LOCUS       NM_006923               1309 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens stromal cell derived factor 2 (SDF2), transcript
            variant 1, mRNA.
ACCESSION   NM_006923
VERSION     NM_006923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1309)
  AUTHORS   Lorenzon,A.R., Moreli,J.B., de Macedo Melo,R., Namba,F.Y.,
            Staff,A.C., Yung,H.W., Burton,G.J. and Bevilacqua,E.
  TITLE     Stromal Cell-Derived Factor (SDF) 2 and the Endoplasmic Reticulum
            Stress Response of Trophoblast Cells in Gestational Diabetes
            Mellitus and In vitro Hyperglycaemic Condition
  JOURNAL   Curr Vasc Pharmacol 19 (2), 201-209 (2021)
   PUBMED   32504504
  REMARK    GeneRIF: Stromal Cell-Derived Factor (SDF) 2 and the Endoplasmic
            Reticulum Stress Response of Trophoblast Cells in Gestational
            Diabetes Mellitus and In vitro Hyperglycaemic Condition.
REFERENCE   2  (bases 1 to 1309)
  AUTHORS   Fujimori,T., Suno,R., Iemura,S.I., Natsume,T., Wada,I. and
            Hosokawa,N.
  TITLE     Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of
            the BiP chaperone cycle to prevent protein aggregation
  JOURNAL   Genes Cells 22 (8), 684-698 (2017)
   PUBMED   28597544
  REMARK    GeneRIF: SDF2 associates with ERdj3 and acts as a component in the
            BiP chaperone cycle to prevent the aggregation of misfolded
            proteins.
REFERENCE   3  (bases 1 to 1309)
  AUTHORS   Takahashi,K., Tanaka,M., Yashiro,M., Matsumoto,M., Ohtsuka,A.,
            Nakayama,K.I., Izumi,Y., Nagayama,K., Miura,K., Iwao,H. and
            Shiota,M.
  TITLE     Protection of stromal cell-derived factor 2 by heat shock protein
            72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant
            human gastric cancer cells
  JOURNAL   Cancer Lett 378 (1), 8-15 (2016)
   PUBMED   27157913
  REMARK    GeneRIF: Hsp72 prevented SDF-2 degradation in a chaperone
            activity-dependent manner avoiding oxaliplatin-induced cell death
            in oxaliplatin-resistant human gastric cancer cells.
REFERENCE   4  (bases 1 to 1309)
  AUTHORS   Lorenzon-Ojea,A.R., Guzzo,C.R., Kapidzic,M., Fisher,S.J. and
            Bevilacqua,E.
  TITLE     Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in
            Endoplasmic Reticulum Stress Pathway in Human Placental Cells
  JOURNAL   Biol Reprod 95 (2), 41 (2016)
   PUBMED   27335075
  REMARK    GeneRIF: These findings suggest that SDF2 may be an important
            regulatory factor by which trophoblast cells can control cell
            survival under ER stress.
REFERENCE   5  (bases 1 to 1309)
  AUTHORS   Siragusa,M., Frohlich,F., Park,E.J., Schleicher,M., Walther,T.C.
            and Sessa,W.C.
  TITLE     Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS
            activation
  JOURNAL   Sci Signal 8 (390), ra81 (2015)
   PUBMED   26286023
  REMARK    GeneRIF: Data indicate a function for stromal cell-derived factor 2
            (SDF2) as a component of the heat-shock proteins 90-endothelial
            nitric oxide synthase (Hsp90-eNOS) complex that is critical for
            signal transduction in endothelial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1309)
  AUTHORS   Song,X.Y., Lee,S.Y., Ma,R.C., So,W.Y., Cai,J.H., Tam,C., Lam,V.,
            Ying,W., Ng,M.C. and Chan,J.C.
  TITLE     Phenotype-genotype interactions on renal function in type 2
            diabetes: an analysis using structural equation modelling
  JOURNAL   Diabetologia 52 (8), 1543-1553 (2009)
   PUBMED   19479237
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1309)
  AUTHORS   Kang,H., Escudero-Esparza,A., Douglas-Jones,A., Mansel,R.E. and
            Jiang,W.G.
  TITLE     Transcript analyses of stromal cell derived factors (SDFs): SDF-2,
            SDF-4 and SDF-5 reveal a different pattern of expression and
            prognostic association in human breast cancer
  JOURNAL   Int J Oncol 35 (1), 205-211 (2009)
   PUBMED   19513569
  REMARK    GeneRIF: SDF-2, SDF-4 and SDF-5 are expressed in mammary tissues
            and cells and that a reduced level of SDF-2 and SDF-4 are
            associated with a poor clinical outcome.
REFERENCE   8  (bases 1 to 1309)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1309)
  AUTHORS   Hamada,T., Tashiro,K., Tada,H., Inazawa,J., Shirozu,M.,
            Shibahara,K., Nakamura,T., Martina,N., Nakano,T. and Honjo,T.
