LOCUS       NM_006843               1605 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens serine dehydratase (SDS), mRNA.
ACCESSION   NM_006843
VERSION     NM_006843.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SDS expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Wang,C.Y., Ku,S.C., Lee,C.C. and Wang,A.H.
  TITLE     Modulating the function of human serine racemase and human serine
            dehydratase by protein engineering
  JOURNAL   Protein Eng Des Sel 25 (11), 741-749 (2012)
   PUBMED   23112234
  REMARK    GeneRIF: S84A serine racemase mutant behaved like serine
            dehydratase, whereas A65S serine dehydratase mutant acquired an
            additional function of using D-serine as a substrate.
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Yamada,T., Komoto,J., Kasuya,T., Takata,Y., Ogawa,H., Mori,H. and
            Takusagawa,F.
  TITLE     A catalytic mechanism that explains a low catalytic activity of
            serine dehydratase like-1 from human cancer cells: crystal
            structure and site-directed mutagenesis studies
  JOURNAL   Biochim Biophys Acta 1780 (5), 809-818 (2008)
   PUBMED   18342636
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Szaflik,J.P., Majsterek,I., Kowalski,M., Rusin,P., Sobczuk,A.,
            Borucka,A.I., Szaflik,J. and Blasiak,J.
  TITLE     Association between sorbitol dehydrogenase gene polymorphisms and
            type 2 diabetic retinopathy
  JOURNAL   Exp Eye Res 86 (4), 647-652 (2008)
   PUBMED   18289528
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Ogawa,H., Gomi,T., Konishi,K., Date,T., Nakashima,H., Nose,K.,
            Matsuda,Y., Peraino,C., Pitot,H.C. and Fujioka,M.
  TITLE     Human liver serine dehydratase. cDNA cloning and sequence homology
            with hydroxyamino acid dehydratases from other sources
  JOURNAL   J Biol Chem 264 (27), 15818-15823 (1989)
   PUBMED   2674117
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Akopov,M.A., Kagan,Z.C., Berezov,T.T. and Filiptsev,P.Ia.
  TITLE     [Kinetic and allosteric properties of L-threonine-L-serine
            dehydratase from human liver]
  JOURNAL   Biokhimiia 44 (2), 282-292 (1979)
   PUBMED   435568
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Akopov,M.A., Kagan,Z.S., Berezov,T.T. and Filiptsev,P.Ia.
  TITLE     [Detection and properties of L-threonine-L-serine dehydratase in
            human liver]
  JOURNAL   Biokhimiia 43 (10), 1860-1872 (1978)
   PUBMED   31199
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Kitagawa,T. and Pitot,H.C.
  TITLE     The regulation of serine dehydratase and glucose-6-phosphatase in
            hyperplastic nodules of rat liver during diethylnitrosamine and
            N-2-fluorenylacetamide feeding
  JOURNAL   Cancer Res 35 (4), 1075-1084 (1975)
   PUBMED   163697
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Kitagawa,T. and Pitot,H.C.
  TITLE     Immunohistochemical demonstration of serine dehydratase in rat
            liver
  JOURNAL   Am J Pathol 78 (2), 309-318 (1975)
   PUBMED   163593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG534053.1, BC020750.1,
            BG566257.1, J05037.1 and BU740747.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006843.2.
