LOCUS       NM_006363               3026 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC23 homolog B, COPII coat complex component
            (SEC23B), transcript variant 1, mRNA.
ACCESSION   NM_006363
VERSION     NM_006363.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Saptarshi,A.N., More,T.A., Dongerdiye,R. and Kedar,P.
  TITLE     Congenital Dyserythropoietic Anemia Type II: High Prevalence of
            c.1385A>G, (p.Tyr462Cys) Mutation in the Indian Population
  JOURNAL   Indian J Pediatr 90 (8), 840 (2023)
   PUBMED   37204595
  REMARK    GeneRIF: Congenital Dyserythropoietic Anemia Type II: High
            Prevalence of c.1385A>G, (p.Tyr462Cys) Mutation in the Indian
            Population.
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Musri,M.M., Venturi,V., Ferrer-Cortes,X., Romero-Cortadellas,L.,
            Hernandez,G., Leoz,P., Ricard Andres,M.P., Morado,M., Fernandez
            Valle,M.D.C., Beneitez Pastor,D., Ortuno Cabrero,A., Moreno
            Gamiz,M., Senent Peris,L., Perez-Valencia,A.I., Perez-Montero,S.,
            Tornador,C. and Sanchez,M.
  TITLE     New Cases and Mutations in SEC23B Gene Causing Congenital
            Dyserythropoietic Anemia Type II
  JOURNAL   Int J Mol Sci 24 (12), 9935 (2023)
   PUBMED   37373084
  REMARK    GeneRIF: New Cases and Mutations in SEC23B Gene Causing Congenital
            Dyserythropoietic Anemia Type II.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Rosato,B.E., Marra,R., D'Onofrio,V., Del Giudice,F., Della
            Monica,S., Iolascon,A., Andolfo,I. and Russo,R.
  TITLE     SEC23B Loss-of-Function Suppresses Hepcidin Expression by Impairing
            Glycosylation Pathway in Human Hepatic Cells
  JOURNAL   Int J Mol Sci 23 (3), 1304 (2022)
   PUBMED   35163229
  REMARK    GeneRIF: SEC23B Loss-of-Function Suppresses Hepcidin Expression by
            Impairing Glycosylation Pathway in Human Hepatic Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Wei,W., Liu,Z., Zhang,C., Khoriaty,R., Zhu,M. and Zhang,B.
  TITLE     A common human missense mutation of vesicle coat protein SEC23B
            leads to growth restriction and chronic pancreatitis in mice
  JOURNAL   J Biol Chem 298 (1), 101536 (2022)
   PUBMED   34954140
  REMARK    GeneRIF: A common human missense mutation of vesicle coat protein
            SEC23B leads to growth restriction and chronic pancreatitis in
            mice.
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Gasparini,P., Miraglia del Giudice,E., Delaunay,J., Totaro,A.,
            Granatiero,M., Melchionda,S., Zelante,L. and Iolascon,A.
  TITLE     Localization of the congenital dyserythropoietic anemia II locus to
            chromosome 20q11.2 by genomewide search
  JOURNAL   Am J Hum Genet 61 (5), 1112-1116 (1997)
   PUBMED   9345103
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Paccaud,J.P., Reith,W., Carpentier,J.L., Ravazzola,M., Amherdt,M.,
            Schekman,R. and Orci,L.
  TITLE     Cloning and functional characterization of mammalian homologues of
            the COPII component Sec23
  JOURNAL   Mol Biol Cell 7 (10), 1535-1546 (1996)
   PUBMED   8898360
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X97065.1, BC001151.1,
            BC095404.1 and CA307855.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_006363.5.
            
            Summary: The protein encoded by this gene is a member of the SEC23
            subfamily of the SEC23/SEC24 family, which is involved in vesicle
            trafficking. The encoded protein has similarity to yeast Sec23p
            component of COPII. COPII is the coat protein complex responsible
            for vesicle budding from the ER. The function of this gene product
            has been implicated in cargo selection and concentration. Multiple
            alternatively spliced transcript variants have been identified in
            this gene. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) uses an alternative splice
            site and lacks a segment in the 5' UTR, as compared to variant 2.
