LOCUS       NM_007190               7148 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens SEC23 interacting protein (SEC23IP), transcript
            variant 1, mRNA.
ACCESSION   NM_007190
VERSION     NM_007190.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7148)
  AUTHORS   Du,Y., Fan,X., Song,C., Chang,W., Xiong,J., Deng,L. and Ji,W.K.
  TITLE     Sec23IP recruits VPS13B/COH1 to ER exit site-Golgi interface for
            tubular ERGIC formation
  JOURNAL   J Cell Biol 223 (12) (2024)
   PUBMED   39352497
  REMARK    GeneRIF: Sec23IP recruits VPS13B/COH1 to ER exit site-Golgi
            interface for tubular ERGIC formation.
REFERENCE   2  (bases 1 to 7148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7148)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7148)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7148)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 7148)
  AUTHORS   McGary,K.L., Park,T.J., Woods,J.O., Cha,H.J., Wallingford,J.B. and
            Marcotte,E.M.
  TITLE     Systematic discovery of nonobvious human disease models through
            orthologous phenotypes
  JOURNAL   Proc Natl Acad Sci U S A 107 (14), 6544-6549 (2010)
   PUBMED   20308572
  REMARK    GeneRIF: Xenopus sec23ip is required for normal neural crest cell
            development, suggesting a role for the human ortholog in
            Waardenburg syndrome neural crest defects.
REFERENCE   7  (bases 1 to 7148)
  AUTHORS   Iinuma,T., Shiga,A., Nakamoto,K., O'Brien,M.B., Aridor,M.,
            Arimitsu,N., Tagaya,M. and Tani,K.
  TITLE     Mammalian Sec16/p250 plays a role in membrane traffic from the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 282 (24), 17632-17639 (2007)
   PUBMED   17428803
REFERENCE   8  (bases 1 to 7148)
  AUTHORS   Shimoi,W., Ezawa,I., Nakamoto,K., Uesaki,S., Gabreski,G.,
            Aridor,M., Yamamoto,A., Nagahama,M., Tagaya,M. and Tani,K.
  TITLE     p125 is localized in endoplasmic reticulum exit sites and involved
            in their organization
  JOURNAL   J Biol Chem 280 (11), 10141-10148 (2005)
   PUBMED   15623529
  REMARK    GeneRIF: p125 is a mammalian-specific component of ER exit sites
            and participates in the organization of this compartment
REFERENCE   9  (bases 1 to 7148)
  AUTHORS   Mizoguchi,T., Nakajima,K., Hatsuzawa,K., Nagahama,M., Hauri,H.P.,
            Tagaya,M. and Tani,K.
  TITLE     Determination of functional regions of p125, a novel mammalian
            Sec23p-interacting protein
  JOURNAL   Biochem Biophys Res Commun 279 (1), 144-149 (2000)
   PUBMED   11112430
REFERENCE   10 (bases 1 to 7148)
  AUTHORS   Tani,K., Mizoguchi,T., Iwamatsu,A., Hatsuzawa,K. and Tagaya,M.
  TITLE     p125 is a novel mammalian Sec23p-interacting protein with
            structural similarity to phospholipid-modifying proteins
  JOURNAL   J Biol Chem 274 (29), 20505-20512 (1999)
   PUBMED   10400679
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB019435.1, BC063800.1,
            AC027672.12 and AI093198.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007190.3.
            
            Summary: This gene encodes a member of the phosphatidic acid
            preferring-phospholipase A1 family. The encoded protein is
            localized to endoplasmic reticulum exit sites and plays a critical
            role in ER-Golgi transport as part of the multimeric coat protein
            II complex. An orthologous gene in frogs is required for normal
            neural crest cell development, suggesting that this gene may play a
            role in Waardenburg syndrome neural crest defects. Alternatively
            spliced transcript variants have been observed for this gene.
