LOCUS       NM_174977               2510 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SEC14 like lipid binding 4 (SEC14L4), transcript
            variant 1, mRNA.
ACCESSION   NM_174977
VERSION     NM_174977.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Kempna,P., Ricciarelli,R., Azzi,A. and Zingg,J.M.
  TITLE     Alternative splicing and gene polymorphism of the human
            TAP3/SEC14L4 gene
  JOURNAL   Mol Biol Rep 37 (7), 3503-3508 (2010)
   PUBMED   20012369
  REMARK    GeneRIF: The isolation of an alternatively spliced hTAP3 cDNA and a
            polymorphism within the coding region of the hTAP3/SEC14L4 gene, is
            reported.
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Mokashi,V., Singh,D.K. and Porter,T.D.
  TITLE     Rat supernatant protein factor-like protein stimulates squalene
            monooxygenase and is activated by protein kinase A
  JOURNAL   Biochem Biophys Res Commun 316 (3), 688-692 (2004)
   PUBMED   15033454
  REMARK    GeneRIF: Discusses cloning of rat SEC14-like protein 3 and mentions
            three human SPF-related genes, known as SEC14-like protein 1, 2 and
            3.
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Kempna,P., Zingg,J.M., Ricciarelli,R., Hierl,M., Saxena,S. and
            Azzi,A.
  TITLE     Cloning of novel human SEC14p-like proteins: ligand binding and
            functional properties
  JOURNAL   Free Radic Biol Med 34 (11), 1458-1472 (2003)
   PUBMED   12757856
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK093448.1, AC004832.3 and
            T72380.1.
            
            On May 17, 2019 this sequence version replaced NM_174977.3.
            
            Summary: The protein encoded by this gene is highly similar to the
            protein encoded by the Saccharomyces cerevisiae SEC14 gene. The
            SEC14 protein is a phophatidylinositol transfer protein that is
            essential for biogenesis of Golgi-derived transport vesicles, and
            thus is required for the export of yeast secretory proteins from
            the Golgi complex. The specific function of this protein has not
            yet been determined. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093448.1, BC136358.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255858.12/ ENSP00000255858.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1896              AK093448.1         1-1896
            1897-2120           AC004832.3         97967-98190         c
            2121-2499           AK093448.1         2121-2499
            2500-2510           T72380.1           142-152
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..2510
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /note="SEC14 like lipid binding 4"
                     /db_xref="GeneID:284904"
                     /db_xref="HGNC:HGNC:20627"
                     /db_xref="MIM:612825"
     exon            1..138
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1305
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /note="isoform a is encoded by transcript variant 1;
                     SEC14p-like protein TAP3; SEC14-like protein 4;
                     tocopherol-associated protein 3; SEC14-like 4"
                     /codon_start=1
                     /product="SEC14-like protein 4 isoform a"
                     /protein_id="NP_777637.1"
                     /db_xref="CCDS:CCDS13878.1"
                     /db_xref="GeneID:284904"
                     /db_xref="HGNC:HGNC:20627"
                     /db_xref="MIM:612825"
                     /translation="MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRA
                     RNFDLQKSEDMLRRHMEFRKQQDLDNIVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNI
                     IGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQKLGRKIEMALMVFDMEGLSL
                     KHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIV
                     ILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRL
                     QYEHTRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMT
                     EVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMHAKKLSYTVEVLLPDKASEE
                     TLQSLKAMRPSPTQ"
     exon            139..214
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            215..258
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..318
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..507
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..603
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            604..664
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..748
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            749..855
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..995
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1165
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..2510
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /note="hexamer: ATTAAA"
     polyA_site      2453
                     /gene="SEC14L4"
                     /gene_synonym="TAP3"
                     /note="major polyA site"
ORIGIN      
        1 acaaccaggc ggcagcggat acaaggccag gcggcggcgg gcgggcggac ctgcgccctg
       61 agcctttctg cgcccgcggg caccatgagc agccgagtcg gggacctgag cccccagcag
      121 caggaagcgc tggccaggtt ccgggagaac ctccaggacc tgctgcccat actgcccaat
      181 gctgatgact acttcctcct gcgctggctg cgagctcgaa actttgacct gcagaaatcc
      241 gaagacatgc tccgaaggca catggagttc cggaagcaac aagacctgga caacattgtc
      301 acatggcagc cccctgaggt catccagctg tatgactcgg gtggtctttg tggctacgac
      361 tacgaaggct gccctgtgta cttcaacatc attgggtccc tcgaccccaa gggtctcctg
      421 ctgtcagcct ccaagcagga tatgatccgg aagcgcatca aagtctgtga gctgctgttg
      481 catgagtgtg agctgcaaac tcagaagctg ggcaggaaga tcgagatggc gctgatggtg
      541 tttgacatgg aggggctgag cctgaaacac ctgtggaagc cagctgtgga ggtctaccag
      601 cagtttttta gcatcctgga agcaaattat cctgagaccc tgaagaattt aattgttatt
      661 cgagccccaa aactgttccc cgtggccttc aacttggtca agtcgttcat gagtgaggag
      721 acacgcagga agattgtgat tctgggagac aactggaagc aggagctgac aaaattcatc
      781 agccccgacc agctgcctgt ggagtttggg gggaccatga ctgaccccga tggcaacccc
      841 aagtgcctga ccaagatcaa ctatgggggt gaggtgccca agagctacta cctgtgcgag
      901 caggtgaggc tgcagtatga gcacacgagg tccgtgggcc gcggctcctc cctgcaggtg
      961 gagaacgaga tcctgttccc gggctgtgtg ctcaggtggc agtttgcttc agatggtggg
     1021 gacatcggct ttggggtttt cctgaagacc aagatggggg agcagcagag tgctagggag
     1081 atgacggagg tgctgcccag ccagcgctac aatgcccaca tggtgcctga ggatgggagc
     1141 ctcacctgcc tccaggctgg cgtctatgtc ctgcgcttcg acaacaccta cagccggatg
     1201 catgccaaga agctcagcta cactgtggag gtgctgcttc ccgacaaggc ctctgaggag
     1261 acgctgcaga gtctcaaggc gatgagaccc tccccaacac agtgaagacc ccagccacct
     1321 ctacctgtgc actccaaccc cttcacaccc acccctctga cccctgcctt cccaggcagg
     1381 gtggtgctgg aggtggctgc agagagccac ttgtcccacg tcaccatttc atctcattgt
     1441 aggctcacct ggcacagtgg ccaagcagga aggggccacc agtgcatagc ccatgctgaa
     1501 gattcagaca ggaacctctt tccctgttcc cagagaatgc ggctgagaat gagaacgctg
     1561 aagatgatcc agtccactga ggatgggtcc tgcttgcaga agctgccctt tcacccatct
     1621 tgacaagatc cagccaccca ggactcaccc atgcctggtg ttccagcttc agggggtgtg
     1681 cgtggttcct aggtcctgtg gacatcacag cttcaggcct gaagagcaga gaagccctgt
     1741 tctctgcatg taggaggtca gcaggggtgg gcaggcccag ctggaggcag ctgggtgagg
     1801 gtcctggttc cagcagagca ctggggccca tccaagtttg ttctgccacc actggatgga
     1861 aaattggaaa tggactgggc gtggtggctc acgcctataa tcccagcagt ttgggaggct
     1921 gagttgggca gatcacctga gatcaggagt tcgggaccag cctgggcaac atggtgaaac
     1981 cctgtctcta ctaaaaatac aaaaattagc cgggcatggt ggcgtgcacc tgtaatccca
     2041 gctactcagg aggctgaggc aggagaatcg cttgtaccca ggaggcggag gttgtagtga
     2101 gctgagatcg tgccactgca ctccagcctg ggcaacagag ccagactccg tctctaaaca
     2161 aacaaacaaa caaacaaaca aataaagaaa gaacattgga catggagagg tggggcctgg
     2221 catgggtaac catcagagga aaaagccatg ctcagccttc cagttgagtg ggtaacgact
     2281 gagtctccag ggaattccca gtgacctccc ctccacacct gctgtgatcc tgccaacatt
     2341 tagctttggt tctcttggca gctgcaccat tcatgggtgc atatacgtag agtctgaaca
     2401 ggtgctctgc tgctagaaac agcaaaccat ctagattaaa ctcctaaagc cagtgccacg
     2461 aggcattcct gttccaactg ggtgtttgag cagattggca aaaaaaaaaa
//
