LOCUS       NM_033127               4486 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SEC16 homolog B, endoplasmic reticulum export factor
            (SEC16B), transcript variant 1, mRNA.
ACCESSION   NM_033127
VERSION     NM_033127.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4486)
  AUTHORS   Mei,H., Yin,B., Yang,W., Zhang,J., Lu,H., Qi,X., Mei,W., Zhang,H.
            and Zhang,J.
  TITLE     Associations between Gene-Gene Interaction and Overweight/Obesity
            of 12-Month-Old Chinese Infants
  JOURNAL   Biomed Res Int 2022, 1499454 (2022)
   PUBMED   35295960
  REMARK    GeneRIF: Associations between Gene-Gene Interaction and
            Overweight/Obesity of 12-Month-Old Chinese Infants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4486)
  AUTHORS   Dai,Z., Wang,Y., Wu,Z., Feng,Z., Sun,X., Qiu,Y., Cheng,J.C., Xu,L.
            and Zhu,Z.
  TITLE     Female-Specific Susceptibility Locus in BOC and SEC16B are
            Associated with Adolescent Idiopathic Scoliosis
  JOURNAL   Spine (Phila Pa 1976) 46 (22), E1178-E1184 (2021)
   PUBMED   33958541
  REMARK    GeneRIF: Female-Specific Susceptibility Locus in BOC and SEC16B are
            Associated with Adolescent Idiopathic Scoliosis.
REFERENCE   3  (bases 1 to 4486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4486)
  AUTHORS   Sahibdeen,V., Crowther,N.J., Soodyall,H., Hendry,L.M.,
            Munthali,R.J., Hazelhurst,S., Choudhury,A., Norris,S.A., Ramsay,M.
            and Lombard,Z.
  TITLE     Genetic variants in SEC16B are associated with body composition in
            black South Africans
  JOURNAL   Nutr Diabetes 8 (1), 43 (2018)
   PUBMED   30026463
  REMARK    GeneRIF: SNPs in several gene loci, including SEC16B were similarly
            associated (albeit not at array-wide signficance (P </= 6.7 x
            10(-7)) with various phenotypes including fat mass, percentage fat
            mass, waist-to-hip ratio linked to body composition in this African
            cohort
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4486)
  AUTHORS   Yamaguchi,M.
  TITLE     Novel protein RGPR-p117: its role as the regucalcin gene
            transcription factor
  JOURNAL   Mol Cell Biochem 327 (1-2), 53-63 (2009)
   PUBMED   19214710
  REMARK    Review article
REFERENCE   7  (bases 1 to 4486)
  AUTHORS   Thorleifsson,G., Walters,G.B., Gudbjartsson,D.F.,
            Steinthorsdottir,V., Sulem,P., Helgadottir,A., Styrkarsdottir,U.,
            Gretarsdottir,S., Thorlacius,S., Jonsdottir,I., Jonsdottir,T.,
            Olafsdottir,E.J., Olafsdottir,G.H., Jonsson,T., Jonsson,F.,
            Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Lauritzen,T., Aben,K.K., Verbeek,A.L., Roeleveld,N., Kampman,E.,
            Yanek,L.R., Becker,L.C., Tryggvadottir,L., Rafnar,T., Becker,D.M.,
            Gulcher,J., Kiemeney,L.A., Pedersen,O., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Genome-wide association yields new sequence variants at seven loci
            that associate with measures of obesity
  JOURNAL   Nat Genet 41 (1), 18-24 (2009)
   PUBMED   19079260
REFERENCE   8  (bases 1 to 4486)
  AUTHORS   Bhattacharyya,D. and Glick,B.S.
  TITLE     Two mammalian Sec16 homologues have nonredundant functions in
            endoplasmic reticulum (ER) export and transitional ER organization
  JOURNAL   Mol Biol Cell 18 (3), 839-849 (2007)
   PUBMED   17192411
  REMARK    GeneRIF: Mammalian cells contain two distinct Sec16 homologues: a
            large protein Sec16L of 2154 aa and a smaller protein Sec16S of
            1060 aa.
