LOCUS       NM_152608               3987 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SDE2 telomere maintenance homolog (SDE2), mRNA.
ACCESSION   NM_152608
VERSION     NM_152608.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3987)
  AUTHORS   Weinheimer,A.S., Paung,Y., Rageul,J., Khan,A., Lo,N., Ho,B.,
            Tong,M., Alphonse,S., Seeliger,M.A. and Kim,H.
  TITLE     Extended DNA-binding interfaces beyond the canonical SAP domain
            contribute to the function of replication stress regulator SDE2 at
            DNA replication forks
  JOURNAL   J Biol Chem 298 (8), 102268 (2022)
   PUBMED   35850305
  REMARK    GeneRIF: Extended DNA-binding interfaces beyond the canonical SAP
            domain contribute to the function of replication stress regulator
            SDE2 at DNA replication forks.
REFERENCE   2  (bases 1 to 3987)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3987)
  AUTHORS   Floro,J., Dai,A., Metzger,A., Mora-Martin,A., Ganem,N.J.,
            Cifuentes,D., Wu,C.S., Dalal,J., Lyons,S.M., Labadorf,A. and
            Flynn,R.L.
  TITLE     SDE2 is an essential gene required for ribosome biogenesis and the
            regulation of alternative splicing
  JOURNAL   Nucleic Acids Res 49 (16), 9424-9443 (2021)
   PUBMED   34365507
  REMARK    GeneRIF: SDE2 is an essential gene required for ribosome biogenesis
            and the regulation of alternative splicing.
REFERENCE   4  (bases 1 to 3987)
  AUTHORS   Rageul,J., Park,J.J., Zeng,P.P., Lee,E.A., Yang,J., Hwang,S.,
            Lo,N., Weinheimer,A.S., Scharer,O.D., Yeo,J.E. and Kim,H.
  TITLE     SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled
            replication forks
  JOURNAL   Nat Commun 11 (1), 5495 (2020)
   PUBMED   33127907
  REMARK    GeneRIF: SDE2 integrates into the TIMELESS-TIPIN complex to protect
            stalled replication forks.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3987)
  AUTHORS   Rageul,J., Park,J.J., Jo,U., Weinheimer,A.S., Vu,T.T.M. and Kim,H.
  TITLE     Conditional degradation of SDE2 by the Arg/N-End rule pathway
            regulates stress response at replication forks
  JOURNAL   Nucleic Acids Res 47 (8), 3996-4010 (2019)
   PUBMED   30698750
  REMARK    GeneRIF: Conditional degradation of SDE2 by the Arg/N-End rule
            pathway regulates stress response at replication forks.
REFERENCE   6  (bases 1 to 3987)
  AUTHORS   Jo,U., Cai,W., Wang,J., Kwon,Y., D'Andrea,A.D. and Kim,H.
  TITLE     PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response
            to Replication Stress
  JOURNAL   PLoS Genet 12 (12), e1006465 (2016)
   PUBMED   27906959
  REMARK    GeneRIF: collectively, this study uncovers a new role for CRL4CDT2
            in protecting genomic integrity against replication stress via
            regulated proteolysis of PCNA-associated SDE2 and provides insights
            into how an integrated UBL domain within linear polypeptide
            sequence controls protein stability and function.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3987)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 3987)
  AUTHORS   Sugioka-Sugiyama,R. and Sugiyama,T.
  TITLE     Sde2: a novel nuclear protein essential for telomeric silencing and
            genomic stability in Schizosaccharomyces pombe
  JOURNAL   Biochem Biophys Res Commun 406 (3), 444-448 (2011)
   PUBMED   21333630
REFERENCE   9  (bases 1 to 3987)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB140971.1, BC016290.1 and AL133288.12.