  TITLE     Isolation and characterization of a novel secretory protein,
            stromal cell-derived factor-2 (SDF-2) using the signal sequence
            trap method
  JOURNAL   Gene 176 (1-2), 211-214 (1996)
   PUBMED   8918255
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ056236.1, BC001406.2,
            AC005726.1 and AW026433.1.
            
            On May 17, 2019 this sequence version replaced NM_006923.3.
            
            Summary: The protein encoded by this gene is believed to be a
            secretory protein. It has regions of similarity to hydrophilic
            segments of yeast mannosyltransferases. Its expression is
            ubiquitous and the gene appears to be relatively conserved among
            mammals. Alternate splicing results in both coding and non-coding
            variants. A pseudogene of this gene is located on chromosome 15.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.346287.1,
                                           SRR5189658.44243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247020.9/ ENSP00000247020.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BQ056236.1         267-278
            13-1060             BC001406.2         1-1048
            1061-1193           AC005726.1         9218-9350
            1194-1299           AW026433.1         3-108               c
            1300-1309           AC005726.1         9457-9466
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1309
                     /gene="SDF2"
                     /note="stromal cell derived factor 2"
                     /db_xref="GeneID:6388"
                     /db_xref="HGNC:HGNC:10675"
                     /db_xref="MIM:602934"
     exon            1..181
                     /gene="SDF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..666
                     /gene="SDF2"
                     /note="SDF-2"
                     /codon_start=1
                     /product="stromal cell-derived factor 2 precursor"
                     /protein_id="NP_008854.2"
                     /db_xref="CCDS:CCDS11238.1"
                     /db_xref="GeneID:6388"
                     /db_xref="HGNC:HGNC:10675"
                     /db_xref="MIM:602934"
                     /translation="MAVVPLLLLGGLWSAVGASSLGVVTCGSVVKLLNTRHNVRLHSH
                     DVRYGSGSGQQSVTGVTSVDDSNSYWRIRGKSATVCERGTPIKCGQPIRLTHVNTGRN
                     LHSHHFTSPLSGNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLS
                     VTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIFMKPSELLKAEAHHAEL"
     exon            182..378
                     /gene="SDF2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..1309
                     /gene="SDF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDF2"
                     /note="hexamer: AATAAT"
     polyA_site      1066
                     /gene="SDF2"
                     /note="major polyA site"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDF2"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="SDF2"
ORIGIN      
        1 gaagatttgg ggctccgcga tacagttagg atggctgtag tacctctgct gttgttgggg
       61 ggtttgtgga gcgctgtggg agcgtccagc ctgggtgtcg ttacttgcgg ctccgtggtg
      121 aagctactca atacgcgcca caacgtccga ctgcactcac acgacgtgcg ctatgggtca
      181 ggtagtgggc agcagtcagt gacaggtgta acctctgtgg atgacagcaa cagttactgg
      241 aggatacggg ggaagagtgc cacagtgtgt gagaggggaa cccccatcaa gtgtggccag
      301 cccatccggc tgacacatgt caacactggc cgaaacctcc atagtcacca cttcacttca
      361 cctctttctg gaaaccagga agtgagtgct tttggtgagg aaggtgaagg tgattatctg
      421 gatgactgga cagtgctctg taatggaccc tactgggtga gagatggtga ggtgcggttc
      481 aaacactctt ccactgaggt actgctgtct gtcacaggag aacaatatgg tcgacctatc
      541 agtgggcaaa aagaggtgca tggcatggcc cagccaagtc agaacaacta ctggaaagcc
      601 atggaaggca tcttcatgaa gcccagtgag ttgttgaagg cagaagccca ccatgcagag
      661 ctgtgaatct agaggctctg agccactgtt aacgcacaat gttcacagac atctgttgct
      721 gcctcacctt gggatccctg ccacaagttc cttgggcagt ggccatgtca ccattgagat
      781 gaagatatac aacagaaaat agtggctgtg tttggaagct tcagccctgc acatttgaac
      841 tagtcactct cccagacttg cgtgggtcag ttctttctga gtagaggact tgctggtaaa
      901 ggggcagatg ctttttatta gtactgataa aacaaactga gggaaacatc cctcttagct
      961 gggaaacttt tactcttcag gagcttggca tcatggactg ttaatgtatg tgattttccc
     1021 cctattttct ctctccaaaa tgataaaaac aataatttta ttatgagtca ctgtgttgtt
     1081 atttattagg tgtgctattt cattagctgc ttaatccttt gagtcctaag actctttgga
     1141 gacgctatga agctccaatg tgggcccttt taagagcttt tcttgcatac aaaccttttc
     1201 tccctctact ttgacttctc tccaggcatc tcatctttaa tagatctttg actaattata
     1261 gctaaaaact ctcagagaat acagcataat aaatagccag tgaaatgtt
//
