LOCUS       NM_014654               5246 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens syndecan 3 (SDC3), mRNA.
ACCESSION   NM_014654 XM_375712
VERSION     NM_014654.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Xiao,X., Li,R., Wu,C., Yan,Y., Yuan,M., Cui,B., Zhang,Y., Zhang,C.,
            Zhang,X., Zhang,W., Hui,R. and Wang,Y.
  TITLE     A genome-wide association study identifies a novel association
            between SDC3 and apparent treatment-resistant hypertension
  JOURNAL   BMC Med 20 (1), 463 (2022)
   PUBMED   36447229
  REMARK    GeneRIF: A genome-wide association study identifies a novel
            association between SDC3 and apparent treatment-resistant
            hypertension.
            Erratum:[BMC Med. 2022 Dec 20;20(1):491. doi:
            10.1186/s12916-022-02717-2.. PMID: 36539737]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5246)
  AUTHORS   Hillemeyer,L., Espinoza-Sanchez,N.A., Greve,B., Hassan,N.,
            Chelariu-Raicu,A., Kiesel,L. and Gotte,M.
  TITLE     The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes
            Ovarian Cancer Pathogenesis
  JOURNAL   Int J Mol Sci 23 (10), 5793 (2022)
   PUBMED   35628603
  REMARK    GeneRIF: The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3
            Promotes Ovarian Cancer Pathogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5246)
  AUTHORS   Santos,N.J., Barquilha,C.N., Barbosa,I.C., Macedo,R.T., Lima,F.O.,
            Justulin,L.A., Barbosa,G.O., Carvalho,H.F. and Felisbino,S.L.
  TITLE     Syndecan Family Gene and Protein Expression and Their Prognostic
            Values for Prostate Cancer
  JOURNAL   Int J Mol Sci 22 (16), 8669 (2021)
   PUBMED   34445387
  REMARK    GeneRIF: Syndecan Family Gene and Protein Expression and Their
            Prognostic Values for Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5246)
  AUTHORS   Hudak,A., Josvay,K., Domonkos,I., Letoha,A., Szilak,L. and
            Letoha,T.
  TITLE     The Interplay of Apoes with Syndecans in Influencing Key Cellular
            Events of Amyloid Pathology
  JOURNAL   Int J Mol Sci 22 (13), 7070 (2021)
   PUBMED   34209175
  REMARK    GeneRIF: The Interplay of Apoes with Syndecans in Influencing Key
            Cellular Events of Amyloid Pathology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5246)
  AUTHORS   Ding,Y., Tan,X., Abasi,A., Dai,Y., Wu,R., Zhang,T., Li,K., Yan,M.
            and Huang,X.
  TITLE     LncRNA TRPM2-AS promotes ovarian cancer progression and cisplatin
            resistance by sponging miR-138-5p to release SDC3 mRNA
  JOURNAL   Aging (Albany NY) 13 (5), 6832-6848 (2021)
   PUBMED   33621194
  REMARK    GeneRIF: LncRNA TRPM2-AS promotes ovarian cancer progression and
            cisplatin resistance by sponging miR-138-5p to release SDC3 mRNA.
REFERENCE   6  (bases 1 to 5246)
  AUTHORS   Nakanishi,T., Kadomatsu,K., Okamoto,T., Ichihara-Tanaka,K.,
            Kojima,T., Saito,H., Tomoda,Y. and Muramatsu,T.
  TITLE     Expression of syndecan-1 and -3 during embryogenesis of the central
            nervous system in relation to binding with midkine
  JOURNAL   J Biochem 121 (2), 197-205 (1997)
   PUBMED   9089390
REFERENCE   7  (bases 1 to 5246)
  AUTHORS   Chernousov,M.A., Stahl,R.C. and Carey,D.J.
  TITLE     Schwann cells secrete a novel collagen-like adhesive protein that
            binds N-syndecan
  JOURNAL   J Biol Chem 271 (23), 13844-13853 (1996)
   PUBMED   8662884
REFERENCE   8  (bases 1 to 5246)
  AUTHORS   Raulo,E., Chernousov,M.A., Carey,D.J., Nolo,R. and Rauvala,H.
