LOCUS       NM_012430               3401 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SEC22 homolog A, vesicle trafficking protein (SEC22A),
            mRNA.
ACCESSION   NM_012430
VERSION     NM_012430.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Mancias,J.D. and Goldberg,J.
  TITLE     The transport signal on Sec22 for packaging into COPII-coated
            vesicles is a conformational epitope
  JOURNAL   Mol Cell 26 (3), 403-414 (2007)
   PUBMED   17499046
  REMARK    GeneRIF: The 200 kDa crystal structure of Sec22 bound to Sec23/24
            reveals that the transport signal is a folded epitope rather than a
            conventional short peptide sequence.
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Tang,B.L., Low,D.Y. and Hong,W.
  TITLE     Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and
            msec22b/ERS-24
  JOURNAL   Biochem Biophys Res Commun 243 (3), 885-891 (1998)
   PUBMED   9501016
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Hay,J.C., Hirling,H. and Scheller,R.H.
  TITLE     Mammalian vesicle trafficking proteins of the endoplasmic reticulum
            and Golgi apparatus
  JOURNAL   J Biol Chem 271 (10), 5671-5679 (1996)
   PUBMED   8621431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG613364.1, BC007122.1,
            AC112503.7 and BX118915.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012430.4.
            
            Summary: The protein encoded by this gene belongs to the member of
            the SEC22 family of vesicle trafficking proteins. This protein has
            similarity to rat SEC22 and may act in the early stages of the
            secretory pathway. [provided by RefSeq, Nov 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.96762.1,
                                           SRR1803617.119793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000492595.6/ ENSP00000417972.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BG613364.1         18-53
            37-1222             BC007122.1         1-1186
            1223-3340           AC112503.7         81218-83335         c
            3341-3401           BX118915.1         582-642
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..3401
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="SEC22 homolog A, vesicle trafficking protein"
                     /db_xref="GeneID:26984"
                     /db_xref="HGNC:HGNC:20260"
                     /db_xref="MIM:612442"
     exon            1..44
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     exon            45..245
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..987
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="SEC22 vesicle trafficking protein-like 2; SEC22
                     vesicle trafficking protein homolog A"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22a"
                     /protein_id="NP_036562.2"
                     /db_xref="CCDS:CCDS3021.1"
                     /db_xref="GeneID:26984"
                     /db_xref="HGNC:HGNC:20260"
                     /db_xref="MIM:612442"
                     /translation="MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKL
                     AQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMK
                     TNTAVRPYCFIEFDNFIQRTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGS
                     ANGVTSAFSVDCKGAGKISSAHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLL
                     QSDGDDFNYIIAFFLGTAACLYQCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNL
                     WQLFFHVTVGAFVTLQIWLRQAQGKAPDYDV"
     exon            246..409
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..604
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..720
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..786
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..3401
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: AATAAA"
     polyA_site      1437
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="major polyA site"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: TATAAA"
     polyA_site      1497
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="major polyA site"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: AATACA"
     polyA_site      1636
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: AATGAA"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
                     /note="hexamer: TATAAA"
     polyA_site      3397
