LOCUS       NM_032970               6340 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SEC22 homolog C, vesicle trafficking protein (SEC22C),
            transcript variant 1, mRNA.
ACCESSION   NM_032970
VERSION     NM_032970.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6340)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6340)
  AUTHORS   Yamamoto,Y., Yurugi,C. and Sakisaka,T.
  TITLE     The number of the C-terminal transmembrane domains has the potency
            to specify subcellular localization of Sec22c
  JOURNAL   Biochem Biophys Res Commun 487 (2), 388-395 (2017)
   PUBMED   28414125
  REMARK    GeneRIF: These results indicate that the splicing-dependent changes
            in the number of TMDs allow Sec22c to regulate the subcellular
            localization in cooperation with ARF4, implying that Sec22c will
            function at the Golgi as well as the ER.
REFERENCE   3  (bases 1 to 6340)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 6340)
  AUTHORS   Tang,B.L., Low,D.Y. and Hong,W.
  TITLE     Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and
            msec22b/ERS-24
  JOURNAL   Biochem Biophys Res Commun 243 (3), 885-891 (1998)
   PUBMED   9501016
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074576.1, BC006178.1,
            AC092047.3 and CB410223.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032970.3.
            
            Summary: This gene encodes a member of the SEC22 family of vesicle
            trafficking proteins. The encoded protein is localized to the
            endoplasmic reticulum and may play a role in the early stages of
            ER-Golgi protein trafficking. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.94772.1,
                                           SRR1803613.54292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264454.8/ ENSP00000264454.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK074576.1         62-95
            35-1409             BC006178.1         1-1375
            1410-5860           AC092047.3         59801-64251
            5861-6340           CB410223.1         39-518              c
FEATURES             Location/Qualifiers
     source          1..6340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..6340
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /note="SEC22 homolog C, vesicle trafficking protein"
                     /db_xref="GeneID:9117"
                     /db_xref="HGNC:HGNC:16828"
                     /db_xref="MIM:604028"
     exon            1..122
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     exon            123..331
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1061
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /note="isoform a is encoded by transcript variant 1;
                     secretion deficient 22C; vesicle-trafficking protein
                     SEC22c; SEC22 vesicle trafficking protein-like 3; SEC22
                     vesicle trafficking protein homolog C; SEC22 vesicle
                     trafficking protein-like protein C"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22c isoform a"
                     /protein_id="NP_116752.1"
                     /db_xref="CCDS:CCDS2700.1"
                     /db_xref="GeneID:9117"
                     /db_xref="HGNC:HGNC:16828"
                     /db_xref="MIM:604028"
                     /translation="MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRL
                     AQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTC
                     IGLASRPYAFLEFDSIIQKVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDV
                     ANGVMNGHTPMHLEPAPNFRMEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAH
                     EEIGNILAFLVPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQIL
                     FHIGVAFLSSYQILTRQLQEKQSDCGV"
     exon            332..495
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..675
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..794
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     exon            795..860
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..6340
