LOCUS       NM_033280                791 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SEC11 homolog C, signal peptidase complex subunit
            (SEC11C), transcript variant 1, mRNA.
ACCESSION   NM_033280
VERSION     NM_033280.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 791)
  AUTHORS   Zhang,N., Cao,S., Sun,R., Wang,Y., Liu,L., Wang,W. and Meng,X.
  TITLE     Signal peptidase 21 suppresses cell proliferation, migration, and
            invasion via the PTEN-PI3K/Akt signaling pathway in lung
            adenocarcinoma
  JOURNAL   PeerJ 10, e14206 (2022)
   PUBMED   36275477
  REMARK    GeneRIF: Signal peptidase 21 suppresses cell proliferation,
            migration, and invasion via the PTEN-PI3K/Akt signaling pathway in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 791)
  AUTHORS   Liaci,A.M., Steigenberger,B., Telles de Souza,P.C., Tamara,S.,
            Grollers-Mulderij,M., Ogrissek,P., Marrink,S.J., Scheltema,R.A. and
            Forster,F.
  TITLE     Structure of the human signal peptidase complex reveals the
            determinants for signal peptide cleavage
  JOURNAL   Mol Cell 81 (19), 3934-3948 (2021)
   PUBMED   34388369
  REMARK    GeneRIF: Structure of the human signal peptidase complex reveals
            the determinants for signal peptide cleavage.
REFERENCE   3  (bases 1 to 791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 791)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 791)
  AUTHORS   Oue,N., Naito,Y., Hayashi,T., Takigahira,M., Kawano-Nagatsuma,A.,
            Sentani,K., Sakamoto,N., Zarni Oo,H., Uraoka,N., Yanagihara,K.,
            Ochiai,A., Sasaki,H. and Yasui,W.
  TITLE     Signal peptidase complex 18, encoded by SEC11A, contributes to
            progression via TGF-alpha secretion in gastric cancer
  JOURNAL   Oncogene 33 (30), 3918-3926 (2014)
   PUBMED   23995782
  REMARK    Erratum:[Oncogene. 2019 Jul;38(28):5748. doi:
            10.1038/s41388-019-0837-z.. PMID: 31175341]
REFERENCE   7  (bases 1 to 791)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 791)
  AUTHORS   Dodson,G. and Steiner,D.
  TITLE     The role of assembly in insulin's biosynthesis
  JOURNAL   Curr Opin Struct Biol 8 (2), 189-194 (1998)
   PUBMED   9631292
  REMARK    Review article
REFERENCE   9  (bases 1 to 791)
  AUTHORS   Shelness,G.S. and Blobel,G.
  TITLE     Two subunits of the canine signal peptidase complex are homologous
            to yeast SEC11 protein
  JOURNAL   J Biol Chem 265 (16), 9512-9519 (1990)
   PUBMED   2188978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM789622.1 and AF212233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033280.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279839.6784.1,
                                           SRR3476690.136078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587834.6/ ENSP00000468633.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BM789622.1         28-36
            10-791              AF212233.1         2-783
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..791
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /note="SEC11 homolog C, signal peptidase complex subunit"
                     /db_xref="GeneID:90701"
                     /db_xref="HGNC:HGNC:23400"
     exon            1..152
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..644
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /EC_number="3.4.21.89"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal peptidase complex catalytic subunit SEC11C;
                     SEC11-like protein 3; SPase 21 kDa subunit; microsomal
                     signal peptidase 21 kDa subunit; SEC11-like 3; signal
                     peptidase complex 21"
                     /codon_start=1
                     /product="signal peptidase complex catalytic subunit
                     SEC11C isoform 1"
                     /protein_id="NP_150596.1"
                     /db_xref="CCDS:CCDS11970.1"
                     /db_xref="GeneID:90701"
                     /db_xref="HGNC:HGNC:23400"
                     /translation="MVRAGAVGAHLPASGLDIFGDLKKMNKRQLYYQVLNFAMIVSSA
                     LMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGR
                     DIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPY
                     VGMVTIIMNDYPKFKYALLAVMGAYVLLKRES"
     exon            153..262
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     exon            263..412
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     exon            413..532
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     exon            533..590
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     exon            591..791
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      771..776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /note="hexamer: AATAAA"
     polyA_site      791
                     /gene="SEC11C"
                     /gene_synonym="SEC11L3; SPC21; SPCS4C"
                     /note="major polyA site"
ORIGIN      
        1 aggtgctccg cagccgtctg tgccacccag agccggcggg ccgctaggtc cccggagacc
       61 ctgctatggt gcgtgcgggc gccgtggggg ctcatctccc cgcgtccggc ttggatatct
      121 tcggggacct gaagaagatg aacaagcgcc agctctatta ccaggtttta aacttcgcca
      181 tgatcgtgtc ttctgcactc atgatatgga aaggcttgat cgtgctcaca ggcagtgaga
      241 gccccatcgt ggtggtgctg agtggcagta tggagccggc ctttcacaga ggagacctcc
      301 tgttcctcac aaatttccgg gaagacccaa tcagagctgg tgaaatagtt gtttttaaag
      361 ttgaaggacg agacattcca atagttcaca gagtaatcaa agttcatgaa aaagataatg
      421 gagacatcaa atttctgact aaaggagata ataatgaagt tgatgataga ggcttgtaca
      481 aagaaggcca gaactggctg gaaaagaagg acgtggtggg aagagcaaga gggtttttac
      541 catatgttgg tatggtcacc ataataatga atgactatcc aaaattcaag tatgctcttt
      601 tggctgtaat gggtgcatat gtgttactaa aacgtgaatc ctaaaatgag aagcagttcc
      661 tgggaccaga ttgaaatgaa ttctgttgaa aaagagaaaa actaatatat ttgagatgtt
      721 ccattttctg tataaaaggg aacagtgtgg agatgttttt gtcttgtcca aataaaagat
      781 tcaccagtaa a
//
