LOCUS       NM_001318086            4975 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SEC24 homolog B, COPII coat complex component
            (SEC24B), transcript variant 5, mRNA.
ACCESSION   NM_001318086 XM_011531538
VERSION     NM_001318086.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Ryan,S.K., Zelic,M., Han,Y., Teeple,E., Chen,L., Sadeghi,M.,
            Shankara,S., Guo,L., Li,C., Pontarelli,F., Jensen,E.H., Comer,A.L.,
            Kumar,D., Zhang,M., Gans,J., Zhang,B., Proto,J.D., Saleh,J.,
            Dodge,J.C., Savova,V., Rajpal,D., Ofengeim,D. and Hammond,T.R.
  TITLE     Microglia ferroptosis is regulated by SEC24B and contributes to
            neurodegeneration
  JOURNAL   Nat Neurosci 26 (1), 12-26 (2023)
   PUBMED   36536241
  REMARK    GeneRIF: Microglia ferroptosis is regulated by SEC24B and
            contributes to neurodegeneration.
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Deng,S.J., Shen,Y., Gu,H.M., Guo,S., Wu,S.R. and Zhang,D.W.
  TITLE     The role of the C-terminal domain of PCSK9 and SEC24 isoforms in
            PCSK9 secretion
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (6), 158660 (2020)
   PUBMED   32058034
  REMARK    GeneRIF: The role of the C-terminal domain of PCSK9 and SEC24
            isoforms in PCSK9 secretion.
REFERENCE   5  (bases 1 to 4975)
  AUTHORS   Yang,X.Y., Zhou,X.Y., Wang,Q.Q., Li,H., Chen,Y., Lei,Y.P., Ma,X.H.,
            Kong,P., Shi,Y., Jin,L., Zhang,T. and Wang,H.Y.
  TITLE     Mutations in the COPII vesicle component gene SEC24B are associated
            with human neural tube defects
  JOURNAL   Hum Mutat 34 (8), 1094-1101 (2013)
   PUBMED   23592378
  REMARK    GeneRIF: results show that functional mutations in SEC24B might
            contribute to the etiology of a subset of human Neural Tube Defects
            (NTDs).
REFERENCE   6  (bases 1 to 4975)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   7  (bases 1 to 4975)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   8  (bases 1 to 4975)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 4975)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   10 (bases 1 to 4975)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC143269.1, AK300278.1,
            BC040137.1, H15283.1 and AC105314.5.
            
            On Aug 13, 2020 this sequence version replaced NM_001318086.1.
            
            Summary: The protein encoded by this gene is a member of the SEC24
            subfamily of the SEC23/SEC24 family, which is involved in vesicle
            trafficking. The encoded protein is thought to be a cargo-binding
            component of the COPII vesicle, and is thought to be involved in
            the transport of secretory proteins from the endoplasmic reticulum
            to the Golgi apparatus. Mutations in this gene have been associated
            with neural tube defects, and are thought to be a result of a
            disruption in interactions with the protein encoded by the VANGL
            planar cell polarity protein 2 (VANGL2) gene. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (5) lacks two in-frame exons in
            the 5' and central coding region, compared to variant 3. The
            encoded isoform (e) is shorter, compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300278.1, SRR18074969.1184376.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-943               BC143269.1         44-986
            944-2374            AK300278.1         835-2265
            2375-3658           BC143269.1         2523-3806
            3659-4535           BC040137.1         3725-4601
            4536-4538           H15283.1           11-13               c
            4539-4975           AC105314.5         67907-68343
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..4975
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="SEC24 homolog B, COPII coat complex component"
                     /db_xref="GeneID:10427"
                     /db_xref="HGNC:HGNC:10704"
                     /db_xref="MIM:607184"
     exon            1..188
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..3754
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="isoform e is encoded by transcript variant 5;
                     protein transport protein Sec24B; secretory protein 24;
                     SEC24 related gene family, member B"
                     /codon_start=1
                     /product="protein transport protein Sec24B isoform e"
                     /protein_id="NP_001305015.1"
                     /db_xref="GeneID:10427"
                     /db_xref="HGNC:HGNC:10704"
                     /db_xref="MIM:607184"
                     /translation="MSAPAGSSHPAASARIPPKFGGAAVSGAAAPAGPGAGPAPHQQN
