LOCUS       NM_012429               4207 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens SEC14 like lipid binding 2 (SEC14L2), transcript
            variant 1, mRNA.
ACCESSION   NM_012429
VERSION     NM_012429.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   Yee Mon,K.J. and Blander,J.M.
  TITLE     TAP-ing into the cross-presentation secrets of dendritic cells
  JOURNAL   Curr Opin Immunol 83, 102327 (2023)
   PUBMED   37116384
  REMARK    GeneRIF: TAP-ing into the cross-presentation secrets of dendritic
            cells.
            Review article
REFERENCE   2  (bases 1 to 4207)
  AUTHORS   Li,Z., Lou,Y., Tian,G., Wu,J., Lu,A., Chen,J., Xu,B., Shi,J. and
            Yang,J.
  TITLE     Discovering master regulators in hepatocellular carcinoma: one
            novel MR, SEC14L2 inhibits cancer cells
  JOURNAL   Aging (Albany NY) 11 (24), 12375-12411 (2019)
   PUBMED   31851620
  REMARK    GeneRIF: Discovering master regulators in hepatocellular carcinoma:
            one novel MR, SEC14L2 inhibits cancer cells.
REFERENCE   3  (bases 1 to 4207)
  AUTHORS   Costa,R., Todt,D., Zapatero-Belinchon,F., Schenk,C.,
            Anastasiou,O.E., Walker,A., Hertel,B., Timmer,L., Bojkova,D.,
            Ruckert,M., Sarrazin,C., Timm,J., Lohmann,V., Manns,M.P.,
            Steinmann,E., von Hahn,T. and Ciesek,S.
  TITLE     SEC14L2, a lipid-binding protein, regulates HCV replication in
            culture with inter- and intra-genotype variations
  JOURNAL   J Hepatol 70 (4), 603-614 (2019)
   PUBMED   30472319
  REMARK    GeneRIF: SEC14L2, a lipid-binding protein, regulates HCV
            replication in culture with inter- and intra-genotype variations.
REFERENCE   4  (bases 1 to 4207)
  AUTHORS   Gong,B., Shen,W., Xiao,W., Meng,Y., Meng,A. and Jia,S.
  TITLE     The Sec14-like phosphatidylinositol transfer proteins
            Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+
            signaling
  JOURNAL   Elife 6, e26362 (2017)
   PUBMED   28463110
  REMARK    GeneRIF: Here, the authors report that the zebrafish/human
            phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase
            proteins to transduce Wnt signals from Frizzled to phospholipase C
            (PLC).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4207)
  AUTHORS   Saeed,M., Andreo,U., Chung,H.Y., Espiritu,C., Branch,A.D.,
            Silva,J.M. and Rice,C.M.
  TITLE     SEC14L2 enables pan-genotype HCV replication in cell culture
  JOURNAL   Nature 524 (7566), 471-475 (2015)
   PUBMED   26266980
  REMARK    GeneRIF: SEC14L2 enabled RNA replication of diverse HCV genotypes
            in several human hepatoma cell lines
REFERENCE   6  (bases 1 to 4207)
  AUTHORS   Shibata,N., Arita,M., Misaki,Y., Dohmae,N., Takio,K., Ono,T.,
            Inoue,K. and Arai,H.
  TITLE     Supernatant protein factor, which stimulates the conversion of
            squalene to lanosterol, is a cytosolic squalene transfer protein
            and enhances cholesterol biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2244-2249 (2001)
   PUBMED   11226224
REFERENCE   7  (bases 1 to 4207)
  AUTHORS   Zimmer,S., Stocker,A., Sarbolouki,M.N., Spycher,S.E., Sassoon,J.
            and Azzi,A.
  TITLE     A novel human tocopherol-associated protein: cloning, in vitro
            expression, and characterization
  JOURNAL   J Biol Chem 275 (33), 25672-25680 (2000)
   PUBMED   10829015
REFERENCE   8  (bases 1 to 4207)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 4207)
  AUTHORS   Solheim,J.C., Harris,M.R., Kindle,C.S. and Hansen,T.H.
  TITLE     Prominence of beta 2-microglobulin, class I heavy chain
            conformation, and tapasin in the interactions of class I heavy
            chain with calreticulin and the transporter associated with antigen
            processing
  JOURNAL   J Immunol 158 (5), 2236-2241 (1997)
   PUBMED   9036970
REFERENCE   10 (bases 1 to 4207)
  AUTHORS   Caras,I.W., Friedlander,E.J. and Bloch,K.
  TITLE     Interactions of supernatant protein factor with components of the
            microsomal squalene epoxidase system. Binding of supernatant
            protein factor to anionic phospholipids
  JOURNAL   J Biol Chem 255 (8), 3575-3580 (1980)
   PUBMED   7364757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096881.1, AC004832.3 and
            AA610131.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012429.4.
