LOCUS       NM_001394319            2722 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens short chain dehydrogenase/reductase family 42E, member
            2 (SDR42E2), transcript variant 2, mRNA.
ACCESSION   NM_001394319
VERSION     NM_001394319.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009019.10.
            
            On May 5, 2021 this sequence version replaced NM_001394319.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602312.3/ ENSP00000473474.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC009019.10        144697-144755
            60-150              AC009019.10        147738-147828
            151-335             AC009019.10        148441-148625
            336-431             AC009019.10        149095-149190
            432-489             AC009019.10        151636-151693
            490-608             AC009019.10        153024-153142
            609-684             AC009019.10        154447-154522
            685-767             AC009019.10        160321-160403
            768-905             AC009019.10        163710-163847
            906-971             AC009019.10        164403-164468
            972-1035            AC009019.10        166372-166435
            1036-1109           AC009019.10        168912-168985
            1110-2722           AC009019.10        172330-173942
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2722
                     /gene="SDR42E2"
                     /note="short chain dehydrogenase/reductase family 42E,
                     member 2"
                     /db_xref="GeneID:100288072"
                     /db_xref="HGNC:HGNC:35414"
     exon            1..59
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..150
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1364
                     /gene="SDR42E2"
                     /EC_number="1.1.1.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative short-chain dehydrogenase/reductase family 42E
                     member 2; putative 3-beta-HSD family protein
                     ENSP00000330812"
                     /codon_start=1
                     /product="putative short-chain dehydrogenase/reductase
                     family 42E member 2 isoform 2"
                     /protein_id="NP_001381248.1"
                     /db_xref="CCDS:CCDS92125.1"
                     /db_xref="GeneID:100288072"
                     /db_xref="HGNC:HGNC:35414"
                     /translation="MKSNPPRSSLEACKAAGQAPQQKTQAKPTKAARQKVLVTGGGGY
                     LGFSLGSHLAKSGTSVILLDRRRPQWELSPETKFIQADVRDEEALYRAFEGVDCVFHV
                     ASYGMSGAEKLQKEQIESINVGGTKLVIDVCVRRRVPRLIYTSTVNVAFGGKPIEQGD
                     EDSVPYFPLDEHVDHYSRTKAIADQLTLMANGMPLPGGGTLRTCVLRPPGIYGPEEQR
                     HLPRVAGHIKKRLFMFRFGDHKARMNWVHVHNLVQAHVLAAEALTTAKGYVASGQAYY
                     INDGESVNLFEWMAPLFEKLGYSQPWIQVPTSWVYLTAAVMERLHLALRPICSLPPLL
                     TRSEVRSVAVTHTFQIAKARAQLGYAPDKFRFADAVELYVQSTTRRPRGSTARTLLRL
                     LLRLLLFLGLLALALHFLGLQPLHAAVERL"
     exon            151..335
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..431
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..489
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..608
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..684
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..767
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..905
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..971
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1035
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1109
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..2722
