LOCUS       NM_001080837            1383 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens SEBOX homeobox (SEBOX), mRNA.
ACCESSION   NM_001080837 XM_940459 XR_017040
VERSION     NM_001080837.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Kwan,J.S., Hsu,Y.H., Cheung,C.L., Dupuis,J., Saint-Pierre,A.,
            Eriksson,J., Handelman,S.K., Aragaki,A., Karasik,D.,
            Pramstaller,P.P., Kooperberg,C., Lacroix,A.Z., Larson,M.G.,
            Lau,K.S., Lorentzon,M., Pichler,I., Sham,P.C., Taliun,D.,
            Vandenput,L., Kiel,D.P., Hicks,A.A., Jackson,R.D., Ohlsson,C.,
            Benjamin,E.J. and Kung,A.W.
  TITLE     Meta-analysis of genome-wide association studies identifies two
            loci associated with circulating osteoprotegerin levels
  JOURNAL   Hum Mol Genet 23 (24), 6684-6693 (2014)
   PUBMED   25080503
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Cinquanta,M., Rovescalli,A.C., Kozak,C.A. and Nirenberg,M.
  TITLE     Mouse Sebox homeobox gene expression in skin, brain, oocytes, and
            two-cell embryos
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8904-8909 (2000)
   PUBMED   10922053
  REMARK    GeneRIF: This publication reported the human SEBOX gene sequence
            and predicted amino acid sequence, in addition to mouse and rat
            Sebox gene sequences.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF573650.1 and AC002094.1.
            
            On Apr 13, 2021 this sequence version replaced NM_001080837.3.
            
            Summary: Homeodomain proteins, such as SEBOX, play a key role in
            coordinating gene expression during development (Cinquanta et al.,
            2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA2148874, SAMEA2162895
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000536498.6/ ENSP00000444503.3
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                KF573650.1         53-131              c
            80-240              AC002094.1         36116-36276
            241-1383            AC002094.1         36423-37565
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1383
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /note="SEBOX homeobox"
                     /db_xref="GeneID:645832"
                     /db_xref="HGNC:HGNC:32942"
                     /db_xref="MIM:610975"
     exon            1..79
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..621
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /note="homeobox OG-9; skin-, embryo-, brain- and
                     oocyte-specific homeobox"
                     /codon_start=1
                     /product="homeobox protein SEBOX"
                     /protein_id="NP_001074306.3"
                     /db_xref="CCDS:CCDS45634.2"
                     /db_xref="GeneID:645832"
                     /db_xref="HGNC:HGNC:32942"
                     /db_xref="MIM:610975"
                     /translation="MPSPVDASSADGGSGLGSHRRKRTTFSKGQLLELERAFAAWPYP
                     NISTHEHLAWVTCLPEAKVQVWFQKRWAKIIKNRKSGILSPGSECPQSSCSLPDTLQQ
                     PWDPQMPGQPPPSSGTPQRTSVCRHSSCPAPGLSPRQGWEGAKAVAPWGSAGASEVHP
                     SLERATPQTSLGSLSDLIYALAIVVNVDHS"
     exon            80..240
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /inference="alignment:Splign:2.1.0"
     exon            241..1383
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /note="hexamer: AATAAA"
     polyA_site      1383
                     /gene="SEBOX"
                     /gene_synonym="OG-9; OG9; OG9X"
                     /note="major polyA site"
ORIGIN      
        1 catggccctc tggcacggcc ctctggcacc ttaccctttg ccagctccat gcccagccct
       61 gtggatgcat cctcagcaga cggtggcagc gggttgggtt cccaccggag aaagcggacc
      121 accttcagca aagggcagct actggagctg gagagggcgt ttgcagcatg gccctacccc
      181 aacatcagca cccatgagca cctggcctgg gtcacttgcc ttcctgaggc caaggtacag
      241 gtgtggttcc agaagcgctg ggccaaaata atcaagaaca ggaagtcagg aattctaagc
      301 cctgggtctg agtgccccca gagctcctgt tctcttccag acaccctcca gcagccctgg
      361 gatccccaaa tgccaggcca acctccaccc tccagcggca cacctcagcg cacctcagtg
      421 tgtcgacata gctcctgtcc agctcctggc ttgagtccac ggcagggctg ggaaggggct
      481 aaagctgtag ccccatgggg atcagctggg gcttcagagg tccacccttc tttagagcga
      541 gctactcccc agacttcact aggcagcctg tctgacctca tctatgcctt ggccattgtc
      601 gtcaatgtgg accactccta gtctttgtcc agaacttgca aggcccctcc tctgactcct
      661 gtggcccacc ctgcccctcc tgggattgaa cacatcagaa gtggattccc tggccccact
      721 ttttatgcaa agggattccc tacgggaaag gagtttagct caggcatccc tcccttccac
      781 tggcctccag gccagcctag atgcaggtcc taagcagact ggggcctggc tcctgccacc
      841 ccacaccctg acccctttgg ggcatatgct cattgttgtg gcaggtggta ccttcagaag
      901 gatgagatga gggtcatgtt ttcctccact cttgccaggc ctggtcccca gttctcacca
      961 gctgatggcc tcctccttct gaaggggcag gctcctgtct cctgaggtct ctccaggcca
     1021 ttaccttgct aactgctaag tgaggtagga gaggagagtg ctgctcctca tctagactgc
     1081 tggagagcca acttctttat gggtcagggc cccctctctt gaccatcgac cacctggaca
     1141 aattaatcag aactacggat gtgaagaggg agtggcatta aagtaatgaa gcaaagatag
     1201 gaagctgggg cttatgttga tttaattttc acaaagatca gattggatgc cctctgatgt
     1261 ggggctgtgg agacaacctg acagatctgg gatggaggca ggtatagcag cattgggttt
     1321 tggtatcacc atcacctgta ataccaacta atctccaaat aaaacccaaa ctctgtacct
     1381 taa
//