            [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes a functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001135.1, SRR1803617.69614.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369075.8/ ENSP00000358071.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3069              AB019435.1         20-3088
            3070-4227           BC063800.1         3067-4224
            4228-6657           AC027672.12        71389-73818         c
            6658-7148           AI093198.1         6-496               c
FEATURES             Location/Qualifiers
     source          1..7148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11-q26.12"
     gene            1..7148
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="SEC23 interacting protein"
                     /db_xref="GeneID:11196"
                     /db_xref="HGNC:HGNC:17018"
                     /db_xref="MIM:617852"
     exon            1..216
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3056
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     intracellular phospholipase A1 beta"
                     /codon_start=1
                     /product="SEC23-interacting protein isoform 1"
                     /protein_id="NP_009121.1"
                     /db_xref="CCDS:CCDS7618.1"
                     /db_xref="GeneID:11196"
                     /db_xref="HGNC:HGNC:17018"
                     /db_xref="MIM:617852"
                     /translation="MAERKPNGGSGGASTSSSGTNLLFSSSATEFSFNVPFIPVTQAS
                     ASPASLLLPGEDSTDVGEEDSFLGQTSIHTSAPQTFSYFSQVSSSSDPFGNIGQSPLT
                     TAATSVGQSGFPKPLTALPFTTGSQDVSNAFSPSISKAQPGAPPSSLMGINSYLPSQP
                     SSLPPSYFGNQPQGIPQPGYNPYRHTPGSSRANPYIAPPQLQQCQTPGPPAHPPPSGP
                     PVQMYQMPPGSLPPVPSSVQSPAQQQVPARPGAPSVQVPSPFLLQNQYEPVQPHWFYC
                     KEVEYKQLWMPFSVFDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRIRKAAYWE
                     EEPAEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVTTNQWHRRLEFPSGETIV
                     MHNPKVIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDNLDEIPDGEMPQVDHLVFVV
                     HGIGPVCDLRFRSIIECVDDFRVVSLKLLRTHFKKSLDDGKVSRVEFLPVHWHSSLGG
                     DATGVDRNIKKITLPSIGRFRHFTNETLLDILFYNSPTYCQTIVEKVGMEINHLHALF
                     MSRNPDFKGGVSVAGHSLGSLILFDILSNQKDLNLSKCPGPLAVANGVVKQLHFQEKQ
                     MPEEPKLTLDESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDD
                     LKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPS
                     ESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLT
                     IRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLH
                     LELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE
                     KQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLC
                     YWESEDTALLLLKEIYRTMNISPEQPQH"
     exon            217..749
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            750..960
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1154
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1244
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1365
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1455
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1597
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1806
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1925
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2078
