LOCUS       NM_001077207            4298 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC31 homolog A, COPII coat complex component
            (SEC31A), transcript variant 5, mRNA.
ACCESSION   NM_001077207
VERSION     NM_001077207.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Tobias,E.S., Lucas-Herald,A.K., Sagar,D., Montezano,A.C.,
            Rios,F.J., De Lucca Camargo,L., Hamilton,G., Gazdagh,G.,
            Diver,L.A., Williams,N., Herzyk,P., Touyz,R.M., Greenfield,A.,
            McGowan,R. and Ahmed,S.F.
  TITLE     SEC31A may be associated with pituitary hormone deficiency and
            gonadal dysgenesis
  JOURNAL   Endocrine 84 (2), 345-349 (2024)
   PUBMED   38400880
  REMARK    GeneRIF: SEC31A may be associated with pituitary hormone deficiency
            and gonadal dysgenesis.
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Jin,L., Pahuja,K.B., Wickliffe,K.E., Gorur,A., Baumgartel,C.,
            Schekman,R. and Rape,M.
  TITLE     Ubiquitin-dependent regulation of COPII coat size and function
  JOURNAL   Nature 482 (7386), 495-500 (2012)
   PUBMED   22358839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Kim,J.H., Hong,J.A., Pih,K.T. and Hwang,I.
  TITLE     Identification and isolation of differentially expressed genes in
            osmotically stressed human oral keratinocytes
  JOURNAL   Arch Oral Biol 46 (4), 335-341 (2001)
   PUBMED   11269867
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
  TITLE     Mammalian homologues of yeast sec31p. An ubiquitously expressed
            form is localized to endoplasmic reticulum (ER) exit sites and is
            essential for ER-Golgi transport
  JOURNAL   J Biol Chem 275 (18), 13597-13604 (2000)
   PUBMED   10788476
REFERENCE   10 (bases 1 to 4298)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021105.13 and AC108469.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001077207.3.
            
            Summary: The protein encoded by this gene shares similarity with
            the yeast Sec31 protein, and is a component of the outer layer of
            the coat protein complex II (COPII). The encoded protein is
            involved in vesicle budding from the endoplasmic reticulum (ER) and
            contains multiple WD repeats near the N-terminus and a proline-rich
            region in the C-terminal half. It associates with the protein
            encoded by the SEC13 homolog, nuclear pore and COPII coat complex
            component (SEC13), and is required for ER-Golgi transport.
            Monoubiquitylation of this protein by CUL3-KLHL12 was found to
            regulate the size of COPII coats to accommodate unusually shaped
            cargo. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (5) encodes the longest isoform
            (1). Both variants 5 and 10 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.119071.1,
                                           SRR1660805.167194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395310.7/ ENSP00000378721.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC021105.13        158813-158878
            67-149              AC021105.13        168026-168108
            150-273             AC021105.13        169044-169167
            274-472             AC021105.13        171038-171236
            473-568             AC021105.13        174144-174239
            569-709             AC021105.13        175215-175355
            710-852             AC021105.13        177880-178022
            853-952             AC021105.13        179542-179641
            953-1114            AC021105.13        182650-182811
            1115-1267           AC021105.13        183006-183158
            1268-1504           AC021105.13        185368-185604
            1505-1579           AC021105.13        186574-186648
            1580-1618           AC108469.5         59967-60005         c
            1619-1696           AC108469.5         59064-59141         c
            1697-1772           AC108469.5         55122-55197         c
            1773-1951           AC108469.5         54385-54563         c
            1952-2078           AC108469.5         52336-52462         c
            2079-2224           AC108469.5         51003-51148         c
            2225-2398           AC108469.5         48864-49037         c
            2399-2572           AC108469.5         46237-46410         c
            2573-2696           AC108469.5         41819-41942         c
            2697-3038           AC108469.5         39573-39914         c
            3039-3097           AC108469.5         26433-26491         c
            3098-3361           AC108469.5         24802-25065         c
            3362-3481           AC108469.5         21988-22107         c
            3482-3553           AC108469.5         18470-18541         c
            3554-4298           AC108469.5         15942-16686         c
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..4298
