LOCUS       NM_021982               6389 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC24 homolog A, COPII coat complex component
            (SEC24A), transcript variant 1, mRNA.
ACCESSION   NM_021982 XM_001128954 XM_001132082 XM_001132097
VERSION     NM_021982.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6389)
  AUTHORS   Gomez-Navarro,N., Maldutyte,J., Poljak,K., Peak-Chew,S.Y., Orme,J.,
            Bisnett,B.J., Lamb,C.H., Boyce,M., Gianni,D. and Miller,E.A.
  TITLE     Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2202080119 (2022)
   PUBMED   35901214
  REMARK    GeneRIF: Selective inhibition of protein secretion by abrogating
            receptor-coat interactions during ER export.
REFERENCE   2  (bases 1 to 6389)
  AUTHORS   Zhang,Z., Yang,B., Zhou,S. and Wu,J.
  TITLE     CircRNA circ_SEC24A upregulates DNMT3A expression by sponging
            miR-26b-5p to aggravate osteoarthritis progression
  JOURNAL   Int Immunopharmacol 99, 107957 (2021)
   PUBMED   34325283
  REMARK    GeneRIF: CircRNA circ_SEC24A upregulates DNMT3A expression by
            sponging miR-26b-5p to aggravate osteoarthritis progression.
REFERENCE   3  (bases 1 to 6389)
  AUTHORS   Chen,X., Zhang,J., Liu,P., Wei,Y., Wang,X., Xiao,J., Wang,C.C. and
            Wang,L.
  TITLE     Proteolytic processing of secretory pathway kinase Fam20C by site-1
            protease promotes biomineralization
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34349020
REFERENCE   4  (bases 1 to 6389)
  AUTHORS   Deng,S.J., Shen,Y., Gu,H.M., Guo,S., Wu,S.R. and Zhang,D.W.
  TITLE     The role of the C-terminal domain of PCSK9 and SEC24 isoforms in
            PCSK9 secretion
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (6), 158660 (2020)
   PUBMED   32058034
  REMARK    GeneRIF: The role of the C-terminal domain of PCSK9 and SEC24
            isoforms in PCSK9 secretion.
REFERENCE   5  (bases 1 to 6389)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6389)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   7  (bases 1 to 6389)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   8  (bases 1 to 6389)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 6389)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   10 (bases 1 to 6389)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304060.1, BC019341.1,
            AJ131244.1, CD677660.1 and BM127845.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021982.2.
            
            Summary: The protein encoded by this gene belongs to a family of
            proteins that are homologous to yeast Sec24. This protein is a
            component of coat protein II (COPII)-coated vesicles that mediate
            protein transport from the endoplasmic reticulum. COPII acts in the
            cytoplasm to promote the transport of secretory, plasma membrane,
            and vacuolar proteins from the endoplasmic reticulum to the golgi
            complex. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.239877.1,
                                           SRR1660805.254531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398844.7/ ENSP00000381823.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK304060.1         1-39
            40-1196             BC019341.1         1-1157
            1197-3807           AK304060.1         1186-3796
            3808-5557           AJ131244.1         3472-5221
            5558-6000           CD677660.1         190-632
            6001-6389           BM127845.1         12-400              c
FEATURES             Location/Qualifiers
     source          1..6389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..6389
                     /gene="SEC24A"
                     /note="SEC24 homolog A, COPII coat complex component"
                     /db_xref="GeneID:10802"
                     /db_xref="HGNC:HGNC:10703"
                     /db_xref="MIM:607183"
     exon            1..389
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..3574