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2174
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2366
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2522
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2625
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2811
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2974
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3076
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..7148
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="hexamer: ATTAAA"
     polyA_site      3460
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="major polyA site"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="hexamer: AATAAA"
     polyA_site      4227
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="major polyA site"
     regulatory      4609..4614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="hexamer: AATAAA"
     polyA_site      4637
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="major polyA site"
     regulatory      7128..7133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
                     /note="hexamer: ATTAAA"
     polyA_site      7148
                     /gene="SEC23IP"
                     /gene_synonym="iPLA1A; iPLA1beta; MSTP053; P125; P125A"
ORIGIN      
        1 agtggtgtgg taccgggtac ccggagacgt gtatcggacg gtgggccgca gccatggccg
       61 agagaaaacc taacggtggc agcggcggcg cctccacttc ctcatcgggc actaacttac
      121 ttttctcctc ctcggccacg gagttcagct tcaatgtgcc cttcatccca gtcacccagg
      181 cctccgcttc tccggcctcc ctgctcttac cgggagagga ttccacagat gttggtgagg
      241 aggacagctt ccttggtcag acttctattc acacatctgc cccacagaca tttagttact
      301 tctctcaggt atcaagcagc agtgatcctt ttgggaatat tggacagtca ccattaacaa
      361 ctgcagcaac ctcagttgga caatcaggat tccccaagcc cctgactgct ctccctttta
      421 caactggatc ccaagatgtc tcgaatgcat tttcaccatc catttcgaag gctcaacctg
      481 gtgctccacc ttcctcactg atgggaataa attcttatct gccttctcag ccaagtagtc
      541 tccctccttc atattttggg aaccaacccc aaggaattcc ccaaccagga tacaatccat
      601 atcgccatac ccctggcagc agcagggcta atccttacat tgcaccaccc cagctgcagc
      661 agtgccaaac accaggccct cctgctcatc ctccaccttc tggaccccct gttcagatgt
      721 accagatgcc tccaggatct ttgccaccgg ttccttcttc agtgcagtca ccggcacagc
      781 agcaggtacc tgccagacct ggggctccct ctgttcaagt gccatctcct tttctacttc
      841 aaaaccaata tgagcctgtt cagccccact ggttttactg caaggaggta gaatacaaac
      901 aactgtggat gccttttagt gtgttcgact ctttgaatct tgaagaaatc tataattcag
      961 ttcagccaga tccggagagc gtggttcttg gcacggatgg agggcgctac gatgtttacc
     1021 tctatgaccg aataaggaag gctgcctact gggaagagga gccagccgaa gtgagacgct
     1081 gtacttggtt ttacaagggg gacacagata gtcgatttat tccctatact gaggagttca
     1141 gtgaaaaact agaggctgaa tataaaaaag ctgtaaccac taatcagtgg caccgaagat
     1201 tagagtttcc aagtggagag acaattgtta tgcacaatcc aaaggttatt gttcagttcc
     1261 agccctcctc agtgccagat gaatggggca ccacgcaaga tggacagaca aggcccaggg
     1321 ttgtaaagcg tggaattgat gataaccttg atgaaattcc cgacggggag atgcctcaag
     1381 ttgaccattt ggtgtttgtg gtgcatggca ttggacctgt gtgtgactta cgctttagga
     1441 gcattattga gtgtgtggat gattttaggg tggtttctct caaattgctg cggacacatt
     1501 tcaagaaatc tttagatgac gggaaagtaa gcagagtgga gttccttcca gttcattggc
     1561 atagttcttt gggtggggac gccacaggtg tggacaggaa tattaagaaa atcactttgc
     1621 caagtattgg tcgatttcgt cactttacca atgaaacttt gctagatatt ttattttata
