LOCUS       NM_152744              10593 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens sidekick cell adhesion molecule 1 (SDK1), transcript
            variant 1, mRNA.
ACCESSION   NM_152744
VERSION     NM_152744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10593)
  AUTHORS   Han,X., Pan,S., Liu,J., Ding,X., Lin,X., Wang,D., Xie,Z., Zeng,C.,
            Liu,F., He,M., Zhou,X., Liu,T., Luo,L. and Liu,Y.
  TITLE     Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations
  JOURNAL   Br J Ophthalmol 108 (6), 865-872 (2024)
   PUBMED   37524447
  REMARK    GeneRIF: Novel loci for ocular axial length identified through
            extreme-phenotype genome-wide association study in Chinese
            populations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10593)
  AUTHORS   Maki-Nevala,S., Sarhadi,V.K., Knuuttila,A., Scheinin,I.,
            Ellonen,P., Lagstrom,S., Ronty,M., Kettunen,E.,
            Husgafvel-Pursiainen,K., Wolff,H. and Knuutila,S.
  TITLE     Driver Gene and Novel Mutations in Asbestos-Exposed Lung
            Adenocarcinoma and Malignant Mesothelioma Detected by Exome
            Sequencing
  JOURNAL   Lung 194 (1), 125-135 (2016)
   PUBMED   26463840
  REMARK    GeneRIF: SDK1 could possibly serve as a candidate gene for
            alterations associated with asbestos exposure.
REFERENCE   3  (bases 1 to 10593)
  AUTHORS   Cadby,G., Mukherjee,S., Musk,A.W., Reid,A., Garlepp,M., Dick,I.,
            Robinson,C., Hui,J., Fiorito,G., Guarrera,S., Beilby,J.,
            Melton,P.E., Moses,E.K., Ugolini,D., Mirabelli,D., Bonassi,S.,
            Magnani,C., Dianzani,I., Matullo,G., Robinson,B., Creaney,J. and
            Palmer,L.J.
  TITLE     A genome-wide association study for malignant mesothelioma risk
  JOURNAL   Lung Cancer 82 (1), 1-8 (2013)
   PUBMED   23827383
  REMARK    GeneRIF: Case-control studies reveal malignant mesothelioma risk
            associated with variants in the SDK1, CRTAM and RASGRF2 genes.
REFERENCE   4  (bases 1 to 10593)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10593)
  AUTHORS   Kaufman,L., Potla,U., Coleman,S., Dikiy,S., Hata,Y., Kurihara,H.,
            He,J.C., D'Agati,V.D. and Klotman,P.E.
  TITLE     Up-regulation of the homophilic adhesion molecule sidekick-1 in
            podocytes contributes to glomerulosclerosis
  JOURNAL   J Biol Chem 285 (33), 25677-25685 (2010)
   PUBMED   20562105
  REMARK    GeneRIF: Data conclude that the up-regulation of sdk-1 in podocytes
            is an important pathogenic factor in glomerulosclerosis and that
            the mechanism involves disruption of the actin cytoskeleton
            possibly via alterations in MAGI-1 function.
REFERENCE   6  (bases 1 to 10593)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: SDK1 may be a susceptibility gene for hypertension in
            Japanese individuals, although the functional relevance of the
            identified polymorphism was not determined.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10593)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   8  (bases 1 to 10593)
  AUTHORS   Kaufman,L., Yang,G., Hayashi,K., Ashby,J.R., Huang,L., Ross,M.J.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     The homophilic adhesion molecule sidekick-1 contributes to
            augmented podocyte aggregation in HIV-associated nephropathy
  JOURNAL   FASEB J 21 (7), 1367-1375 (2007)
   PUBMED   17307840
REFERENCE   9  (bases 1 to 10593)
  AUTHORS   Kaufman,L., Hayashi,K., Ross,M.J., Ross,M.D. and Klotman,P.E.