                     /gene="SEC24A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein transport protein Sec24A; SEC24-related protein A;
                     SEC24 related gene family, member A; SEC24 family, member
                     A"
                     /codon_start=1
                     /product="protein transport protein Sec24A isoform 1"
                     /protein_id="NP_068817.1"
                     /db_xref="CCDS:CCDS43363.1"
                     /db_xref="GeneID:10802"
                     /db_xref="HGNC:HGNC:10703"
                     /db_xref="MIM:607183"
                     /translation="MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQE
                     SVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHS
                     GPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPT
                     VSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGP
                     PPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQ
                     LTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHL
                     TTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTS
                     IPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRW
                     KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLF
                     VFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQESLSQPQ
                     MLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAF
                     KLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSG
                     QQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLT
                     RKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDT
                     QLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSM
                     TASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQT
                     GTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
                     LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTP
                     ESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQ
                     QQVNK"
     exon            390..857
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1031
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1109
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1270
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1443
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1546
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1673
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1783
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1896
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2015
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2071
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2278
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2399
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2558
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2732
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2843
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3019
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3157
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3262
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3355
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3459
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..6389
                     /gene="SEC24A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3883..3888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC24A"
                     /note="hexamer: AATAAA"
     polyA_site      3909
                     /gene="SEC24A"
                     /note="major polyA site"
     regulatory      6365..6370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC24A"
                     /note="hexamer: AATAAA"
     polyA_site      6389
                     /gene="SEC24A"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcc agggcctccc tccttctctc taggtttggc tgccgccttc tagccgggcg
