LOCUS       NM_006323               5083 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SEC24 homolog B, COPII coat complex component
            (SEC24B), transcript variant 1, mRNA.
ACCESSION   NM_006323 XM_941759 XM_945425
VERSION     NM_006323.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Ryan,S.K., Zelic,M., Han,Y., Teeple,E., Chen,L., Sadeghi,M.,
            Shankara,S., Guo,L., Li,C., Pontarelli,F., Jensen,E.H., Comer,A.L.,
            Kumar,D., Zhang,M., Gans,J., Zhang,B., Proto,J.D., Saleh,J.,
            Dodge,J.C., Savova,V., Rajpal,D., Ofengeim,D. and Hammond,T.R.
  TITLE     Microglia ferroptosis is regulated by SEC24B and contributes to
            neurodegeneration
  JOURNAL   Nat Neurosci 26 (1), 12-26 (2023)
   PUBMED   36536241
  REMARK    GeneRIF: Microglia ferroptosis is regulated by SEC24B and
            contributes to neurodegeneration.
REFERENCE   2  (bases 1 to 5083)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5083)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5083)
  AUTHORS   Deng,S.J., Shen,Y., Gu,H.M., Guo,S., Wu,S.R. and Zhang,D.W.
  TITLE     The role of the C-terminal domain of PCSK9 and SEC24 isoforms in
            PCSK9 secretion
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (6), 158660 (2020)
   PUBMED   32058034
  REMARK    GeneRIF: The role of the C-terminal domain of PCSK9 and SEC24
            isoforms in PCSK9 secretion.
REFERENCE   5  (bases 1 to 5083)
  AUTHORS   Yang,X.Y., Zhou,X.Y., Wang,Q.Q., Li,H., Chen,Y., Lei,Y.P., Ma,X.H.,
            Kong,P., Shi,Y., Jin,L., Zhang,T. and Wang,H.Y.
  TITLE     Mutations in the COPII vesicle component gene SEC24B are associated
            with human neural tube defects
  JOURNAL   Hum Mutat 34 (8), 1094-1101 (2013)
   PUBMED   23592378
  REMARK    GeneRIF: results show that functional mutations in SEC24B might
            contribute to the etiology of a subset of human Neural Tube Defects
            (NTDs).
REFERENCE   6  (bases 1 to 5083)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   7  (bases 1 to 5083)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   8  (bases 1 to 5083)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 5083)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   10 (bases 1 to 5083)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC143268.1, BC040137.1,
            H15283.1 and AC105314.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006323.4.
            
            Summary: The protein encoded by this gene is a member of the SEC24
            subfamily of the SEC23/SEC24 family, which is involved in vesicle
            trafficking. The encoded protein is thought to be a cargo-binding
            component of the COPII vesicle, and is thought to be involved in
            the transport of secretory proteins from the endoplasmic reticulum
            to the Golgi apparatus. Mutations in this gene have been associated
            with neural tube defects, and are thought to be a result of a
            disruption in interactions with the protein encoded by the VANGL
            planar cell polarity protein 2 (VANGL2) gene. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) lacks an in-frame exon in the
            5' coding region and uses an alternate in-frame splice site in the
            central coding region, compared to variant 3. The encoded isoform
            (a) is shorter, compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040137.1, SRR1803612.239683.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265175.5/ ENSP00000265175.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BC143268.1         44-85