  TITLE     Sidekick-1 is upregulated in glomeruli in HIV-associated
            nephropathy
  JOURNAL   J Am Soc Nephrol 15 (7), 1721-1730 (2004)
   PUBMED   15213259
  REMARK    GeneRIF: dysregulation of sdk-1 protein may play an important role
            in HIV-associated nephropathy pathogenesis
REFERENCE   10 (bases 1 to 10593)
  AUTHORS   Yamagata,M., Weiner,J.A. and Sanes,J.R.
  TITLE     Sidekicks: synaptic adhesion molecules that promote lamina-specific
            connectivity in the retina
  JOURNAL   Cell 110 (5), 649-660 (2002)
   PUBMED   12230981
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073316.6, AY310398.1,
            AC015968.4, DB065853.1, AL833354.1 and AC017000.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152744.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin superfamily. The protein contains six
            immunoglobulin-like domains and thirteen fibronectin type III
            domains. Fibronectin type III domains are present in both
            extracellular and intracellular proteins and tandem repeats are
            known to contain binding sites for DNA, heparin and the cell
            surface. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY310398.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404826.7/ ENSP00000385899.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC073316.6         137100-137295
            197-633             AC073316.6         137296-137732
            634-1294            AY310398.1         438-1098
            1295-1485           AC015968.4         125022-125212       c
            1486-2329           AY310398.1         1290-2133
            2330-2466           AC015968.4         89620-89756         c
            2467-2614           AC015968.4         65829-65976         c
            2615-4464           AY310398.1         2419-4268
            4465-4563           DB065853.1         410-508
            4564-6716           AL833354.1         510-2662
            6717-7195           AY310398.1         6521-6999
            7196-10593          AC017000.5         145300-148697
FEATURES             Location/Qualifiers
     source          1..10593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.2"
     gene            1..10593
                     /gene="SDK1"
                     /note="sidekick cell adhesion molecule 1"
                     /db_xref="GeneID:221935"
                     /db_xref="HGNC:HGNC:19307"
                     /db_xref="MIM:607216"
     exon            1..633
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..6977
                     /gene="SDK1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein sidekick-1; sidekick homolog 1, cell adhesion
                     molecule"
                     /codon_start=1
                     /product="protein sidekick-1 isoform 1"
                     /protein_id="NP_689957.3"
                     /db_xref="CCDS:CCDS34590.1"
                     /db_xref="GeneID:221935"
                     /db_xref="HGNC:HGNC:19307"
                     /db_xref="MIM:607216"
                     /translation="MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRP
                     GPEPSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDV
                     APYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQ
                     KLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSY
                     PRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPF
                     IHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGV
                     RITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP
                     ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRP
                     EDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPK
