatatt gccatttttc caaagaaaca
     3781 tgttaaaaaa aaaaattata agacatggac tagtcctcat tagcatgttt gcatagcaac
     3841 cagtcaagag catttacact atttctgctg atatactcac cttagaactg ctcagaaccc
     3901 tggtgcttta tttttgtttt aatcttttgt tgccagtgat gattttccta ttctgcaaat
     3961 agtgtatttc ctggattaca catagtatgg tttcctgaag tattctgata aatgtgtttt
     4021 ttaaaacctc aatatacttt ttagaaaagg agcatctggt tatgcataaa gcagagctaa
     4081 aactaaattt ctttcatgtc ctccctactt cctcagtgtc aatcagatta aagtgtgtaa
     4141 tcctatttta tgtgtgtata gtcttttttg aaacagctgc ttaaaattta gtttattttt
     4201 tgtgtcttag gattcctgag taaataacta catctacaaa ctgctacatg ggttttagca
     4261 gatattaata aaaatgggat cactggcttt aactataaaa aaaaaaaaaa aaaaaaaaaa
     4321 aaaaaaaa
//
