LOCUS       NM_002999               2613 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens syndecan 4 (SDC4), mRNA.
ACCESSION   NM_002999
VERSION     NM_002999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Sertdemir,A.L., Sahin,A.T., Duran,M., Celik,M., Tatar,S., Oktay,I.
            and Alsancak,Y.
  TITLE     Association between syndecan-4 and subclinical atherosclerosis in
            ankylosing spondylitis
  JOURNAL   Medicine (Baltimore) 103 (3), e37019 (2024)
   PUBMED   38241528
  REMARK    GeneRIF: Association between syndecan-4 and subclinical
            atherosclerosis in ankylosing spondylitis.
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Pocas,J., Marques,C., Gomes,C., Otake,A.H., Pinto,F., Ferreira,M.,
            Silva,T., Faria-Ramos,I., Matos,R., Ribeiro,A.R., Senra,E.,
            Cavadas,B., Batista,S., Maia,J., Macedo,J.A., Lima,L., Afonso,L.P.,
            Ferreira,J.A., Santos,L.L., Polonia,A., Osorio,H., Belting,M.,
            Reis,C.A., Costa-Silva,B. and Magalhaes,A.
  TITLE     Syndecan-4 is a maestro of gastric cancer cell invasion and
            communication that underscores poor survival
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2214853120 (2023)
   PUBMED   37155874
  REMARK    GeneRIF: Syndecan-4 is a maestro of gastric cancer cell invasion
            and communication that underscores poor survival.
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Hudak,A., Roach,M., Pusztai,D., Pettko-Szandtner,A., Letoha,A.,
            Szilak,L., Azzouz,M. and Letoha,T.
  TITLE     Syndecan-4 Mediates the Cellular Entry of Adeno-Associated Virus 9
  JOURNAL   Int J Mol Sci 24 (4), 3141 (2023)
   PUBMED   36834552
  REMARK    GeneRIF: Syndecan-4 Mediates the Cellular Entry of Adeno-Associated
            Virus 9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Matsuzaki,Y., Wang,X., Tanino,Y. and Ikeda,K.
  TITLE     Insufficient Syndecan-4 is associated with chronic lung disease
            development in preterm infants
  JOURNAL   Pediatr Int 65 (1), e15413 (2023)
   PUBMED   36334036
  REMARK    GeneRIF: Insufficient Syndecan-4 is associated with chronic lung
            disease development in preterm infants.
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   Zhu,Y., Zheng,D., Lei,L., Cai,K., Xie,H., Zheng,J. and Yu,C.
  TITLE     High expression of syndecan-4 is related to clinicopathological
            features and poor prognosis of pancreatic adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 1042 (2022)
   PUBMED   36199068
  REMARK    GeneRIF: High expression of syndecan-4 is related to
            clinicopathological features and poor prognosis of pancreatic
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2613)
  AUTHORS   Yu,H., Humphries,D.E., Watkins,M. and Karlinsky,J.B.
  TITLE     Molecular cloning of the human ryudocan promoter
  JOURNAL   Biochem Biophys Res Commun 212 (3), 1139-1144 (1995)
   PUBMED   7626103
REFERENCE   7  (bases 1 to 2613)
  AUTHORS   Woods,A. and Couchman,J.R.
  TITLE     Syndecan 4 heparan sulfate proteoglycan is a selectively enriched
            and widespread focal adhesion component
  JOURNAL   Mol Biol Cell 5 (2), 183-192 (1994)
   PUBMED   8019004
REFERENCE   8  (bases 1 to 2613)
  AUTHORS   Barillari,G., Gendelman,R., Gallo,R.C. and Ensoli,B.
  TITLE     The Tat protein of human immunodeficiency virus type 1, a growth
            factor for AIDS Kaposi sarcoma and cytokine-activated vascular
            cells, induces adhesion of the same cell types by using integrin
            receptors recognizing the RGD amino acid sequence
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 7941-7945 (1993)
   PUBMED   7690138
REFERENCE   9  (bases 1 to 2613)
  AUTHORS   Kojima,T., Inazawa,J., Takamatsu,J., Rosenberg,R.D. and Saito,H.
  TITLE     Human ryudocan core protein: molecular cloning and characterization
            of the cDNA, and chromosomal localization of the gene
  JOURNAL   Biochem Biophys Res Commun 190 (3), 814-822 (1993)
   PUBMED   7916598
REFERENCE   10 (bases 1 to 2613)
  AUTHORS   David,G., van der Schueren,B., Marynen,P., Cassiman,J.J. and van
            den Berghe,H.
  TITLE     Molecular cloning of amphiglycan, a novel integral membrane heparan
            sulfate proteoglycan expressed by epithelial and fibroblastic cells
  JOURNAL   J Cell Biol 118 (4), 961-969 (1992)
   PUBMED   1500433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D13292.1 and AL021578.4.
            
            On Nov 23, 2018 this sequence version replaced NM_002999.3.