                     GPAQNQMQVPSGYGLHHQNYIAPSGHYSQGPGKMTSLPLDTQCGDYYSALYTVPTQNV
                     TPNTVNQQPGAQQLYSRGPPAPHIVGSTLGSFQGAASSASHLHTSASQPYSSFVNHYN
                     SPAMYSASSSVASQGFPSTCGHYAMSTVSNAAYPSVSYPSLPAGDTYGQMFTSQNAPT
                     VRPVKDNSFSGQNTAISHPSPLPPLPSQQHHQQQSLSGYSTLTWSSPGLPSTQDNLIR
                     NHTGSLAVANNNPTITVADSLSCPVMQNVQPPKSSPVVSTVLSGSSGSSSTRTPPTAN
                     HPVEPVTSVTQPSELLQQKGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAP
                     DPAPEPDPASAPAPASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNATAPLISGVQPSN
                     PVYSGFQQYPQYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVP
                     NLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTI
                     VRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNS
                     TVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRI
                     GFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNAL
                     PNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSS
                     TKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYP
                     SFHYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLS
                     LANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLAD
                     VYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALM
                     APSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRI
                     DRLTDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIED
                     VLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEF
                     FQHLIEDRTEAAFSYYEFLLHVQQQICK"
     exon            189..932
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1115
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1196
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1438
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1620
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1723
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1850
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1960
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2073
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2192
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2248
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2455
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2579
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2738
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2912
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3023
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3199
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3337
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3442
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3535
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3639
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..4975
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4514..4519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="hexamer: ATTAAA"
     polyA_site      4535
                     /gene="SEC24B"
                     /gene_synonym="SEC24"
                     /note="major polyA site"
ORIGIN      
        1 cccttccctc cgcccacctc cctgaagcgg agccgccgtc gccaccagcg ccgtcatgtc
       61 ggcccccgcc gggtcctctc acccggccgc cagcgcccgg atcccgccca agttcggcgg
      121 agcggccgtc tcaggagccg cagcgcccgc gggcccgggt gcgggcccgg cgccgcacca
      181 gcagaacggt ccagcccaga atcaaatgca ggttccatct ggatatggat tgcatcatca
      241 aaactatatt gctccctcag gacattactc tcaaggacct gggaaaatga cctcattgcc
      301 attggatacc cagtgtggtg attactactc tgctctctat acagtaccaa cacaaaatgt
      361 gactcctaac acagtgaacc agcaaccagg agcacagcag ttgtacagca ggggtcctcc
      421 tgcccctcat attgtgggat ccactctagg atctttccaa ggtgctgcat cgtcagcatc
      481 ccatttgcat acgagtgcct cccaaccata ctcctctttt gtgaatcact acaatagtcc
      541 agccatgtac tctgccagct cttctgttgc gtctcaggga tttccctcta cttgtggtca
      601 ttatgctatg tcaactgttt ctaatgccgc gtatcctagt gtttcatatc cctctctgcc
      661 tgctggtgat acatatgggc aaatgtttac ctcacagaat gctccgactg ttaggccagt
      721 taaagataat tcattctctg gtcaaaatac agctatcagc catccatcgc cacttccacc
      781 tctaccatca caacagcacc accagcagca aagtctttca ggatacagta ctctaacgtg
      841 gtcatctcca ggccttccat cgactcaaga caatctcatc cgaaaccaca caggatccct
      901 ggctgtagcg aacaacaacc caaccattac tgttgcagat tctttatcct gtcctgttat
      961 gcaaaatgtt cagcctccca agtccagccc agtggtatcc actgttttat caggatcctc
     1021 aggatcctca tcaacaagaa cacctcccac tgcaaatcac ccagttgagc ctgtgacctc
     1081 agttacacag ccatcagagc tattacaaca aaaaggtgtt gacagctctt ctaccacaag
     1141 cagtgcttct ccaatgccca acagttatga tgccctggaa ggaggcagtt acccagatat