  TITLE     Isolation of a neuronal cell surface receptor of heparin binding
            growth-associated molecule (HB-GAM). Identification as N-syndecan
            (syndecan-3)
  JOURNAL   J Biol Chem 269 (17), 12999-13004 (1994)
   PUBMED   8175719
REFERENCE   9  (bases 1 to 5246)
  AUTHORS   Chernousov,M.A. and Carey,D.J.
  TITLE     N-syndecan (syndecan 3) from neonatal rat brain binds basic
            fibroblast growth factor
  JOURNAL   J Biol Chem 268 (22), 16810-16814 (1993)
   PUBMED   8344959
REFERENCE   10 (bases 1 to 5246)
  AUTHORS   Carey,D.J., Evans,D.M., Stahl,R.C., Asundi,V.K., Conner,K.J.,
            Garbes,P. and Cizmeci-Smith,G.
  TITLE     Molecular cloning and characterization of N-syndecan, a novel
            transmembrane heparan sulfate proteoglycan
  JOURNAL   J Cell Biol 117 (1), 191-201 (1992)
   PUBMED   1556152
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445235.30, AF248634.1 and
            BQ887307.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014654.3.
            
            Summary: The protein encoded by this gene belongs to the syndecan
            proteoglycan family. It may play a role in the organization of cell
            shape by affecting the actin cytoskeleton, possibly by transferring
            signals from the cell surface in a sugar-dependent mechanism.
            Allelic variants of this gene have been associated with obesity.
            [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF248634.1, DRR138527.701311.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142586,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339394.7/ ENSP00000344468.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL445235.30        77005-77129         c
            126-1078            AF248634.1         8-960
            1079-1582           BQ887307.1         272-775
            1583-5246           AL445235.30        37837-41500         c
FEATURES             Location/Qualifiers
     source          1..5246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..5246
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /note="syndecan 3"
                     /db_xref="GeneID:9672"
                     /db_xref="HGNC:HGNC:10660"
                     /db_xref="MIM:186357"
     exon            1..310
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1501
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /note="syndecan proteoglycan 3; syndecan neural type;
                     N-syndecan"
                     /codon_start=1
                     /product="syndecan-3"
                     /protein_id="NP_055469.3"
                     /db_xref="CCDS:CCDS30661.1"
                     /db_xref="GeneID:9672"
                     /db_xref="HGNC:HGNC:10660"
                     /db_xref="MIM:186357"
                     /translation="MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRA
                     AGAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPD
                     VALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVS
                     TTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTT
                     VATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTL
                     PLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVV
                     AVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVG
                     GVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA"
     exon            311..428
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1042
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1334