            Variants 1, 2, 3 and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.30702.1, BC095404.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650089.1/ ENSP00000497473.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1513              X97065.1           59-1571
            1514-2628           BC001151.1         1568-2682
            2629-2669           BC095404.1         2679-2719
            2670-3017           BC095404.1         2721-3068
            3018-3026           CA307855.1         18-26               c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3026
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="SEC23 homolog B, COPII coat complex component"
                     /db_xref="GeneID:10483"
                     /db_xref="HGNC:HGNC:10702"
                     /db_xref="MIM:610512"
     exon            1..33
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            34..268
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2351
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SEC23-like protein B; SEC23 homolog B, coat complex II
                     component; SEC23-related protein B; protein transport
                     protein Sec23B; transport protein SEC23B"
                     /codon_start=1
                     /product="protein transport protein Sec23B isoform 1"
                     /protein_id="NP_006354.2"
                     /db_xref="CCDS:CCDS13137.1"
                     /db_xref="GeneID:10483"
                     /db_xref="HGNC:HGNC:10702"
                     /db_xref="MIM:610512"
                     /translation="MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTP
                     LKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQRNQFPPAYGGIS
                     EVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPP
                     DALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARP
                     AQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGL
                     LEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYE
                     MLANRTAANGHCIDIYACALDQTGLLEMKCCANLTGGYMVMGDSFNTSLFKQTFQRIF
                     TKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
                     CGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQFVTHYQHSSTQRRIRVTTIARNWADV
                     QSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKED
                     PTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPI
                     LYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYEN
                     FKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQET
                     GAPILTDDVSLQVFMDHLKKLAVSSAC"
     exon            269..326
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            327..413
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            414..650
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            651..736
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            737..881
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1040
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1156
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1280
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1361
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1451
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1558
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1712
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1790
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1952
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2039
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2195
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2261
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..3026
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2608..2613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="hexamer: AATAAA"
     polyA_site      2628
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="major polyA site"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="hexamer: AATACA"
     polyA_site      2733
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="major polyA site"
