LOCUS       NM_004892               6927 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SEC22 homolog B, vesicle trafficking protein (SEC22B),
            mRNA.
ACCESSION   NM_004892
VERSION     NM_004892.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6927)
  AUTHORS   Choi,J.H., Park,S.Y., Lee,W.J., Lee,C.J., Kim,J.H., Jang,T.Y.,
            Jeon,S.E., Jun,Y. and Nam,J.S.
  TITLE     SEC22B inhibition attenuates colorectal cancer aggressiveness and
            autophagic flux under unfavorable environment
  JOURNAL   Biochem Biophys Res Commun 665, 10-18 (2023)
   PUBMED   37148741
  REMARK    GeneRIF: SEC22B inhibition attenuates colorectal cancer
            aggressiveness and autophagic flux under unfavorable environment.
REFERENCE   2  (bases 1 to 6927)
  AUTHORS   Yamada,K., Motohashi,S., Oikawa,T., Tago,N., Koizumi,R., Ono,M.,
            Tachibana,T., Yoshida,A., Yoshida,S., Shimoda,M., Oka,M., Yoneda,Y.
            and Yoshida,K.
  TITLE     Extended-synaptotagmin 1 engages in unconventional protein
            secretion mediated via SEC22B+ vesicle pathway in liver cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (36), e2202730119 (2022)
   PUBMED   36044553
  REMARK    GeneRIF: Extended-synaptotagmin 1 engages in unconventional protein
            secretion mediated via SEC22B(+) vesicle pathway in liver cancer.
REFERENCE   3  (bases 1 to 6927)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6927)
  AUTHORS   Donkervoort,S., Krause,N., Dergai,M., Yun,P., Koliwer,J.,
            Gorokhova,S., Geist Hauserman,J., Cummings,B.B., Hu,Y., Smith,R.,
            Uapinyoying,P., Ganesh,V.S., Ghosh,P.S., Monaghan,K.G.,
            Edassery,S.L., Ferle,P.E., Silverstein,S., Chao,K.R., Snyder,M.,
            Ellingwood,S., Bharucha-Goebel,D., Iannaccone,S.T., Dal Peraro,M.,
            Foley,A.R., Savas,J.N., Bolduc,V., Fasshauer,D., Bonnemann,C.G. and
            Schwake,M.
  TITLE     BET1 variants establish impaired vesicular transport as a cause for
            muscular dystrophy with epilepsy
  JOURNAL   EMBO Mol Med 13 (12), e13787 (2021)
   PUBMED   34779586
REFERENCE   5  (bases 1 to 6927)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6927)
  AUTHORS   Xu,D., Joglekar,A.P., Williams,A.L. and Hay,J.C.
  TITLE     Subunit structure of a mammalian ER/Golgi SNARE complex
  JOURNAL   J Biol Chem 275 (50), 39631-39639 (2000)
   PUBMED   11035026
REFERENCE   7  (bases 1 to 6927)
  AUTHORS   Parlati,F., McNew,J.A., Fukuda,R., Miller,R., Sollner,T.H. and
            Rothman,J.E.
  TITLE     Topological restriction of SNARE-dependent membrane fusion
  JOURNAL   Nature 407 (6801), 194-198 (2000)
   PUBMED   11001058
REFERENCE   8  (bases 1 to 6927)
  AUTHORS   Zhang,T., Wong,S.H., Tang,B.L., Xu,Y. and Hong,W.
  TITLE     Morphological and functional association of Sec22b/ERS-24 with the
            pre-Golgi intermediate compartment
  JOURNAL   Mol Biol Cell 10 (2), 435-453 (1999)
   PUBMED   9950687
REFERENCE   9  (bases 1 to 6927)
  AUTHORS   Paek,I., Orci,L., Ravazzola,M., Erdjument-Bromage,H., Amherdt,M.,
            Tempst,P., Sollner,T.H. and Rothman,J.E.
  TITLE     ERS-24, a mammalian v-SNARE implicated in vesicle traffic between
            the ER and the Golgi
  JOURNAL   J Cell Biol 137 (5), 1017-1028 (1997)
   PUBMED   9166403
REFERENCE   10 (bases 1 to 6927)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD619408.1, AK289875.1,
            AA135767.1, BU741516.1, AI085383.1 and AC245008.1.
            
            On May 17, 2019 this sequence version replaced NM_004892.5.