     1201 gctttcttca tcagcaagca gtcctgctcc tgatcccgcc cctgaacctg atcctgcttc
     1261 tgctccagct ccagcttcag ctccagctcc tgtcgtccct cagccttcaa aaatggctaa
     1321 gccttttggc tatggctatc caacacttca gcctggttat cagaatgcta cagcaccact
     1381 tatttctgga gtacagccca gtaacccggt atattctgga ttccagcagt atcctcaata
     1441 tcctggtgtg aaccagctat cctccagtat aggaggattg agtcttcaga gttctccaca
     1501 accagaaagc ctgagacctg taaaccttac tcaggagagg aatattttac ctatgactcc
     1561 tgtttgggct cctgtaccta acttgaatgc agacctcaaa aaattaaact gtagcccaga
     1621 ttcatttcgg tgtactttga caaatattcc acagacacag gctttactga ataaagctaa
     1681 gcttccttta ggattgttgt tacatccctt cagagaccta acgcaattac cagtgataac
     1741 atcaaatacc attgtgaggt gccgatcctg tcgaacgtat attaacccct ttgtatcctt
     1801 cattgatcaa cgtagatgga aatgcaattt gtgctataga gtaaacgatg ttcctgaaga
     1861 atttatgtat aaccccctta cccgatctta tggagagcct cataaacgac cagaagttca
     1921 gaattcaact gtggagttca ttgcttcttc agattacatg ctgcgtcctc ctcaacctgc
     1981 agtttacttg tttgttttag atgtgtctca taatgcagtg gaagctggat atttgacaat
     2041 tttgtgccag tcactcctag aaaatctaga caagcttcct ggagattcac gaacaagaat
     2101 aggattcatg acctttgata gcactattca tttctacaat ttacaagaag gattatcaca
     2161 gcctcaaatg ttgattgtgt ctgatataga tgatgttttt ctacctacac cggatagttt
     2221 acttgtgaat ctatatgaaa gtaaagagct tataaaagac ttactgaatg cattaccaaa
     2281 catgttcacc aatacaagag aaacacacag tgcccttggt cctgcacttc aggctgcctt
     2341 taaattaatg tctccaacag gtggccgtgt gtctgtattt cagacacagt taccttcctt
     2401 gggtgcagga cttctgcaat ccagagaaga tcctaatcag agatcaagta caaaggtggt
     2461 acaacatctt ggccctgcaa ctgattttta taagaaactt gcattagatt gctcgggaca
     2521 gcaaactgca gtggatttgt tccttttaag ttcacagtat tctgatcttg cttctctagc
     2581 ttgcatgtcc aagtattctg cagggtgcat ctattattat ccatcattcc actatactca
     2641 caatccttca caagcagaaa agttacaaaa agacctaaaa cggtatctca caagaaaaat
     2701 tgggtttgaa gctgttatga gaataaggtg tactaaaggt ctttcaatgc acacttttca
     2761 cggtaacttc tttgtccgtt ctactgattt gttatccctt gccaacatca atcctgatgc
     2821 tggatttgcg gtgcagttgt caattgaaga aagtttaaca gatacttcct tagtatgttt
     2881 tcaaacagcc ctattatata catcaagcaa aggtgagcgg agaattagag tacatacact
     2941 ttgtttgcca gtggtaagtt cactagcaga tgtatatgcg ggagtggatg tacaagctgc
     3001 catctgcctt ctggcaaaca tggctgtgga tcggtccgtt tcatcaagtc tgtcagatgc
     3061 aagagatgcc ttagtgaatg ctgtagtgga ctcattgtct gcatatggct caactgtctc
     3121 aaatttacag cactctgcat tgatggcgcc cagctccctc aagttgtttc ctctctatgt
     3181 tttggccctt ctcaaacaga aagcatttag aacgggtaca agcacacggc tggatgatcg
     3241 tgtatatgcc atgtgtcaga taaagtctca gccacttgtt catctaatga aaatgattca
     3301 tcccaactta tacaggatag acagattgac agatgagggt gcagtacatg ttaatgacag
     3361 gattgtacca cagccacctc ttcaaaaatt gtctgcagag aagctgacaa gagaaggtgc
     3421 tttccttatg gactgtggct ctgtttttta catttgggtt gggaaaggct gtgacaataa
     3481 cttcatagag gatgtgcttg gatatactaa ttttgcatca ataccacaga aaatgacaca
     3541 tcttccagag ctagatacac tttcatcaga aagagccaga tccttcataa cttggcttag
     3601 agacagcaga ccattaagtc caatccttca catagtaaaa gatgagagtc ctgccaaagc
     3661 agaatttttt cagcatttga ttgaagaccg gacagaggct gcattttctt actatgaatt
     3721 tttgcttcat gttcagcagc agatttgtaa gtgaagtaga ataaaattga ataagaaaaa
     3781 gatctataac ctaggtaaag cataatctgt cagagaagcg cgtgagaaat ttgaaatgaa
     3841 ggcatttgtt aatacaagat gcaacgcaca gcactctgtc tgaggctttg gtaaaaagta
     3901 aaggggaaga aagaacttga cagatctttt tcaactcaaa ttaatggtaa cgatgatgct
     3961 gtttcaccaa gtatattttg aattggtttc tacacatttc cagtagtatg gcagtacagt
     4021 gctctgttca ttgcaagctg gcaaatttat gtagctatgt ggaatgatat gtcataatgt
     4081 aaaattagat aaattctttt ttcttataat taatataaca tttctggact tgaactctgg
     4141 caagagatgc caaaaggcat tggtaccgtg ttatttgttt atatgaatta ctttttaaca
     4201 aggaatgttt cttattcatt aaatgaattc aacattttct ctgtaaaaac aatagagttt
     4261 cagtacatga actatagaaa aaaatctata tataatgtac ataaatgtta catttgtaaa
     4321 gaaaatgtaa aaatgtaact atagcatatg aattgcttaa actgtgctgc attgttggat
     4381 gacaactctt tttgtcacag ttagagaatg aggttgacta atgcatatta tgaattgagt
     4441 ccacaaagga acacaaaact ctttgtaatt ctgttaaatc ttttatgtag atttatttat
     4501 gatcagccta ctaattaaaa ctatttcgct tgacagtatg gtttggtgat tttttggggt
     4561 ttttgtttga ttggtttttt gtggggattg gtgggttttt ttacatacag gatgtattga
     4621 atttactaat tggggaagtg cagtgatact gcatttcagt tagtaatata tatgaatcag
     4681 gccaggcgcg gtggctcacg cctgtaatcc cagcgctttg ggaggccaag gtgggcagat
     4741 gacttgaggt caggtgttca tgacctgcct gaccaacatg atgaaacccc atctctgcta
     4801 aaaataccaa aattagccag gggtgctggc gggcacctgt aatcccagct actcaggagg
     4861 ctgaagcagt agaatcgctt gaacctggag gctgaggttg cagtgagcta agatcacgcc
     4921 actgcactcc agcctgggca acagagtgag actccatctt aaaaaaaaaa aaaaa
//
