LOCUS       NM_014300               1079 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SEC11 homolog A, signal peptidase complex subunit
            (SEC11A), transcript variant 2, mRNA.
ACCESSION   NM_014300
VERSION     NM_014300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1079)
  AUTHORS   Zhou,Z., Hu,Q., Guo,H. and Wang,X.
  TITLE     CircSEC11A knockdown alleviates oxidative stress and apoptosis and
            promotes cell proliferation and angiogenesis by regulating
            miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular
            endothelial cells (HBMECs)
  JOURNAL   Clin Hemorheol Microcirc 84 (3), 247-262 (2023)
   PUBMED   36872771
  REMARK    GeneRIF: CircSEC11A knockdown alleviates oxidative stress and
            apoptosis and promotes cell proliferation and angiogenesis by
            regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain
            microvascular endothelial cells (HBMECs).
REFERENCE   2  (bases 1 to 1079)
  AUTHORS   Suematsu,H., Sakamaki,K., Oue,N., Hiroshima,Y., Kimura,Y.,
            Onuma,S., Hashimoto,I., Nagasawa,S., Aoyama,T., Yamada,T.,
            Tamagawa,H., Ogata,T., Rino,Y., Masuda,M., Yasui,W., Miyagi,Y. and
            Oshima,T.
  TITLE     Clinical Significance of SEC11A Expression in Patients With Locally
            Advanced Gastric Cancer
  JOURNAL   Anticancer Res 42 (12), 5885-5890 (2022)
   PUBMED   36456166
  REMARK    GeneRIF: Clinical Significance of SEC11A Expression in Patients
            With Locally Advanced Gastric Cancer.
REFERENCE   3  (bases 1 to 1079)
  AUTHORS   Yao,Y., Liu,X.Q., Yang,F.Y. and Mu,J.W.
  TITLE     MiR-873-5p modulates progression of tongue squamous cell carcinoma
            via targeting SEC11A
  JOURNAL   Oral Dis 28 (6), 1509-1518 (2022)
   PUBMED   33675129
  REMARK    GeneRIF: MiR-873-5p modulates progression of tongue squamous cell
            carcinoma via targeting SEC11A.
REFERENCE   4  (bases 1 to 1079)
  AUTHORS   Liaci,A.M., Steigenberger,B., Telles de Souza,P.C., Tamara,S.,
            Grollers-Mulderij,M., Ogrissek,P., Marrink,S.J., Scheltema,R.A. and
            Forster,F.
  TITLE     Structure of the human signal peptidase complex reveals the
            determinants for signal peptide cleavage
  JOURNAL   Mol Cell 81 (19), 3934-3948 (2021)
   PUBMED   34388369
  REMARK    GeneRIF: Structure of the human signal peptidase complex reveals
            the determinants for signal peptide cleavage.
REFERENCE   5  (bases 1 to 1079)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1079)
  AUTHORS   Oue,N., Naito,Y., Hayashi,T., Takigahira,M., Kawano-Nagatsuma,A.,
            Sentani,K., Sakamoto,N., Zarni Oo,H., Uraoka,N., Yanagihara,K.,
            Ochiai,A., Sasaki,H. and Yasui,W.
  TITLE     Signal peptidase complex 18, encoded by SEC11A, contributes to
            progression via TGF-alpha secretion in gastric cancer
  JOURNAL   Oncogene 33 (30), 3918-3926 (2014)
   PUBMED   23995782
  REMARK    GeneRIF: SPC18 contributes to malignant progression through
            promotion of TGF-alpha secretion in gastric cancer.
            Erratum:[Oncogene. 2019 Jul;38(28):5748. doi:
            10.1038/s41388-019-0837-z.. PMID: 31175341]
REFERENCE   7  (bases 1 to 1079)
  AUTHORS   Guffanti,A., Iacono,M., Pelucchi,P., Kim,N., Solda,G., Croft,L.J.,
            Taft,R.J., Rizzi,E., Askarian-Amiri,M., Bonnal,R.J., Callari,M.,
            Mignone,F., Pesole,G., Bertalot,G., Bernardi,L.R., Albertini,A.,
            Lee,C., Mattick,J.S., Zucchi,I. and De Bellis,G.
  TITLE     A transcriptional sketch of a primary human breast cancer by 454
            deep sequencing
  JOURNAL   BMC Genomics 10, 163 (2009)
   PUBMED   19379481
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1079)
  AUTHORS   Yasui,W., Oue,N., Sentani,K., Sakamoto,N. and Motoshita,J.
  TITLE     Transcriptome dissection of gastric cancer: identification of novel
            diagnostic and therapeutic targets from pathology specimens
  JOURNAL   Pathol Int 59 (3), 121-136 (2009)
   PUBMED   19261089
  REMARK    Review article
REFERENCE   9  (bases 1 to 1079)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1079)
  AUTHORS   Shelness,G.S. and Blobel,G.