            
            Summary: The protein encoded by this gene is a member of the SEC22
            family of vesicle trafficking proteins. It seems to complex with
            SNARE and it is thought to play a role in the ER-Golgi protein
            trafficking. This protein has strong similarity to Mus musculus and
            Cricetulus griseus proteins.[provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2942478.1,
                                           SRR18074969.856995.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000578049.4/ ENSP00000463393.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CD619408.1         32-36
            6-1121              AK289875.1         1-1116
            1122-1185           AA135767.1         64-127
            1186-1813           BU741516.1         18-645              c
            1814-1883           AI085383.1         9-78                c
            1884-6927           AC245008.1         191295-196338       c
FEATURES             Location/Qualifiers
     source          1..6927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..6927
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="SEC22 homolog B, vesicle trafficking protein"
                     /db_xref="GeneID:9554"
                     /db_xref="HGNC:HGNC:10700"
                     /db_xref="MIM:604029"
     exon            1..214
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..787
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="ER-Golgi SNARE of 24 kDa; SEC22 vesicle trafficking
                     protein-like 1; SEC22 vesicle trafficking protein homolog
                     B"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22b"
                     /protein_id="NP_004883.3"
                     /db_xref="CCDS:CCDS83523.1"
                     /db_xref="GeneID:9554"
                     /db_xref="HGNC:HGNC:10700"
                     /db_xref="MIM:604029"
                     /translation="MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKL
                     NEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKK
                     VPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRG
                     EALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL"
     exon            215..324
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..485
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..632
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..6927
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="major polyA site"
     regulatory      4413..4418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="hexamer: AATAAA"
     polyA_site      4441
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
     regulatory      5792..5797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="hexamer: AATAAT"
     polyA_site      5810
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
     regulatory      5835..5840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="hexamer: GATAAA"
     polyA_site      5862
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
     regulatory      6472..6477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
                     /note="hexamer: AATAAA"
     polyA_site      6498
                     /gene="SEC22B"
                     /gene_synonym="ERS-24; SEC22L1"
ORIGIN      
        1 acctcagcgg gaagcggaga cgcaagcagc tggatctccg gtaactgaga catagggtat
       61 aactgttgtc gcggcggagg aagtgaggac ggcgccaagg gccttccggg ccagtgttgg
      121 atccctgtag tttgtgaaga tggtgttgct aacaatgatc gcccgagtgg cggacgggct
      181 cccgctggcc gcctcgatgc aggaggacga acagtctggc cgggaccttc aacaatatca
      241 gagtcaggct aagcaactct ttcgaaagtt gaatgaacag tcccctacca gatgtacctt
      301 ggaagcagga gccatgactt ttcactacat tattgagcag ggggtgtgtt atttggtttt
      361 atgtgaagct gccttcccta agaagttggc ttttgcctac ctagaagatt tgcactcaga
      421 atttgatgaa cagcatggaa agaaggtgcc cactgtgtcc cgaccctatt cctttattga
      481 atttgatact ttcattcaga aaaccaagaa gctctacatt gacagtcgtg ctcgaagaaa