                     PAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASA
                     TLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRI
                     VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSH
                     SHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQ
                     FRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHN
                     GVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF
                     SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADA
                     PEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKP
                     GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEY
                     KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATL
                     QFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRF
                     RMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNG
                     NPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGP
                     WSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD
                     LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAP
                     GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ
                     FTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARS
                     LRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLR
                     LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGL
                     LQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK
                     KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPP
                     PESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAA
                     GDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPL
                     APVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAE
                     GSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSA
                     TSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMAL
                     SSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVK
                     STFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSD
                     YEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQS
                     AGGVYTPAGPGARTPLTGFSSFV"
     exon            634..793
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..900
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1048
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1182
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1294
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1485
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1569
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1764
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1881
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2049
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2152
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2329
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2466
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2614
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2755
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2937
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3053
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3246
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3345
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3537
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3659
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3769
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3920
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4158
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4274
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4464
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4563
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4758
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4960
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..5064
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5065..5135
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5271
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5272..5331
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5433
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5549
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5550..5736
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5737..5874
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            5875..6036
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6037..6162
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6163..6327
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6328..6465
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6466..6586
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6587..6716
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     exon            6717..10593
                     /gene="SDK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7975..7980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDK1"
                     /note="hexamer: AATAAA"
     polyA_site      8002
                     /gene="SDK1"
                     /note="major polyA site"
     regulatory      10567..10572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDK1"
                     /note="hexamer: AATAAA"
     polyA_site      10593
                     /gene="SDK1"
                     /note="major polyA site"
ORIGIN      
        1 gcactttctt ctcagcgccg ggcgggggcg gcggcggcgg cggctcctcc gcgcccggcg
       61 gacccctcgg agctagcgcg gcgggctcgg gactgcgtga gcgccggacg cgaatttccc
      121 ccgttgacaa cttcttctcg cccggctcgt ccccggcccg cgccgcgccc ctcacgcggg
      181 gacccaggac gccgcccctc agcgctgggc ggccgctcac ctcgggccgg ggggcgccgc
      241 gcctcccgcg gagtggccgc gcccgctcgg agccgtcccg cctgtcctgc ccgcccgtcc
      301 gtccggcgcg gcgctcgggg tggcggctgc tcggcatggc ccggggcgcc cggccctcgg
      361 cggccggtgg cggcggcggc ggcgcggagc cccctgagcg cgcgggcccc gggcggccgc
      421 ggggatcccc gcccggccgc gcccgcccct cgctggcgcc gcgccccggc ccggagccct
      481 cgcgaccccg ggcggcgccc gagacctccg gcggggacac ggcgggcgcg gggcggtgcg
      541 gcgggcggcg ggcggcaaag ttggggccgg gccgccgcgg ctggtgggcg ctgctggcgc
      601 tgcagctgca cttgctccgg gcgctggcgc aagatgatgt tgctccatat tttaaaacgg
      661 agccaggcct accacagatc cacctggaag ggaaccgcct tgttctcacc tgccttgccg
      721 aagggagctg gcctttggag ttcaagtgga tgcgcgatga cagtgagctc accacctaca
      781 gcagcgaata taagtacatt attccatctt tgcagaagct cgatgctggg ttttaccgct
      841 gcgtggtgcg aaacagaatg ggagcactcc tgcaaagaaa atcagaagtt caagtcgcat
      901 atatgggaag tttcatggat acggaccaga ggaaaacagt ttctcaagga cgtgcagcga
      961 ttctaaacct gctgcccatc accagctacc ccagacctca agtgacttgg tttagagaag
     1021 ggcacaagat tattccaagc aacagaatag ccatcacatt ggagaatcag ctggtgatcc
     1081 tcgccaccac aaccagtgat gccggggcat actacgtgca ggccgtgaat gagaaaaatg
     1141 gagaaaacaa gacaagccca ttcattcatt tgagcatagc aagagatgtt ggcacacctg
     1201 aaaccatggc cccaaccatt gtggttcccc cgggcaacag aagtgtggtg gctggatcca
     1261 gtgagaccac cttggaatgt atagccagtg ccaggcctgt ggaggacctg agtgtgacct
     1321 ggaagaggaa tggagtgaga atcaccagtg gcctccacag ctttggaaga cgcctcacca
     1381 tcagcaaccc gacgtccgcg gacaccgggc catacgtctg cgaggcggcg ctgccgggga
     1441 gcgcttttga accggccagg gcgacggcct ttcttttcat catagagcca ccatatttta
     1501 ctgctgagcc cgagagtcgg atttcagctg aagtagaaga aactgtggac atcggatgtc
     1561 aagccatggg ggtccccctt cccaccctcc agtggtacaa ggatgccatc tccatcagca