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6318..6323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /note="hexamer: AATAAA"
     polyA_site      6340
                     /gene="SEC22C"
                     /gene_synonym="SEC22L3"
                     /note="major polyA site"
ORIGIN      
        1 acggcctacc tgcgcctggg ctgccggtga cctgggccga gccctcccgg tcggctaaga
       61 ttgctgagga ggcggcgggt agctggcagg cgccgacttc cgaaggccgc cgtccgggcg
      121 aggtgtcctc atgacttctc ttgtggacca tgtccgtgat cttttttgcc tgcgtggtac
      181 gggtaaggga tggactgccc ctctcagcct ctactgattt ttaccacacc caagattttt
      241 tggaatggag gagacggctc aagagtttag ccttgcgact ggcccagtat ccaggtcgag
      301 gttctgcaga aggttgtgac tttagtatac atttttcttc tttcggggac gtggcctgca
      361 tggctatctg ctcctgccag tgtccagcag ccatggcctt ctgcttcctg gagaccctgt
      421 ggtgggaatt cacagcttcc tatgacacta cctgcattgg cctagcctcc aggccatacg
      481 cttttcttga gtttgacagc atcattcaga aagtgaagtg gcattttaac tatgtaagtt
      541 cctctcagat ggagtgcagc ttggaaaaaa ttcaggagga gctcaagttg cagcctccag
      601 cggttctcac tctggaggac acagatgtgg caaatggggt gatgaatggt cacacaccga
      661 tgcacttgga gcctgctcct aatttccgaa tggaaccagt gacagccctg ggtatcctct
      721 ccctcattct caacatcatg tgtgctgccc tgaatctcat tcgaggagtt caccttgcag
      781 aacattcttt acaggttgcc catgaggaaa ttggaaacat tctggctttt cttgttcctt
      841 tcgtagcctg cattttccag tgttatttgt acctgttcta cagtccagcc aggactatga
      901 aggtggtgct tatgctgctc tttatttgcc tgggcaacat gtacctgcac gggctgagga
      961 acctctggca aatccttttc cacataggag tggcttttct gtcttcatat cagatactaa
     1021 caaggcagct tcaggagaag cagtctgact gtggagtatg aggatgacac tgtgatgaat
     1081 ggattctttg attttctttt gaggatcaat ctatgtttct ctttctgctt ctctacttta
     1141 cactccagtt tccatccttt tcagccaact ggactgaaaa accaggaatt ggggatgtta
     1201 aacagttgca gtggaagtca tgaggttgct tgatacccag ccttggttct gtgccaagca
     1261 ttactgcagg atctccagcc agttcagcac gtttacctag gacagctgga tctgggggct
     1321 catccagaaa gagctttatt ggaagagaga aaggaaatat tttggtcttt taagttgaat
     1381 gatacagtaa accacttgat tcaataacac tggttttagt cattgagagt tgtctccaag
     1441 gaaccacttt aaaatccaaa tcagctttca gtctaaacat aacttgatta gttttttttt
     1501 tcagagggtc agtacaggat gaattaaaaa cctaaaaata tggttcataa atgtaagcta
     1561 gataaatttt gtttacattt tttcaatatc ttaggttcga tatacctttg gaatatttaa
     1621 ttatattttg gatataaatt ggacttcatt tagggtgagg gcaaacttaa gctgagaaaa
     1681 tggttaagaa atctgagttt atttaattta tatgtaacct tttatagtgg tgggactgtt
     1741 tgggtacaga gatgttttat atttatttgc agggtatatc cgaatatttt aaaaattaat
     1801 tgaataacca gtacttctag atgataagtt tgtcagcatg agcagaaatg agaatttcag
     1861 gattacttac aattgaccac aacctggagt aggtgaatga acatggattc agtggcactt
     1921 tacagatccg cttgggaggg gctgctgtca tcagcctttt cagtagagct gagtgcctgt
     1981 tgttttaatg atgatgacta ctgtaccctg tgtacctgtt cccagagcgc ctccaaaatt
     2041 aattactcct ctgcaccttt cccagtcatc ttaattagct tgagggcctc attttttatg
     2101 aacaagagtt aagtatctgt taacttttta aagcttgata gagatataat taacacatac
     2161 tctggaaagt tactctcttt cactgtcaaa aaattgattg atcacagttt tccaaaatat
     2221 ggttctggat aagatccctt aggtttcccg aaatttcagc ctggcttgtt ttgtaccacg
     2281 caggaggtca ttttgggagt ttgctctttg gattgttctt ggtagaagtc tggaatctga
     2341 atagttcaac cacagttgca tggaacactt tgagtgttca actgcattat gtggtcttga
     2401 taaattttta aaaatcctat tttgatagtt tttaaaagtg gaaaaccatt acaagagttg
     2461 agtggatagg gaatgtaaga atgtagtttt agaaaaattc aattatattt ggttatcact
     2521 ggtattgtat tgttattgag ctaccttgtt atcattttaa gaaaaataag tttatatact
     2581 gggaactatg ttgggaaaat gttgccatag taactttatt ttttataata gaattttcta
     2641 tttttgacca aacataaaat atttggatat gggccaggca tgatggctca tgcctgtatt
     2701 cccagcactt tggaaggcca aagcaggaga ctcggttgag gccagtagtt tgagaccagc
     2761 ctggacaaca tagtaagatt catctctaca aaaaaaaaaa ttagccggat gtgatggcac
     2821 atgcctgtaa tcccagcact ttgggagtct gaggcaggag gatcccttga gtccaggagt
     2881 ttgaggcttc catgagctat aatcacacca ctgcacccca gcctgcatga cagagtgaaa
     2941 ccctgtctct aaaaagtctg aatatgaaaa ttatattggc agcatactca gacataaact
     3001 ccaaagttgt ctctacactg atttcacatc tgcataattt tctgcatacc cagcaggtga
