LOCUS       NM_001304993            1306 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens serine dehydratase like (SDSL), transcript variant 2,
            mRNA.
ACCESSION   NM_001304993 XM_005253830
VERSION     NM_001304993.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1306)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1306)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1306)
  AUTHORS   Yamada,T., Komoto,J., Kasuya,T., Takata,Y., Ogawa,H., Mori,H. and
            Takusagawa,F.
  TITLE     A catalytic mechanism that explains a low catalytic activity of
            serine dehydratase like-1 from human cancer cells: crystal
            structure and site-directed mutagenesis studies
  JOURNAL   Biochim Biophys Acta 1780 (5), 809-818 (2008)
   PUBMED   18342636
  REMARK    GeneRIF: The crystal structure of SDSL has been determined.
            Site-directed mutagenesis studies suggest that having a glycine at
            residue 72 of SDSL is the major reason for the reduction of its
            catalytic activity, in comparison with the liver enzyme (SDS).
REFERENCE   5  (bases 1 to 1306)
  AUTHORS   Ogawa,H., Gomi,T., Nishizawa,M., Hayakawa,Y., Endo,S., Hayashi,K.,
            Ochiai,H., Takusagawa,F., Pitot,H.C., Mori,H., Sakurai,H.,
            Koizumi,K., Saiki,I., Oda,H., Fujishita,T., Miwa,T., Maruyama,M.
            and Kobayashi,M.
  TITLE     Enzymatic and biochemical properties of a novel human serine
            dehydratase isoform
  JOURNAL   Biochim Biophys Acta 1764 (5), 961-971 (2006)
   PUBMED   16580895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010178.40 and BC091479.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001304993.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091479.1, SRR5189655.222857.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403593.9/ ENSP00000385790.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC010178.40        6427-6459           c
            34-1306             BC091479.1         1-1273
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1306
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /note="serine dehydratase like"
                     /db_xref="GeneID:113675"
                     /db_xref="HGNC:HGNC:30404"
                     /db_xref="MIM:620735"
     exon            1..98
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            99..293
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1109
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /EC_number="5.1.1.3"
                     /note="serine dehydratase related sequence 1; L-serine
                     deaminase; serine dehydratase 2; L-threonine dehydratase;
                     L-serine dehydratase/L-threonine deaminase; glutamate
                     racemase; cancerous serine dehydratase"
                     /codon_start=1
                     /product="serine dehydratase-like"
                     /protein_id="NP_001291922.1"
                     /db_xref="CCDS:CCDS9170.1"
                     /db_xref="GeneID:113675"
                     /db_xref="HGNC:HGNC:30404"
                     /db_xref="MIM:620735"
                     /translation="MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPS
                     GSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQV
                     VQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKA
                     VLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVT
                     LPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPAC
                     GAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQALKTHLGQV"
     exon            294..333
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            334..473
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            474..562
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            563..790
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            791..915
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1306
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /note="hexamer: AATAAA"
     polyA_site      1306
                     /gene="SDSL"
                     /gene_synonym="cSDH; SDH 2; SDHL; SDS-RS1; TDH"
                     /note="major polyA site"
ORIGIN      
        1 gaagctggac agagccggtt cctggaaaga gctggttccc tggcaggctg gagggcagga
       61 gctggggcca cgctggtctg ggatagttgg gcagggaggc tgtctacctg gtctccagaa
      121 tggacggccc tgtggcagag catgccaagc aggagccctt tcacgtggtc acacctctgt
      181 tggagagctg ggcgctgtcc caggtggcgg gcatgcctgt cttcctcaag tgtgagaatg
      241 tgcagcccag cggctccttc aagattcggg gcattgggca tttctgccag gagatggcca
      301 agaagggatg cagacacctg gtgtgctcct cagggggtaa tgcgggcatc gctgctgcct
      361 atgctgctag gaagctgggc attcctgcca ccatcgtgct ccccgagagc acctccctgc
      421 aggtggtgca gaggctgcag ggggaggggg ccgaggttca gctgactgga aaggtctggg
      481 acgaggccaa tctgagggcg caagagttgg ccaagaggga cggctgggag aatgtccccc
      541 cgtttgacca ccccctaata tggaaaggcc acgccagcct ggtgcaggag ctgaaagcag
      601 tgctgaggac cccaccaggt gccctggtgc tggcagttgg gggtgggggt ctcctggccg
      661 gggtggtggc tggcctgctg gaggtgggct ggcagcatgt acccatcatt gccatggaga
      721 cccatggggc acactgcttc aatgcggcca tcacagccgg caagctggtc acacttccag
      781 acatcaccag tgtggccaag agcctgggtg ccaagacggt ggccgctcgg gccctggagt
      841 gcatgcaggt gtgcaagatt cactctgaag tggtggagga caccgaggct gtgagcgctg
      901 tgcagcagct cctggatgat gagcgtatgc tggtggagcc tgcctgtggg gcagccttag
      961 cagccatcta ctcaggcctc ctgcggaggc tccaggccga gggctgcctg cccccttccc
     1021 tgacttcagt tgtggtaatc gtgtgtggag gcaacaacat caacagccga gagctgcagg
     1081 ctttgaaaac ccacctgggc caggtctgag gggtcccatc ctggccccaa agacccctga
     1141 gaggcccatg gacagtcctg tgtctggatg aggaggactc agtgctggca gatggcagtg
     1201 gaagctgccc tgtgcaactg tgctggctgc ctcctgaagg aagccctcct ggactgcttc
     1261 ttttggctct ccgacaactc cggccaataa acactttctg aattga
//