            
            Summary: This gene encodes a cytosolic protein which belongs to a
            family of lipid-binding proteins including Sec14p, alpha-tocopherol
            transfer protein, and cellular retinol-binding protein. The encoded
            protein stimulates squalene monooxygenase which is a downstream
            enzyme in the cholesterol biosynthetic pathway. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified for this gene. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.161299.1,
                                           SRR1803615.12584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615189.5/ ENSP00000478755.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2744              AL096881.1         75-2818
            2745-3831           AC004832.3         32517-33603
            3832-4207           AA610131.1         34-409              c
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4207
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="SEC14 like lipid binding 2"
                     /db_xref="GeneID:23541"
                     /db_xref="HGNC:HGNC:10699"
                     /db_xref="MIM:607558"
     exon            1..153
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1311
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     supernatant protein factor; SEC14-like protein 2; squalene
                     transfer protein; alpha-tocopherol-associated protein;
                     tocopherol-associated protein 1"
                     /codon_start=1
                     /product="SEC14-like protein 2 isoform 1"
                     /protein_id="NP_036561.1"
                     /db_xref="CCDS:CCDS13876.1"
                     /db_xref="GeneID:23541"
                     /db_xref="HGNC:HGNC:10699"
                     /db_xref="MIM:607558"
                     /translation="MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRA
                     RSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDI
                     IGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGL
                     KHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIM
                     VLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQ
                     QYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMT
                     EVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEE
                     KMKQLGAGTPK"
     exon            154..229
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..273
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..333
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..522
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..618
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..679
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..763
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..870
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1010
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1180
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..4207
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2744
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="major polyA site"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3509
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
     regulatory      4174..4179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="hexamer: AATAAA"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
                     /note="hexamer: AATAAA"
     polyA_site      4194
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
     polyA_site      4207
                     /gene="SEC14L2"
                     /gene_synonym="C22orf6; SPF; TAP; TAP1"
ORIGIN      
        1 gactttactc cgggtggcgg cgaggacgag tctgtgctcc atcagctgcc gcacccgccg
       61 cctcccgccc ccaaacccca tccccgcggt tgagccacga tgagcggcag agtcggcgat
      121 ctgagcccca ggcagaagga ggcattggcc aagtttcggg agaatgtcca ggatgtgctg
      181 ccggccctgc cgaatccaga tgactatttt ctcctgcgtt ggctccgagc cagaagcttc
      241 gacctgcaga agtcggaggc catgctccgg aagcatgtgg agttccgaaa gcaaaaggac
      301 attgacaaca tcattagctg gcagcctcca gaggtgatcc aacagtatct gtcagggggt
      361 atgtgtggct atgacctgga tggctgccca gtctggtacg acataattgg acctctggat
      421 gccaagggtc tgctgttctc agcctccaaa caggacctgc tgaggaccaa gatgcgggag
      481 tgtgagctgc ttctgcaaga gtgtgcccac cagaccacaa agttggggag gaaggtggag
      541 accatcacca taatttatga ctgcgagggg cttggcctca agcatctctg gaagcctgct
      601 gtggaggcct atggagagtt tctctgcatg tttgaggaaa attatcccga aacactgaag