     1621 ggctccagaa tcctcgatac aaagtgctcg ccagcggagg cctgcgcatc cagaagctgc
     1681 gtccagagga ctccggaatc ttccagtgct tcgccagcaa tgaaggaggg gagatccaga
     1741 cccacaccta cctggatgta accaatatcg ctccagtgtt cacccagcgg ccagtggaca
     1801 ccacagttac tgacgggatg acagccattc taaggtgtga ggtgtccggg gctcccaaac
     1861 ccgccatcac ctggaaaaga gaaaaccaca ttctggccag tggctctgtc cggattccta
     1921 ggttcatgct tcttgaatcg gggggtctac agatcgcgcc cgtcttcatc caggatgccg
     1981 gcaactacac ctgctatgcg gccaacacag agggctccct gaatgcatcg gccacgctca
     2041 ctgtgtggaa tcggacgtcc atcgtccacc ctcctgagga ccacgtggtg attaagggga
     2101 ccacggccac gctgcactgt ggtgccacac atgacccccg ggtttcactc cgctacgttt
     2161 ggaagaagga caacgtggcc ctgactccat cgagcacgtc taggatcgtg gtggagaagg
     2221 acgggtccct tctcatcagc cagacgtggt caggcgacat cggtgactac agctgcgaga
     2281 ttgtttctga aggagggaat gactccagga tggcccggct ggaagtgatt gaactgcctc
     2341 attcacctca gaacctcctg gtcagcccta attcttccca cagccacgcc gtggtgctct
     2401 cttgggtccg gccctttgat ggaaacagtc ctattcttta ttacatcgtg gagctctctg
     2461 aaaacaactc tccatggaag gtgcatctgt caaacgttgg ccctgagatg acaggcgtca
     2521 ccgtgagtgg cctgactccg gctcgtacct atcaattccg ggtgtgcgcg gtgaatgaag
     2581 tgggcagggg ccagtacagc gccgagacaa gcaggttgat gctacctgaa gaaccaccca
     2641 gtgctccccc gaaaaatata gtggccagtg ggcggactaa tcagtccatt atggtccagt
     2701 ggcagccacc cccagaaaca gagcacaacg gggtgttgcg tggatacatc ctcaggtacc
     2761 gcctggctgg ccttcccgga gagtaccagc agcggaacat caccagcccg gaggtgaact
     2821 actgcctggt gacagacctg atcatctgga cacagtatga gatacaggtg gcggcgtaca
     2881 acggggccgg tctgggcgtc ttcagcaggg cagtgaccga gtacaccttg cagggagtgc
     2941 ccaccgcgcc cccgcagaac gtgcagacgg aagccgtgaa ctccaccacc attcagttcc
     3001 tgtggaaccc tccgcctcag cagtttatca atggcatcaa ccagggatac aagcttctgg
     3061 catggccggc agatgccccc gaggctgtca ctgtggtcac tattgcccca gatttccacg
     3121 gagtccacca tggacacata acgaacctga agaagtttac cgcctacttc acttccgttc
     3181 tgtgcttcac cacccctggg gacgggcctc ccagcacacc tcagctggtc tggactcagg
     3241 aagacaaacc aggagctgtg ggacatctga gtttcacaga gatcttggac acatctctca
     3301 aggtcagctg gcaggagccc ctggagaaaa atggcatcat tactggctat cagatctctt
     3361 gggaagtgta cggcaggaac gactctcgtc tcacgcacac cctgaacagc acgacgcacg
     3421 agtacaagat ccaaggcctc tcatctctca ccacctacac catcgacgtg gccgctgtga
     3481 ctgccgtggg cactggcctg gtgacttcat ccaccatttc ttctggagtg cccccagacc
     3541 ttcctggtgc cccatccaac ctggtcattt ccaacatcag ccctcgctcc gccacccttc
     3601 agttccggcc aggctatgac gggaaaacgt ccatctccag gtggattgtt gaggggcagg
     3661 tgggagctat cggcgacgag gaggagtggg tcaccctcta tgaagaggag aatgagcctg
     3721 atgcccagat gctggagatc ccaaacctca caccctacac tcactacaga tttcgaatga
     3781 agcaagtgaa cattgttggg ccgagcccct acagtccgtc ttcccgggtc atccagaccc
     3841 tgcaggcccc acccgacgtg gctccaacca gcgtcacggt ccgtactgcc agtgagacca
     3901 gcctgcggct tcgctgggtg cccctgccgg attctcagta caacgggaac cccgagtccg
     3961 tgggctacag gattaagtac tggcgctcag acctccagtc ctcagcagtg gcccaagtcg
     4021 tcagtgaccg gctggagaga gaattcacca tcgaggagct ggaggagtgg atggaatacg
     4081 agctgcagat gcaggccttc aacgccgtcg gggctgggcc gtggagcgag gtggtgcggg
     4141 gccggacgcg ggagtcagtt ccttcagccg cccctgagaa cgtgtcagcc gaggctgtca
     4201 gctcgaccca gattttactg acatggacat ccgtgccgga acaggaccag aatgggctca
     4261 tactgggcta caagatcctg ttccgggcca aagacctgga tcccgagccc aggagccaca
     4321 tcgtgcgagg gaaccacacg cagtcggccc tgctggcagg cctgcgcaag ttcgtgctct
     4381 acgagctcca ggtgctggcg ttcacccgca tcgggaacgg ggtccccagc acgcccctca
     4441 tcctggagcg caccaaagac gatgccccag gcccaccagt gaggctcgtg ttccccgaag
     4501 tgagactcac ctccgtgcgg atagtgtggc aacctccgga ggagcccaac ggcatcatcc
     4561 tggggtacca gattgcctac cgcctggcca gcagcagccc ccacaccttc accaccgtgg
