LOCUS       NM_022044                825 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens stromal cell derived factor 2 like 1 (SDF2L1), mRNA.
ACCESSION   NM_022044
VERSION     NM_022044.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 825)
  AUTHORS   Zhang,L., Zhang,Z., Qin,L., Shi,X., Su,Q. and Mo,W.
  TITLE     SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in
            Nasopharyngeal Carcinoma
  JOURNAL   Biomed Res Int 2020, 1970936 (2020)
   PUBMED   33134371
  REMARK    GeneRIF: SDF2L1 Inhibits Cell Proliferation, Migration, and
            Invasion in Nasopharyngeal Carcinoma.
            Erratum:[Biomed Res Int. 2022 May 12;2022:9898479. doi:
            10.1155/2022/9898479.. PMID: 35601144]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 825)
  AUTHORS   Benvenuto,G., Todeschini,P., Paracchini,L., Calura,E., Fruscio,R.,
            Romani,C., Beltrame,L., Martini,P., Ravaggi,A., Ceppi,L., Sales,G.,
            Donati,F., Perego,P., Zanotti,L., Ballabio,S., Grassi,T., Delle
            Marchette,M., Tognon,G., Sartori,E., Adorni,M., Odicino,F.,
            D'Incalci,M., Bignotti,E., Romualdi,C. and Marchini,S.
  TITLE     Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive
            and prognostic factors for therapy response and survival in
            high-grade serous ovarian cancer
  JOURNAL   Int J Cancer 147 (2), 565-574 (2020)
   PUBMED   32096871
  REMARK    GeneRIF: Expression profiles of PRKG1, SDF2L1 and PPP1R12A are
            predictive and prognostic factors for therapy response and survival
            in high-grade serous ovarian cancer.
REFERENCE   3  (bases 1 to 825)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 825)
  AUTHORS   Hanafusa,K., Wada,I. and Hosokawa,N.
  TITLE     SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum
            localization and chaperone activity of ERdj3 protein
  JOURNAL   J Biol Chem 294 (50), 19335-19348 (2019)
   PUBMED   31624144
  REMARK    GeneRIF: The ERdj3-SDF2L1 complex suppressed ER protein
            aggregation, and this suppression did not require substrate
            transfer to BiP.
REFERENCE   5  (bases 1 to 825)
  AUTHORS   Sasako,T., Ohsugi,M., Kubota,N., Itoh,S., Okazaki,Y., Terai,A.,
            Kubota,T., Yamashita,S., Nakatsukasa,K., Kamura,T., Iwayama,K.,
            Tokuyama,K., Kiyonari,H., Furuta,Y., Shibahara,J., Fukayama,M.,
            Enooku,K., Okushin,K., Tsutsumi,T., Tateishi,R., Tobe,K.,
            Asahara,H., Koike,K., Kadowaki,T. and Ueki,K.
  TITLE     Hepatic Sdf2l1 controls feeding-induced ER stress and regulates
            metabolism
  JOURNAL   Nat Commun 10 (1), 947 (2019)
   PUBMED   30814508
  REMARK    GeneRIF: In diabetic patients, insufficient induction of Sdf2l1
            correlates with progression of insulin resistance and
            steatohepatitis. Therefore, failure to build an ER stress response
            in the liver may be a causal factor in obesity-related diabetes and
            nonalcoholic steatohepatitis, for which Sdf2l1 could serve as a
            therapeutic target and sensitive biomarker.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 825)
  AUTHORS   Fujimori,T., Suno,R., Iemura,S.I., Natsume,T., Wada,I. and
            Hosokawa,N.
  TITLE     Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of
            the BiP chaperone cycle to prevent protein aggregation
  JOURNAL   Genes Cells 22 (8), 684-698 (2017)
   PUBMED   28597544
  REMARK    GeneRIF: SDF2L1 associates with ERdj3 and acts as a component in
            the BiP chaperone cycle to prevent the aggregation of misfolded
            proteins.
REFERENCE   7  (bases 1 to 825)
  AUTHORS   Tiwari,A., Schuiki,I., Zhang,L., Allister,E.M., Wheeler,M.B. and
            Volchuk,A.
