LOCUS       NM_002998               3307 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens syndecan 2 (SDC2), mRNA.
ACCESSION   NM_002998
VERSION     NM_002998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Li,B., Liu,S., Gao,Y., Zheng,L. and Lu,Y.
  TITLE     Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA
            for colorectal cancer screening
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 10241-10253 (2023)
   PUBMED   37270460
  REMARK    GeneRIF: Combined detection of SDC2/ADHFE1/PPP2R5C methylation in
            stool DNA for colorectal cancer screening.
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   You,L., Dou,Y., Zhang,Y., Xiao,H., Lv,H., Wei,G.H. and Xu,D.
  TITLE     SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression
            through Co-option of PDK1
  JOURNAL   Int J Biol Sci 19 (11), 3483-3498 (2023)
   PUBMED   37496999
  REMARK    GeneRIF: SDC2 Stabilization by USP14 Promotes Gastric Cancer
            Progression through Co-option of PDK1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Siri,G., Alesaeidi,S., Dizghandi,S.E., Alani,B., Mosallaei,M. and
            Soosanabadi,M.
  TITLE     Analysis of SDC2 gene promoter methylation in whole blood for
            noninvasive early detection of colorectal cancer
  JOURNAL   J Cancer Res Ther 18 (Supplement), S354-S358 (2022)
   PUBMED   36510988
  REMARK    GeneRIF: Analysis of SDC2 gene promoter methylation in whole blood
            for noninvasive early detection of colorectal cancer.
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Beauvais,D.M., Nelson,S.E., Adams,K.M., Stueven,N.A., Jung,O. and
            Rapraeger,A.C.
  TITLE     Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with
            EGFR and RON kinase to sustain carcinoma cell cycle progression
  JOURNAL   J Biol Chem 298 (6), 102029 (2022)
   PUBMED   35569509
  REMARK    GeneRIF: Plasma membrane proteoglycans syndecan-2 and syndecan-4
            engage with EGFR and RON kinase to sustain carcinoma cell cycle
            progression.
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Lin,J., Zhang,L., Chen,M., Chen,J., Wu,Y., Wang,T., Lu,Y., Ba,Z.,
            Cheng,X., Xu,R., Tian,T., Sun,A., Zhang,T. and Chen,M.
  TITLE     Evaluation of combined detection of multigene mutation and
            SDC2/SFRP2 methylation in stool specimens for colorectal cancer
            early diagnosis
  JOURNAL   Int J Colorectal Dis 37 (6), 1231-1238 (2022)
   PUBMED   35499710
  REMARK    GeneRIF: Evaluation of combined detection of multigene mutation and
            SDC2/SFRP2 methylation in stool specimens for colorectal cancer
            early diagnosis.
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Brown,K.J. and Parish,C.R.
  TITLE     Histidine-rich glycoprotein and platelet factor 4 mask heparan
            sulfate proteoglycans recognized by acidic and basic fibroblast
            growth factor
  JOURNAL   Biochemistry 33 (46), 13918-13927 (1994)
   PUBMED   7524669
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Labarrere,C.A., Pitts,D., Halbrook,H. and Faulk,W.P.
  TITLE     Natural anticoagulant pathways in normal and transplanted human
            hearts
  JOURNAL   J Heart Lung Transplant 11 (2 Pt 1), 342-347 (1992)
   PUBMED   1315572
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Sage,H., Vernon,R.B., Funk,S.E., Everitt,E.A. and Angello,J.
  TITLE     SPARC, a secreted protein associated with cellular proliferation,
            inhibits cell spreading in vitro and exhibits Ca+2-dependent
            binding to the extracellular matrix
  JOURNAL   J Cell Biol 109 (1), 341-356 (1989)
   PUBMED   2745554
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Marynen,P., Zhang,J., Cassiman,J.J., Van den Berghe,H. and David,G.
  TITLE     Partial primary structure of the 48- and 90-kilodalton core
            proteins of cell surface-associated heparan sulfate proteoglycans
            of lung fibroblasts. Prediction of an integral membrane domain and
            evidence for multiple distinct core proteins at the cell surface of
            human lung fibroblasts
  JOURNAL   J Biol Chem 264 (12), 7017-7024 (1989)
   PUBMED   2523388
REFERENCE   10 (bases 1 to 3307)
  AUTHORS   Lories,V., De Boeck,H., David,G., Cassiman,J.J. and Van den
            Berghe,H.
