LOCUS       NM_174975               2054 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens SEC14 like lipid binding 3 (SEC14L3), transcript
            variant 1, mRNA.
ACCESSION   NM_174975
VERSION     NM_174975.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Jiang,Z., Yang,G., Wang,G., Wan,J., Zhang,Y., Song,W., Zhang,H.,
            Ni,J., Zhang,H., Luo,M., Wang,K. and Peng,B.
  TITLE     SEC14L3 knockdown inhibited clear cell renal cell carcinoma
            proliferation, metastasis and sunitinib resistance through an
            SEC14L3/RPS3/NFkappaB positive feedback loop
  JOURNAL   J Exp Clin Cancer Res 43 (1), 288 (2024)
   PUBMED   39425205
  REMARK    GeneRIF: SEC14L3 knockdown inhibited clear cell renal cell
            carcinoma proliferation, metastasis and sunitinib resistance
            through an SEC14L3/RPS3/NFkappaB positive feedback loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Zhu,Q., Wan,N.B., Deng,H.W., Lu,L.L., Zhang,Y., He,X., Liu,H. and
            He,Y.
  TITLE     SEC14L3 plays a tumor-suppressive role in breast cancer through a
            Wnt/beta-catenin-related way
  JOURNAL   Exp Cell Res 417 (1), 113161 (2022)
   PUBMED   35447102
  REMARK    GeneRIF: SEC14L3 plays a tumor-suppressive role in breast cancer
            through a Wnt/beta-catenin-related way.
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Pan,X., Wu,Y., Peng,H., Cai,X., Hu,Z., Lin,X. and Peng,X.E.
  TITLE     Genome-wide DNA methylation profiling in nonalcoholic fatty liver
            reveals predictive aberrant methylation in PRKCE and SEC14L3
            promoters
  JOURNAL   Dig Liver Dis 54 (4), 521-528 (2022)
   PUBMED   34108094
  REMARK    GeneRIF: Genome-wide DNA methylation profiling in nonalcoholic
            fatty liver reveals predictive aberrant methylation in PRKCE and
            SEC14L3 promoters.
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Gong,B., Shen,W., Xiao,W., Meng,Y., Meng,A. and Jia,S.
  TITLE     The Sec14-like phosphatidylinositol transfer proteins
            Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+
            signaling
  JOURNAL   Elife 6, e26362 (2017)
   PUBMED   28463110
  REMARK    GeneRIF: Here, the authors report that the zebrafish/human
            phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase
            proteins to transduce Wnt signals from Frizzled to phospholipase C
            (PLC).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Bartel,S., Schulz,N., Alessandrini,F., Schamberger,A.C., Pagel,P.,
            Theis,F.J., Milger,K., Noessner,E., Stick,S.M., Kicic,A.,
            Eickelberg,O., Freishtat,R.J. and Krauss-Etschmann,S.
  TITLE     Pulmonary microRNA profiles identify involvement of Creb1 and
            Sec14l3 in bronchial epithelial changes in allergic asthma
  JOURNAL   Sci Rep 7, 46026 (2017)
   PUBMED   28383034
  REMARK    GeneRIF: Creb1/Crtc1-3 and Sec14l3 could be important for early
            responses of the bronchial epithelium to Th2-stimuli.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Saito,K., Tautz,L. and Mustelin,T.
  TITLE     The lipid-binding SEC14 domain
  JOURNAL   Biochim Biophys Acta 1771 (6), 719-726 (2007)
   PUBMED   17428729
  REMARK    Review article
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Mokashi,V., Singh,D.K. and Porter,T.D.
  TITLE     Rat supernatant protein factor-like protein stimulates squalene
            monooxygenase and is activated by protein kinase A
  JOURNAL   Biochem Biophys Res Commun 316 (3), 688-692 (2004)
   PUBMED   15033454
  REMARK    GeneRIF: Discusses cloning of rat SEC14-like protein 3 and mentions
            three human SPF-related genes, known as SEC14-like protein 1, 2 and
            3.
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Ye,X., Ji,C., Yin,G., Tang,R., Zeng,L., Gu,S., Ying,K., Xie,Y.,
            Zhao,R.C. and Mao,Y.
  TITLE     Characterization of a human Sec14-like protein cDNA SEC14L3 highly
            homologous to human SPF/TAP
  JOURNAL   Mol Biol Rep 31 (1), 59-63 (2004)
   PUBMED   15040456
  REMARK    GeneRIF: we report a human SPF/TAP homology SEC14L3 with 2082 base
            pairs in length and contains an open reading frame encoding a 400
            amino acids protein. Analysis shows that SEC14L3 is mapped to 22q12
            and expresses only in the liver
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Kempna,P., Zingg,J.M., Ricciarelli,R., Hierl,M., Saxena,S. and
            Azzi,A.
  TITLE     Cloning of novel human SEC14p-like proteins: ligand binding and
            functional properties
  JOURNAL   Free Radic Biol Med 34 (11), 1458-1472 (2003)
   PUBMED   12757856
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004832.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 27, 2019 this sequence version replaced NM_174975.4.