     4621 aggtcggcgc cacagtgagg cagttcacag ccaccgacct ggccccggag tccgcataca
     4681 tcttcaggct gtccgccaag acgaggcagg gctgggggga gccactggag gccaccgtca
     4741 tcaccaccga gaagagagag cggccggcac cccccagaga gctcctggtg ccccaggcag
     4801 aagtgaccgc acgcagcctc cggctccagt gggtcccggg cagcgacggg gcctccccca
     4861 tccggtactt caccatgcag gtgcgagagc tgcctcgggg tgagtggcag acctactcct
     4921 cgtccatcag ccatgaggcg acagcatgcg tcgttgacag actgaggccc ttcacctcct
     4981 acaagctgcg cctgaaagcc accaacgaca ttggggacag tgacttcagt tcagagacag
     5041 aggcggtgac cacgctgcag gatgttccag gagagccccc gggatctgtc tcagcgacgc
     5101 cacacaccac gtcctctgtc ctgatacagt ggcagcctcc gagggacgaa agcctgaatg
     5161 gccttcttca gggatacagg atctactaca gggagctgga gtatgaagcc gggtcaggca
     5221 ctgaggccaa gacgctcaaa aaccctatag ctttacatgc tgagctcaca gcccaaagca
     5281 gcttcaagac ggtgaacagc agctccacat cgacgatgtg tgaactaaca catttaaaga
     5341 agtaccggcg ctatgaagta ataatgaccg cctataacat catcggcgag agcccagcca
     5401 gcgcgcccgt ggaggtcttt gtcggcgagg ctgccccggc catggccccg cagaacgtgc
     5461 aggtgacccc actcacggcc agccagctgg aggtcacgtg ggacccacca cccccggaga
     5521 gccagaatgg gaacatccaa ggctacaaga tttactactg ggaggcagac agccagaacg
     5581 aaacggagaa aatgaaggtc ctcttcctcc ccgagcccgt ggtgaggctg aagaacctga
     5641 ccagccatac caagtacctg gtcagcatat cagccttcaa cgccgccgga gatggaccta
     5701 agagtgaccc ccagcagggg cgcacccacc aggccgcccc tggggccccc agctttctgg
     5761 cgttctcaga aataacctcc accacgctca acgtgtcctg gggcgagcct gcggcggcca
     5821 acggcatcct gcagggctat cgggtggtgt acgagccctt ggcccctgta caaggggtga
     5881 gcaaggtggt gaccgtggaa gtgagaggga actggcagcg ctggctgaag gtgcgggacc
     5941 tcaccaaggg agtgacctat ttcttccgtg tccaagcgcg gaccatcacc tacgggcccg
     6001 agctccaagc caatatcaca gccgggccag ccgagggatc cccgggctcg cctagagatg
     6061 tcctggtcac caagtccgcc tctgaactga cgctgcagtg gactgaggga cactctggcg
     6121 acacacctac cacgggctat gtgatcgagg cccggccctc agatgaaggc ttatgggaca
     6181 tgtttgtgaa ggacatcccg cggagcgcca catcctacac cctcagcctg gataagctcc
     6241 ggcaaggagt gacttacgag ttccgggtgg tggctgtgaa tgaggcgggc tacggggagc
     6301 ccagcaaccc ctccacggct gtgtcagctc aagtggaagc cccattctac gaggagtggt
     6361 ggttcctcct ggtgatggct ctgtccagcc tgatcgtcat cctgctggtg gtgttcgccc
     6421 tcgtcctgca cgggcagaat aagaagtata agaactgcag cacaggaaag gggatctcca
     6481 ccatggagga gtctgtgacc ctggacaacg gaggatttgc tgccctggag ctcagcagcc
     6541 gccacctcaa tgtcaagagc accttctcca agaagaacgg gaccaggtcc ccaccccggc
     6601 ctagccccgg cggcctgcac tactcagacg aggacatctg caacaagtac aacggcgccg
     6661 tgctgaccga gagcgtgagc ctcaaggaga agtcggcaga tgcatcagaa tctgaggcca
     6721 cggactctga ctacgaggac gcgctgccca agcactcctt cgtgaaccac tacatgagcg
     6781 accccaccta ctacaactca tggaagcgca gggcccaggg ccgcgcacct gcgccgcaca
     6841 ggtacgaggc ggtggcgggc tccgaggcgg gcgcgcagct gcacccggtc atcaccacgc
     6901 agagcgcggg cggcgtctac acccccgctg gccccggcgc gcgaactccg ctcaccggct
     6961 tctcctcctt cgtgtgagca aagcgccgcg cctccctcag ggcggaacgg aggcaacttt
     7021 ccggagtcta tttttgttaa gacaatcaac tccaataact gagctgaagt ttttgtttaa
     7081 aaagaaaaaa atctgataag tgatgatttt acctacttgt ggacactaga tttcaattag
     7141 gaaggttttt ttaaacggct ttttgtaact tcgctgcagg aagcaggttt gtttcttttt
     7201 cttttctttt taagagaagg tgtatttcac tggtgcaatg gcttggcacc tccggggcct
     7261 gggaggacct cagacctccc cagccctggg tttctccgtc ttcaagacca actaggaagg
     7321 gtcaagcggg gagagggagt ggagggtcag gtgagatctc agagctgccc cggccggccc
     7381 ccgtctcttt ctacctcctc ttccagagaa ccagcggctc acacccttct caacgcagga
     7441 catcctcggc ggctcctggg gtttgaagag caaacgtttt tccctgggct cagtgcgttt
     7501 tgtcccaact tcatctgttt ctgaaatgtt ctcacttggc agtgtctagt caaggagtcg
     7561 gctttcaggt tcctgacggc caggcaggga tgctaaggtg tggctcagcc gtcactgtct
