LOCUS       NM_080489               1485 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens syndecan binding protein 2 (SDCBP2), transcript
            variant 1, mRNA.
ACCESSION   NM_080489
VERSION     NM_080489.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Du,Y., Li,L.L., Chen,F. and Du,Y.
  TITLE     Targeting SDCBP2 in acute myeloid leukemia
  JOURNAL   Cell Signal 112, 110889 (2023)
   PUBMED   37714445
  REMARK    GeneRIF: Targeting SDCBP2 in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1485)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1485)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1485)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1485)
  AUTHORS   Zimmermann,P.
  TITLE     The prevalence and significance of PDZ domain-phosphoinositide
            interactions
  JOURNAL   Biochim Biophys Acta 1761 (8), 947-956 (2006)
   PUBMED   16884951
  REMARK    Review article
REFERENCE   8  (bases 1 to 1485)
  AUTHORS   Mortier,E., Wuytens,G., Leenaerts,I., Hannes,F., Heung,M.Y.,
            Degeest,G., David,G. and Zimmermann,P.
  TITLE     Nuclear speckles and nucleoli targeting by PIP2-PDZ domain
            interactions
  JOURNAL   EMBO J 24 (14), 2556-2565 (2005)
   PUBMED   15961997
REFERENCE   9  (bases 1 to 1485)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
REFERENCE   10 (bases 1 to 1485)
  AUTHORS   Borrell-Pages,M., Fernandez-Larrea,J., Borroto,A., Rojo,F.,
            Baselga,J. and Arribas,J.
  TITLE     The carboxy-terminal cysteine of the tetraspanin L6 antigen is
            required for its interaction with SITAC, a novel PDZ protein
  JOURNAL   Mol Biol Cell 11 (12), 4217-4225 (2000)
   PUBMED   11102519
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002727.2, BU684857.1 and
            BM987490.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_080489.4.
            
            Summary: The protein encoded by this gene contains two class II PDZ
            domains. PDZ domains facilitate protein-protein interactions by
            binding to the cytoplasmic C-terminus of transmembrane proteins,
            and PDZ-containing proteins mediate cell signaling and the
            organization of protein complexes. The encoded protein binds to
            phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in
            nuclear PIP2 organization and cell division. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. Read-through transcription also exists between this
            gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa)
            gene, as represented in GeneID:100528031. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002727.2, ERR279868.3115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360779.4/ ENSP00000354013.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-778               BC002727.2         36-813
            779-1419            BU684857.1         11-651              c
            1420-1485           BM987490.1         15-80               c
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1485
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="syndecan binding protein 2"
                     /db_xref="GeneID:27111"
                     /db_xref="HGNC:HGNC:15756"
                     /db_xref="MIM:617358"
     exon            1..55
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            56..128
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..953
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="isoform a is encoded by transcript variant 1;
                     syndecan binding protein (syntenin) 2"
                     /codon_start=1
                     /product="syntenin-2 isoform a"
                     /protein_id="NP_536737.3"
                     /db_xref="CCDS:CCDS42848.1"
                     /db_xref="GeneID:27111"
                     /db_xref="HGNC:HGNC:15756"
                     /db_xref="MIM:617358"
                     /translation="MSSLYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLY
                     PNLAELENYMGLSLSSQEVQESLLQIPEGDSTAVSGPGPGQMVAPVTGYSLGVRRAEI
                     KPGVREIHLCKDERGKTGLRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDC
                     AGWSSHKAHQVVKKASGDKIVVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKG
                     SSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKL
                     PPVLLHHTMDHSIPDA"
     exon            129..198
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..299
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..458
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..634
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..806
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..898
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1485
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="hexamer: AATAAA"
     polyA_site      1419
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="major polyA site"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="hexamer: AATAAA"
     regulatory      1466..1471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
     polyA_site      1485
                     /gene="SDCBP2"
                     /gene_synonym="SITAC; SITAC18; ST-2; ST2"
ORIGIN      
        1 agattcagca gcggcagcag ctggagaagg tcgtggagca gcaccttgcc tgcagggtgt
       61 tctgagaatc agccatgtca tccctgtacc catctctaga ggacctaaaa gtggaccaag
      121 ccattcaggc ccaggtcaga gcctcaccca agatgccagc cctgccagtc caggcaacag
      181 ccatttcccc accaccagtt ttgtacccaa acttggcaga actggaaaat tatatgggtc
      241 tttccctctc cagccaagaa gtccaggaga gcctgcttca gattccagag ggtgacagta
      301 cagcggtctc gggccccggg cccggccaga tggtggcacc ggtaaccggg tacagcctgg
      361 gcgtgcggcg agctgagatc aagcccgggg tgcgcgagat ccacctgtgc aaggacgagc
      421 gcggcaagac cgggctgagg ctgcggaagg tcgaccaggg gctctttgtg cagttggtcc
      481 aggccaacac ccctgcatcc cttgtggggc tgcgctttgg ggaccagctc ctgcagattg
      541 acgggcgtga ctgtgctggg tggagctcgc acaaagccca tcaggtggtg aagaaggcat
      601 caggcgataa gattgtcgtg gtggttcggg acaggccgtt ccagcggact gtcaccatgc
      661 acaaggacag catgggccac gtcggcttcg tgatcaagaa ggggaagatt gtctctctgg
      721 tcaaagggag ttctgcggcc cgcaacgggc tcctcaccaa ccactacgtg tgtgaggtgg
      781 acgggcagaa tgttatcggg ctgaaggaca aaaagatcat ggagattctg gccacggctg
      841 ggaacgttgt caccctgacc atcatcccca gtgtgatcta cgagcacatg gtcaaaaagt
      901 tgcctccagt cctgctccac cacaccatgg accactccat cccagatgcc tgaagccact
      961 gcagggcagg gcaggcaggg ggggcttccc gccctcctgc agcaaagggc aaccaccctc
     1021 ggatgatggg ttgcagccgg cctgctgctt aaggtggggg ctgccatgag gggggcgtgt
     1081 ccaggagggt gaccatggga tggcttatac acacaggcct ccttggagcc tcagactcca
     1141 agctaggctg aggctcaggc agggcccaca ggcagccgat tctcttgtgc tgatttaaat
     1201 gctggacacg gaggcaggct gtttaaacgc tgcttaaagt cgcaactggg cccctttcaa
     1261 gaaattttgc tctaccagga aaacagttac acattttaag agaacagagc tacgttcttt
     1321 gtgagagctt tttccttgcc ttgacttgct ctttgtcaca gactgcataa gttgtcagcc
     1381 ttgactatct tttgaataaa gatttgattt taaacaaaac cctgtccgca aaggtaattg
     1441 attcccccaa aactattgaa aataaaataa aaaggtaact gaaaa
//