      541 tctaggctcc atcaacactg aattgcaaga tgtgcagagg atcatggtgg ccaatattga
      601 agaagtgtta caacgaggag aagcactctc agcattggat tcaaaggcta acaatttgtc
      661 cagtctgtcc aagaaatacc gccaggatgc gaagtacttg aacatgcgtt ccacttatgc
      721 caaacttgca gcagtagctg tatttttcat catgttaata gtgtatgtcc gattctggtg
      781 gctgtgaaat aatgaataca gtcactggta agggagaacc tagaacccag taggtgtata
      841 ttttcaggaa actgagctca cagagatgtg tattagaatc caagtggaac ttctgcctct
      901 aaagaccttg caagaaaaga gatgccctga aaatgaaagg ttgcacctca tttaatgaag
      961 cttaacccta tgtagaaagt ctctttcggg ggcagaggct ttctctgggt gccaagccat
     1021 atatattagg gaatagtaga ttgttaattt cgttttttcc ctcccagtgc attttaaaaa
     1081 cagcactggc tggggcattc tcattctctg atggagccat caatgagatt taacttagtc
     1141 aacctgtgct agcaacattc tgaaattcct tcaaagaagg cagtcctttg ggaaggtgtt
     1201 tttttttttt tttttttttt tgactctaat caacattcct tttgttggtg acatttgtga
     1261 ttttcagtaa tctgagtttt tgatggcctt ttaaacaaga ctccagtatg tgaaggttaa
     1321 ttgctgtgct ccacagatct tgtctattgg cccctgtaga aagttaacct ttgttgtttt
     1381 ccttttataa tttgcttatt gcacaattgc tttagggtaa gtgaattata ttaagatgcc
     1441 ttgaaattat agcactcctt gattaagaag ctaaaatgtt tctctcattt actccttaaa
     1501 caaaagactt aaattagttt gggtcattat tacttttatt ttgcagcatt tggtttgtta
     1561 ttagcgtaag agcaagtata ggatatggag aggcccctgg cttcatgaga acaaaggcag
     1621 gcccaggtta taattacagc tttctcctgc cccttcttta ctttctctac cacagttttc
     1681 tccactgttt gttttcctct tgccacaatt tgctaacatt taaaaaattt tcctgcaccc
     1741 agtagtttca tatcctgtag acatcctctt aggacattct caaatttcaa aataaaaaat
     1801 attcatctat gtagttaatt aaagttaaag tttttgcaga tcaactactc aaactactaa
     1861 atacatttac ctgagaaaaa gtctctgaga gcacttcatt cctgttttag ttcgtgtaaa
     1921 ttctctgaga atgttctgga gatagataac tcatttacag tggtttctat taactaatta
     1981 aagtacccat gattttttcc ttttctgctc agggatgatg gagatttcct tttaccttct
     2041 gaggtagaat tttttaatgg ggaaaatagg ccttttaaat attattgcca gggtctgcaa
     2101 tataacttaa aattcctgta catactgcaa atatttcttt aaattgcaca ggaaaatgag
     2161 cgaacttttt atttcttaat atctttggca aaaaacttta accagtaagc aattttataa
     2221 ccctgaggga tcatcaaaga tactatcctg attcctggta aggaaaaata tattatttcc
     2281 ttataacaag gcaaggagaa atgctatttt attcctgata atttatataa ctagaataat
     2341 ttttttcctt tcttttatgg acctaaatct gccaattggg aattttgtgc atgaaatatg
     2401 aagttacttt ttatagataa tcagtgcttt taagtcccta aaaggctcct gctgaagtaa
     2461 tgatgatgtt aataataaaa gcctttgaaa ggctgaaaac ctacatagtg gtaccatagt
     2521 atttggagct tctataggag tggagagggg cagctcattg ttgagagttg catgctgcaa
     2581 cctaatggtc agcaatgaaa taaatacttg tagaatgttc acttcagtgt gaagttttgt
     2641 tatctagtta atttatatac atatatcctt tgtagataca tttctatcta atcttgttgg
     2701 gctaattaag aaataagggg tggggtaatt gtcaacaaag ggagaagaaa gtggtttaag
     2761 atcagggcag cagaaaaatt agagaacaag aatatcataa tatggctcct ggttttcttt
     2821 ataagaggca gtgggaagat ctgactagat gaaatgtatc atcaaccaaa ctggcatcta
     2881 aaatagaatg ggataaatac tgtatggggt tattggaggc atattaagaa aggacaccta
     2941 atttattttg ggaagaagta tgttaagaga agactttcta gagaaggaga atggggcatt
     3001 ctaggaagag tcaatggcat gtgcaaaggc atgaataaag acagtgaggc atattttgga
     3061 aatgtaacag cttgattcag cttagcccat agggtaagca tagacaacag aggagacttg
     3121 aggaatgaga actagatggg tacactatca taaagggact tgtctatcat gctgaggagt
     3181 ttagaccatc ttaatggtag tggccaagga tggcatcaga tttatagttt caagtgatca
     3241 taatattggc ataaaagata tattagggag gaagcctgaa gtagggagat gaaaataagg
     3301 agccatcaaa ggcagaatga aacttaggca gatttcaagt gattttcaaa aatgttgtga
     3361 tcagaggtac cagataataa ctattacata acactttctt tgttaggagc ttatttctca
     3421 cactgaccaa agcttttgaa gtaagtactc tttacaccac tatataaata aaccttacaa
     3481 aggattctgc tttgaggcat gagagagtta agtcatttgc ccaaagtcac agagttagaa
     3541 agtaatagag ctaagatttg aacctaggca gtttggctcc agagtctgtg ctcttacgct
     3601 atattaccac caagaggtca aataaatacc aaagaatgta ttttcgaatt taacaatgag
     3661 gaacttaatc atacaggcag aagtaattcc agagcactgg agacagaagc cagattgcca