     1681 acagccccac ctactgtcag acaattgtgg aaaaagtagg aatggagata aaccatctgc
     1741 atgcactctt tatgagtcgg aacccagact tcaaaggagg tgtctctgtt gctggtcaca
     1801 gtttaggttc tttaatattg tttgacatcc tgtctaatca aaaagatttg aatttatcaa
     1861 agtgccctgg acctcttgct gttgctaatg gagttgtgaa gcagctacat tttcaggaaa
     1921 agcagatgcc tgaagagcca aagctgactt tggatgagtc gtatgacctt gttgttgaaa
     1981 ataaagaagt cctaactttg caagaaactc tggaagcact tagcctctct gaatatttta
     2041 gcacttttga aaaggaaaag attgatatgg agtccctgct tatgtgtaca gttgatgacc
     2101 tgaaggaaat ggggataccc cttggaccca gaaagaagat agctaacttt gtagaacata
     2161 aagcagccaa actgaaaaaa gcagcgtcag aaaagaaggc agtggcggcc acttctacaa
     2221 aaggacaaga gcaaagtgcc cagaagacta aagacatggc ttccctcccc tcagaatcca
     2281 atgagccaaa gaggaaactt ccagttggtg cttgcgtgtc ttctgtgtgt gtgaattatg
     2341 aatcttttga agttggcgcc ggacaggttt ctgttgctta caactcatta gattttgaac
     2401 cagagatatt ctttgccttg gggtctccaa ttgctatgtt tctcactatt cgaggagttg
     2461 ataggataga tgagaattac agccttccta cctgtaaagg gttcttcaat atttatcatc
     2521 cgcttgatcc agtggcatat agattagaac ctatgattgt tccagatttg gacctaaaag
     2581 ctgttctcat tccacatcac aaaggcagaa aaagacttca tttagaattg aaagagagtc
     2641 tctctcgtat gggatctgat ttgaagcagg gttttattag ctctctcaaa agtgcttggc
     2701 agacattaaa tgagtttgcc cgtgctcata cgtcttcaac ccagttgcaa gaagaattgg
     2761 agaaggtggc caatcagatc aaagaagaag aagaaaagca agtagttgaa gcagaaaagg
     2821 ttgttgaaag tccagatttt tccaaggatg aggactactt aggaaaggtt ggaatgttaa
     2881 atggaggccg ccgaattgac tacgttctcc aagaaaaacc aatagagagt tttaatgaat
     2941 accttttcgc tcttcagagt cacttatgct attgggaatc tgaagatact gctctgttac
     3001 tacttaaaga aatttatcga acaatgaaca ttagtccaga acagccccag cattgatcaa
     3061 acttcagttt tactgtactt tcttgtctgc acagaaagtc ccagtacaac ttccattgct
     3121 gagaaaatcc tcagaggact ttcccacttc gctcctgtga tggatgacag aagagtgatt
     3181 cattaacaat tgctcagcca caattctcgg atatagggat tcaaaagaca ggacacagaa
     3241 ctaacacagt gaaaaaaatc agtaccacat ttggacagta taggtgagaa aacataatta
     3301 taaaaatgat gccatgaaaa attccacaga tcagtttagt tgtatagttg tcaaagttat
     3361 atgtgatatc aatgaagaaa tatttgtagc atgtaaacgg ttatttctgt ttcttaaaaa
     3421 gtattgttag tgggctatta aacttggatt tttcttttta ttaatgcagt atgttctttt
     3481 tattcaagta tgaacttgtt gagaaactat agtaatatga tttttaagag atttatgttc
     3541 tacttaaaat gtgaattgta cttctgagct gccttaatgc aaggtcattt atatttgtta
     3601 agaggaaata atcaagatca ctcatatccc aactgaatct gaggttttat aaatccctca
     3661 aacgattgct gagagcctga ttgtggaaag aagtgagatg caccttattt tcaagaagtc
     3721 ctgggaagcg ctctcctagc acgtccattt ccaggaggag aagcaagcag atgagaggtt
     3781 ttccattttg tcatccaagg tagctgtgca cttgccttgt tgctgaagtt ccaataatgt
     3841 gaaaaccaaa gtagaggttt ttttcttctt ctttttgttt tctattaatt tcacttatac
     3901 caaagtgttt gaaagtatga aatgtgttgc ttctgagtta tataaggcta cttcatgaca
     3961 agactgcttt gtaatatttc actttgtttt actacaaatt cagatcactt tgttttacta
     4021 taaattcaga ttatccaaat attttcctaa tactatgtgg gaatgctgat tttcttttgt
     4081 tacgtagtgg aaacattttg cattgtttac atagttctca tggaacatgg aaatttttga
     4141 aagtgatata tgatacacat tttttgtgta tgtattctaa ttagtgtgaa taaagcagta
     4201 acattaatgc attttttaag cagcaaactt atgtatttct cttgtcttcc ttaaaagtgt
     4261 ccccatgaac tcagtgttta ttcccttttc attttgagta cctgcttata tggtcagtat
     4321 gtaacgttag cattggctcc taatggtaga attagaacag caagattgta gagctgtaat
     4381 tgactccaga caacatagat ttcagccacc tcattctaca gctgaggcca ggacaataaa