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..5246
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5057..5062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /note="hexamer: AAGAAA"
     polyA_site      5078
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
     regulatory      5226..5231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /note="hexamer: AATAAA"
     polyA_site      5246
                     /gene="SDC3"
                     /gene_synonym="SDCN; SYND3"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgcgg agctgcgagg cggagccggg cggccgagcc gggagcccgc gagcctagag
       61 cgcgtcggtc cagccgccgg gccgcgccgc cgccaagcag ccgccccgcg cgccgcgcct
      121 cgggaacaaa ggcgcccgcc cgccgcccgc cgcccgcgcc cgcgccgccg ccatgaagcc
      181 ggggccgccg caccgtgccg gggccgccca cggggccggc gccggggccg gggccgcggc
      241 cgggcccggg gcccgcgggc tgctcctgcc accgctgctg ctgctgctgc tggcggggcg
      301 cgccgcgggg gcccagcgct ggcgcagtga gaacttcgag agacccgtgg acctggaggg
      361 ctctggggat gatgactcct ttcccgatga tgaactggat gacctctact cggggtcggg
      421 ctcgggctac ttcgagcagg agtcgggcat tgagacagcc atgcgcttca gcccagatgt
      481 agccctggcg gtgtccacca cacctgcggt gctgcccacc acgaacatcc agcctgtggg
      541 cacaccattt gaagagctcc cctctgagcg ccccaccctg gagccagcca ccagccccct
      601 ggtggtgaca gaagtcccgg aagagcccag ccagagagcc accaccgtct ccactaccat
      661 ggctaccact gctgccacaa gcacagggga cccgactgtg gccacagtgc ctgccacagt
      721 ggccaccgcc acccccagca cccctgcagc accccctttt acggccacca ctgctgttat
      781 aaggaccact ggcgtacgga ggcttctgcc tctcccactg accacagtgg ctacggcacg
      841 ggccactacc cccgaggcgc cctccccgcc caccacggcg gctgtcttgg acaccgaggc
      901 cccaacaccc aggctggtca gcacagctac ctcccggcca agagcccttc ccaggccggc
      961 caccacccag gagcctgaca tccctgagag gagcaccctg cccctgggga ccactgcccc
     1021 tggacccaca gaggtggctc agaccccaac tccagagacc ttcctgacca caatccggga
     1081 tgagccagag gttccggtga gtggggggcc cagtggagac ttcgagctgc cagaagaaga
     1141 gaccacacaa ccagacacag ccaatgaggt ggtagctgtg ggaggggctg cggccaaggc
     1201 atcatctcca cctgggacac tgcccaaggg tgcccgcccg ggccctggcc tcctggacaa
     1261 tgccatcgac tcgggcagct cagctgctca gctgcctcag aagagtatcc tggagcggaa
     1321 ggaggtgctc gtagctgtga ttgtgggcgg ggtggtgggc gccctctttg ctgccttctt
     1381 ggtcacactg ctcatctatc gtatgaagaa aaaggatgag ggcagctaca cgctggagga
     1441 acccaagcag gcgagcgtca cataccagaa gcctgacaag caggaggagt tctatgccta
     1501 gtggagccac agtgcctccc tgcagcctca acaccaccct gctgtccagt ccccagcctg
     1561 gccccaccag cccaagcctg ggactgggcc tggaacctgg ccccagttct tctctgccct
     1621 ctctcccaag gtctgcccag gctgccagcc tcacacagat cttccccgag gaagaggggc
     1681 tgctgccatc tgccccagac tgtgccctta cgagctcatc tcttgttccc ctcatccctg
     1741 ccaccagtct ggggcttcag gacctcatgt cagatggatg ggaggaagaa agctcctgat
     1801 tggctggtgg tggaagaaag ggtggggctt gagatgagcc tgagccctga cttggcaccc
     1861 acagtgctca ctgagatctc ctttttgggg cagagaggca ctcaggctgg tttccaggac
     1921 aaacatttgg taaacacagc ccttgaaatc atctagacac tgcaacctct tgctcgtatc
     1981 ccagggcctc tctctagctg ggtgagaggg tgtcccttgt caccagcctg ttttgtcctg
     2041 gtctctctgg ggttgttgaa tctctcctct tgcctgccaa gtacacatgt acccagactt
     2101 catttctttc tgcatcttcc cccaagaaac agcttcctga gggtgctggg gcagccactg
     2161 gtgaggaggg gctgctctga tgtccctcct atgaggggac tctgcacaga caccattgcc
     2221 cacactatca ccatattttc actcagtcac acacaagaca aaagcatgca atgacaaaac
     2281 catacgcaat cctgaccgcc cagccaatca agacatatca cagaacacac gcgtccttcc
     2341 aagaatgttt atcctcatgc atcacttaca cacccccaga cacgtactgc aatgcaagtc