     7621 gtgtcactgc agtggtgcgg tcctcaggct tttctgcctg tctttccccc ttccttctca
     7681 cctgacagcg agggagaggg aagcctctta gggctggaag ccaccacgct ggccctctcc
     7741 ttccccgaac acagcacacg gtcaactccg cgggacacga ggacacggga cggcgtctcc
     7801 agaattgctt gttacgtagg aagcgtgcat tgttaaccag agtattttta aaatcttttt
     7861 atcttttttt aaactatgtc acatgaaatg aatgcgtctt tgctgtctcc aggtgccttt
     7921 ttattaattg ttcagctttg tacatgggaa agatgaaaag caacagtgtc tgcaaataaa
     7981 gcaaaacagc tctgagaaca cacgctcccg actcgcctcg tgcacaccag gccgtcccct
     8041 ccctctgtcc tggcttctgc tggctgctcg cagcagccac cgcttctcca ccactggcgc
     8101 tgctgctgcc ccctctccca gtccgaggcc agcttttagc cttaacaggt tttttggaaa
     8161 tgtttctttt ttttatttaa aattgtcatt gtttggttta aatttttcag ctagatgaaa
     8221 agagtatgaa ctactttgga aaacttaaca gctcagagat ggccatgcct ccagcccctc
     8281 acgtcatctt tgcaacagac gactgggctg ccatggtcca cccctcagcc cgggtcccgg
     8341 gtctggatgg aacgggagca ctgctggtgc ccactggcgt gtgtgccccg ggtccctgta
     8401 agtgccccct caccagcagc agcgtgacac acacaagact caagaccacc ctgtcagtgc
     8461 cccccagtgc acggcaaacg ggcaggtgcc gttcccccag tgacctgagg gtaggggaca
     8521 actgagcagt atctgaccag tgccacccag gagccagtct cctggccaca tgcagaaagt
     8581 gtggcccctg cttacctaga tgttttgtgc acctccatgg gcagagggtg tggatattgc
     8641 ctggattctg tgctgtcagc gttgctgagt atggccccag gagaccaagg agagttttgt
     8701 ataggctgga aaaccccttt tcagtctttc caaaattaga gggtatggca agtttccttt
     8761 tttctctcct cccttccttc ccctccttcc tttcctttac ccctcctttc cttccttcct
     8821 cccttcctct cttctttcct ccctccctcc ctccttccct cccttccttc ctctctttcc
     8881 tccttccttc cctcccttct ttccctccct cccttcctct ctcccctatt ccttcttcct
     8941 tttctcctcc tttttctgag tggaggggga aatattctaa accaaaaatc ctagatgctc
     9001 tgcccaaagc cacttctgca tgagaatcgc aacccacagt tccccggatg agactcacca
     9061 cagtggacag tgccacctcc ttcccctcgg ccccggagag ggcgaagtgg gcgggaagcc
     9121 aggatgtgag cactggaatt tcttggaaga gaagcgataa atggagacca tggccagcgc
     9181 tgctttctgt gcactctgat gactgctctc tgcagccatg aggatgtggc tttacatgcc
     9241 agggagagtg ttgagacgtc ttaggttgag gatgagcaga ttcgagatat gtttgttgct
     9301 ctcgggtttt cgatacaaca tcatgacact tctgtttcaa gctcatgttt tccgtctccc
     9361 ctccactctt agtaaacctt gatctgtacg gagcggcctg tccgaggcta cgccggcctc
     9421 ctggctgctg ctggactgtg cttaggacag cgcccatgcc tcggagggac tctgtcccat
     9481 gagaaccacc tgtgcaaagg aacagagctg gatgtttcca ggtagatttt ggcctcccag
     9541 agcaatgcgg catttgagaa gcaacagttc ctaactcctt atcttcaggg aaggaaaaga
     9601 aaatcacagc ctaggaagat ggaggttgga ttttaatctc ggttttaaaa agaggacaaa
     9661 caaaatgtct ctaagccagg ctagatggaa tgtgctcccg ctctctcctg ccgtgctgaa
     9721 agtcatgcct tgcggatgcc tcatgacagc agtggctgag tctccccacc cacccccaac
     9781 gtggctcatt tcagattgct tcggccccac cctgcaagga tgtggtcacg gagtggccag
     9841 gaggctccgt ctgagccaca gggatgggtg tgcagagctc cctcctcctg gggtgccagg
     9901 gcagagattc caggcaggtg agcccagaga gagctgccag gccacacccc ctcggcctcc
     9961 tgcacggcca ccttctgggt gaatcggtcc agcccaagcc cctctcccca gcctcgcctt
    10021 cagcctctct cccagcctgc ttttataagg cgcacttcac tcaatgctgt agccaaaaaa
    10081 cgaggggccc cagggagagg ggacccagat ggccacacac ggaacgcgcc tccacagccc
    10141 cgggaggtgg ctcactctgt acaggtcttc ggaggccgtg tttgtatcta actgtgactg
    10201 ggctgaagca tgatgtttgc ctaatggttc gtagcatggt ttttatttct tacgcattct
    10261 tggcacacag tgtagctatc ctcctgacga gcaacccgtc tgcgtaccta agtgtggctc
    10321 cccgtgggtc agcgtcctgg tagcatggat ccagtctgaa aggtgaggac aacgtggaaa
    10381 ctcatgagct gagcctgccc gctgggacac gtctccttcc cgcgtcacct tctggtttag
    10441 ggagccgtca ggtccctaaa cgttccctac aactttttct gaaattgtgc agaaaaacag
    10501 atctcattaa aagaaaaaaa gaaacaactt gtaggaagac agagaggtgc tatgggtaca
    10561 atttttaata aaaacattat tttgttcctt aaa
//