     4441 tgcctttccc agactgggta gtggcagatc tgggatggaa tatggttttc ttgattccct
     4501 ttcagccttc atttctctct ctcaggacta ctacttttta attacttttc acttaatttc
     4561 ccaatactga tgaaataaag aaaaatgagg gttatttata tacatttcaa taaaatccaa
     4621 tttgattttt caacttacat ctgatttttg tttgtgtcat tcagcctgtc ttctgagtaa
     4681 tgggcagaga aggaccaggg ttcgtagaag aagcatgtgg cagctgagtg gcagcagtct
     4741 tgccctttca ttttaatact tgagtacaca gaaaatagaa tttttgagtg actctgcctg
     4801 tggatatata tactcataca tacatatata tatatacaca cacacatatg tatgtatgta
     4861 tgtattacta ttcagtctct taaaaaccaa aaaacagtag atcccctgag ggtagagtct
     4921 ttatgtatga acatattgtt cactgttgta accaccttgc aggatttcag tctataaact
     4981 aggtgagaat ccagctgctg agtgaagctt gatctctgcc tcttcctcag gagcagctca
     5041 tcccctgaca acctcccctc ccagccccta atctggttta atgccctcct tttccccaga
     5101 taaagaaagt catgtctgta gttattccaa aagtgtttca tgtgtagagt ttggcacaaa
     5161 aagtaaaaag cgccagcatc tgaagtcaaa ggtgaaagag tcatcacagt actgatgaag
     5221 acacccaggc ctcgtcagct atgttaacgt gctgtatgac aagaggaacc tgctttctaa
     5281 gtctgctgga cacgcgtgct tcttgaatcc aaccagacaa gcatgttttc tcaaaaccac
     5341 agtataagac aaggaaactg cacagattcg agtgattttt gaggtaagta tgttattgga
     5401 aaggtgtgat ctatatagaa ccctgtacat gaaaaggagg agatgccgct atcttggcag
     5461 ggatgatcat gtatttgaaa tagtaactca cagcatttgg tctcatgata agagtactga
     5521 agattatccc agaaaaccta ggatgattgg tatttatagt accattgttt caggttttta
     5581 tgacttgagg catctaacta tcttaatgct gtactttagt gtttaccaag cagctttctg
     5641 gtggaaactt gaactgcaga cactgagtgt tttggttttc ctccaagtta tagttctcat
     5701 tgtaacttaa taagttggca ttccagctta gtttgagtca gtttcccagg gctgggtcct
     5761 cagaggagag tggatagaat tcagttcctc tatgagctgg ggtgctgaca ttgtgttcct
     5821 gctgttgact gtccctgcgg tgcacgggac agactgtcag ctaacctgtc ttcatgacat
     5881 ttctataata ctcctcaggg ggttaacccc atctctacta aaaataaaaa aaattagctg
     5941 ggcatggtgg catgtgcctg tagtcccagc tacaggaggc tgaggcagga gaattgcttg
     6001 aacccaggag gtggaggttg cagtgagttg ggatctcgcc actgcactct agcctgagtg
     6061 acagagcgag actctgtctc aaaaaaaaat aaatgaataa aaaataaaac agcaactctt
     6121 gcagatttcc cgaatgtatt ggtcccagag aacactgaaa ataatgtcat gttgttaaca
     6181 ccagtgggag tttgggaaat aattccagct ctttaatact tctttcagct tcagattaag
     6241 tgaaatgagt ttcacatatt tcaatatatg aaattttatg atgacacata aaacaggcca
     6301 ggggttattg aggacacatc tgtgagatag tgggcaatgc tacatattcg ttagtggatg
     6361 tgctgcagtt caggttcatg gacaggtggg actggtgtgg ttgggataac ccaccatgtt
     6421 tgtctttcat ttcttgtata aagagtggtt tttaaaagac cttactatgg aattttcaca
     6481 aatactcaaa agtatggaga atggtacagt gaatccccat gtgccctttt cccagcttca
     6541 ggggtggtgt cagtgataat gatttggctc tgtgtcccca cccaaatctc atcttgaatt
     6601 gtaatcccca cgtgtcaggg gagggacctg gtgggaggtg attggatcat gggggctgtt
     6661 tccccatgct gttcttgtga tagtgaggga gttctcacaa gatctgatgg ttttaaaagt
     6721 ggcagttttc cctgcactct ctcctgccac cttgtgaaga aggtgcctgc ttcccctttg
     6781 cctttcgtca caattgtaag ttccccgagg ttcgtcatga ttgtaagttt cctgaggtct
     6841 ccccaaccat gcagaactgt gagtcacttg aacccctttt gtttataaat tgcccagtct
     6901 caggtagtac cttgatagca gtgtgaaaat ggactaatac agtcagggac ctaaaagaca
     6961 ggtaaagaga tgtggccagg tgaagacgga aaaaggacag tgcattccag acctgtggaa
     7021 agacgcgagg ttggaaagaa catcacaact ggggcgactg aagaaattat gttgttaagc
     7081 acgaaatgca gagagagagc tatgtgaatg tgttgagtgt gattttcatt aaacaatttt
     7141 taaagaaa
//