       61 ttcgcggccc cgccggcccg actctcaagc ctcagctccc aggctaggct gtggccgccg
      121 gtggcctggg gagagtgcgg cgccatgcct cgggcttaat gcgccccccc ctcttctccc
      181 agtcttcagt cttaagtcgt tagcctcctc cctccgcttt cagcagtggt ctttcagctc
      241 tcttcttgtg cgctgttgtc gaccccgacc agccccttcc aacccagtca tcatgtccca
      301 gccgggaata ccggcctccg gcggcgcccc agccagcctc caggcccaga acggagccgc
      361 cttggcctcg gggtctccct acaccaacgg tcctgtccaa aatgcattgc tgtcttcaca
      421 agagtcagtg agccaaggat acaatttcca gcttccagga tcctaccctc atccaatacc
      481 agcaaagact ttgaatccag tctctggaca gtctaactat ggtggttctc agggatctgg
      541 gcagactctt aatagaccac ctgtggcctc taatccagtg acaccttcgc ttcatagtgg
      601 tcctgctccc cgaatgccat tacctgcttc tcagaaccca gctactacac caatgccttc
      661 tagtagcttt cttcctgaag ccaacctgcc accacctttg aattggcaat ataactatcc
      721 atccacagcc tcacaaacaa accattgtcc tcgtgcatca tcccaaccaa ctgtatctgg
      781 aaatacaagt ttaaccacaa atcatcaata tgtttcttct ggatatcctt cacttcaaaa
      841 tagcttcata aagtcaggtc cttctgtacc tcccttagtg aatccacctc tgcctacaac
      901 ttttcaacca ggagctcctc atgggccccc tccagctgga ggcccacccc cagtgagggc
      961 cctcacgccc ctgacatcat catatagaga tgtaccccag cccttattta attcagctgt
     1021 caaccaagaa ggtattacat caaataccaa taacggatct atggtggtcc acagtagtta
     1081 cgacgagatt gaaggaggtg gcttattggc aacaccacag cttactaaca agaatcccaa
     1141 aatgagccga agtgttggat attcatatcc ctccttacca cctggttatc agaacacaac
     1201 accacctggt gcaactggag taccaccctc ttccttgaat tacccaagtg ggccacaagc
     1261 ctttactcag actcccttag gtgctaatca tttaaccaca agcatgagtg gattaagtct
     1321 acaaccagag ggtctaagag ttgtcaatct tcttcaagaa agaaacatgc ttccgtcaac
     1381 acctttgaag cctccagttc caaatttgca tgaagacatc cagaaactca actgtaaccc
     1441 agagttattt cgatgcacgc tgactagcat tcctcagacg caggccttat tgaataaagc
     1501 caaacttcct ttggggctgc tgcttcatcc tttcaaagac ttagtgcaat tgcctgtggt
     1561 tacctccagt acaattgtga gatgccgttc atgcaggacg tacatcaatc ctttcgtcag
     1621 ctttcttgat caaaggagat ggaagtgtaa cttatgttat cgagtcaatg atgttcctga
     1681 agaattcttg tacaaccctt tgaccagagt ttatggagaa cctcacagaa gaccagaagt
     1741 tcaaaatgct actattgagt ttatggctcc ttcagaatac atgttacgac cacctcagcc
     1801 tccagtgtat ctctttgtat ttgatgtgtc tcacaatgca gtcgaaactg gatacttgaa
     1861 ttcagtttgc cagagtttgt tagacaatct ggatttgctt cctggcaaca ctagaacaaa
     1921 aattggcttc ataacatttg acagtacaat ccatttctac ggtcttcagg aaagtctctc
     1981 tcaacctcag atgctaatag tttcagatat tgaagatgtt tttataccta tgccagagaa
     2041 cttattagta aacttaaatg aaagtaaaga gctcgtgcaa gatttactga aaactttgcc
     2101 acaaatgttt accaagactc tggagaccca gagtgccttg ggtcctgcac tgcaggctgc
     2161 ctttaagctg atgtctccaa ctggtggtcg aatgtctgtc tttcaaacac aactcccaac
     2221 tcttggagtg ggagccctga aaccacgaga ggaaccaaac cacaggtcat ctgctaagga
     2281 tatacacatg acaccatcca ctgacttcta taagaaatta gccttggact gttctggtca
     2341 gcaagttgct gttgacttat tccttctcag tggacagtat tctgatttgg cttctctggg
     2401 ttgtatttct cggtattcag caggtagtgt ctattactat ccctcttacc atcatcagca
     2461 caacccagtc caagtacaga aattacagaa ggaactacag agatacctta ctcggaagat
     2521 tggctttgag gcagtcatga ggattcggtg caccaaaggt ctttccattc atactttcca
     2581 tggaaacttc tttgttaggt caaccgactt actgtctttg cctaacgtca acccagacgc
     2641 tgggtatgca gtacagatgt cagtggaaga gagtcttact gacactcagt tggtttcttt
     2701 tcagtcagca ctcttgtata catccagcaa aggcgaaaga agaattcgtg ttcatacttt
     2761 gtgtttgcca gtagtttcga ctctgaatga tgtctttctt ggagctgatg ttcaagcaat
     2821 ttcagggtta ttggccaata tggctgttga cagatctatg actgccagtc tgagtgacgc
     2881 tcgggatgct ctagtgaatg cagtcattga ctccctttca gcttaccgtt cttcagtctt
     2941 aagtaaccag cagcctggac tcatggttcc tttttctttg cggcttttcc cactttttgt
     3001 gttggctctc cttaaacaga aatcattcca gactgggaca aatgcacgtc tagatgaacg
     3061 catttttgct atgtgtcaag tgaaaaacca gcccttggtt taccttatgc tcacaactca
     3121 tcccagtttg tatagagttg acaatctctc agatgaggga gcactcaaca tcagtgatag
     3181 aaccatacct cagcccccca ttcttcagct ttcagtggag aagctgagca gagatggagc