            
            Summary: The protein encoded by this gene is highly similar to the
            protein encoded by the Saccharomyces cerevisiae SEC14 gene. The
            SEC14 protein is a phophatidylinositol transfer protein that is
            essential for biogenesis of Golgi-derived transport vesicles, and
            thus is required for the export of yeast secretory proteins from
            the Golgi complex. The specific function of this protein has not
            yet been determined. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Jul 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY240872.1, BC101004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215812.9/ ENSP00000215812.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC004832.3         80580-80692         c
            114-189             AC004832.3         79182-79257         c
            190-233             AC004832.3         78887-78930         c
            234-293             AC004832.3         78694-78753         c
            294-482             AC004832.3         77183-77371         c
            483-578             AC004832.3         75657-75752         c
            579-639             AC004832.3         75009-75069         c
            640-723             AC004832.3         73495-73578         c
            724-830             AC004832.3         70761-70867         c
            831-970             AC004832.3         70230-70369         c
            971-1140            AC004832.3         69985-70154         c
            1141-2054           AC004832.3         67904-68817         c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..2054
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="SEC14 like lipid binding 3"
                     /db_xref="GeneID:266629"
                     /db_xref="HGNC:HGNC:18655"
                     /db_xref="MIM:612824"
     exon            1..113
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1262
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SEC14p-like protein TAP2; SEC14-like protein 3;
                     tocopherol-associated protein 2; SEC14-like 3"
                     /codon_start=1
                     /product="SEC14-like protein 3 isoform 1"
                     /protein_id="NP_777635.1"
                     /db_xref="CCDS:CCDS13877.1"
                     /db_xref="GeneID:266629"
                     /db_xref="HGNC:HGNC:18655"
                     /db_xref="MIM:612824"
                     /translation="MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRA
                     RNFDLQKSEALLRKYMEFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDI
                     IGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTERLGKKIETIVMIFDCEGLGL
                     KHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKII
                     VLGNNWKEGLLKLISPEELPAQFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKT
                     QYEHSVQINRGSSHQVEYEILFPGCVLRWQFSSDGADIGFGVFLKTKMGERQRAGEMT
                     DVLPSQRYNAHMVPEDGNLTCSEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQK
                     YDKELTPV"
     exon            114..189
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..233
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..293
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..482
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..578
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..639
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..723
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..830
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..970
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1140
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2054
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="hexamer: AATAAA"
     polyA_site      1544
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="major polyA site"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="SEC14L3"
                     /gene_synonym="TAP2"
                     /note="major polyA site"
ORIGIN      
        1 aaactaggct tggcctcttg cctatagtgg ccaccactcc tcaagcccca gccagcacca
       61 tgagcggccg agttggagac ctgagcccca aacaggcaga gaccctggcc aagttccgag
      121 aaaacgtcca ggatgtgctt cctgccctgc ccaaccctga tgattatttc cttctacgct
      181 ggctccgagc tcggaatttt gacttgcaga agtcggaggc tttgctccgc aagtacatgg
      241 agttccggaa gaccatggat attgaccata tccttgattg gcagccccca gaggtgatcc
      301 agaagtacat gcctgggggc ctgtgtggct atgaccgtga tggctgcccc gtgtggtatg
      361 acatcattgg gccacttgat cccaaggggt tgctcttctc agtcaccaag caggacctgc
      421 tcaagaccaa gatgagggac tgtgagcgca tcctgcatga gtgtgacctg cagacagaga
      481 ggctagggaa gaagattgag accatcgtga tgatatttga ctgtgagggc ctgggactga
      541 aacacttctg gaaacctctg gtagaagtgt accaggagtt ctttggcctc cttgaagaga
      601 attacccaga gaccctgaag ttcatgctca tcgtgaaagc taccaaactg ttccctgtgg
      661 gctacaacct catgaagcca ttcctgagtg aggacactcg caggaaaatt attgtgttgg
      721 gaaataactg gaaggaaggt ttgctgaaac tcatcagtcc tgaggaactg cctgcccagt
      781 ttgggggcac cctgactgac ccagatggga accccaaatg tttaaccaag attaactatg
      841 gcggggagat ccccaagtcc atgtacgtgc gggaccaggt gaagactcag tacgagcact
      901 cggtgcagat caaccgcggc tcatcacacc aagtggaata cgagatccta tttccaggct
      961 gcgttctcag gtggcagttc tcatctgatg gtgcggacat cggcttcgga gttttcctga
     1021 agaccaagat gggggagcga cagcgggcag gggagatgac agatgttcta cccagccagc
     1081 gctataacgc ccacatggtg cccgaggatg ggaacctcac ctgctcagag gccggcgtct
     1141 atgtcctacg cttcgacaac acctatagct ttgtccacgc caagaaggtc agcttcacag
     1201 tggaggtcct gctccctgac gagggcatgc agaaatatga taaggagctc acccctgtct
     1261 aggtggctcc ctcatttctc agagacctcc taaccctttg atttctctgt ttatatccta
     1321 cactccctcc ctccctgaaa ttgattgtta gtcctcctga ctctgtgacg ttagtgagta
     1381 cagaaagaga tgccctgggg aaaactcatc tactgtggtc agatcaagaa aggtatgaga
     1441 ggcacaacct tggagggtac caaggttgca gaagaggaaa aagcaagggt aaaggcaaga
     1501 agtgggtgtc atgaaactca ataaatagca aaatgaatcc cctagccttt gtcctcacct
     1561 accctaaggc aggtgtgtat gcttgaattc cttccgtatg gctgtgagca acttgggttg
     1621 gagacatatc taaatccttt ttacttccac tccctatata tagtagatgc tcagtgtata
     1681 tttgtggcat tgaatggagg accagaaggt agggtgcagg tgactcaaca gctgtacatg
     1741 attaggagga gcctatgtgg ggtggatttc agcaccttgg acaggagcag atgtgtggtg
     1801 gggttggact ctcttctgga gacccagaca attcagtctc cagatttctg gcagtggctg
     1861 tcttttgagg gccccagcca caaaggccac atgcctctga taggagctgc ctacatcagg
     1921 ctttgtctga cttgcacgct cagcttccca ccctaaccca cttcccttgt tgcacatagc
     1981 ttatgtttta gggactttcc tggaagcaaa ggcagtcaca tctggcataa tcataataaa
     2041 gaaaacaact atca
//