            
            Summary: This gene encodes one of three enzymes that are involved
            in metabolizing serine and glycine. L-serine dehydratase converts
            L-serine to pyruvate and ammonia and requires pyridoxal phosphate
            as a cofactor. The encoded protein can also metabolize threonine to
            NH4+ and 2-ketobutyrate. The encoded protein is found predominantly
            in the liver. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.600160.1,
                                           SRR5189664.1638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257549.9/ ENSP00000257549.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BG534053.1         1-340
            341-775             BC020750.1         340-774
            776-1336            BG566257.1         103-663
            1337-1426           J05037.1           1304-1393
            1427-1605           BU740747.1         16-194              c
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1605
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /note="serine dehydratase"
                     /db_xref="GeneID:10993"
                     /db_xref="HGNC:HGNC:10691"
                     /db_xref="MIM:182128"
     exon            1..120
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            121..275
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1109
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /note="L-serine deaminase; L-serine dehydratase; L-serine
                     ammonia-lyase; TDH; L-threonine dehydratase; hepatic
                     serine dehydratase"
                     /codon_start=1
                     /product="L-serine dehydratase/L-threonine deaminase"
                     /protein_id="NP_006834.2"
                     /db_xref="CCDS:CCDS9169.1"
                     /db_xref="GeneID:10993"
                     /db_xref="HGNC:HGNC:10691"
                     /db_xref="MIM:182128"
                     /translation="MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG
                     IGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNE
                     GATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKP
                     GAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITS
                     VAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAA
                     VYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK"
     exon            276..315
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            316..455
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            456..547
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            548..775
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            776..900
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1605
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1587..1592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /note="hexamer: AATATA"
     polyA_site      1605
                     /gene="SDS"
                     /gene_synonym="hSDH; SDH"
                     /note="major polyA site"
ORIGIN      
        1 gaccattcag aagactgtcc acccgtcctc agccccctct cttcgtgggc tatctactca
       61 gttgatccct ccctcgctgg cttggctctg actcctgctc agacccatca cctttgccgg
      121 gaatgatgtc tggagaaccc ctgcacgtga agacccccat ccgtgacagc atggccctgt
      181 ccaaaatggc cggcaccagc gtctacctca agatggacag tgcccagccc tccggctcct
      241 tcaagatccg gggcattggg cacttctgca agaggtgggc caagcaaggc tgtgcacatt
      301 ttgtctgctc ctcggcgggc aacgcaggca tggcggctgc atatgcggcc aggcaactcg
      361 gcgtccccgc caccatcgtg gtgcccagca ccacacctgc tctcaccatt gagcgcctca
      421 agaatgaagg tgccacagtc aaggtggtgg gtgagttatt ggatgaagcc ttcgagctgg
      481 ccaaggccct agcgaagaac aacccgggtt gggtctacat tccccccttt gatgaccccc
      541 tcatctggga aggccacgct tccatcgtga aagagctgaa ggagacactg tgggaaaagc
      601 cgggggccat cgcgctgtca gtgggcggcg ggggcctgct gtgtggagtg gtccaggggc
      661 tgcaggaggt gggctggggg gacgtgcctg tcatcgccat ggagactttt ggtgcccaca
      721 gcttccacgc tgccaccacc gcaggcaaac ttgtctccct gcccaagatc accagtgttg
      781 ccaaggccct gggcgtgaag actgtggggg ctcaggccct gaagctgttt caggaacacc
      841 ccattttctc tgaagttatc tcggaccagg aggctgtggc cgccattgag aagttcgtgg
      901 atgatgagaa gatcctggtg gagcccgcct gcggggcagc cctggccgct gtctatagcc
      961 acgtgatcca gaagctccaa ctggagggga atctccgaac cccgctgcca tccctcgtgg
     1021 tcatcgtctg cgggggcagc aacatcagcc tggcccagct gcgggcgctc aaggaacagc
     1081 tgggcatgac aaataggttg cccaagtgag gacggacccc ttaccgatct gtgctctcct
     1141 agcccaagag acccctggag gggctggagt tttatccagc gcctcgtcgt atgtttggct
     1201 gagcacctgt ggcctgggtg caggttaact tcttgttatc aggagcccac tatgcagagg
     1261 ccaaaggtcg gcagccagcg aggctatgaa ttggaccttt ttggtatctg tgtgactgct
     1321 ctgtgcccat ccttagccaa cttgctggcg tgacaagtgc ccacaagtaa cacaccaggt
     1381 acccagagca gggtggacag gagagacctg aatcacagca gtgaggaatt cctcaaagct
     1441 gtgacctcgc ccctgaactt gttcccagtg aaggtcaaca gggccaccaa ccagggttga
     1501 ggaaccatct cagccatcct cccaggaagc ccacccctga cccttactaa tttttctaat
     1561 gtgcaaactt tttcattgaa aaataaaata tatttatgaa acaaa
//