     2401 actagtcatg gtcacatgac agtgacagtg tggcctcctc ctaccccaaa tacacccaca
     2461 ctctggcacc acacacattg tctccagctt tcaggcttac tggggagggt ggaatcgagc
     2521 cagaacaatc agcccatatt gggtccccct aagttgcccc gtcatactca gtcccatgcc
     2581 atggtgccca caccaaccat gcagccgcca accccagcca gtgtcagaca caatcccatg
     2641 tggatgcaca gtctcactcc acatgacctg ctctcaatgc tggagggaaa caggcaggcc
     2701 cttgcctttc tcggaaaaag tgtggggcca cagccctttt agggcattgc atgcaggtgg
     2761 gcctggcttc acccctacct gcttcctccc caccgcagct ggcagagggg gaggtttggg
     2821 gccagacccc cactagctgg gagcctgggg gctcctctaa ggctgaggaa ggaaatttgg
     2881 ccccaggttg ttggggggtc ttgggtctcc caggacggaa ggcccagggc agggaggggg
     2941 catgtggttg ggctccttta tctccctgtg tccccttcct gctttgagct agggggctga
     3001 ctctgcctcc caggacacaa gtctccaaag tgcctgtgag ggcgggccct ccgcaccctc
     3061 tgccctctgc ctggcaggcc aacctcagcc cacctgccca gaggccctcc ctgtggacac
     3121 cccctcacct atttggccaa acaattctgg ctgcagcttc aggggccatg gctggaagca
     3181 gcccctgcag atccctcagg ccccgaggtc agggtttgag ggatgagacc aggtgatagt
     3241 gggggagggg ttacttcctt tgttacctag caagtagggc tatttccatc ggtattttaa
     3301 atgtggggtc acagatcttt tggggagggt gtgcttggca gggggcctct tggagccaaa
     3361 gggatgtggt gtgagttgcg attggctggc actcacaccc ccacccctca cccacatccc
     3421 agattcaagt caggaaggca ggttttattt cagggccctt ttcaagatgc cctggcagca
     3481 gatttctgca ggatgagggg tagcggtgtg taggcagtga gggggaggtt ccaggggctg
     3541 tcccacagcc tgtcttttcc aggctgggct ccatcttcca gtcccaaaac cctccttcac
     3601 agggcccaga ggcttgtgag gaagccaggt ggacccagcc ttagaagagt gggcatgggg
     3661 ggcccctgat atctggaggg ggcgggttgg cctcagtcat ctttggagca gaagggctgg
     3721 gtcctggggc cacagaccac aaggctcagc ctccctaccc tgctccctgg ggtgctgctg
     3781 tcttggagag cacagctctg gtgagacggc ctgggcaggc cgaggctgag aaaccaggga
     3841 ggatagagga gaaaagggct tgggccccca gccccagaag atgctggacc ccaggtggga
     3901 gacccaacag tgggtgcagt ttctcagtag ggctggagcc aatggtgggg gtggccccgg
     3961 caggcctggc tcctcacatc ccaggggttg gcttctgatt tggggcttgg gctccaggca
     4021 ctggcttctc ttctctgtgt ccttagcatt tgagagaaga ggccaggggc cttgttcatg
     4081 gatccctgga cccaaggcag atgtccaggc tttatcctcc tgaggatgag gagtctgacc
     4141 agcccaaatc tgccctggcc ggcctgaccg gggcaaggca gtccaagaga gttcagtgag
     4201 gaccagctag gctctcccag gtgcaatgtg ggtgcagggc cctcatgtcc ccctacccct
     4261 gcctgtgatg gagtgttctg aggggctttg gcatttgctg gaagcacagg gagttccaaa
     4321 tgagagggag cttctgtggc ttgagagcct ctggggcctt ggctgccaga gcacgaggca
     4381 ggccaggacc tggagagccc agaccctgtc tccaggaggc caggaggcca gatgggggcc
     4441 ttgcctgaaa gactggtccc cttgatcgct ggaggcatgt gggtggcaac cagggctggg
     4501 cagggcttag ggtgtgtggg ccaaaccccc ctggggttgg caaagccgcc tgtcaggcct
     4561 cctggtgggg gcccctggac acagggagca gaccctctgc ctcatggggt aggagtggct
     4621 gcctcctgtg ttctctggat ttcttctccc aacaactaca accctggact tgcctcccca
     4681 ggcctcttgc ctgtaaatag aagcccgcaa actgtacaga tttacagagg catcgagact
     4741 gggccctggg agttgccatc tgagagccga tggccccagc atcccccagg tgcctgcctg
     4801 gcaccacagt gaccctggcc tcagcgtggc aaatgcatgt aaatattttt cgtaggcagc
     4861 gtggctccag agagccccct gaagacagtg tccctccctc ctgtgagtcc tttctcctgt
     4921 acagaacctg cctggggtgg gtgggggtct gccattccct cccccaggcc ttccctgccc
     4981 cttctctccc ctgtaacctg tttattaacc atacctgtcc tgagttcatg gccaaaacct
     5041 taaataagaa aaacaaaaga aaaagacagt ggaaaaaaga gaccaaggcg cctgccccac
     5101 tgcgggtact ctcctgttcc agccttgtga aggaactggt tttgtttttg tttttttttt
     5161 tttttttttt tttttgtttg tttgtttttt taacacttcc tgtgctgtgc ccatttataa
     5221 gaggaaataa aattaagctg aaatga
//