  TITLE     SDF2L1 interacts with the ER-associated degradation machinery and
            retards the degradation of mutant proinsulin in pancreatic
            beta-cells
  JOURNAL   J Cell Sci 126 (Pt 9), 1962-1968 (2013)
   PUBMED   23444373
  REMARK    GeneRIF: SDF2L1 increases the time that misfolded proteins have to
            achieve a correctly folded conformation and thus that SDF2L1 can
            act as a buffer for substrate availability for ERAD in pancreatic
            beta-cells.
REFERENCE   8  (bases 1 to 825)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 825)
  AUTHORS   Fukuda,S., Sumii,M., Masuda,Y., Takahashi,M., Koike,N.,
            Teishima,J., Yasumoto,H., Itamoto,T., Asahara,T., Dohi,K. and
            Kamiya,K.
  TITLE     Murine and human SDF2L1 is an endoplasmic reticulum
            stress-inducible gene and encodes a new member of the Pmt/rt
            protein family
  JOURNAL   Biochem Biophys Res Commun 280 (1), 407-414 (2001)
   PUBMED   11162531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY359118.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022044.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359118.1, SRR1163658.485658.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248958.5/ ENSP00000248958.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               AY359118.1         17-841
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..825
                     /gene="SDF2L1"
                     /note="stromal cell derived factor 2 like 1"
                     /db_xref="GeneID:23753"
                     /db_xref="HGNC:HGNC:10676"
                     /db_xref="MIM:607551"
     exon            1..222
                     /gene="SDF2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..701
                     /gene="SDF2L1"
                     /note="SDF2-like 1; PWP1-interacting protein 8; stromal
                     cell-derived factor 2-like protein 1;
                     dihydropyrimidinase-like 2; SDF2-like protein 1"
                     /codon_start=1
                     /product="stromal cell-derived factor 2-like protein 1
                     precursor"
                     /protein_id="NP_071327.2"
                     /db_xref="CCDS:CCDS13792.1"
                     /db_xref="GeneID:23753"
                     /db_xref="HGNC:HGNC:10676"
                     /db_xref="MIM:607551"
                     /translation="MWSAGRGGAAWPVLLGLLLALLVPGGGAAKTGAELVTCGSVLKL
                     LNTHHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGSEGGCPRGSPVRCGQ
                     AVRLTHVLTGKNLHTHHFPSPLSNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAV
                     RFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMPSANTHNTWKAMEGIFIKPSVEPSAGH
                     DEL"
     exon            223..419
                     /gene="SDF2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..825
                     /gene="SDF2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      804..809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDF2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      825
                     /gene="SDF2L1"
                     /note="major polyA site"
ORIGIN      
        1 ccctgggccc gaggggctgg agccgggccg gggcgatgtg gagcgcgggc cgcggcgggg
       61 ctgcctggcc ggtgctgttg gggctgctgc tggcgctgtt agtgccgggc ggtggtgccg
      121 ccaagaccgg tgcggagctc gtgacctgcg ggtcggtgct gaagctgctc aatacgcacc
      181 accgcgtgcg gctgcactcg cacgacatca aatacggatc cggcagcggc cagcaatcgg
      241 tgaccggcgt agaggcgtcg gacgacgcca atagctactg gcggatccgc ggcggctcgg
      301 agggcgggtg cccgcgcggg tccccggtgc gctgcgggca ggcggtgagg ctcacgcatg
      361 tgcttacggg caagaacctg cacacgcacc acttcccgtc gccgctgtcc aacaaccagg
      421 aggtgagtgc ctttggggaa gacggcgagg gcgacgacct ggacctatgg acagtgcgct
      481 gctctggaca gcactgggag cgtgaggctg ctgtgcgctt ccagcatgtg ggcacctctg
      541 tgttcctgtc agtcacgggt gagcagtatg gaagccccat ccgtgggcag catgaggtcc
      601 acggcatgcc cagtgccaac acgcacaata cgtggaaggc catggaaggc atcttcatca
      661 agcctagtgt ggagccctct gcaggtcacg atgaactctg agtgtgtgga tggatgggtg
      721 gatggagggt ggcaggtggg gcgtctgcag ggccactctt ggcagagact ttgggtttgt
      781 aggggtcctc aagtgccttt gtgattaaag aatgttggtc tatga
//
