LOCUS       NM_006364               3843 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC23 homolog A, COPII coat complex component
            (SEC23A), mRNA.
ACCESSION   NM_006364
VERSION     NM_006364.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3843)
  AUTHORS   Wang,Q., Lin,X., Lai,K., Liu,Y., Qin,T., Tan,H., Li,J., Lin,Z.,
            Zhang,X., Li,X., Lin,H. and Chen,W.
  TITLE     Novel compound heterozygous variants of the SEC23A gene in a
            Chinese family with cranio-lenticulo-sutural dysplasia based on
            data from a large cohort of congenital cataract patients
  JOURNAL   BMC Med Genomics 16 (1), 241 (2023)
   PUBMED   37828500
  REMARK    GeneRIF: Novel compound heterozygous variants of the SEC23A gene in
            a Chinese family with cranio-lenticulo-sutural dysplasia based on
            data from a large cohort of congenital cataract patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3843)
  AUTHORS   Cheng,Q., Liu,K., Xiao,J., Shen,K., Wang,Y., Zhou,X., Wang,J.,
            Xu,Z. and Yang,L.
  TITLE     SEC23A confers ER stress resistance in gastric cancer by forming
            the ER stress-SEC23A-autophagy negative feedback loop
  JOURNAL   J Exp Clin Cancer Res 42 (1), 232 (2023)
   PUBMED   37670384
  REMARK    GeneRIF: SEC23A confers ER stress resistance in gastric cancer by
            forming the ER stress-SEC23A-autophagy negative feedback loop.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3843)
  AUTHORS   Tong,Y., Zhou,Z., Tang,J. and Feng,Q.
  TITLE     MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein
            Endothelial Cells by Regulating SEC23A
  JOURNAL   Biochem Genet 60 (6), 2000-2014 (2022)
   PUBMED   35190931
  REMARK    GeneRIF: MiR-29b-3p Inhibits the Inflammation Injury in Human
            Umbilical Vein Endothelial Cells by Regulating SEC23A.
REFERENCE   4  (bases 1 to 3843)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3843)
  AUTHORS   Cattin-Ortola,J., Welch,L.G., Maslen,S.L., Papa,G., James,L.C. and
            Munro,S.
  TITLE     Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate
            expression at the cell surface and syncytia formation
  JOURNAL   Nat Commun 12 (1), 5333 (2021)
   PUBMED   34504087
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3843)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   7  (bases 1 to 3843)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   8  (bases 1 to 3843)
  AUTHORS   Tang,B.L., Kausalya,J., Low,D.Y., Lock,M.L. and Hong,W.
  TITLE     A family of mammalian proteins homologous to yeast Sec24p
  JOURNAL   Biochem Biophys Res Commun 258 (3), 679-684 (1999)
   PUBMED   10329445
REFERENCE   9  (bases 1 to 3843)
  AUTHORS   Pagano,A., Letourneur,F., Garcia-Estefania,D., Carpentier,J.L.,
            Orci,L. and Paccaud,J.P.
  TITLE     Sec24 proteins and sorting at the endoplasmic reticulum
  JOURNAL   J Biol Chem 274 (12), 7833-7840 (1999)
   PUBMED   10075675
REFERENCE   10 (bases 1 to 3843)
  AUTHORS   Paccaud,J.P., Reith,W., Carpentier,J.L., Ravazzola,M., Amherdt,M.,
            Schekman,R. and Orci,L.
  TITLE     Cloning and functional characterization of mammalian homologues of
            the COPII component Sec23
  JOURNAL   Mol Biol Cell 7 (10), 1535-1546 (1996)
   PUBMED   8898360
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC335582.1, BC036649.1,
            BM541968.1 and X97064.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006364.3.
            
            Summary: The protein encoded by this gene is a member of the SEC23
            subfamily of the SEC23/SEC24 family. It is part of a protein
            complex and found in the ribosome-free transitional face of the
            endoplasmic reticulum (ER) and associated vesicles. This protein
            has similarity to yeast Sec23p component of COPII. COPII is the
            coat protein complex responsible for vesicle budding from the ER.