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
     polyA_site      3401
                     /gene="SEC22A"
                     /gene_synonym="SEC22L2"
ORIGIN      
        1 acttcggggc gcgtcactcg gagcggcggg tcccgtctcg acaggtcttc tctgttggtt
       61 gaaatgtcta tgattttatc tgcctcagtc attcgtgtca gagatggact gccactttct
      121 gcttctactg attatgaaca aagcacagga atgcaggagt gcagaaagta ttttaaaatg
      181 ctttcgagga aacttgctca acttcctgat agatgtacac tgaaaactgg acattataac
      241 attaatttta ttagctctct gggagtgagc tacatgatgt tgtgcactga aaattaccca
      301 aatgttctcg ccttctcttt cctggatgag cttcagaagg agttcattac tacttataac
      361 atgatgaaga caaatactgc tgtcagacca tactgtttca ttgaatttga taacttcatt
      421 cagaggacca agcagcgata taataatccc aggtctcttt caacaaagat aaatctttct
      481 gacatgcaga cggaaatcaa gctgaggcct ccttatcaaa tttccatgtg cgaactgggg
      541 tcagccaatg gagtcacatc agcattttct gttgactgta aaggtgctgg taagatttct
      601 tctgctcacc agcgactgga accagcaact ctgtcaggga ttgtaggatt tatccttagt
      661 cttttatgtg gagctctgaa tttaattcga ggctttcatg ctatagaaag tctcctgcag
      721 agtgatggtg atgattttaa ttacatcatt gcatttttcc ttggaacagc agcctgcctt
      781 taccagtgtt atttacttgt ctactacacc ggctggcgga atgtcaaatc ttttttgact
      841 tttggcttaa tctgtctatg caacatgtat ctctatgaac tgcgcaacct ctggcagctt
      901 ttctttcatg tgactgtggg agcatttgtt acactacaga tctggctaag gcaagcccag
      961 ggcaaggctc ccgattatga tgtctgacac catccttcag atctattgcc ttggcttcag
     1021 ggggataagg agggaacata tcataactgc actgtgatga agaagctgtt ccccacagag
     1081 gagaagctct gctttctttc tctccaactt tcctttttta aaatcagcat gatgtgcctg
     1141 tgagcatgga agagtcctct cagaagaatg ttggccatga gactatcatt cagaggagga
     1201 ggggatttct ctcttcaagg ccgtaacagt ggaagaacag tcatatgcca ttggaagtct
     1261 tggccagcag tcctgaatcc ttcctgaaga gttcagaaaa tagatgtggt attgctctga
     1321 ggaccaggca ggaggaactc tacaacctga gtttgccttt gtgaggcatt agtatagacc
     1381 aaataaaaag ctgcagaaat tggaaagttt atgttttaaa taaatgactg tgataaatat
     1441 cagattattt gcacacttat ggtactacga gtttataaag tccaagatgg tgtgaaattg
     1501 gttcttttta cttttatatt tttgcttgaa tcttaactct ggaaatcacc tgatgtagaa
     1561 gaagactgtg atgagctcgt ctgtggaaca tcacaagtat cgaaaataca gtaatggatg
     1621 tttcctttct aatccacatt tattgtttct tttgaaatca cgtctaaaaa atatgactca
     1681 cactatagcc gttgtttccc aaacttcagt ctctttagta ctacttgtat tattttctta
     1741 atatttatct tttaaatttt aaagtttttt taaaaaaatg aatcctgctc caagtggaaa
     1801 accagtatca gtttgccata aataaaaggt aaccacaaaa taagtaagat gaacacaaaa
     1861 aatgttgttc agttctagct agaaactaat gcctagaaag gctccgaatc ttaggctctt
     1921 tctttgtggc agtgagggag atgttaccag caccagcatg aggcactgtc tctggaatag
     1981 tcagaggata aaaggaaact gtaaagggaa tgacattctc actgtgattc agcattattc
     2041 tatgttgtgc atcacttaaa gacatgttgt gtgccaccag tggcatgggt ccgcactatg
     2101 gaaatgcttg actgtagtaa gaatcagaag gtggctttcc tagcaactca ttattttatg
     2161 gctttgagga attaagcccc tagtatctga gagaacttac ttgttttttg ataacgtttt
     2221 aaagattgtt taagcagtta tgaattaata atataggaag cacagttgga ttccactagc
     2281 aaaatctata actctcatgg ttttggaagt catcttcatg ggtgattttc ctttgttttt
     2341 taaagaaaat atttcaaaca aggaattcat aggatactga aatttgatat catccagaaa
     2401 aacagatccc attacattgt aattgttgtt actaggcata tttattaagt agagaaatag
     2461 agggtaaaaa gttagtgaac tgtcttgttt gcgtgaacca gtatttgtgg atatgtctag
     2521 aactgtaaaa tcttgcttaa ctagaacctt agtctgcacc ctccttttag gagaatgagg
     2581 taaaaggaag acaataagct tatgatatca gggattcatg taaaacagga aatagtagtt
     2641 ggctccagtc ttctcctcta acaaaagtat gcatattctg agagataccc caaggcatca
     2701 caagatcctg aatcatcaaa acaccattga attgtgttgg gcattttgta gccaggaaag
     2761 tgaagtggtt caatttagaa agggtttcag gccaggcacg gtgactcagg cctgtaatcc
     2821 cagcactttg ggaggccgag acaggcagat cacttgagac cagtagtttg agaatcagcc
     2881 tggccaacgt ggtgaaacct catctctact aaaaatacaa aatttagctg ggtgtggttg
     2941 cgcgtgcctt tagtcccagc tactcgggag gctgaggcag gagaatcgct tgaacccagg
     3001 aggtggaagt tggcagtgag ccaagatcac gccactgtac tccagcctgg ccaacagagc
     3061 gagactctgt ctcaaaaaag aaaggttttc taaactaatg gttaaaacag aattttcttg
     3121 taaataggga agttggagca ttctggttga gattttgctc tgtattgaca cagctcgcac
     3181 cagtttggtt caggagctac ctccttgtca ttgaattgac gagttacaat gtttggtatt
     3241 cggatacatt cagcaagaac acttgaaaac tcctcaccaa ctatttttaa aggcttactt
     3301 tgtttttgtt tttatttttt cactggctat tttggataag aggatgttta catcttaatg
     3361 taaaaaaatg aaaacaggta taaatgtttt atgtatagaa a
//