            
            On Nov 22, 2018 this sequence version replaced NM_152608.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648319.1, SRR1803614.20450.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272091.8/ ENSP00000272091.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CB140971.1         23-78
            57-2589             BC016290.1         1-2533
            2590-2590           AL133288.12        9031-9031           c
            2591-3987           BC016290.1         2535-3931
FEATURES             Location/Qualifiers
     source          1..3987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..3987
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="SDE2 telomere maintenance homolog"
                     /db_xref="GeneID:163859"
                     /db_xref="HGNC:HGNC:26643"
                     /db_xref="MIM:620743"
     exon            1..151
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1387
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="UPF0667 protein C1orf55; protein SDE2 homolog;
                     replication stress response regulator SDE2"
                     /codon_start=1
                     /product="splicing regulator SDE2"
                     /protein_id="NP_689821.3"
                     /db_xref="CCDS:CCDS41473.1"
                     /db_xref="GeneID:163859"
                     /db_xref="HGNC:HGNC:26643"
                     /db_xref="MIM:620743"
                     /translation="MAEAAALVWIRGPGFGCKAVRCASGRCTVRDFIHRHCQDQNVPV
                     ENFFVKCNGALINTSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACR
                     DLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQKRLERLQRKLVEPKHCFTSPDYQQQC
                     HEMAERLEDSVLKGMQAASSKMVSAEISENRKRQWPTKSQTDRGASAGKRRCFWLGME
                     GLETAEGSNSESSDDDSEEAPSTSGMGFHAPKIGSNGVEMAAKFPSGSQRARVVNTDH
                     GSPEQLQIPVTDSGRHILEDSCAELGESKEHMESRMVTETEETQEKKAESKEPIEEEP
                     TGAGLNKDKETEERTDGERVAEVAPEERENVAVAKLQESQPGNAVIDKETIDLLAFTS
                     VAELELLGLEKLKCELMALGLKCGGTLQERAARLFSVRGLAKEQIDPALFAKPLKGKK
                     K"
     exon            152..269
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..381
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..551
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..672
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..1165
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..3987
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="major polyA site"
     regulatory      3865..3870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="hexamer: ATTAAA"
     polyA_site      3892
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
     regulatory      3960..3965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="hexamer: AATAAA"
     polyA_site      3987
                     /gene="SDE2"
                     /gene_synonym="C1orf55; dJ671D7.1"
                     /note="major polyA site"
ORIGIN      
        1 agagaggctt gaggttcggg tagtcggtga catggcggag gccgcggcgc tggtgtggat
       61 tcgcggccct ggcttcgggt gcaaggcggt gcggtgtgcc tcgggtcggt gcaccgtccg
      121 ggattttatc caccggcact gccaagatca gaatgttcca gtggaaaact tctttgtgaa
      181 atgcaatgga gcactcatta acaccagtga cacagtgcag catggagctg tttatagttt
      241 ggaacccaga ctttgcggtg gaaaaggagg ttttggatct atgctccgag cacttggtgc
      301 tcagattgag aagacaacca atcgagaagc ttgtcgggat ctcagtggaa ggagactacg
      361 cgatgtcaat catgaaaaag caatggctga atgggtaaaa caacaagccg agcgagaggc
      421 tgaaaaggag cagaagcggc tggagcgact gcagcggaag cttgtagaac ccaagcactg
      481 cttcaccagc cccgactacc agcagcagtg ccatgagatg gctgagcgtc tggaggattc
      541 cgtcctcaaa ggtatgcagg ctgcctccag caagatggtt tcagcagaaa tcagtgagaa
      601 tcggaaacgg caatggccta ctaaatctca aacagacaga ggagccagtg cgggaaagag
      661 gagatgcttc tggttgggca tggagggact agagactgca gaagggtcca actctgagag
      721 ttcagatgat gacagtgaag aagcaccaag cacttcagga atgggtttcc atgctccaaa
