LOCUS       NM_198597               4445 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC24 homolog C, COPII coat complex component
            (SEC24C), transcript variant 2, mRNA.
ACCESSION   NM_198597
VERSION     NM_198597.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4445)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4445)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4445)
  AUTHORS   Rebensburg,S.V., Wei,G., Larue,R.C., Lindenberger,J., Francis,A.C.,
            Annamalai,A.S., Morrison,J., Shkriabai,N., Huang,S.W.,
            KewalRamani,V., Poeschla,E.M., Melikyan,G.B. and Kvaratskhelia,M.
  TITLE     Sec24C is an HIV-1 host dependency factor crucial for virus
            replication
  JOURNAL   Nat Microbiol 6 (4), 435-444 (2021)
   PUBMED   33649557
  REMARK    GeneRIF: Sec24C is an HIV-1 host dependency factor crucial for
            virus replication.
REFERENCE   4  (bases 1 to 4445)
  AUTHORS   Deng,S.J., Shen,Y., Gu,H.M., Guo,S., Wu,S.R. and Zhang,D.W.
  TITLE     The role of the C-terminal domain of PCSK9 and SEC24 isoforms in
            PCSK9 secretion
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (6), 158660 (2020)
   PUBMED   32058034
  REMARK    GeneRIF: The role of the C-terminal domain of PCSK9 and SEC24
            isoforms in PCSK9 secretion.
REFERENCE   5  (bases 1 to 4445)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4445)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   7  (bases 1 to 4445)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   8  (bases 1 to 4445)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   9  (bases 1 to 4445)
  AUTHORS   Tani,K., Oyama,Y., Hatsuzawa,K. and Tagaya,M.
  TITLE     Hypothetical protein KIAA0079 is a mammalian homologue of yeast
            Sec24p
  JOURNAL   FEBS Lett 447 (2-3), 247-250 (1999)
   PUBMED   10214955
REFERENCE   10 (bases 1 to 4445)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022400.9, AL596994.1,
            BC018928.2, D38555.1 and CA419040.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198597.2.
            
            Summary: The protein encoded by this gene is a member of the SEC24
            subfamily of the SEC23/SEC24 family, which is involved in vesicle
            trafficking. The encoded protein has similarity to yeast Sec24p
            component of COPII. COPII is the coat protein complex responsible
            for vesicle budding from the ER. The product of this gene may play
            a role in shaping the vesicle, as well as in cargo selection and
            concentration. Alternatively spliced transcript variants encoding
            the same protein have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR
            region, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.4989.1,
                                           SRR1803614.201498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345254.9/ ENSP00000321845.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC022400.9         77083-77083
            2-13                AL596994.1         1-12
            14-418              BC018928.2         1-405
            419-3215            D38555.1           439-3235
            3216-4443           D38555.1           3237-4464
            4444-4445           CA419040.1         33-34               c
FEATURES             Location/Qualifiers
     source          1..4445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..4445
                     /gene="SEC24C"
                     /note="SEC24 homolog C, COPII coat complex component"
                     /db_xref="GeneID:9632"
                     /db_xref="HGNC:HGNC:10705"
                     /db_xref="MIM:607185"
     exon            1..66
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            67..266
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3379
                     /gene="SEC24C"
                     /note="SEC24 family, member C; SEC24-related protein C;
                     SEC24 related gene family, member C"
                     /codon_start=1
                     /product="protein transport protein Sec24C"
                     /protein_id="NP_940999.1"
                     /db_xref="CCDS:CCDS7332.1"
                     /db_xref="GeneID:9632"
                     /db_xref="HGNC:HGNC:10705"
                     /db_xref="MIM:607185"