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="SEC31 homolog A, COPII coat complex component"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
     exon            1..66
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..149
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3733
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="isoform 1 is encoded by transcript variant 5; yeast
                     Sec31p homolog; protein transport protein Sec31A;
                     web1-like protein; SEC31-related protein A; SEC31-like
                     protein 1; SEC31 homolog A, COPII coating complex
                     component"
                     /codon_start=1
                     /product="protein transport protein Sec31A isoform 1"
                     /protein_id="NP_001070675.1"
                     /db_xref="CCDS:CCDS3596.1"
                     /db_xref="GeneID:22872"
                     /db_xref="HGNC:HGNC:17052"
                     /db_xref="MIM:610257"
                     /translation="MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLE
                     IFELDLSDPSLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYD
                     PSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMT
                     PGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSG
                     LAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELL
                     LSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIM
                     GGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRR
                     PVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQ
                     SQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALAL
                     NKVDGANVALKDSDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTFNISVS
                     GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSK
                     ITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDS
                     LLQTQACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTS
                     TVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGHE
                     SPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHGENPPPPGFIMHGNVNPNAAGQ
                     LPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYIS
                     SASSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPG
                     TTGTLPAASELPASQRTGPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
                     PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAP
                     GAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDA
                     SKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAF
                     MPVLKVVLTQANKLGV"
     exon            150..273
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..472
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..568
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..709
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..852
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..952
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1114
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1267
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1504
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1579
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1618
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1696
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1772
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1951
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2078
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2224
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2398
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2572
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2696
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..3038
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3097
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3361
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3481
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3553
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..4298
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4146
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="major polyA site"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
                     /note="hexamer: AATAAA"
     polyA_site      4298
                     /gene="SEC31A"
                     /gene_synonym="ABP125; ABP130; HPBKS; HSPC275; HSPC334;
                     NEDSOSB; SEC31L1"
ORIGIN      
        1 gaatgctggg agagtccgac gagcgctgca ctaacgcagg atccggctgc cgaaggtcct
       61 cgccagcagg atgaagttaa aggaagtaga tcgtacagcc atgcaggcat ggagccctgc
      121 ccagaatcac cccatttacc tagcaacagg aacatctgct cagcaattgg atgcaacatt
      181 tagtacgaat gcttcccttg agatatttga attagacctc tctgatccat ccttggatat
      241 gaaatcttgt gccacattct cctcttctca caggtaccac aagttgattt gggggcctta
      301 taaaatggat tccaaaggag atgtctctgg agttctgatt gcaggtggtg aaaatggaaa