      661 cgtctttttg ttgttaaagc ccccaaactg tttcctgtgg cctataacct catcaaaccc
      721 ttcctgagtg aggacactcg taagaagatc atggtcctgg gagcaaattg gaaggaggtt
      781 ttactgaaac atatcagccc tgaccaggtg cctgtggagt atgggggcac catgactgac
      841 cctgatggaa accccaagtg caaatccaag atcaactacg ggggtgacat ccccaggaag
      901 tattatgtgc gagaccaggt gaaacagcag tatgaacaca gcgtgcagat ttcccgtggc
      961 tcctcccacc aagtggagta tgagatcctc ttccctggct gtgtcctcag gtggcagttt
     1021 atgtcagatg gagcggatgt tggttttggg attttcctga agaccaagat gggagagagg
     1081 cagcgggcag gggagatgac agaggtgctg cccaaccaga ggtacaactc ccacctggtc
     1141 cctgaagatg ggaccctcac ctgcagtgat cctggcatct atgtcctgcg gtttgacaac
     1201 acctacagct tcattcatgc caagaaggtc aatttcactg tggaggtcct gcttccagac
     1261 aaagcctcag aagagaagat gaaacagctg ggggcaggca ccccgaaata acaccttctc
     1321 ctatagcagg cctggccccc tcagtgtctc cctgtcaatt tctacccctt gtagcagtca
     1381 ttttcgcaca accctgaagc ccaaagaaac tgggctggag gacagacctc aggagctttc
     1441 atttcagtta ggcagaggaa gagcgactgc agtgggtctc cgtgtctatc aaatacctaa
     1501 ggagtcccca ggagctggct ggccatcgtg ataggatctg tctgtcctgt aaactgtgcc
     1561 aacttcacct gtccagggac agcgaagctg ggggtggcgg ggggcatgta ccacagggtg
     1621 gcagcaggga aaaaaattag aaaagggtga aagattggga cttaacactt cagggaagtc
     1681 agctgccggg gagaaacttg ctcctaaatg aacacataag tttagatcgc aatgaggagt
     1741 agcagggtag ctggttgcta gagttacggt ggggatcaga aactcttcca aacattttag
     1801 cactgaggct ggggtagctt ttggcttttc ccaggtctca ggaggtggcc tgagtcagca
     1861 cacatcttcc cactcggtag acaggctggc ctctccctca ctttgagact ttggcaactc
     1921 ctgggccaca cggcctgcct ctttgattac taatgattgt cagtgactca gagcttcctg
     1981 ggacttcggg tacccacccg ctgttctcca tgcaaacaaa gcgccaggga aatgacccac
     2041 agggatcgca gctgcaggga gggccaggga ggttgggggt gggagtgaat gctaaaagca
     2101 gatcgtccag tgcccttttc agtgctaccg gcctctcacc aagcagtcct ccatgtgagc
     2161 aaccccgaga caaaaatgct aagtgggatc aagagagcag cactcggaga gggtgtttgc
     2221 cagtctgagt gtcccgcggt gcccgccaac ccgcttcctg actgacctga gcaaggtctt
     2281 actaagcagt cccatctctg tgggaggcat gcaacgcgtg cagggagttc aggtgccggt
     2341 cggcgtagcc aggcctggag gccccccagg caggaggccg cccaaaggcg gggccggcgt
     2401 ctcgcagact aggggctggg ggcggccaca gacggcctcg aaaccacagc ccttacccca
     2461 atcccacgag ccccgccaac gaaccacagg tgctgggctt tagagaacat gggaaggcgg
     2521 ccccagacct ggcgggaacg cctttccctc agagccaggc cccggccccg tctgggaagc
     2581 tcatcttgcg aagctgaggg agctcagggc aaaggccagg ctagcgcgga ccggaagggg
     2641 ccgaggctgc acgggcctct gccagaacgc tcaggacatc ccggcctggg tttacaacgc
     2701 tgttaggaaa attaaccaat gaataaagca acgttcagtg cgcagggagt gaaattcaat
     2761 gcccaccgct aggctcctcg ctgcctctca ctcaagaggc ccaaactcag acggcgtcag
     2821 ggacccggac ccagcagccg tttcacgcca atagataggg cgcatgcgca gaaatcctcc
     2881 tcggctctct agcgtgagct ttcccaaggg gccacgccca gcttgccttc tgattggtcc
     2941 agctggtggg ttgtcttccg ccatctttga tcagggcact aaggatgctc cccacggcct
     3001 tcacagtgac ggcggagacc ctgccccgcc agctgctcag tacgtgccgc gtagcccgtg
     3061 cgagccaagt gtgagtccgg gcgagcgcct gcggagctag cactgggccc agaatgagag
     3121 ggaggcggag gagcagcgat cacgtggttt tagggactgt ctaataattc cacgccagca
     3181 ttgccggtgt ttcagggggt gggaaccgct gcgttcccca tcaacttttc tcccacccac
     3241 caccctcccc aacctacaag cccagctcag cttgaggtaa ctgctgaccg gactgtccta
     3301 tacagcccta caagacagag gcgcctaggg ctgaaagcgg gggcctccgt agggagccag
     3361 cgggggcctc aatagttact cattttctct acctttgatg aaaataagag ctaattctta
     3421 ataaggccta ccgggtatca cgcaaaaacc ctgtgcttac tattacactt tgggttgttg
     3481 caaagattaa aggaaataag ccgtgcaaag cgcttaagag cttggtataa gtaagtgctc
     3541 gtcaatgttg gctactctca ttttttttgc agacgtggga actggggctc agggaggcta
     3601 acagccagta ggcggcacag ctaggatttg aacccaggat tgtctccaac gccgctcaat
     3661 tatacccgcc aaggagtcac agagacttag tgaagtgcac acattgctca cctgggtgaa
     3721 ctgaggtcca gcgggggaag gcttcctcct gttgtaatca ctaaccccaa ctctgtctcc
     3781 cttgcccgat tcattcattc gttaattaat tcatccaaca tcctgtcccc aagaagctca
     3841 gtctggggac atactgatcc agttaaatgc gagtgcttcc tagttataca tggcgactgc
     3901 tgagaaggga ctccagagtc caggcaccta cctcccaggg gctcaccgtt cactcctcta
     3961 gcctcattta gagctcgcat taagagcacg ggatctggat ccacactgtt tggattcaaa
     4021 tcacaacttc accacttagc agctgtgtgt tctgggaaaa tgacccacct tctctgtgcc
     4081 tccattttct cacctgtaaa acgggctccc aggctggtgg gagggtttca ggtgtaagac
     4141 atggagagtc ctttagcgaa catgtagact ggcaataaac tcaataaatg gtgactgtta
     4201 taattaa
//