            43-4643             BC040137.1         1-4601
            4644-4646           H15283.1           11-13               c
            4647-5083           AC105314.5         67907-68343
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..5083
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="SEC24 homolog B, COPII coat complex component"
                     /db_xref="GeneID:10427"
                     /db_xref="HGNC:HGNC:10704"
                     /db_xref="MIM:607184"
     exon            1..188
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..3862
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="isoform a is encoded by transcript variant 1;
                     protein transport protein Sec24B; secretory protein 24;
                     SEC24 related gene family, member B"
                     /codon_start=1
                     /product="protein transport protein Sec24B isoform a"
                     /protein_id="NP_006314.2"
                     /db_xref="CCDS:CCDS47124.1"
                     /db_xref="GeneID:10427"
                     /db_xref="HGNC:HGNC:10704"
                     /db_xref="MIM:607184"
                     /translation="MSAPAGSSHPAASARIPPKFGGAAVSGAAAPAGPGAGPAPHQQN
                     GPAQNQMQVPSGYGLHHQNYIAPSGHYSQGPGKMTSLPLDTQCGDYYSALYTVPTQNV
                     TPNTVNQQPGAQQLYSRGPPAPHIVGSTLGSFQGAASSASHLHTSASQPYSSFVNHYN
                     SPAMYSASSSVASQGFPSTCGHYAMSTVSNAAYPSVSYPSLPAGDTYGQMFTSQNAPT
                     VRPVKDNSFSGQNTAISHPSPLPPLPSQQHHQQQSLSGYSTLTWSSPGLPSTQDNLIR
                     NHTGSLAVANNNPTITVADSLSCPVMQNVQPPKSSPVVSTVLSGSSGSSSTRTPPTAN
                     HPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEEEEEDEEAGVDS
                     SSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAPASAPAPVVP
                     QPSKMAKPFGYGYPTLQPGYQNATAPLISGVQPSNPVYSGFQQYPQQYPGVNQLSSSI
                     GGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNLNADLKKLNCSPDSFRCTLTN
                     IPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSFIDQRRW
                     KCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLF
                     VLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQ
                     MLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAF
                     KLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCS
                     GQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYL
                     TRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTD
                     TSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRS
                     VSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFR
                     TGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQ
                     KLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDT
                     LSSERARSFITWLRDSRPLSPILHIVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHV
                     QQQICK"
     exon            189..932
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1115
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1220
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1301
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1543
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1728
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1831
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1958
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2068
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2181
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2300
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2356