REFERENCE   9  (bases 1 to 4486)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4486)
  AUTHORS   Misawa,H. and Yamaguchi,M.
  TITLE     Molecular cloning and sequencing of the cDNA coding for a novel
            regucalcin gene promoter region-related protein in rat, mouse and
            human liver
  JOURNAL   Int J Mol Med 8 (5), 513-520 (2001)
   PUBMED   11605020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356279.8, BX481418.1, AB063357.1, AK098627.1, AV697113.1,
            AK090971.1 and AA086201.1.
            
            On Aug 13, 2020 this sequence version replaced NM_033127.3.
            
            Summary: SEC16B is a mammalian homolog of S. cerevisiae Sec16 that
            is required for organization of transitional endoplasmic reticulum
            (ER) sites and protein export (Bhattacharyya and Glick, 2007
            [PubMed 17192411]).[supplied by OMIM, Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063357.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308284.11/ ENSP00000308339.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL356279.8         25578-25713         c
            137-143             BX481418.1         2-8
            144-2420            AB063357.1         1-2277
            2421-3056           AK098627.1         898-1533
            3057-3512           AB063357.1         2914-3369
            3513-3609           AB063357.1         3371-3467
            3610-3885           AV697113.1         118-393
            3886-4128           AB063357.1         3744-3986
            4129-4167           AK090971.1         2088-2126
            4168-4486           AA086201.1         11-329              c
FEATURES             Location/Qualifiers
     source          1..4486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..4486
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /note="SEC16 homolog B, endoplasmic reticulum export
                     factor"
                     /db_xref="GeneID:89866"
                     /db_xref="HGNC:HGNC:30301"
                     /db_xref="MIM:612855"
     exon            1..175
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            176..532
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..3416
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine zipper transcription regulator 2; protein
                     transport protein Sec16B; regucalcin gene promotor region
                     related protein; protein SEC16 homolog B; regucalcin gene
                     promoter region-related protein p117"
                     /codon_start=1
                     /product="protein transport protein Sec16B isoform 1"
                     /protein_id="NP_149118.2"
                     /db_xref="CCDS:CCDS44281.1"
                     /db_xref="GeneID:89866"
                     /db_xref="HGNC:HGNC:30301"
                     /db_xref="MIM:612855"
                     /translation="MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGE
                     RFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYEGGYRNQLYSRPG
                     YENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEH
                     HYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLA
                     SESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFY
                     IPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIRE
                     DVHKVDIMTFCQQKAAQSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQD
                     CKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLY
                     YGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDPLQTLFQLMSG
                     RIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLVEAAHFC
                     YLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIP
                     SFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLS
                     DPLVLERRSGDRDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQ
                     DFSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPFPLQPGSYPAGGGAGQTGTPRPF
                     YSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKP
                     QTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGW
                     FSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTPSPESPPLPDVSA
                     FSRGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPLY
                     NPSQVPQLPTATSLNRPNRLAQRRYPTQPC"
     exon            533..645
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            646..766
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            767..875
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1020
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1169
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1231
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1367
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1598
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1696
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1778
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1896
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2008
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2114
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2255
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2360
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2436
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2736
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2804
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2957
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3056
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3165
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3245
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3344
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..4486
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4460..4465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /note="hexamer: ATTAAA"
     polyA_site      4486
                     /gene="SEC16B"
                     /gene_synonym="LZTR2; PGPR-p117; RGPR; RGPR-p117; SEC16S"
                     /note="major polyA site"
ORIGIN      
        1 agctccatgg aggttgggca gttgcaaagg taactgacat gatgtagatc tgagggcctg
       61 gggagtcttg gtagatgtgg cacctggact ttgacagtct ccaagaggag aggaggcact
      121 cttgggccag gtccctggag cagcgctgaa ggaaggtggg aagccatcag agcaggaaga
      181 taaaataact gcacaactta ctcaaaaccc aggacaaatt cagagagtca aggatggaac
      241 tttgggctcc ccagaggctg ccccagacac gagggaaggc cacagcaccc tcaaaggatc
      301 cagaccgagg gtttcggaga gatggacatc atcggcctgt ccctcactct tggcacaatg
      361 gagagaggtt tcaccaatgg caagacaacc gtgggagccc ccagccacag caggagccca
      421 gggcagacca tcagcagcag ccccattatg catccaggcc aggggactgg catcagcctg
      481 tgtctggagt tgactattac gaaggtggtt atcgcaatca gttgtattca aggccaggtt
      541 atgagaattc atatcagagc tatcagtctc ccacaatgag ggaggaatat gcttatggaa
      601 gttattacta tcatggacac ccacagtggc tgcaggaaga aagagtgcca aggcaacgga
      661 gtccttatat ctggcacgaa gattaccgag agcaaaagta ccttgatgaa catcattatg
      721 aaaaccagca cagtccattt ggaacaaata gtgagaccca cttccaatct aacagtagga
      781 acccttgtaa agacagccct gcttccaact ctggacagga gtggccgggg gagctgtttc
      841 cagggagcct gcttgctgag gcccagaaaa ataagccatc attggctagt gagtccaacc
      901 ttctccagca gcgtgagtct ggtctcagct ccagcagcta tgagctcagt cagtacatca
      961 gagatgcccc ggagcgggat gatcccccag cttcagcagc ttggagtcca gttcaggctg
     1021 atgtctcctc agctggtccc aaagcaccca tgaagttcta catccctcat gttcctgtga
     1081 gtttcgggcc aggaggtcag ctggtgcatg taggtcccag ctctcccact gacgggcaag
     1141 cagcccttgt tgaactgcac agcatggagg ttattcttaa tgattccgaa gagcaagagg
     1201 agatgagaag tttctcagga cccttgatta gggaagatgt acataaggtg gatattatga
     1261 cgttttgcca gcagaaagca gctcagagct gcaaatctga gacactgggg agcagagact
     1321 cagctctact gtggcagctc ttggttctcc tttgtcgcca gaatgggtcc atggtggggt