      781 aattggtagc aatggtgtcg agatggcagc caaatttccc agtggttctc agagggcgag
      841 agtagtgaat acagaccatg gatcaccaga acaactgcag atcccggtga ctgactctgg
      901 gaggcatatt ttagaagact catgtgctga gctgggggag tccaaagagc acatggaaag
      961 caggatggtt acagaaacag aagagaccca ggagaagaag gcagagagta aagaacccat
     1021 agaagaggag cccactgggg ctggactgaa taaggataaa gagacagaag aaaggactga
     1081 tggggaaaga gttgctgagg tagcacctga agaaagggaa aacgttgccg ttgccaaact
     1141 gcaggaaagc cagccaggaa acgcagttat tgataaggaa actatagatt tattggcgtt
     1201 cacctctgtt gcagaactgg agttgctggg tttggagaag ctcaaatgtg aactgatggc
     1261 ccttggactg aaatgtgggg gcactctgca ggagcgggca gcaagactct tctctgtcag
     1321 aggactggca aaggagcaaa ttgacccggc tttatttgcc aagcctttga aagggaagaa
     1381 aaaatgagta tcatcagagc tgattcctat ttgtttatag tgtctaccat ttacaacctg
     1441 cataatgtgg actcttgacc agtattcctg ttgatattaa aagctaactt tttagtaacc
     1501 caattctaac tatccccttt ttccttgtca gggctgtaga attaatgtct gaaaccatct
     1561 gggccttaaa ttttctttgt ctggttttct atagtgtatt taataaatat agggctattc
     1621 acattttttg gtttgatctt ggtgtcattt aggtaatgaa tctatccaag aaatctatcc
     1681 ttttgaccca ggttatcaaa tttgtagaca taaggttatt tataatggtc ccttcttacc
     1741 cttttaatgt ctttaggagc tgtgttgata atttcctttt cattatgata ctggtaattt
     1801 ctgttctcac tttcctaatc aggttgggta ggggtttatc agttttactg atctgacttt
     1861 ttattttatt ttattttttt tgagacagtc ttacactgtc tcccaggctg gagtgcagtg
     1921 gcgcgatctc ggcttactgc aagctctgcc ttccgggttc atgccattct cctgcctcag
     1981 cctccccagt agctgggact acaggctccc accaccacgc ccggctaatt ttttatattt
     2041 ttagtggaga ctgggtttca ctgtgttagc caggatggtc tcgatctctt tacctcgtgg
     2101 tccacccgcc tcagcctccc agagtgctgg gattacaggc gtgagccacc gtgcctggcc
     2161 gacgatataa cttttaaaga accaaccttt ggttttattt ttctcaattg tttatataat
     2221 taatttctgt tattttcttt cttctattta gcttgagtct cctttgatct tttttcttta
     2281 gttccttaag ataagcctta ggtcattgat cttagacgtt atttaaaata catatttaaa
     2341 gctatacatt ttcttttaag cattacttta gttgcgactt tacaatttta ttatgtcgta
     2401 tttttattat tcagttctaa ttttcttttt tttttctttt tgagatggaa tttcgctttt
     2461 gttgcccagg ctagagtgca atggtacgat ctcagctcac tgcaacctct gcctcctggg
     2521 ttcaagcgat tctcctgcct cagcctcctc agtagctggg attacaggct ccagccacca
     2581 tacctggctg atttttgtat ttttagtaga gatggggttt caccacattg gccaggctgg
     2641 tctcgaactc ctgacctcag gtgatccacc cactttggcc tcccaaagtg ctgggattac
     2701 aggtgtgagc caccatgccc agcctctgat tattttctaa tttcctccct cagttcttct
     2761 ttgacccatg gattatcaga agtgggttgt ctgatcagca aacatttgtt ttttttcctc
     2821 ttaatatctt cttgttgctg atttctactt taattccatt gaggtcagaa aatatcctct
     2881 ttatgatttc aatcctctta gttttattga gactcgtttt atgacccaat atgttgtctg
     2941 tcatggtgag tgtaccatac acagtttaaa agaatgcgta ttttaggcca ggtgtggtgg
     3001 ctcatgcctg taatccagca tgagattaca tgctgagatt acagctgtaa tctgtaattt
     3061 gagaggctga ggtgggagga tcatttcgag accagcctgg gcaatgtata gtgagaccat
     3121 gtctctaaga aaaacaatat gtaatttgaa ttgttgggtt aatatgtttt gtaatatcga
     3181 tgagattaag tggttgatag tattgttcag atcttctatg tctttactga tccttttgtt
     3241 tatttctatc aggtgctgag aaaggatgtt aaaatcttca attatgattg tggaattgtc
     3301 tatttcttaa attctaccag tttttgtatg aagctctaat aacttatgtc ttcctaatgt
     3361 attgaccatt ttatcattat gaaatttccc tctgtctctg gtaatttggg tttgaaatct
     3421 actttatctt atgtgaatat agccactgca gccttcttaa gcttagtgtt tgcacagtat
     3481 acctctttct attaatttac tttgtgcttc tgtgcctatt taaagtagtt tctttaaaca
     3541 acatatactt gagacttgca tttttatctg ttctctctgt atcttttaat aagtttaaca
     3601 ttaaatgtaa ttattaatag gtttctaatt tacatgtttc ctgtttagat aagattattt
     3661 tataattgta ttttaattta ttggctcttt agctatactg ttttaataat ttttttaagt
     3721 tggatgttct agtgattaca atatacattc ttaatttttc agtctaccta gagttgatgt
     3781 gccacttcac ataaaatgta gaaatcttgt aagtatgtac atccatttat catacctgtc
     3841 ttttatgctg tagttgtcat acatattaaa tctacatatt taaatattgt aagtcctgtc
     3901 ataagttaca atttctgctt taaataatga tatgtatttt aaagaaatta agaggaaaaa
     3961 ataaaatctt ttgtatttat tcacata
//