                     /gene="SDR42E2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2701..2706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDR42E2"
                     /note="hexamer: AATAAA"
     polyA_site      2722
                     /gene="SDR42E2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgcgg agactggcgc agcgcgggga gcacgcagcg ccgcgggagc ccgggccagg
       61 tggtcggttt ctgggtctgc atggctcagt agaggatgaa gtccaacccc ccacgctcct
      121 ccctagaggc ctgcaaagct gcaggccagg cgccgcagca gaagactcaa gccaaaccta
      181 caaaggctgc caggcagaag gttctagtga ctggaggagg aggctacctg ggcttcagcc
      241 tgggatccca cctagccaag agcggcactt ccgtcattct gcttgaccgc cgcagacccc
      301 agtgggaact gtccccggaa accaagttca tccaggctga tgtccgagat gaagaagccc
      361 tgtaccgtgc cttcgaaggg gtggactgtg tcttccacgt ggcttcctat ggaatgtccg
      421 gggctgagaa gctgcagaaa gagcagattg agtctataaa tgttggaggc accaaactag
      481 tgattgatgt ctgtgttcgc cggcgggttc caaggctcat ctataccagc actgtcaatg
      541 ttgcatttgg agggaagccc atagagcagg gcgatgagga ctctgtgcca tatttcccat
      601 tggacgagca cgtagaccac tactcccgaa ccaaagccat cgccgaccaa ttgaccctca
      661 tggccaatgg gatgcctctc ccaggaggag gcactcttcg gacgtgtgtg ctccggcctc
      721 cagggatcta cggccctgaa gagcagaggc acctgccccg tgtggcgggc cacatcaaga
      781 agaggctgtt catgttccga tttggggacc acaaggcacg gatgaactgg gtccacgtac
      841 acaatctggt gcaggcacac gtgctggcgg ccgaggccct caccacggcc aagggctacg
      901 tggctagtgg gcaggcgtac tacatcaacg atggggagag cgtcaacctc tttgagtgga
      961 tggccccact gtttgagaag ctggggtaca gccagccctg gatccaggtg cctacttcct
     1021 gggtttacct gacagcagca gttatggagc gcctccatct ggccctgaga cccatctgca
     1081 gcctcccacc gctgctcact cgtagtgagg tgcgcagcgt ggccgtgacg cacaccttcc
     1141 agatagccaa ggcccgcgcc cagctcggct acgcgccgga taagtttagg ttcgccgacg
     1201 ccgtggagct atacgtgcag tccacgaccc ggcggccccg cggctccacg gcgcggaccc
     1261 tcctgcgcct gctgctcagg ctgctgctgt tcctcggctt gctcgccctg gccctgcact
     1321 tcctaggcct gcagcctctg cacgccgccg tggagcgcct gtgaccgtcc gccgtccgcc
     1381 gcccgctagg gtcggccccg ctgcaccctc gcccacgccc ggctccctgg gcttgtacca
     1441 gcccctgccc cgccttctgg gtttgagcgc gcctccgctc cgccccttga atcctggtca
     1501 cgcccccgag ccgctctcca gacctagccc ggaccgccga cttctggcca cgcccctatc
     1561 tactcccaga ccttgccttg cgcccttcct gtgttttggc cccgcccctg tcctgtcccg
     1621 ccccgccctc cgaagtgggc acgctcctgc tccgccccct gaatcctggc cacgtccctg
     1681 gtcggcccag acgcgtagcc ccgagtctct ttccatgttt tgaccacgcc cttgacccgc
     1741 ccttcaaatt gggcacgcct tcttccccgc tcactgattt cctggcctag cccctgagca
     1801 gacctccaga cctagccccg cccccgtttt ataaccccgc ccctgcttca cggcttgggc
     1861 acgcctcttc cccgccccct gacttcagag cctagtcctg agccgctctc caggcctaac
     1921 cccgccttca tgtcatagcc acgccccttc ccgcccttcc atgtttgggc acgccttctg
     1981 agtcctggtc acgcctctgt cccgccccct gaatctttcc tacgtccatg accctccctc
     2041 caggccctgg ccctgcccct tttttcctcc ctccggcctg tccggtttct gatatgggcc
     2101 aaggctcaca gcttcctccg ccttctggac cttctcctag tccctgccca gtcccggccc
     2161 acccccagat tctccctcat tctggtttcg ccccctttct ggtcctcccc gcgcgcttga
     2221 gcccaccctt tggcttctcc ttttgggtct gtccttgctc ctgcctctgg acccggtccc
     2281 gcccttctcg cgtgtaattg agtcctggcc ccgccccctc cctctctggc ttcacccctt
     2341 tccagctccg cctcccgggt aggttctccc cggaaccagg ctgccgcgtc gctatgggct
     2401 aacgcaggct cgggtgacgt tggtatgagt ttgcgccgtc ggctgctgct ctgtctggta
     2461 acattgcatt cgatccaccc cgacccaatg ttctgggctt ctcattcaca cagatctgtg
     2521 tgttgacagc cagggtttgg ggaaaaaccg agactcaagc ttctgccgag cccgacttgg
     2581 cctttttggg ttcctgtctg aggatgacag catagtaagc acaggtttta gtaccagaaa
     2641 gagcatgaaa aatttaaaaa aaaaaactct taaaataatt ggatgtctcg atgaagtacc
     2701 aataaagcta taatgggaaa aa
//