            The encoded protein is suggested to play a role in the ER-Golgi
            protein trafficking. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036649.1, SRR1803614.13931.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307712.11/ ENSP00000306881.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC335582.1         294-295
            3-855               BC036649.1         9-861
            856-875             BM541968.1         849-868
            876-1892            BC036649.1         882-1898
            1893-2546           X97064.1           1827-2480
            2547-3843           BC036649.1         2553-3849
FEATURES             Location/Qualifiers
     source          1..3843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..3843
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /note="SEC23 homolog A, COPII coat complex component"
                     /db_xref="GeneID:10484"
                     /db_xref="HGNC:HGNC:10701"
                     /db_xref="MIM:610511"
     exon            1..204
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            205..446
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2523
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /note="SEC23-related protein A; Sec23 homolog A, coat
                     complex II component"
                     /codon_start=1
                     /product="protein transport protein Sec23A"
                     /protein_id="NP_006355.2"
                     /db_xref="CCDS:CCDS9668.1"
                     /db_xref="GeneID:10484"
                     /db_xref="HGNC:HGNC:10701"
                     /db_xref="MIM:610511"
                     /translation="MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTP
                     LKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGIS
                     ELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPP
                     TALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGP
                     QVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLE
                     CTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEAL
                     ANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTK
                     DMHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICG
                     LSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQT
                     QIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPS
                     SFRFSETFSLYPQFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILY
                     AYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFR
                     HLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGA
                     PILTDDVSLQVFMDHLKKLAVSSAA"
     exon            447..504
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            505..591
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            592..828
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            829..908
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1053
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1212
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1328
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1452
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1533
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1623
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1730
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1884
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1962
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2124
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2211
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2367
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2433
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3843
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3821..3826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /note="hexamer: AATAAA"
     polyA_site      3843
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagagg cggcgccagc catgttggcc gggcggaggt cttcgctgag gcccggggcg
       61 gggtggcgcc acccctgatt gcggtgccac ggactgctcc tgctgggcgg agaggacaga
      121 ttttgcaaag cggaggctgc gacgggtcct gcagggggac agtgaggaaa gggccgcctc
      181 gtctccgctc ctgggggacc gcagaaataa gaatcaaact ccacaatgac aacctatttg
      241 gaattcattc aacaaaatga agaacgagat ggagtccgat ttagttggaa tgtttggcca
      301 tcaagtcgac tggaagctac aagaatggtt gttcctgtgg cagccctgtt tacaccactg