            
            Summary: The protein encoded by this gene is a transmembrane (type
            I) heparan sulfate proteoglycan that functions as a receptor in
            intracellular signaling. The encoded protein is found as a
            homodimer and is a member of the syndecan proteoglycan family. This
            gene is found on chromosome 20, while a pseudogene has been found
            on chromosome 22. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13292.1, SRR1803616.32426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372733.3/ ENSP00000361818.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1516              D13292.1           1-1516
            1517-1517           AL021578.4         37654-37654         c
            1518-2266           D13292.1           1517-2265
            2267-2613           D13292.1           2267-2613
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2613
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /note="syndecan 4"
                     /db_xref="GeneID:6385"
                     /db_xref="HGNC:HGNC:10661"
                     /db_xref="MIM:600017"
     exon            1..100
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..637
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /note="syndecan proteoglycan 4; syndecan 4 (amphiglycan,
                     ryudocan); ryudocan core protein; ryudocan amphiglycan"
                     /codon_start=1
                     /product="syndecan-4 precursor"
                     /protein_id="NP_002990.2"
                     /db_xref="CCDS:CCDS13350.1"
                     /db_xref="GeneID:6385"
                     /db_xref="HGNC:HGNC:10661"
                     /db_xref="MIM:600017"
                     /translation="MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPD
                     DEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTE
                     PKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILF
                     AVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA"
     exon            101..239
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /inference="alignment:Splign:2.1.0"
     exon            240..286
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /inference="alignment:Splign:2.1.0"
     exon            287..485
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..2613
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2591..2596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /note="hexamer: AATAAA"
     polyA_site      2613
                     /gene="SDC4"
                     /gene_synonym="SYND4"
                     /note="major polyA site"
ORIGIN      
        1 actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt
       61 cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat
      121 cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga
      181 tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga
      241 tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa
      301 ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga
      361 ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa
      421 caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct
      481 ggcagctctg attgtgggtg gcatcgtggg catcctcttt gccgtcttcc tgatcctact
      541 gctcatgtac cgtatgaaga agaaggatga aggcagctat gacctgggca agaaacccat
      601 ctacaagaaa gcccccacca atgagttcta cgcgtgaagc ttgcttgtgg gcactggctt
      661 ggactttagc ggggagggaa gccaggggat tttgaagggt ggacattagg gtagggtgag
      721 gtcaacctaa tactgacttg tcagtatctc cagctctgat tacctttgaa gtgttcagaa
      781 gagacattgt cttctactgt tctgccaggt tcttcttgag ctttgggcct cagttgccct
      841 ggcagaaaaa tggattcaac ttggcctttc tgaaggcaag actgggattg gatcacttct
      901 taaacttcca gttaagaatc taggtccgcc ctcaagccca tactgaccat gcctcatcca
      961 gagctcctct gaagccaggg ggctaacgga tgttgtgtgg agtcctggct ggaggtcctc
     1021 ccccagtggc cttcctccct tcctttcaca gccggtctct ctgccaggaa atgggggaag
     1081 gaactagaac cacctgcacc ttgagatgtt tctgtaaatg ggtacttgtg atcacactac
     1141 gggaatctct gtggtatata cctggggcca ttctaggctc tttcaagtga cttttggaaa
     1201 tcaacctttt ttatttgggg gggaggatgg ggaaaagagc tgagagttta tgctgaaatg
     1261 gatttataga atatttgtaa atctattttt agtgtttgtt cgttttttta actgttcatt
     1321 cctttgtgca gagtgtatat ctctgcctgg gcaagagtgt ggaggtgccg aggtgtcttc
     1381 attctctcgc acatttccac agcacctgct aagtttgtat ttaatggttt ttgtttttgt
     1441 ttttgtttgt ttcttgaaaa tgagagaaga gccggagaga tgatttttat taattttttt
     1501 tttttttttt tttttttact atttatagct ttagataggg cctcccttcc cctcttcttt
     1561 ctttgttctc tttcattaaa ccccttcccc agtttttttt ttatacttta aaccccgctc
     1621 ctcatggcct tggccctttc tgaagctgct tcctcttata aaatagcttt tgccgaaaca
     1681 tagttttttt ttagcagatc ccaaaatata atgaagggga tggtgggata tttgtgtctg
     1741 tgttcttata atatattatt attcttcctt ggttctagaa aaatagataa atatattttt
     1801 ttcaggaaat agtgtggtgt ttccagtttg atgttgctgg gtggttgagt gagtgaattt
     1861 tcatgtggct gggtgggttt ttgccttttt ctcttgccct gttcctggtg ccttctgatg
     1921 gggctggaat agttgaggtg gatggttcta ccctttctgc cttctgtttg ggacccagct
     1981 ggtgttcttt ggtttgcttt cttcaggctc tagggctgtg ctatccaata cagtaaccac
     2041 atgcggctgt ttaaagttaa gccaattaaa atcacataag attaaaaatt ccttcctcag
     2101 ttgcactaac cacgtttcta gaggcgtcac tgtatgtagt tcatggctac tgtactgaca
     2161 gcgagagcat gtccatctgt tggacagcac tattctagag aactaaactg gcttaacgag
     2221 tcacagcctc agctgtgctg ggacgaccct tgtctccctg ggtagggggg ggggaatggg
     2281 ggagggctga tgaggcccca gctggggcct gttgtctggg accctccctc tcctgagagg
     2341 ggaggcctgg tggcttagcc tgggcaggtc gtgtctcctc ctgaccccag tggctgcggt
     2401 gaggggaacc accctccctt gctgcaccag tggccattag ctcccgtcac cactgcaacc
     2461 cagggtccca gctggctggg tcctcttctg cccccagtgc ccttcccctt gggctgtgtt
     2521 ggagtgagca cctcctctgt aggcacctct cacactgttg tctgttactg attttttttg
     2581 ataaaaagat aataaaacct ggtactttct aaa
//