  TITLE     Heparan sulfate proteoglycans of human lung fibroblasts. Structural
            heterogeneity of the core proteins of the hydrophobic
            cell-associated forms
  JOURNAL   J Biol Chem 262 (2), 854-859 (1987)
   PUBMED   2948951
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK825252.1, BC049836.1,
            BC030133.2 and AA114891.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002998.3.
            
            Summary: The protein encoded by this gene is a transmembrane (type
            I) heparan sulfate proteoglycan and is a member of the syndecan
            proteoglycan family. The syndecans mediate cell binding, cell
            signaling, and cytoskeletal organization and syndecan receptors are
            required for internalization of the HIV-1 tat protein. The
            syndecan-2 protein functions as an integral membrane protein and
            participates in cell proliferation, cell migration and cell-matrix
            interactions via its receptor for extracellular matrix proteins.
            Altered syndecan-2 expression has been detected in several
            different tumor types. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.250362.1,
                                           SRR1660809.243341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302190.9/ ENSP00000307046.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               CK825252.1         179-364
            187-669             BC049836.1         64-546
            670-3289            BC030133.2         815-3434
            3290-3307           AA114891.1         20-37               c
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..3307
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="syndecan 2"
                     /db_xref="GeneID:6383"
                     /db_xref="HGNC:HGNC:10659"
                     /db_xref="MIM:142460"
     exon            1..519
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1065
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="syndecan proteoglycan 2; heparan sulfate
                     proteoglycan 1, cell surface-associated; fibroglycan;
                     heparan sulfate proteoglycan core protein; cell
                     surface-associated heparan sulfate proteoglycan 1"
                     /codon_start=1
                     /product="syndecan-2 precursor"
                     /protein_id="NP_002989.2"
                     /db_xref="CCDS:CCDS6272.1"
                     /db_xref="GeneID:6383"
                     /db_xref="HGNC:HGNC:10659"
                     /db_xref="MIM:142460"
                     /translation="MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVY
                     PIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTK
                     SPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFA
                     IFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA"
     exon            520..631
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..765
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..901
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..3307
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="hexamer: AATAAA"
     polyA_site      2160
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="major polyA site"
     regulatory      2936..2941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="hexamer: ATTAAA"
     polyA_site      2958
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="hexamer: AATAAA"
     regulatory      3284..3289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
                     /note="hexamer: AGTAAA"
     polyA_site      3289
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
     polyA_site      3307
                     /gene="SDC2"
                     /gene_synonym="CD362; HSPG; HSPG1; SYND2"
ORIGIN      
        1 agataccccc ggagctccag ccgcgcggat cgcgcgctcc cgccgctctg cccctaaact
       61 tctgccgtag ctccctttca agccagcgaa tttattcctt aaaaccagaa actgaacctc