      361 aaagagagac ctgacttacc acctattcaa tatgaacctg ttctgtgtag taggaccact
      421 tgccgtgcag ttttgaatcc tttatgtcaa gtggattatc gagcaaaact ttgggcttgc
      481 aacttttgtt accaaaggaa tcagtttcca cctagttatg ctggtatatc tgaactgaat
      541 cagcctgctg aacttttacc tcagttttct agcattgaat atgtagttct gcgtggtcct
      601 cagatgcctt tgatattcct ctatgtggtt gatacttgca tggaagatga agatttacaa
      661 gccctgaaag aatccatgca gatgtcatta agtcttttac cacctacagc tttggttgga
      721 cttattactt ttgggagaat ggttcaggtt catgaacttg gatgtgaagg catttcaaaa
      781 agctatgtct tcagaggaac aaaagatttg tctgccaaac aactgcagga aatgctgggg
      841 ctctctaaag taccacttac tcaagcaaca cgtggtcctc aggtacagca gccacctcct
      901 tccaacagat tcttacaacc agtacagaaa atagacatga atctcacaga tcttctggga
      961 gaactccagc gagacccttg gcctgtacca cagggaaaga gacctttgcg ttcctctggg
     1021 gtggcacttt ccatagctgt aggactgctg gagtgtactt ttcccaacac tggtgctcgt
     1081 atcatgatgt tcattggtgg tcctgctact caggggcctg gaatggtggt tggagatgag
     1141 ttgaagacac ctataagatc gtggcatgac attgacaaag acaatgccaa atatgttaaa
     1201 aagggaacta agcattttga agcattggct aatcgagctg ctacaactgg ccatgttatt
     1261 gatatctatg cgtgtgcatt agatcagaca ggtctcctgg agatgaaatg ctgtcccaac
     1321 cttactggag gatacatggt aatgggtgat tctttcaata cttccttatt caaacaaact
     1381 tttcaaagag tctttaccaa agacatgcat ggacagttta aaatgggctt tggtggtacg
     1441 ctagaaataa agacctcaag ggaaataaag atttcaggag ctattggacc ctgtgtgtca
     1501 ctcaattcta aaggaccctg tgtgtctgaa aatgagatag gaacaggtgg cacatgtcag
     1561 tggaagatat gtggacttag tcccactaca accttagcca tatattttga ggttgtcaat
     1621 cagcataatg ctccaattcc tcaaggaggg cgtggtgcaa tccagtttgt gactcagtat
     1681 cagcattcaa gtgggcagag acgcatccga gtgaccacca ttgctaggaa ctgggcagat
     1741 gctcaaactc aaatccaaaa cattgctgca tcttttgacc aggaggcagc tgccattctt
     1801 atggcccggc tagcaatata tagagcagaa acagaagaag gtccagatgt gcttaggtgg
     1861 ctggacagac agctcattcg actgtgtcag aaatttggag aatatcataa agatgaccca
     1921 agttccttca gattttcaga aactttctcc ctttatccac agtttatgtt tcatttaaga
     1981 agatcttctt tcctgcaagt ttttaacaat agtcctgatg agagttcata ttatcgtcac
     2041 cattttatgc gtcaagatct gacccagtct ctaattatga ttcagcctat cctgtatgcg
     2101 tattctttta gtggaccacc agagccggtt cttcttgata gcagtagcat tcttgcagat
     2161 cgtattcttc tcatggacac attcttccag attttgattt atcatggtga gaccatagca
     2221 cagtggcgga agtcaggata ccaggatatg cctgagtatg aaaatttccg ccaccttctg
     2281 caagccccag tggatgatgc acaggaaatt cttcactcca gatttccaat gccaagatac
     2341 attgacactg aacatggagg cagccaggcc cgtttcctcc tttcaaaagt caacccttca
     2401 cagactcata ataatatgta tgcctggggg caggagtctg gagcacctat tcttacagat
     2461 gatgttagtt tacaagtgtt tatggatcac ttgaagaaac ttgctgtgtc cagtgctgct
     2521 tgaagtgcta ataatgttaa agacacttaa gaagatgaaa taatattcaa atttcatttt
     2581 ttcctttttc catttatctg tggaaaccaa cagatattgc tctatatttt ttgtattagt
     2641 atggtttgag acaacatatg gaaaatgttc acatttgtag attaagctgg aattataatg
     2701 agagcaataa gaacaaattt attttgctta ccacagtgtt atagctggtt ctagaaattt
     2761 gaagtcttta taacttaatt atgtttaata aaaaatagag tctgcctcgt actacagatg
     2821 taactcattt gtatattgca gacagaccca aagtggcact gaattttctt gctcaccttt
     2881 taaaaacttg ttccttaatt ttagccagaa agcaaaaaaa caatagtaat gataaatgtg
     2941 aacatttttg cttattcatt gaatattttt ctgtaatttt cagcacttat gtatacactt
     3001 tttctgtact tactaggtta aggcagattt atttttatga tttgtttagg aattatttga
     3061 ttttataatg gtaattttca tgatgataat gtttttggtt atttggaaag atagtttaga
     3121 gatgaaaggt ttttttgggt aacaatcccg cagctgacaa aaaatgtgaa atttccacaa
     3181 aatatccaac ttatgtgact aaacgcagta gtttttttaa aaggggagat agaaaataaa
     3241 tggttttgtt ggagtgcatt ttagtaagcc tttgcagtaa aatgacggtt gtaactacta
     3301 aaccaaattt agttttcaca gcatggtttt gttgttttcc ccttgttttt cagaggtaaa
     3361 ttttgcatta tatccttcag tattttaaca ctattttggc agtttacaca ttactttttg
     3421 tttttccttc ctttttgtga aatgtattaa gttgtggttc ttattgaaac agtattatat
     3481 aatgtttgct taattatatc atgtgatgct cagttctatt ttgatttatt cattagtatt
     3541 cacttttacc tttaaagttt acttgtagca aatatgttta cattgataaa gccagatatg
     3601 ttttgacaat gaaatttaca tatcaagtac tgcaaataaa aggtggtgct atgatatatg
     3661 cttaggagga cagttttaat gattgtactt gcatgaacac aatcatatga tggtaaagca
     3721 gaaacttaag aaaaaattgt ttatgtgtta tattcaatta gcttaaataa gttgctttgt
     3781 tatattttat ttgaattgaa ctacgctagg cctaaatgcc aataaaatat acttttcact
     3841 gtt
//