     regulatory      3003..3008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
                     /note="hexamer: AATATA"
     polyA_site      3026
                     /gene="SEC23B"
                     /gene_synonym="CDA-II; CDAII; CDAN2; CWS7; HEMPAS;
                     hSec23B"
ORIGIN      
        1 gttgcagctg tgggtgagga cggctctagc tagttccctt ttagactatg gcgacatacc
       61 tggagttcat ccagcagaat gaagaacggg atggtgtgcg ttttagttgg aacgtgtggc
      121 cttccagccg gctggaggct acaagaatgg ttgtacccct ggcttgtctc cttactcctt
      181 tgaaagaacg tccagaccta cctcctgtac aatatgaacc tgtgctttgc agcaggccaa
      241 cttgtaaagc tgttctcaac ccactttgtc aggttgatta tcgagcaaaa ctttgggcct
      301 gtaatttctg ttttcaaaga aatcagtttc ctccagctta tggaggcata tctgaggtga
      361 atcaacctgc cgaattgatg ccccagtttt ctacaattga gtacgtgata cagcgaggtg
      421 ctcagtcccc tctgatcttt ctctatgtgg ttgacacatg cctggaggaa gatgaccttc
      481 aagcactcaa agagtccctg cagatgtccc tgagtcttct tcctccagat gctctggtgg
      541 gtctgatcac atttggaagg atggtgcagg ttcatgagct aagctgtgaa ggaatctcca
      601 aaagttatgt cttccgaggg accaaggatt taactgcaaa gcaaatacag gatatgttgg
      661 gcctgaccaa gccagccatg cccatgcagc aagcacgacc tgcacaacca caggagcacc
      721 cttttgcttc aagcagattt ctgcagcctg ttcacaagat tgatatgaac ctcactgatc
      781 ttcttgggga gctacagagg gacccatggc cagtaactca ggggaagaga cctttgcgat
      841 ccactggtgt ggctttgtcc attgctgttg gcttgctgga gggcactttt ccaaacacag
      901 gagccaggat catgctgttt actggaggtc cccctaccca agggcctggc atggtggttg
      961 gagatgaatt aaagattcct attcgttctt ggcatgatat tgagaaagat aatgcacgat
     1021 tcatgaaaaa ggcaaccaag cactatgaga tgcttgctaa tcgaacagct gcaaatggtc
     1081 actgcattga tatttatgct tgtgcccttg atcaaactgg acttttggag atgaagtgtt
     1141 gtgcaaatct tactggaggc tacatggtaa tgggagattc tttcaacact tctctcttca
     1201 agcagacatt ccaaagaatc tttactaaag attttaatgg agatttccga atggcatttg
     1261 gtgctacttt ggacgtaaag acctctcggg aactgaagat tgcaggagcc attggtccat
     1321 gcgtatctct gaatgtgaaa ggaccgtgtg tgtcagaaaa tgagcttggt gttggtggca
     1381 cgagtcagtg gaaaatctgt ggcctagatc ctacatctac acttggcatc tattttgaag
     1441 ttgtcaatca gcacaacacc ccgatccccc aaggaggcag aggagccatc cagtttgtca
     1501 cgcattatca gcactccagc acccagagac gcatccgcgt gaccaccatc gcccgaaatt
     1561 gggcagatgt acagagtcag ctcaggcaca tagaagcagc atttgaccag gaggctgcgg
     1621 cagtgttgat ggcacggctt ggggtgttcc gagcggagtc agaggagggg cccgatgtgc
     1681 tccggtggct ggaccgacaa ctcatccgac tgtgtcaaaa gtttggacag tataacaaag
     1741 aagaccccac ttcttttagg ttatcagatt ccttttctct atatcctcag tttatgttcc
     1801 atctgagaag atctccattt cttcaagtgt ttaacaacag tcctgatgag tcgtcatatt
     1861 acagacatca ttttgcccgg caggacctga cccagtccct catcatgatc cagcccattc
     1921 tctactctta ctcctttcat gggccaccag agccagtact cttggatagc agcagcattc
     1981 tagctgacag aattttgctg atggatactt tctttcaaat tgtcatttat cttggtgaga
     2041 ccatagccca gtggcgtaaa gctggctacc aggacatgcc cgagtatgaa aacttcaagc
     2101 accttctgca ggcaccactg gatgatgctc aagaaattct gcaagcacgc ttcccgatgc
     2161 cacgttacat caacacggag catggaggca gtcaggctcg attccttttg tccaaagtga
     2221 acccatctca gacacacaat aacctgtatg cttggggaca ggaaactgga gcacccatcc
     2281 taactgatga tgttagcctg caggtgttca tggaccattt gaagaagctg gctgtctcca
     2341 gtgcctgtta agctgaggat acaaccagga aatgcaacgg tgtcagattg tgttcaaaat
     2401 gtctagaaag gcttgataac attcctgtta cttttctagc agattttaac aaataatcaa
     2461 ggacatttta tatgtaactc tttagattat aatttatttg tattcctgtc tttgtccttt
     2521 ttcttgcact ataaaattat aaggtcataa atgttttggt acttgtagat gtttatgtgc
     2581 tttttgtatc ctaactttta gaatctaaat aaaatcagag gtaatgtatt ttggcagctt
     2641 gtttaggtga gaatcttaat gatcataaag gaaataaatc tagatgcaga aagtactggc
     2701 taaaatattg ctaatacaaa tgtgatttcc tgaggtctct gtgtgagtgt gtatgtgttt
     2761 taagtgactt ccttaagagg tgtttcctga acctaattct cataattaaa gtaatgtata
     2821 tgcaggatca aaatgaaaca aatatacctt atcctaaaga gctcataaca aataagttac
     2881 ctccactcta taaactcaga cctacttttt gaagataact gcttttaacc tctccttaca
     2941 agatttttgt tgttgatgta tttaatttta gcccatgtct caattctcat tttcaaagaa
     3001 tcaatatatt aatatacctt tggtca
//