     3241 tttcctcatg gatgcaggct ctgtactgat gctttgggtt ggaaaaaatt gtacacagaa
     3301 ttttctcagc caagttctag gagttcaaaa ctatgcatca attccacagc ctatgacaga
     3361 ccttccagaa cttgatacac cagaatctgc cagaataata gctttcatct cttggcttag
     3421 agagcagaga ccatttttcc caatacttta tgtaataagg gatgagagtc caatgaaagc
     3481 aaacttcctt caaaacatga tagaagacag aacagaatct gcattatcat attatgaatt
     3541 cctgttgcat atacagcaac aagtgaataa atgaatgaat gaagaaattt gacttatttt
     3601 taaggaatgt cacgatagtg cagaatacct ggaaatgtgt aataccttct ttttctatta
     3661 tgtttgtgga ctaatgtgat gattgagatg ttctcactgt gatttcaaca acctatagca
     3721 aataaaagac cacagcagag aatcaaacat gcaactctga aatactgtat ttttcaaatc
     3781 agaatatagc tacgtatgat tggatacttt tttcttgcca attatgtttg agttgttatg
     3841 gattaaaata agaatattgc agaggcaaag tacattttgt aaaataaaga tttctgtgtt
     3901 ctacatgtat atttctcatt tttaattttt ctgaatcttt ggctgctaca tttaaaacct
     3961 cacaaaccta agtgttgcag ggaagttaca aattgattgg tagtgatgtt tttaaaataa
     4021 aaacaatgga aagtaaatat aatgtaggaa aactagaatt cattccccac acgtgtcttt
     4081 tttttttctt tgttaaggga aaggatcatg ttgactaaaa ctaaactaat tctagtatag
     4141 cttgagaaaa atatgaagaa acacattcaa gctttaaaat ctgtcagtat tctttatgct
     4201 tgaagaacaa agtcactttg atttgaagtg agaactatca ttaggtggtt ttctgatttc
     4261 ctgatgaaga gttggacata ctgtcttaat ctatagtgaa aagaatttga gctgtcttca
     4321 taaacactgg gactagcaat gataataggg agataagaaa ctttaattat cttgatcctt
     4381 taagtggatt ttatttggtg catttctgct ctgggtatat aataaaagtg ggggtttttg
     4441 gtgaaatgag tgaagaaatg aaaggtttct aaagtgctat ccaaatacat cagtaacatt
     4501 tttctaagga gtttaattgt taaattggaa gtcattcata agaaatattt atgcttgaat
     4561 atgaaaatct atgaaagcat aaatgctgct gtttgatttg gtggatatta agattataca
     4621 catccaacat attaaagtta tgaaagaaac ttgacttctg aaaatcctta agagactgct
     4681 ttcttgattc agctagagaa atattatagt caaaactatt gagtgaattt tgtttacaaa
     4741 taggtaaatt atacatttgt atatttaaag tgctgtgaca tagtatcttt aagagtttgg
     4801 ctcagttttc acagattcat tttgtcttaa gaatttctta aatatgttca tgtataatac
     4861 ttgatcaaaa tatttttggg ttttttgttt tgttttaatg ggttagaaaa tgtttacaat
     4921 cttggtctta tatgatcacc aatggaatag taacttccag gtttatatca atatgagctg
     4981 actttaactg agttgtttgg gatagggaag aagcagtccc tctacagtat acaactactg
     5041 cttgccagct ggatcaaaat aatcatgttt tatgaaaata tctcccttaa gcagtgttaa
     5101 ggttggtttg cagtgtgtaa gtggcacatt gaactggaag ttttcttgaa agctgcttca
     5161 tctattaaga agcaattttc aaattgtagc gaattatatt atcccctctt ttaaagaaac
     5221 agtcgttata tgctgatgtt tcttaaaata actaaaatgt tcctcttaat gtgattttaa
     5281 atggagttat ttgtaggtcc tttcttagta gtaaagaatc ttctagaggg aaacatttgt
     5341 gcttttaggg ataatcttcc ttgtgcctca ctacatccct aagtgggtat gactcttgtt
     5401 attaccacat gcttttttag tatatttcac aaatttactt ttaaatatta ttttagatac
     5461 ggtgtaacat gtgcaattca gaataatttt ataacaggtc atgaaaaaca taactttagt
     5521 taggattcac aatatttgtt ctccacataa tgagagaatg aatgagcctt tggagatact
     5581 gatataaggc aattattttt tgcaatgttg aatgtgtttt ttagtttgat tctttttttt
     5641 tcccccaata gggcactacc tgccatatca tcttgtatta ctttttgatg taaagcgact
     5701 aatatttaca ctatgccata ttttttttaa ttatagttgt aaattatgaa agatccttga
     5761 attttctaca gatctacaac tactaatgta acagacaagg gcaatcttgg tatttaaatc
     5821 tgagcatggc agttctacca taaaaagtac tctatttttc taatttctag gatttttaaa
     5881 ataacatttc tgtaagtctg acatactaat agtcactcaa gcagtaccat ttattttagt
     5941 ttgcatatat tttcactgtt tttaatttaa tgtattgagt ctaatagact gttttgcaat
     6001 aattagaata aagatttatt tcttctaatc aaagatgcat aacagctatt atctagggga
     6061 ccaccaaatg tgatttcaaa attttgttaa ctattacaaa tgtaatcctt atatagaaat
     6121 tttaattttg taaagtagtg tataatattg taatattaaa ttcttgttct taaattcaaa
     6181 tatgtattga tcttcaatgt gctgtgttaa atcttgcttc tctgaaaagt tggagacaag
     6241 atttgtcttc ctttttacag tttgtaattt tcactgtttt attcctgtta aaaaaaaaaa
     6301 aaagtcattt gtaacccatg cagaccattg tttgatctat gctaacttat caacttggct
     6361 attcaataaa gttaattgaa aagagctta
//