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2563
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2687
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2846
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3020
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3131
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3307
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3445
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3550
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3643
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3747
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..5083
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4622..4627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="hexamer: ATTAAA"
     polyA_site      4643
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="major polyA site"
ORIGIN      
        1 cccttccctc cgcccacctc cctgaagcgg agccgccgtc gccaccagcg ccgtcatgtc
       61 ggcccccgcc gggtcctctc acccggccgc cagcgcccgg atcccgccca agttcggcgg
      121 agcggccgtc tcaggagccg cagcgcccgc gggcccgggt gcgggcccgg cgccgcacca
      181 gcagaacggt ccagcccaga atcaaatgca ggttccatct ggatatggat tgcatcatca
      241 aaactatatt gctccctcag gacattactc tcaaggacct gggaaaatga cctcattgcc
      301 attggatacc cagtgtggtg attactactc tgctctctat acagtaccaa cacaaaatgt
      361 gactcctaac acagtgaacc agcaaccagg agcacagcag ttgtacagca ggggtcctcc
      421 tgcccctcat attgtgggat ccactctagg atctttccaa ggtgctgcat cgtcagcatc
      481 ccatttgcat acgagtgcct cccaaccata ctcctctttt gtgaatcact acaatagtcc
      541 agccatgtac tctgccagct cttctgttgc gtctcaggga tttccctcta cttgtggtca
      601 ttatgctatg tcaactgttt ctaatgccgc gtatcctagt gtttcatatc cctctctgcc
      661 tgctggtgat acatatgggc aaatgtttac ctcacagaat gctccgactg ttaggccagt
      721 taaagataat tcattctctg gtcaaaatac agctatcagc catccatcgc cacttccacc
      781 tctaccatca caacagcacc accagcagca aagtctttca ggatacagta ctctaacgtg
      841 gtcatctcca ggccttccat cgactcaaga caatctcatc cgaaaccaca caggatccct
      901 ggctgtagcg aacaacaacc caaccattac tgttgcagat tctttatcct gtcctgttat
      961 gcaaaatgtt cagcctccca agtccagccc agtggtatcc actgttttat caggatcctc
     1021 aggatcctca tcaacaagaa cacctcccac tgcaaatcac ccagttgagc ctgtgacctc
     1081 agttacacag ccatcagagc tattacaaca aaaaggcgtg cagtatggtg aatatgttaa
     1141 taaccaagct agctccgcac caactccctt gtcatcaact tccgatgatg aggaagagga
     1201 ggaggaggat gaggaagcag gtgttgacag ctcttctacc acaagcagtg cttctccaat
     1261 gcccaacagt tatgatgccc tggaaggagg cagttaccca gatatgcttt cttcatcagc
     1321 aagcagtcct gctcctgatc ccgcccctga acctgatcct gcttctgctc cagctccagc
     1381 ttcagctcca gctcctgtcg tccctcagcc ttcaaaaatg gctaagcctt ttggctatgg
     1441 ctatccaaca cttcagcctg gttatcagaa tgctacagca ccacttattt ctggagtaca
     1501 gcccagtaac ccggtatatt ctggattcca gcagtatcct caacagtatc ctggtgtgaa
     1561 ccagctatcc tccagtatag gaggattgag tcttcagagt tctccacaac cagaaagcct
     1621 gagacctgta aaccttactc aggagaggaa tattttacct atgactcctg tttgggctcc
     1681 tgtacctaac ttgaatgcag acctcaaaaa attaaactgt agcccagatt catttcggtg
     1741 tactttgaca aatattccac agacacaggc tttactgaat aaagctaagc ttcctttagg
     1801 attgttgtta catcccttca gagacctaac gcaattacca gtgataacat caaataccat
     1861 tgtgaggtgc cgatcctgtc gaacgtatat taaccccttt gtatccttca ttgatcaacg
     1921 tagatggaaa tgcaatttgt gctatagagt aaacgatgtt cctgaagaat ttatgtataa
     1981 cccccttacc cgatcttatg gagagcctca taaacgacca gaagttcaga attcaactgt
     2041 ggagttcatt gcttcttcag attacatgct gcgtcctcct caacctgcag tttacttgtt
     2101 tgttttagat gtgtctcata atgcagtgga agctggatat ttgacaattt tgtgccagtc
     2161 actcctagaa aatctagaca agcttcctgg agattcacga acaagaatag gattcatgac