      361 tattattctc tatgatcctt ctaaaattat agctggagac aaggaagttg tgattgccca
      421 gaatgacaag catactggcc cagtgagagc cttggatgtg aacattttcc agactaatct
      481 ggtagcttct ggtgctaatg aatctgaaat ctacatatgg gatctaaata attttgcaac
      541 cccaatgaca ccaggagcca aaacacagcc gccagaagat atcagctgca ttgcatggaa
      601 cagacaagtt cagcatattt tagcatcagc cagtcccagt ggccgggcca ctgtatggga
      661 tcttagaaaa aatgagccaa tcatcaaagt cagtgaccat agtaacagaa tgcattgttc
      721 tgggttggca tggcatcctg atgttgctac tcagatggtc cttgcctccg aggatgaccg
      781 gttaccagtg atccagatgt gggatcttcg atttgcttcc tctccacttc gtgtcctgga
      841 aaaccatgcc agggggattt tggcaattgc ttggagcatg gcagatcctg aattgttact
      901 gagctgtgga aaagatgcta agattctctg ctccaatcca aacacaggag aggtgttata
      961 tgaacttccc accaacacac agtggtgctt cgatattcag tggtgtcccc gaaatcctgc
     1021 tgtcttatca gctgcttcgt ttgatgggcg tatcagtgtt tattctatca tgggaggtag
     1081 cacagatggt ttaagacaga aacaagttga caagctttca tcatcttttg ggaatcttga
     1141 tccctttggc acaggacagc cccttcctcc gttacaaatt ccacagcaga ctgctcagca
     1201 tagtatagtg ctgcctctga agaagccgcc caagtggatt cgaaggcctg ttggtgcttc
     1261 tttttcattt ggaggcaaac tggttacgtt tgagaatgtc agaatgcctt ctcatcaggg
     1321 agctgagcag cagcagcagc agcaccatgt gttcattagt caggttgtaa cagaaaagga
     1381 gttcctcagc cgatcagacc aacttcagca ggctgtgcag tcacaaggat ttatcaatta
     1441 ttgccaaaaa aaaattgatg cttctcagac tgaatttgag aaaaatgtgt ggtccttttt
     1501 gaaggtaaac tttgaggatg attctcgtgg aaaatacctt gaacttctag gatacagaaa
     1561 agaagatcta ggaaagaaga ttgctttggc cttgaacaaa gtggatggag ccaatgtggc
     1621 tcttaaagac tctgaccaag tagcacagag tgatggggag gagagccctg ctgctgaaga
     1681 gcagctcttg ggagagcaca ttaaagagga aaaagaagaa tctgaatttc taccctcatc
     1741 tggaggaaca tttaatatct ctgtcagtgg ggacattgat ggtttaatta ctcaggcttt
     1801 gctgacgggc aattttgaga gtgctgttga cctttgttta catgataacc gcatggccga
     1861 tgccattata ttggccatag caggtggaca agaactcttg gctcgaaccc agaaaaaata
     1921 cttcgcaaaa tcccaaagca aaattaccag gctcatcact gcagtggtga tgaagaactg
     1981 gaaagagatt gttgagtctt gtgatcttaa aaattggaga gaggctttag ctgcagtatt
     2041 gacttatgca aagccggatg aattttcagc cctttgtgat cttttgggaa ccaggcttga
     2101 aaatgaagga gatagcctcc tgcagactca agcatgtctc tgctatattt gtgcagggaa
     2161 tgtagagaaa ttagttgcat gttggactaa agctcaagat ggaagccacc ctttgtcact
     2221 tcaggatctg attgagaaag ttgtcatcct gcgaaaagct gtgcaactca ctcaagccat
     2281 ggacactagt actgtaggag ttctcttggc tgcgaagatg agtcagtatg ccaatttgtt
     2341 ggcagctcag ggcagtattg ctgcagcctt ggcttttctt cctgacaaca ccaaccagcc
     2401 aaatatcatg cagcttcgtg acagactttg tagagcacaa ggagagcctg tagcaggaca
     2461 tgaatcacct aaaattccgt acgagaaaca gcagctcccc aagggcaggc ctggaccagt
     2521 tgctggccac caccagatgc caagagttca aactcaacaa tattatcccc atggagaaaa
     2581 tcctccacct ccgggtttca taatgcatgg aaatgttaat ccaaatgctg ctggtcagct
     2641 tcccacatct ccaggtcata tgcacaccca ggtaccacct tatccacagc cacagcctta
     2701 tcaaccagcc cagccgtatc ccttcggaac aggggggtca gcaatgtatc gacctcagca
     2761 gcctgttgct cctcctactt caaacgctta ccctaacacc ccttacatat cttctgcttc
     2821 ttcctatact gggcagtctc agctgtacgc agcacagcac caggcctctt cacctacctc
     2881 cagccctgct acttctttcc ctcctccccc ttcctctgga gcatccttcc agcatggcgg
     2941 accaggagct ccaccatcat cttcagctta tgcactgcct cctggaacaa caggtacact
     3001 gcctgctgcc agtgagctgc ctgcgtccca aagaacaggt cctcagaatg gttggaatga
     3061 ccctccagct ttgaacagag tacccaaaaa gaagaagatg cctgaaaact tcatgcctcc
     3121 tgttcccatc acatcaccaa tcatgaaccc gttgggtgac ccccagtcac aaatgctgca
     3181 gcaacagcct tcagctccag taccactgtc aagccagtct tcattcccac agccacatct
     3241 tccaggtggc cagcccttcc atggcgtaca gcaacctctt ggtcaaacag gcatgccacc
     3301 atctttttca aagcccaata ttgaaggtgc cccaggggct cctattggaa ataccttcca
     3361 gcatgtgcag tctttgccaa caaaaaaaat taccaagaaa cctattccag atgagcacct
     3421 cattctaaag accacatttg aggatcttat tcagcgctgc ctttcttcag caacagaccc
     3481 tcaaaccaag aggaagctag atgatgccag caaacgtttg gagtttctgt atgataaact
     3541 tagggaacag acactttcac caacaatcac cagtggttta cacaacattg caaggagcat
     3601 tgaaactcga aactactcag aaggattgac catgcatacc cacatagtta gcaccagcaa
     3661 cttcagtgag acctctgctt tcatgccagt tctcaaagtt gttctcaccc aggccaataa
     3721 gctgggtgtc taaaaggaca gcttctcttc cactcaatat tgccattttt ccaaagaaac
     3781 atgttaaaaa aaaaaattat aagacatgga ctagtcctca ttagcatgtt tgcatagcaa
     3841 ccagtcaaga gcatttacac tatttctgct gatatactca ccttagaact gctcagaacc
     3901 ctggtgcttt atttttgttt taatcttttg ttgccagtga tgattttcct attctgcaaa
     3961 tagtgtattt cctggattac acatagtatg gtttcctgaa gtattctgat aaatgtgttt
     4021 tttaaaacct caatatactt tttagaaaag gagcatctgg ttatgcataa agcagagcta
     4081 aaactaaatt tctttcatgt cctccctact tcctcagtgt caatcagatt aaagtgtgta
     4141 atcctatttt atgtgtgtat agtctttttt gaaacagctg cttaaaattt agtttatttt
     4201 ttgtgtctta ggattcctga gtaaataact acatctacaa actgctacat gggttttagc
     4261 agatattaat aaaaatggga tcactggctt taactata
//
