LOCUS       NM_183352               1359 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SEC13 homolog, nuclear pore and COPII coat complex
            component (SEC13), transcript variant 1, mRNA.
ACCESSION   NM_183352
VERSION     NM_183352.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Jiang,C., Dai,X., He,S., Zhou,H., Fang,L., Guo,J., Liu,S.,
            Zhang,T., Pan,W., Yu,H., Fu,T., Li,D., Inuzuka,H., Wang,P., Xiao,J.
            and Wei,W.
  TITLE     Ring domains are essential for GATOR2-dependent mTORC1 activation
  JOURNAL   Mol Cell 83 (1), 74-89 (2023)
   PUBMED   36528027
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Valenstein,M.L., Rogala,K.B., Lalgudi,P.V., Brignole,E.J., Gu,X.,
            Saxton,R.A., Chantranupong,L., Kolibius,J., Quast,J.P. and
            Sabatini,D.M.
  TITLE     Structure of the nutrient-sensing hub GATOR2
  JOURNAL   Nature 607 (7919), 610-616 (2022)
   PUBMED   35831510
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
  TITLE     Mammalian homologues of yeast sec31p. An ubiquitously expressed
            form is localized to endoplasmic reticulum (ER) exit sites and is
            essential for ER-Golgi transport
  JOURNAL   J Biol Chem 275 (18), 13597-13604 (2000)
   PUBMED   10788476
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Mammoto,A., Sasaki,T., Kim,Y. and Takai,Y.
  TITLE     Physical and functional interaction of rabphilin-11 with mammalian
            Sec13 protein. Implication in vesicle trafficking
  JOURNAL   J Biol Chem 275 (18), 13167-13170 (2000)
   PUBMED   10747849
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Shaywitz,D.A., Orci,L., Ravazzola,M., Swaroop,A. and Kaiser,C.A.
  TITLE     Human SEC13Rp functions in yeast and is located on transport
            vesicles budding from the endoplasmic reticulum
  JOURNAL   J Cell Biol 128 (5), 769-777 (1995)
   PUBMED   7876304
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Swaroop,A., Yang-Feng,T.L., Liu,W., Gieser,L., Barrow,L.L.,
            Chen,K.C., Agarwal,N., Meisler,M.H. and Smith,D.I.
  TITLE     Molecular characterization of a novel human gene, SEC13R, related
            to the yeast secretory pathway gene SEC13, and mapping to a
            conserved linkage group on human chromosome 3p24-p25 and mouse
            chromosome 6
  JOURNAL   Hum Mol Genet 3 (8), 1281-1286 (1994)
   PUBMED   7987303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN344033.1 and BC091506.1.
            
            On Nov 22, 2018 this sequence version replaced NM_183352.2.
            
            Summary: The protein encoded by this gene belongs to the SEC13
            family of WD-repeat proteins. It is a constituent of the
            endoplasmic reticulum and the nuclear pore complex. It has
            similarity to the yeast SEC13 protein, which is required for
            vesicle biogenesis from endoplasmic reticulum during the transport
            of proteins. Multiple alternatively spliced transcript variants
            have been found. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an exon in the 5' coding region, compared to variant 3. It
            encodes isoform 1 which has a shorter and distinct N-terminus,
            compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091506.1, L09260.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350697.8/ ENSP00000312122.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CN344033.1         89-102
            15-1359             BC091506.1         1-1345
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..1359
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /note="SEC13 homolog, nuclear pore and COPII coat complex
                     component"
                     /db_xref="GeneID:6396"
                     /db_xref="HGNC:HGNC:10697"
                     /db_xref="MIM:600152"
     exon            1..63
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1029
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SEC13-related protein; SEC13 homolog, nuclear pore and
                     COPII coating complex component; protein SEC13 homolog;
                     SEC13-like protein 1; GATOR complex protein SEC13; GATOR2
                     complex protein SEC13"
                     /codon_start=1
                     /product="protein SEC13 homolog isoform 1"
                     /protein_id="NP_899195.1"
                     /db_xref="CCDS:CCDS2599.1"
                     /db_xref="GeneID:6396"
                     /db_xref="HGNC:HGNC:10697"
                     /db_xref="MIM:600152"
                     /translation="MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRN
                     GGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGH
                     DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP
                     AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDV
                     AWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANI
                     LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQQNEQ"
     exon            64..108
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            109..224
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            225..376
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            377..510
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            511..644
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            645..768
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            769..915
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1359
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1338..1343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /note="hexamer: AATAAA"
     polyA_site      1359
                     /gene="SEC13"
                     /gene_synonym="D3S1231E; npp-20; SEC13L1; SEC13R"
                     /note="major polyA site"
ORIGIN      
        1 gttccgaggc gccgccggga gctgccacgt ccgagacctg gagcagccac cgccgcaatc
       61 atggtgtcag taattaacac tgtggatacc tcccatgagg acatgattca cgacgcccag
      121 atggactact atggcacccg cctggcaacc tgctcatcag acaggtccgt caaaatcttt
      181 gatgtgcgca atggagggca gatccttatc gccgacctca ggggtcatga gggtcctgtg
      241 tggcaagtgg cctgggctca ccccatgtac ggcaacatcc tggcatcgtg ctcctatgac
      301 cggaaagtca ttatctggag agaggaaaac ggcacctggg agaagagcca cgagcatgcg
      361 ggacacgact cctcagtgaa ctcggtgtgc tgggcccccc atgactacgg cctgatcctg
      421 gcctgtggga gctcggatgg ggccatctcc ctgctgactt acaccgggga aggccaatgg
      481 gaagtaaaga agatcaacaa cgctcacacc attggctgca atgccgtcag ctgggcccct
      541 gctgttgtac ctggaagcct catagaccac ccatcggggc agaaacccaa ttacatcaag
      601 aggtttgcat caggtggctg tgacaacctc atcaagctgt ggaaggagga ggaggacggc
      661 cagtggaagg aggagcagaa gctagaagcg cacagtgact gggttcgaga tgtggcctgg
      721 gccccctcca tcggcctgcc caccagcacc atcgccagct gctcccagga tggtcgtgtg
      781 ttcatttgga cctgtgatga tgcctcaagc aatacgtggt cccctaaatt gttgcacaag
      841 ttcaacgatg tggtgtggca tgtgagctgg tccatcacag ccaacatcct ggctgtctct
      901 ggtggagaca ataaggtgac cctgtggaag gagtcagttg atgggcagtg ggtgtgcatc
      961 agtgatgtca acaagggcca gggctccgta tcagcatcag tgacagaggg ccagcagaac
     1021 gagcagtgac aagacaggtg gggcctggct ccccacccgc cagctccagg actgcccctt
     1081 cctgggccaa ctaaccagac aactgggaag agcccccaac tccaacagga ttattttccc
     1141 aggaggagtt acagatgcag ccacagattg atcatctgcc ttaacgtgat cggagatgct
     1201 ttgtaatcta ctgtccagct gaaagcactc atgttacgag gaagaaacta caagtgatgt
     1261 tcaaatctat tttgggtcat ttttatgtac ctttgggttc aggcattatt tggggggttt
     1321 tgtttccaaa ggaactaaat aaagtcatat tgcttataa
//
