LOCUS       NM_001007069            2070 bp    mRNA    linear   PRI 13-MAR-2025
DEFINITION  Homo sapiens syndecan binding protein (SDCBP), transcript variant
            4, mRNA.
ACCESSION   NM_001007069
VERSION     NM_001007069.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Yu,J., Yu,S., Bai,J., Zhu,Z., Gao,Y. and Li,Y.
  TITLE     SDCBP modulates tumor microenvironment, tumor progression and
            anti-PD1 efficacy in colorectal cancer
  JOURNAL   Cancer Gene Ther 31 (5), 755-765 (2024)
   PUBMED   38555398
  REMARK    GeneRIF: SDCBP modulates tumor microenvironment, tumor progression
            and anti-PD1 efficacy in colorectal cancer.
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Li,R., Ma,Z., Zheng,W., Xiao,Y., Wang,Z., Yi,J., Wang,Y. and
            Chen,C.
  TITLE     Anaplasma phagocytophilum Ats-1 enhances exosome secretion through
            Syntenin-1
  JOURNAL   BMC Microbiol 23 (1), 271 (2023)
   PUBMED   37759206
  REMARK    GeneRIF: Anaplasma phagocytophilum Ats-1 enhances exosome secretion
            through Syntenin-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Liu,J., Bai,W., Zhou,T., Xie,Y., Yang,B., Sun,J., Wang,Y., Li,X.,
            Hou,X., Liu,Z., Fu,D., Yan,J., Jiang,W., Zhao,K., Zhou,B., Yuan,S.,
            Guo,Y., Wang,H., Chang,A., Gao,S., Shi,L., Huang,C., Yang,S. and
            Hao,J.
  TITLE     SDCBP promotes pancreatic cancer progression by preventing YAP1
            from beta-TrCP-mediated proteasomal degradation
  JOURNAL   Gut 72 (9), 1722-1737 (2023)
   PUBMED   36828627
  REMARK    GeneRIF: SDCBP promotes pancreatic cancer progression by preventing
            YAP1 from beta-TrCP-mediated proteasomal degradation.
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Lee,K.M., Seo,E.C., Lee,J.H., Kim,H.J. and Hwangbo,C.
  TITLE     The Multifunctional Protein Syntenin-1: Regulator of Exosome
            Biogenesis, Cellular Function, and Tumor Progression
  JOURNAL   Int J Mol Sci 24 (11), 9418 (2023)
   PUBMED   37298370
  REMARK    GeneRIF: The Multifunctional Protein Syntenin-1: Regulator of
            Exosome Biogenesis, Cellular Function, and Tumor Progression.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Meyer,A., Sienes,R.E., Nijim,W., Zanotti,B., Umar,S., Volin,M.V.,
            Van Raemdonck,K., Lewis,M., Pitzalis,C., Arami,S., Al-Awqati,M.,
            Chang,H.J., Jetanalin,P., Schett,G., Sweiss,N. and Shahrara,S.
  TITLE     Syntenin-1-mediated arthritogenicity is advanced by reprogramming
            RA metabolic macrophages and Th1 cells
  JOURNAL   Ann Rheum Dis 82 (4), 483-495 (2023)
   PUBMED   36593091
  REMARK    GeneRIF: Syntenin-1-mediated arthritogenicity is advanced by
            reprogramming RA metabolic macrophages and Th1 cells.
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Fernandez-Larrea,J., Merlos-Suarez,A., Urena,J.M., Baselga,J. and
            Arribas,J.
  TITLE     A role for a PDZ protein in the early secretory pathway for the
            targeting of proTGF-alpha to the cell surface
  JOURNAL   Mol Cell 3 (4), 423-433 (1999)
   PUBMED   10230395
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Lin,D., Gish,G.D., Songyang,Z. and Pawson,T.
  TITLE     The carboxyl terminus of B class ephrins constitutes a PDZ domain
            binding motif
  JOURNAL   J Biol Chem 274 (6), 3726-3733 (1999)
   PUBMED   9920925
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Lin,J.J., Jiang,H. and Fisher,P.B.
  TITLE     Melanoma differentiation associated gene-9, mda-9, is a human gamma
            interferon responsive gene
  JOURNAL   Gene 207 (2), 105-110 (1998)
   PUBMED   9511750
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Grootjans,J.J., Zimmermann,P., Reekmans,G., Smets,A., Degeest,G.,
            Durr,J. and David,G.
  TITLE     Syntenin, a PDZ protein that binds syndecan cytoplasmic domains
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13683-13688 (1997)
   PUBMED   9391086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG772269.1, BC013254.2 and
            U83463.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001007069.1.