                     /translation="MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAY
                     NGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQ
                     RLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGF
                     GPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAS
                     GGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQP
                     GYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIE
                     DDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQ
                     VPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFC
                     SCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMI
                     DVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLA
                     QPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQ
                     AGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQT
                     LAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLR
                     RDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDR
                     LNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAY
                     RGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKS
                     DVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASE
                     ERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSK
                     KVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKE
                     IRQLLS"
     exon            267..402
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            403..575
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            576..944
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1081
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1193
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1321
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1460
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1576
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1701
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1893
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1987
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2104
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2275
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2372
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2518
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2657
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2776
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2956
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3148
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3238
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..4445
                     /gene="SEC24C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4429..4434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC24C"
                     /note="hexamer: AATAAA"
     polyA_site      4445
                     /gene="SEC24C"
                     /note="major polyA site"
ORIGIN      
        1 ggaaccggaa gtggagcctg ggagccttga cgttaggaac gaagtctaac ctggatctgg
       61 agccgggtga gatcaaattg ggaatgcttt cataatgaac gtcaaccagt cagttccacc
      121 tgtgccacca tttgggcagc cccagcccat ctacccaggg tatcatcagt ccagctatgg
      181 tgggcaatca gggtccacag cccccgccat tccctatgga gcctacaatg gcccagtacc
      241 aggctatcag caaacacctc cccaaggtat gtcaagagcc ccaccttcct cgggggcacc
      301 tccagcctca acagcacagg ctccttgtgg ccaggctgca tatggccagt ttggccaagg
      361 agatgtacag aatgggccaa gctccactgt tcagatgcaa aggctgcctg ggtctcagcc
      421 atttgggtcc ccattggccc ctgtgggcaa ccagccacct gtgcttcagc cctatggccc
      481 tcccccgaca agtgcacagg tggctacgca gctgtctgga atgcagatca gcggtgctgt
      541 ggccccagcc cctccttctt cagggctggg ctttggccca ccaacatcgc tggcttcagc
      601 ctcaggaagt ttccctaact ctggtctgta tggctcctat cctcagggcc aggctcctcc
      661 ccttagccag gcccaaggtc atcctgggat ccagactccc cagcgatctg ccccatcaca
      721 ggcctccagc ttcacacccc cagcttcagg gggtcctcgg ctgccttcga tgactggtcc
      781 actcctgcct ggacagagtt ttggagggcc ctcagtgagc cagcccaacc atgtgtcttc
      841 acctcctcaa gctctgcccc ctggcaccca gatgactggg cccctgggac cactgccacc
      901 tatgcactcc ccgcagcagc caggctatca gccccaacaa aatggttcct tcggaccagc
      961 ccggggccct cagtctaatt atggaggccc ctacccagca gcacccacct ttggcagtca