     1381 ctgacatcgc tgagctgcta atgcaagact gcaagaagct ggagaagtac aagcggcagc
     1441 cccctgtggc caacctcatc aacctgaccg atgaggactg gccagtgctg agctctggga
     1501 ccccgaacct gctcacggga gagatccccc ccagtgtgga gacacctgcg cagatcgtgg
     1561 agaaattcac taggctgctc tactatggaa ggaagaagga agccttggag tgggccatga
     1621 agaaccactt gtggggccat gctttgttcc tgtccagcaa gatggaccca cagacctaca
     1681 gctgggtcat gagtggcttc accagcacgc tggcgctcaa tgacccactg cagaccctct
     1741 tccagctcat gtcggggagg attccacagg cagccacgtg ttgtggagaa aagcagtggg
     1801 gagactggag gcctcacttg gctgtgattc tgtcgaatca ggctggggac ccagagctgt
     1861 atcagcgtgc gattgttgcc attggggaca ccctggctgg gaaggggctt gtggaggcag
     1921 ctcacttctg ctatctcatg gctcacgtgc cctttggcca ctacaccgtg aagacagacc
     1981 atctggtctt gctgggcagc agccacagtc aagagttttt gaaatttgca acaactgagg
     2041 caatccagag gacggaaatc ttcgagtact gtcagatgct gggccgcccc aaatccttca
     2101 tcccttcttt ccaggtgtat aagctccttt atgcttcccg tctggcagat tatggcctcg
     2161 tgtcccaggc tttgcattac tgcgaagcca ttggtgcagc tgtcttgagc cagggagaga
     2221 gcagtcaccc tgtgctatta gtggaactca tcaagctagc agagaaactg aagctgtcag
     2281 atcctctggt tttagaaaga cgcagtggag acagggacct ggagccagat tggctagcgc
     2341 aacttcggag gcagctggag caaaaggtag caggagacat tggggatcct catcctactc
     2401 gctcagatat ttcgggagcc ggaggaacaa caacagaaaa cactttctac caggactttt
     2461 ctggatgtca aggctactct gaagcccctg ggtaccgctc agctctgtgg ctgacacctg
     2521 agcagacctg cctgctccag cccagcccac agcagccctt tcccctccag ccgggctcct
     2581 acccagcagg agggggtgca gggcagacag ggacaccgag gcctttttac tcagttcctg
     2641 agacccatct accagggact ggcagcagcg tggcagtgac agaggccact ggaggaacag
     2701 tctgggagga aatgctgcag acacacctgg gccctggaga gaacacagtg tctcaagaaa
     2761 cttcccagcc tcctgatggc caagaggtca tttccaaacc acagacacca ttggctgcta
     2821 gaccacgaag tatttctgag agttccgcca gttcagccaa ggaggatgag aaggagtcct
     2881 ctgatgaggc tgataaaaac tctccccgaa atactgccca gagaggcaag ctcggagatg
     2941 ggaaggagca tacaaagagc tcagggtttg gctggttcag ctggtttcga tcgaagccca
     3001 ccaagaacgc atcccccgct ggagacgagg actcctcaga cagccctgac tctgaggaga
     3061 cccccagagc atcttctccc caccaggctg gcctgggcct ctcactgaca ccttcccctg
     3121 agtccccacc tctgccggat gttagtgcct tctccagggg cagaggtggg ggtgaaggcc
     3181 gaggatccgc atccagcggg ggagcagctg cgggcgctgg ggttggaggc ttgtctggac
     3241 cagagagtgt ttcctttgag ctctgctcca accctggtgt tcttcttcct ccacctgcct
     3301 taaaaggggc tgttcctctt tacaacccat ctcaggtgcc tcagctgccc acggccacta
     3361 gcctgaatcg gccaaatcgc ctagctcagc gtcgctatcc cacccagcca tgctgagaat
     3421 aaacacacgt cccaggctca tctcccagga ctgaaacttt cttgctctct ttttctcaat
     3481 ctcccagccc ctctctacca tattgggacc ctcaagaggt ttgtgctagc ccgatgcctc
     3541 caccgggcac ttagaaggca agaggacagg atctctcaag acacagcaca attcagtctc
     3601 ttaagattag cttcacaatg atggaaatta tttcatcagg tggaaagtct gggtctaata
     3661 gcagactgca catgagcaga gtgacatggt ggtggcactt atggtggtgg cttgagagcc
     3721 ttggggaaat tagggcccta acagctagaa tcaaagatga taccgcaggg ccctgtagca
     3781 agaaatggga agcaggggga ggggcagggg ctcagaacaa tattctagac caactttgac
     3841 tacttcctgt cttagtaata gaccaataca tggctctatt tagcaaagtt tttatactga
     3901 aacttgatta ttgctgccct ttataatttc ctcttcaatg atatttcagc agtttccctc
     3961 ttggtcctag ttttgtgcac atttttttga atgtggttca gattaattat atttctctca
     4021 ctttcttagc tggtcctatt ttttcacatt ctggcatgtg gctatcaagt tagattgctg
     4081 taggcatcat attgtcatgg taactactga acctaatgat gcagatggat ggcacatcag
     4141 tataataaat gatggaaaac ggttcctaaa aattcatccc tttcataaga ggggaagaat
     4201 gagtgcctga tattgttaat acctcccttt ctacctcagg cctttgcaaa ttgatgttca
     4261 gagggtcact ggagtgagag ggaggagggg ggcgtcttgg aaatttccat ttctcttttc
     4321 aaacccaaaa taggaatgac tcttgctgtt tgtcagattt gctgaaaatt gctcctcaca
     4381 aagaacattt ttttttgtac atgtaattgt aaatacaggt ttagtacgtt aatgttctat
     4441 agttctgata ttgataataa ttaaacccag ataattttat agcaaa
//