     3721 tatgggttaa agagtgtgta aaccactagg aagtaaagac atagaactac tctcacaagt
     3781 gcttttctgg ttattgtgac gctgaacttc atggcttgtt ttaattaaga catcttacaa
     3841 gtgtcaaaat ttggaaatat ttggacactg tacactctgg ttatttaaat atctaacaat
     3901 ggttcttgag cattttgaga aacctttgaa aatctgatga aaggtatgtg ccattactct
     3961 agaaaaatgt tcctgtgtac atgcacatca agtatcacat actgtttcag gctgttcaaa
     4021 gactacaaag tctgttcatg acctaatggt ccatgttccc tcagttaaga gctccagaga
     4081 taaaggatgt ggaactcaaa ggtaagtacc cagagccttg aaaactccat ctgtgacttg
     4141 gaagaattct acaatttgaa ttaactttgt ggagagagat atatttttga aaaattgtgt
     4201 gtaccaaaaa aatttcatat caaataatat tttcctgtag tgcattcaag gatctggttc
     4261 cacagcaaaa aattgttttg gtctcagttc ctcaaaatca catttaagga gcttgagatt
     4321 tatattttct acttaataag tcttacaaaa gcaagttaag aaggaaaatg gacaatcatt
     4381 tctgcacata tagggtttaa taaaacatgt ataataaaat atctcatatt ttaaatttcc
     4441 accttattgg tagctttcat gacaaagggc tagggtgctg atggccatac aattaaggtt
     4501 tttggttagt tagttagcag aactaactga ctcctacctg gtgggttttt cttttgtttg
     4561 gttggttggt tggttggttt tttcccagat ggctcaggag gaaggtaaat agcagtcatt
     4621 gtatgtgtga cagagtttga gatagaatga gcatattgaa tctcacatcc tattcttatt
     4681 actgtcaggc agcgttgacc tagcagtata aaactatctg aagcaatgta gtcactcagt
     4741 tctcataaag tttatttcaa gtactgtaac aattcatgtt tggattagaa aagtcactag
     4801 aaatttgact tccatatagt aatctatact tttttctctc atttccttca ttttttgagc
     4861 cgtaagtgta aggcattttg ctggtattat tacaatggtt atgaggagtt tctttgcttg
     4921 cccaaggtca catagctagc aagttaaagt agattcaaat ccaggcctgc tagataccaa
     4981 attattattt aagagtactt ttcactactc ctaaataatg acacagatac gtttgtctta
     5041 cacatttcac tttattgtca agttattagt atgtttattt tcaaaagtta ttttttgcaa
     5101 tttcttttta ttattccgta ctttttaaat ttacttcatt atcacgtctt cctttattct
     5161 ttttaaatag tttttgcttt tgttattttg ttttcccttt tttactcttg gtttgtaata
     5221 cctctttcct tatttgctcc tttctcattt gatctcaatg ttaatccaac tgttttccac
     5281 atctgattca ctaaaatttt agcccttaaa aaaaaaattc ctgtttttcc tatctccttt
     5341 tgtccattct cttctccttg cctcacttct tttatctttt tccattttac tttcattttt
     5401 tgtttctcta gatgttgttt tgacatatga gttaatgtac tggtacaatt ttgcatctgt
     5461 aaattagagc ttcagaatca actgagtgta tttattcttt atttttaggc ctaaatttat
     5521 cttacctttt attgatttta taatatacta tactctttca ttttagtctg catatgttag
     5581 ccaaagaaga tatgcccctg ttttaagaaa tctctgtaaa aaatgtcaag tgtgacaaga
     5641 attcttcaag aaacaagctc ctctagtttg tcttctatat ttagagcttc aacagttacc
     5701 tatattactg gtaactccca aatatacctt caaacttgtt ttttgggccc aagttttttg
     5761 cttcatatat atctgttttg aatatcccat aaataattgc atctaaagca tacctccact
     5821 ccattgttct caaagataaa accaaacctg tgctgcttct tatatttcta gtatttaagc
     5881 gtcacctgcc acccctttac ctgagctaca agtcacgcat tgcattagac tcctctgctt
     5941 tcttctttca cctctaacta gactattaac caaaaatttt ttaatataac tttcaaaagg
     6001 tattttatta catcatttcc atcctttatg tttgggttca agccctcatt aactttaaca
     6061 tggattcttg gagtaccctc cttactgatt ttgttacaca tgtccctctt ttagtcagta
     6121 ctaccatgat aataccatgg ataataattt tttcattttt atttttagtc ttgctctgtc
     6181 gccgaggcta gagtgcagtg gcgcgatctc agctcactgc aacctccacc tcccgggttc
     6241 aagtgattct cctgcctcag cctactgagt agctgggatt acaggcacct gccacagctc
     6301 ctggctaatt tttgtatttt tagtagagat ggagtttcac cgtcttgaac tcctgacctc
     6361 atgatccacc ctcctcggcc tcccaaagtg ctgggattac aggcatgggc cactgcgccc
     6421 ggccaataat ttttgtgtgt gtgtgtgcta atcatactac attttcttta gaataaaaga
     6481 tcacatactt gtttgccatt cgcagtctgg ccccattgtg ccattctaga cttacctcct
     6541 gccactcccc accagctttg ttttgtctta gccacacaaa ataatctagc gtctctaacc
     6601 agtcaaacat tttaccttgt gccttggctc actctgtgcc ttttctccag aatatctttc
     6661 tgtgtacttt tctcccatcc ttttaccttt aaacctgctg ctatggtttg catgttgttt
     6721 ggcccctcca aaactcatgt tgtagttcaa ttgccaatgt aatagtgttg ggagatggta
     6781 cttttaagag gtaattaggt tgctaagatg gattaacatc tttctcttga cactgagact
     6841 gggttctcct gggaatggtt agttcccaag agagtgagtt gttataaaac aatgctgcct
     6901 cttctatttt gcgctttttg tttgcac
//