     3061 attttcagtt tttctgggag acaattttga agagatggtg aaatagaatg ggaagttaag
     3121 gaggggaggt aaaatgtttt aaatgagaag aacaaaaaag ctttaaaagt caataacact
     3181 ttgggaagct gaggtgggca gatcacgagg tcaagagatc gagaccatcc tggctaacat
     3241 ggtgaaaccc catctctact aaaaatacaa aaattagctg ggcacggtgg cttgtgcctg
     3301 tagccccagc tactcaggag gctgaggcag gagaatctct tgaacccggg aggtggaggt
     3361 tgcagtgagc cgagatcgag ccactgcact ccagcctggt gacaaagcaa gactccgtct
     3421 caaaaaaaaa aaaaaaaaaa gtcggtaaga acggcttaaa aatggactgt tttcttttcc
     3481 tatgtggcat tgggttgcca tgtagacctg taccccaggt gctttgggca tctgagccta
     3541 tgatccatat tcagcaggca gtaaagaaac ggtccttgaa gatgagtcct tcctggtaat
     3601 gcttcctgac caccgaggca ctaccagaga tgttatccac accaggtcga atgtgtggat
     3661 atcagttaac atctacatgg ggtgagattg acttttgcaa acaaaaggga aaagatgcac
     3721 tagaaaaaca gtacaagtaa tgaccacaaa aacattgttt gactgaaatc cagctagcta
     3781 aaagaatcct cagctcactg aaggaagaga ctgaaaatag gaaagaagtt ctggtgattt
     3841 catccgaggg aaatccccag gcttaggttt gacttggttc agggttggag gtttatagcc
     3901 tcttgtgtga tccttgatac cagcaaactg gttccaaatc ccaggagtta tcctcactcc
     3961 accatggact cactgttgtt gtagcacttt tgttttccca gtagttaaat gctacctgtg
     4021 cagctgacat cactggacta gatctgggaa tagatgaaat aatgttgaaa acaaaacttt
     4081 agaggtgcct tctggtatca gatgctgcaa ggccttgagc atcagagtgt gttaagtccc
     4141 atctactgta tcaaggccag agtgtggctc catgctctta ggaagggttt cccaaccacg
     4201 gggccagagc ccaaaaggtt tccccttccc taatatgcta atgaacgaaa catgtaaatc
     4261 tgttttcccc tgttaggcta gtcttactgt gatgagaagt gtacctggct ttccttttcc
     4321 tgggtggaga cagctggggc atattcgggt ggcattccct ctcagtacca gaggccccac
     4381 tgcctgcagc tggaggcatg tgaccataag ctcctgcttt tgctttttgg gcttgcatcc
     4441 ctcttttctg tgaactctgg agaatgctgg aattaaaaca tttaagcatt ttgattaaat
     4501 gagcttgagc tcctctgttc ttttctaggt gctcttgttc tccaactctc ctgcctcttt
     4561 ctacctctgc cctatacatt ccagctctgg agacagagtc tgaaactgga gtctctggag
     4621 ggatgagaaa accatcttta attgtaacaa atggggtggg tagacgagct tcagagtggg
     4681 agcagattgc attgaggttc aactctccca cccatgcctg ggagtcaagt cttggagagg
     4741 agtaacactt ggtggtcagc acagctcaga gtcagagaca atagccagca ggccagcaag
     4801 gctggctgtg tgaggcacag gaagcagggc ataggtaggg agcagagctg ggggttctct
     4861 ctctgctgga agatagcagc tgccccttgg catatggggg ttgcacactg caccttgtag
     4921 ccagggctgc tatttgctgt tctgtgaagg agttggccac tcattgtgac atgcaggaca
     4981 gtggccttct gagaacctgc tgcttgcttg catagtgcag cacaagtgag gacaggcagg
     5041 ggtgggagca tttatggtga tcagatgtgc ctggcaagcc cctgttcaga cattgctcac
     5101 attccaaatg ttttcgtgta gaatattgca caggtctggg gacgctctac ctgtgccctg
     5161 tgagtgttaa taatggtgga gaaagagtgt agctgtgccc ttgagagaga aggtgaggga
     5221 aagagtgcac cagtcagctg accgtcagct ggctaggctc ttcactgagt cctatgtcgc
     5281 agtgcacaaa tcactgccca tcaggcctca gtttcctcat ctggtaaatg gtgataacat
     5341 caatctgccc ccccgccagg gtgctgttat gagggtcaaa agtggtagtg gagggtaata
     5401 ctgggtgagt ccattgtgtg tgggaggaga aaggctttac attcacctgg tacatgaagg
     5461 tttttctgct tcaggcagca cagcacagcc atttcttctg gcctttacaa aaaggcattt
     5521 tgttatacta cagtgtaaac ctcatttttt tcactccaaa aggtagcagc ccctcttctt
     5581 cccaccctgg acctgccttt cactccctgg gcacagagcg catggtacca ttgatgtttg
     5641 gtttattcca ggatccaagg agctggttct gctggttgga ccaaacctcg tgagccagcc
     5701 acccctgacc caaatgagga gagctctgat tctcccatcc gggagcagtg atgtcaaact
     5761 tctgctgctg gggaaatctc atcagcaggg agcctgtgga aaagggcatg tcagtgaaat
     5821 ctgggaatgg ctggattcgg aaacatctgc ccatgtgtat tgatggcaga gctgttgccc
     5881 acaagcgcct tttatttagg gtaaaattaa caaatccatt ctattcctct gacccatgct
     5941 tagtacatat gacctttaac ccttacattt atatgattct ggggttgctt cagaagtgtt
     6001 atttcatgaa tcattcatat gatttgatcc cccaggattc tattttgttt aatgggcttt
     6061 tctactaaaa gcataaaata ctgaggctga tttagtcagg gcaaaaccat ttactttaca
     6121 tattcgtttt caatacttgc tgttcatgtt acacaagctt cttacggttt tcttgtaaca
     6181 ataaatattt tgagtaaata atgggtacat tttaacaaac tcagtagtac aacctaaact
     6241 tgtataaaag tgtgtaaaaa tgtatagcca tttatatcct atgtataaat taaatgaggt
     6301 ggcttcagaa atggcagaat aaatctaaag tgtttattaa
//