     2221 ctttgatagc actattcatt tctacaattt acaagaagga ttatcacagc ctcaaatgtt
     2281 gattgtgtct gatatagatg atgtttttct acctacaccg gatagtttac ttgtgaatct
     2341 atatgaaagt aaagagctta taaaagactt actgaatgca ttaccaaaca tgttcaccaa
     2401 tacaagagaa acacacagtg cccttggtcc tgcacttcag gctgccttta aattaatgtc
     2461 tccaacaggt ggccgtgtgt ctgtatttca gacacagtta ccttccttgg gtgcaggact
     2521 tctgcaatcc agagaagatc ctaatcagag atcaagtaca aaggtggtac aacatcttgg
     2581 ccctgcaact gatttttata agaaacttgc attagattgc tcgggacagc aaactgcagt
     2641 ggatttgttc cttttaagtt cacagtattc tgatcttgct tctctagctt gcatgtccaa
     2701 gtattctgca gggtgcatct attattatcc atcattccac tatactcaca atccttcaca
     2761 agcagaaaag ttacaaaaag acctaaaacg gtatctcaca agaaaaattg ggtttgaagc
     2821 tgttatgaga ataaggtgta ctaaaggtct ttcaatgcac acttttcacg gtaacttctt
     2881 tgtccgttct actgatttgt tatcccttgc caacatcaat cctgatgctg gatttgcggt
     2941 gcagttgtca attgaagaaa gtttaacaga tacttcctta gtatgttttc aaacagccct
     3001 attatataca tcaagcaaag gtgagcggag aattagagta catacacttt gtttgccagt
     3061 ggtaagttca ctagcagatg tatatgcggg agtggatgta caagctgcca tctgccttct
     3121 ggcaaacatg gctgtggatc ggtccgtttc atcaagtctg tcagatgcaa gagatgcctt
     3181 agtgaatgct gtagtggact cattgtctgc atatggctca actgtctcaa atttacagca
     3241 ctctgcattg atggcgccca gctccctcaa gttgtttcct ctctatgttt tggcccttct
     3301 caaacagaaa gcatttagaa cgggtacaag cacacggctg gatgatcgtg tatatgccat
     3361 gtgtcagata aagtctcagc cacttgttca tctaatgaaa atgattcatc ccaacttata
     3421 caggatagac agattgacag atgagggtgc agtacatgtt aatgacagga ttgtaccaca
     3481 gccacctctt caaaaattgt ctgcagagaa gctgacaaga gaaggtgctt tccttatgga
     3541 ctgtggctct gttttttaca tttgggttgg gaaaggctgt gacaataact tcatagagga
     3601 tgtgcttgga tatactaatt ttgcatcaat accacagaaa atgacacatc ttccagagct
     3661 agatacactt tcatcagaaa gagccagatc cttcataact tggcttagag acagcagacc
     3721 attaagtcca atccttcaca tagtaaaaga tgagagtcct gccaaagcag aattttttca
     3781 gcatttgatt gaagaccgga cagaggctgc attttcttac tatgaatttt tgcttcatgt
     3841 tcagcagcag atttgtaagt gaagtagaat aaaattgaat aagaaaaaga tctataacct
     3901 aggtaaagca taatctgtca gagaagcgcg tgagaaattt gaaatgaagg catttgttaa
     3961 tacaagatgc aacgcacagc actctgtctg aggctttggt aaaaagtaaa ggggaagaaa
     4021 gaacttgaca gatctttttc aactcaaatt aatggtaacg atgatgctgt ttcaccaagt
     4081 atattttgaa ttggtttcta cacatttcca gtagtatggc agtacagtgc tctgttcatt
     4141 gcaagctggc aaatttatgt agctatgtgg aatgatatgt cataatgtaa aattagataa
     4201 attctttttt cttataatta atataacatt tctggacttg aactctggca agagatgcca
     4261 aaaggcattg gtaccgtgtt atttgtttat atgaattact ttttaacaag gaatgtttct
     4321 tattcattaa atgaattcaa cattttctct gtaaaaacaa tagagtttca gtacatgaac
     4381 tatagaaaaa aatctatata taatgtacat aaatgttaca tttgtaaaga aaatgtaaaa
     4441 atgtaactat agcatatgaa ttgcttaaac tgtgctgcat tgttggatga caactctttt
     4501 tgtcacagtt agagaatgag gttgactaat gcatattatg aattgagtcc acaaaggaac
     4561 acaaaactct ttgtaattct gttaaatctt ttatgtagat ttatttatga tcagcctact
     4621 aattaaaact atttcgcttg acagtatggt ttggtgattt tttggggttt ttgtttgatt
     4681 ggttttttgt ggggattggt gggttttttt acatacagga tgtattgaat ttactaattg
     4741 gggaagtgca gtgatactgc atttcagtta gtaatatata tgaatcaggc caggcgcggt
     4801 ggctcacgcc tgtaatccca gcgctttggg aggccaaggt gggcagatga cttgaggtca
     4861 ggtgttcatg acctgcctga ccaacatgat gaaaccccat ctctgctaaa aataccaaaa
     4921 ttagccaggg gtgctggcgg gcacctgtaa tcccagctac tcaggaggct gaagcagtag
     4981 aatcgcttga acctggaggc tgaggttgca gtgagctaag atcacgccac tgcactccag
     5041 cctgggcaac agagtgagac tccatcttaa aaaaaaaaaa aaa
//