      121 ggcacgggaa aggagtccgc ggaggagcaa aaccacagca gagcaagaag agcttcagag
      181 agcagccttc ccggagcacc aactccgtgt cgggagtgca gaaaccaaca agtgagaggg
      241 cgccgcgttc ccggggcgca gctgcgggcg gcgggagcag gcgcaggagg aggaagcgag
      301 cgcccccgag ccccgagccc gagtccccga gcctgagccg caatcgctgc ggtactctgc
      361 tccggattcg tgtgcgcggg ctgcgccgag cgctgggcag gaggcttcgt tttgccctgg
      421 ttgcaagcag cggctgggag cagccggtcc ctggggaata tgcggcgcgc gtggatcctg
      481 ctcaccttgg gcttggtggc ctgcgtgtcg gcggagtcga gagcagagct gacatctgat
      541 aaagacatgt accttgacaa cagctccatt gaagaagctt caggagtgta tcctattgat
      601 gacgatgact acgcttctgc gtctggctcg ggagctgatg aggatgtaga gagtccagag
      661 ctgacaacat ctcgaccact tccaaagata ctgttgacta gtgctgctcc aaaagtggaa
      721 accacgacgc tgaatataca gaacaagata cctgctcaga caaagtcacc tgaagaaact
      781 gataaagaga aagttcacct ctctgactca gaaaggaaaa tggacccagc cgaagaggat
      841 acaaatgtgt atactgagaa acactcagac agtctgttta aacggacaga agtcctagca
      901 gctgtcattg ctggtggagt tattggcttt ctctttgcaa tttttcttat cctgctgttg
      961 gtgtatcgca tgagaaagaa ggatgaagga agctatgacc ttggagaacg caaaccatcc
     1021 agtgctgctt atcagaaggc acctactaag gagttttatg cgtaaaactc caacttagtg
     1081 tctctattta tgagatcact gaacttttca aaataaagct tttgcataga ataatgaaga
     1141 tctttgtttt ttgttttcat taaagagcca ttctggcact ttaatgataa aatcccattg
     1201 tatttaaaac atttcatgta tttctttaga acaacataaa attaaaattt aacatctgca
     1261 gtgttctgtg aatagcagtg gcaaaatatt atgttatgaa aaccctcgat gttcatggaa
     1321 ttggtttaaa cttttatgcg caaatacaaa atgattgtct ttttcctatg actcaaagat
     1381 gaaagctgtt tcatttgtgt cagcatgtct cagattgacc ttaccaagtt ggtcttactt
     1441 tgttaattta tctgttgtcc ccttcctctc ctctgccctc ccttcttgtg cccttaaaac
     1501 caaaccctat gccttttgta gctgtcatgg tgcaatttgt ctttggaaaa ttcagataat
     1561 ggtaatttag tgtatatgtg attttcaaat atgtaaactt taacttccac tttgtataaa
     1621 tttttaagtg tcagactatc cattttacac ttgctttatt tttcattacc tgtagctttg
     1681 ggcagatttg caacagcaaa ttaatgtgta aaattggatt attactacaa aaccgtttag
     1741 tcatatctat ctaatcagat cttcttttgg gaggatttga tgtaagttac tgacaagcct
     1801 cagcaaaccc aaagatgtta acagtatttt aagaagttgc tgcagattcc tttggccact
     1861 gtatttgtta atttcttgca atttgaaggt acgagtagag gtttaaagaa aaatcagttt
     1921 ttgttcttaa aaatgcattt aagttgtaaa cgtcttttta agcctttgaa gtgcctctga
     1981 ttctatgtaa cttgttgcag actggtgtta atgagtatat gtaacagttt aaaaaaaaag
     2041 ttggtatttt ataagcacag acaattctaa tggtaacttt tgtagtctta tgaatagaca
     2101 taaattgtaa tttgggaaca taaaaactac tgaataaatc atgtggccta atattgaaaa
     2161 tgtcactgtt ataaattttg tacatttttg atcaaatgta catctcccct ttgctaacgg
     2221 ccgtctgctc tcaaggatga cgtgggtttg atttctaagt gtttcacagt gtctgtaaat
     2281 caagaccaaa gagcctgtcg atgagactgt ttattaccag attcacttct gaattggcca
     2341 gaggaaatct gaatgtatta tcctgtgtgt gtctaggtag agatattgga aggctgccag
     2401 gggatttcga agtttgcaac ctttatagga taactgatgg caatattaag acagacgcct
     2461 gcttttgcaa ataacttaca agactgtaaa ttccaaagat ctgaatgggg ctttcctgat
     2521 gttggtatct aaggcttagg cctatagatt gatttacctt tggaattgtg ctccaaatgt
     2581 ctactgaagc ttaaccgaag aactaataaa tggactacag tagctcacgt tacagggaag
     2641 gagggtaggc agggaggctc tgtgtgttaa aatgagggtc tcactgcttt aggattgaag
     2701 tggctggaaa gagtgatgcc tggggaagga gatggagtta tgagggtact gtggctggta
     2761 ctttctgtac taaacatttc ctttttctat tttaccacta attttgtttt aaactgtgag
     2821 ccgtccaagt cagaagaaga cagcaaaaaa agcaactttt ccaacataca atttactttt
     2881 aataaagtat gaatatttca ttttgagaac attccctgga attgccacat aattcattaa
     2941 aaacattttt ttaagcaaca cttggaacag tgtttacttt aaatccttaa tggccttaat
     3001 taattctcag attcctgccc catcacttac agaaccaatt cactttagag tgactaaaag
     3061 gaaacgatag cctagctttc taaagccacg ctgtgtccct caattacaga gggtaggaat
     3121 gggtatacct ctaactgtgc aaagcagagt gaaattcaat tcatagaata acaactgctg
     3181 ggaatatccg tgccaggaaa agaaaaattt ctggcaaata ttttgtcact gctgtaaagc
     3241 aaaatatttg tgaaagtgcc aaaataaagt ctgtcatgcc aaaagtaaat cattgtatag
     3301 actgaca
//