     1021 gcctgggcct cctcagccac tgcctcctaa gcgcctggac cctgatgcca tcccaagccc
     1081 tattcaggtc attgaagatg acaggaacaa ccggggtaca gagccatttg ttactggagt
     1141 acggggccag gtgccaccct tagtcactac caacttcctg gtgaaagacc aagggaatgc
     1201 aagtccccga tacatccgat gtacatccta taatatccct tgcacatctg acatggctaa
     1261 gcaggctcag gtgcccctgg cagcagtcat caaaccgctg gcaaggctgc ccccagagga
     1321 ggcttcaccg tatgttgtgg accatgggga atctggccct ttgcgctgca accgctgcaa
     1381 agcatacatg tgtcccttca tgcagttcat tgaaggaggg aggcgtttcc agtgctgttt
     1441 ttgcagctgt atcaatgatg ttccccccca gtattttcag cacctggatc ataccggcaa
     1501 acgtgtggat gcttatgacc gccctgagct atccctgggc tcttatgaat tcttggccac
     1561 tgtagattac tgcaagaaca ataagttccc cagccctcct gcctttatct tcatgattga
     1621 cgtctcctac aatgccatca ggactggtct tgttaggctc ctctgtgagg agctcaagtc
     1681 actgttagac tttctaccta gggagggtgg ggcagaagag tcagcaatcc gcgttggctt
     1741 tgtcacctac aataaggtgc tccacttcta taatgtgaag agctcattgg cccagccaca
     1801 gatgatggtt gtgtctgatg tggctgacat gtttgtgcca ctgctggatg gcttcctggt
     1861 caacgtcaat gagtctcggg cagttatcac cagcttattg gatcagattc cagaaatgtt
     1921 tgcagacaca agggaaacag agacagtatt tgtaccagtt atccaggctg gaatggaggc
     1981 tctgaaggct gctgagtgtg cagggaagct ctttctattc catacatccc tgcccattgc
     2041 agaggcccca gggaaactga agaacagaga tgacaggaag ctgatcaata cagacaagga
     2101 gaagactctg ttccagcctc agacaggtgc ctatcagacc ctggccaaag agtgtgtggc
     2161 ccaaggctgc tgtgtagatc tctttctctt ccctaaccag tatgtggatg tggccacact
     2221 ctctgttgtg ccccagctca ctggtggctc tgtctacaaa tatgcttcct ttcaggtgga
     2281 gaacgaccag gagcggttcc tgagtgacct gcgtcgtgat gtccagaagg ttgttggctt
     2341 tgatgctgtg atgcgggtcc ggacaagcac tggtatccgt gctgtagatt tctttggagc
     2401 tttctacatg agcaacacga cagatgtgga gctggctggg ctagatgggg acaaaacagt
     2461 gactgtggag ttcaagcatg acgatcggct caatgaagag agcggagctc tcctgcagtg
     2521 tgccctgctt tacaccagct gtgcagggca gcgtcggctc cgcatccata atctggccct
     2581 gaactgctgc acccagctgg ctgatctata tcgaaactgt gagactgaca cgctcatcaa
     2641 ctacatggcc aagtttgcat atcggggagt cctgaatagc cctgtgaagg ctgttcgtga
     2701 cacgctcatc acccagtgtg cccagatcct ggcctgttac agaaagaact gtgctagccc
     2761 ctcctctgca ggacagttga tccttcctga gtgcatgaag ctactcccag tttacctgaa
     2821 ctgtgtgttg aagagtgatg tcctgcagcc tggagctgaa gtcactactg atgaccgtgc
     2881 ctatgtccga cagctagtta cctccatgga tgtgactgag accaatgtct tcttctaccc
     2941 tcggctctta cctttgacaa agtctcccgt tgagagtact accgaaccac cagcagttcg
     3001 agcctctgaa gagcgtctaa gcaatgggga tatatattta ctggagaatg ggctcaacct
     3061 cttcctctgg gtgggagcaa gcgtccaaca gggtgttgtc cagagccttt tcagcgtctc
     3121 ctccttcagt cagatcacca gtggtttgag tgttctgcca gttctggata atccactgtc
     3181 caagaaggtt cgaggcctca ttgatagctt acgggcacag agatcccggt acatgaagct
     3241 taccgtggtg aaacaggaag acaagatgga gatgctgttc aagcacttcc tggtggaaga
     3301 caagagtctg agtgggggag catcttatgt ggactttctc tgtcatatgc acaaggagat
     3361 tcggcagcta ctgagctaaa gcaagtgggt aaatggcata gggcccaggc tagcttccag
     3421 aaagcacccc aggatgtcag agaaattggg acagtaacat atcttatgta agctgacctc
     3481 agtctctctg gggggagggg gagatataag gagacacctt ctttctgggc tcaagtatcc
     3541 tgccactctg tcatgtcctg ctgatggaag gtgcccctgt tccctcattc taccctcttt
     3601 ttcctgctaa tcctgtcata atgaatgtag cttctcagtt cactgtatat gattcggtat
     3661 tgggggtttg gaggcaccca gaccctggca atattatgtg tccctttgga ccagtctccc
     3721 aagaggagag gggcaggcag gaaagagtgg ggatcctaag gttactacag ggggctcagt
     3781 gtcatccaca acttcctata ttagggataa aacatatagg tgcacaagag ctggggtata
     3841 gcccataggt ggtggagaga aaagtggtca gtccttcttg ggcctggagg ttagcagtca
     3901 agtttctctg ctttcactgc tcgctcgctc tctcctgcaa tgattgatga tcactccgtg
     3961 gatagagagg cacactgtca gaggtgaccg gagaactgag ttgcaaaata tattaagatc
     4021 tggtagaggt accagcttcc tttccagctg gagaggcccc aacactggat ggttctgtag
     4081 ggagcctagg gagcctggtc atcaacttgc aatacctcac agagccagtt cacatcccac
     4141 tctgagctcc cacgagaaac actgcttctc caggcccggg gttgttgggg agagaggcag
     4201 aggcagctgg agcgccgttc tctcctgctg ggacaccgct tgggctttgg tattgactga
     4261 gtggctgaca gttatcttcc aaccccaact ggcttggggg caggacaagg gctaggcttg
     4321 atggtggcca ggcttgcctg ctccccacct gggatgcccc tgctctggac ctctcatttc
     4381 tcttcattgg tttatttttc aatgcatctt taatttgtaa agaaataaaa taaattaaga
     4441 tgtaa
//