            
            Summary: The protein encoded by this gene was initially identified
            as a molecule linking syndecan-mediated signaling to the
            cytoskeleton. The syntenin protein contains tandemly repeated PDZ
            domains that bind the cytoplasmic, C-terminal domains of a variety
            of transmembrane proteins. This protein may also affect
            cytoskeletal-membrane organization, cell adhesion, protein
            trafficking, and the activation of transcription factors. The
            protein is primarily localized to membrane-associated adherens
            junctions and focal adhesions but is also found at the endoplasmic
            reticulum and nucleus. Alternative splicing results in multiple
            transcript variants encoding different isoforms. Related
            pseudogenes have been identified on multiple chromosomes. [provided
            by RefSeq, Jan 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013254.2, SRR14038191.1397892.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               BG772269.1         99-339
            242-298             BC013254.2         221-277
            299-468             U83463.1           268-437
            469-2070            BC013254.2         448-2049
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..2070
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /note="syndecan binding protein"
                     /db_xref="GeneID:6386"
                     /db_xref="HGNC:HGNC:10662"
                     /db_xref="MIM:602217"
     exon            1..43
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            44..109
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..952
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /note="isoform 3 is encoded by transcript variant 4;
                     melanoma differentiation associated protein-9; scaffold
                     protein Pbp1; pro-TGF-alpha cytoplasmic domain-interacting
                     protein 18; syntenin-1; syndecan binding protein
                     (syntenin); syndecan-binding protein 1"
                     /codon_start=1
                     /product="syntenin-1 isoform 3"
                     /protein_id="NP_001007070.1"
                     /db_xref="CCDS:CCDS47862.1"
                     /db_xref="GeneID:6386"
                     /db_xref="HGNC:HGNC:10662"
                     /db_xref="MIM:602217"
                     /translation="MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGN
                     LYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGLVARPSSINYMVAPVTGNDVGI
                     RRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQI
                     NGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKIT
                     SIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEH
                     IIKRMAPSIMKSLMDHTIPEV"
     exon            110..188
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            189..298
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            299..457
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            458..633
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            634..805
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            806..897
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     exon            898..2070
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /note="hexamer: AATAAA"
     polyA_site      2070
                     /gene="SDCBP"
                     /gene_synonym="MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18"
                     /note="major polyA site"
ORIGIN      
        1 agtgaccgga ggcggcggcg gcgagcggtt ccttgtgggc tagaagaatc ctgcaaaaat
       61 gtctctctat ccatctctcg aagacttgaa ggtagacaaa gtaattcagg ctcaaactgc
      121 tttttctgca aaccctgcca atccagcaat tttgtcagaa gcttctgctc ctatccctca
      181 cgatggaaat ctctatccca gactgtatcc agagctctct caatacatgg ggctgagttt
      241 aaatgaagaa gaaatacgtg caaatgtggc cgtggtttct ggtgcaccac ttcaggggtt
      301 ggtagcaaga ccttccagta taaactatat ggtggctcct gtaactggta atgatgttgg
      361 aattcgtaga gcagaaatta agcaagggat tcgtgaagtc attttgtgta aggatcaaga
      421 tggaaaaatt ggactcaggc ttaaatcaat agataatggt atatttgttc agctagtcca
      481 ggctaattct ccagcctcat tggttggtct gagatttggg gaccaagtac ttcagatcaa
      541 tggtgaaaac tgtgcaggat ggagctctga taaagcgcac aaggtgctca aacaggcttt
      601 tggagagaag attaccatga ccattcgtga caggcccttt gaacggacga ttaccatgca
      661 taaggatagc actggacatg ttggttttat ctttaaaaat ggaaaaataa catccatagt
      721 gaaagatagc tctgcagcca gaaatggtct tctcacggaa cataacatct gtgaaatcaa
      781 tggacagaat gtcattggat tgaaggactc tcaaattgca gacatactgt caacatctgg
      841 gactgtagtt actattacaa tcatgcctgc ttttatcttt gaacatatta ttaagcggat
      901 ggcaccaagc attatgaaaa gcctaatgga ccacaccatt cctgaggttt aaaattcacg
      961 gcaccatgga aatgtagctg aacgtctcca gtttccttct ttggcaactt ctgtattatg
     1021 cacgtgaagc cttcccggag ccagcgagca tatgctgcat gaggaccttt ctatcttaca
     1081 ttatggctgg gaatcttact ctttcatctg ataccttgtt cagatttcaa aatagttgta
     1141 gccttatcct ggttttacag atgtgaaact ttcaagagat ttactgactt tcctagaata
     1201 gtttctctac tggaaacctg atgcttttat aagccattgt gattaggatg actgttacag
     1261 gcttagcttt gtgtgaaaac cagtcacctt tctcctaggt aatgagtagt gctgttcata
     1321 ttactttagt tctatagcat acttgcatct ttaacatgct atcatagtac atttagaatg
     1381 attgcctttg attttttttt taaattctgt gtgtgtgtgt gtaaaatgcc aattaagaac
     1441 actggtttca ttccatgtaa gcattaaaca gtgtatgtag gtttcaagag attgtgatga
     1501 ttcttaaatt ttaactacct tcacttaata tgcttgaact gtcgccttaa ctatgttaag
     1561 catctagact aaaagccaaa atataattat tgctgccttt ctaaaaaccc aaaatgtagt
     1621 tctctattaa cctgaaatgt acactagccc agaacagttt aatggtactt actgagctat
     1681 agcatagctg cttagttgtt tttgagattt tttagtcaac acataatgga aacttctttc
     1741 ttctaaaagt tgccagtgcc acttttaaga agtgaatcac tatatgtgat gtaaaagtta
     1801 ttacactaaa caggataaac ttttgactcc ccttttgttc atttgtggat taagtggtat
     1861 aatacttaat tttggcattt gactcttaag attatgtaac ctagctactt tgggatggtc
     1921 ttagaatatt tttctgataa cttgttcctt ttcctgactc ctccttgcaa acaaaatgat
     1981 agttgacact ttatcctgat ttttttcttc tttttggttt atgtctattc taattaaata
     2041 tgtataaata aagttacatt ttagtctgtc
//