  TITLE     Two subunits of the canine signal peptidase complex are homologous
            to yeast SEC11 protein
  JOURNAL   J Biol Chem 265 (16), 9512-9519 (1990)
   PUBMED   2188978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC360846.1 and BC014508.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014300.3.
            
            Summary: This gene encodes a member of the peptidase S26B family.
            The encoded protein is an 18kDa subunit of the signal peptidase
            complex and has been linked to cell migration and invasion, gastric
            cancer and lymph node metastasis. Alternative splicing results in
            multiple transcript variants. A related pseudogene has been
            identified on chromosome 8. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            exon in the central coding region, compared to variant 1. It
            encodes a longer protein (isoform 2) compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014508.1, SRR5189664.106682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268220.12/ ENSP00000268220.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               DC360846.1         323-593
            272-1079            BC014508.1         576-1383
FEATURES             Location/Qualifiers
     source          1..1079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2-q25.3"
     gene            1..1079
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /note="SEC11 homolog A, signal peptidase complex subunit"
                     /db_xref="GeneID:23478"
                     /db_xref="HGNC:HGNC:17718"
                     /db_xref="MIM:618258"
     exon            1..115
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..604
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /EC_number="3.4.21.89"
                     /note="isoform 2 is encoded by transcript variant 2;
                     signal peptidase complex (18kD); signal peptidase complex
                     catalytic subunit SEC11A; endopeptidase SP18; SEC11-like
                     protein 1; SPase 18 kDa subunit; microsomal signal
                     peptidase 18 kDa subunit; signal peptidase complex 18"
                     /codon_start=1
                     /product="signal peptidase complex catalytic subunit
                     SEC11A isoform 2"
                     /protein_id="NP_055115.1"
                     /db_xref="CCDS:CCDS45340.1"
                     /db_xref="GeneID:23478"
                     /db_xref="HGNC:HGNC:17718"
                     /db_xref="MIM:618258"
                     /translation="MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITG
                     SESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIH
                     EKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYP
                     KFKYAVLFLLGLFVLVHRE"
     exon            116..225
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            226..375
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            376..495
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            496..553
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            554..1079
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      876..881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /note="hexamer: ATTAAA"
     polyA_site      894
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /note="major polyA site"
     regulatory      1057..1062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /note="hexamer: AATAAA"
     polyA_site      1079
                     /gene="SEC11A"
                     /gene_synonym="1810012E07Rik; SEC11L1; sid2895; SPC18;
                     SPCS4A"
                     /note="major polyA site"
ORIGIN      
        1 agtagttccg cccgctggtc atcgcgccct ttcccctgcc ggtgtcctgc tcgccgtccc
       61 cgccatgctg tctctagact ttttggacga tgtgcggcgg atgaacaagc ggcagctcta
      121 ttatcaagtc ctaaattttg gaatgattgt ctcatcggca ctaatgatct ggaaggggtt
      181 aatggtaata actggaagtg aaagtccgat tgtagtggtg ctcagtggca gcatggaacc
      241 tgcatttcat agaggagatc ttctctttct aacaaatcga gttgaagatc ccatacgagt
      301 gggagaaatt gttgttttta ggatagaagg aagagagatt cctatagttc accgagtctt
      361 gaagattcat gaaaagcaaa atgggcatat caagtttttg accaaaggag ataataatgc
      421 ggttgatgac cgaggcctct ataaacaagg acaacattgg ctagagaaaa aagatgttgt
      481 ggggagagcc aggggatttg ttccttatat tggaattgtg acgatcctca tgaatgacta
      541 tcctaaattt aagtatgcag ttctcttttt gctgggttta ttcgtgctgg ttcatcgtga
      601 gtaagaagcc tgccttgctg ttcctgggaa gatgccatag ttttcgttac tggatgtttg
      661 gagtagatac tggtctgtga ttggtggaat ggagaacaca cgtgttggtg cttctgggta
      721 gcactggttt gcattagttt atgtttccat gccagagttt gtgtgggcgg gcgcatgtgc
      781 accacagagt gcactcgagg ggactttcag tcacaggatt tcataattgt cattgtcaca
      841 ctttcaaatt tttgtacatc agtgaatttt tttatattaa aaggttgagc caaagccccc
      901 agtgtttgta ttttgaagcc aagcttcact tctaaagtgc ctacagagac ttgtaaatga
      961 aaatgcagct ctgcacgagt ttgaaaccgt catacctcct tctattagga atggcatata
     1021 ctgaggtggt cgtaagtctt aacttctaaa attttaaata aaagactttg cacattgaa
//
