LOCUS       NM_018115               3003 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens SDA1 domain containing 1 (SDAD1), transcript variant
            1, mRNA.
ACCESSION   NM_018115
VERSION     NM_018115.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Zhang,Y., Liang,X., Luo,S., Chen,Y., Li,Y., Ma,C., Li,N. and Gao,N.
  TITLE     Visualizing the nucleoplasmic maturation of human pre-60S ribosomal
            particles
  JOURNAL   Cell Res 33 (11), 867-878 (2023)
   PUBMED   37491604
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Zeng,M., Zhu,L., Li,L. and Kang,C.
  TITLE     miR-378 suppresses the proliferation, migration and invasion of
            colon cancer cells by inhibiting SDAD1
  JOURNAL   Cell Mol Biol Lett 22, 12 (2017)
   PUBMED   28725241
  REMARK    GeneRIF: miR-378 inhibits the proliferation, migration and invasion
            of colon cancer cells by targeting SDAD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Fox,M., Urano,J. and Reijo Pera,R.A.
  TITLE     Identification and characterization of RNA sequences to which human
            PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind
  JOURNAL   Genomics 85 (1), 92-105 (2005)
   PUBMED   15607425
  REMARK    GeneRIF: PUM2 and DAZL, are capable of binding the same mRNA
            sequences in the 3'UTR of human SDAD1 mRNA.
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Babbio,F., Farinacci,M., Saracino,F., Carbone,M.L. and Privitera,E.
  TITLE     Expression and localization studies of hSDA, the human ortholog of
            the yeast SDA1 gene
  JOURNAL   Cell Cycle 3 (4), 486-490 (2004)
   PUBMED   14976432
  REMARK    GeneRIF: hSDA is the human ortholog of the yeast SDA1 gene
REFERENCE   7  (bases 1 to 3003)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BJ989617.1, BC048351.1, AK001360.1 and BU619826.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018115.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.107927.1,
                                           SRR1803616.247190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356260.10/ ENSP00000348596.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               BJ989617.1         25-275
            252-1215            BC048351.1         1-964
            1216-1827           AK001360.1         968-1579
            1828-2149           BC048351.1         1577-1898
            2150-2751           AK001360.1         1902-2503
            2752-3003           BU619826.1         14-265              c
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..3003
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /note="SDA1 domain containing 1"
                     /db_xref="GeneID:55153"
                     /db_xref="HGNC:HGNC:25537"
     exon            1..194
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2168
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SDA1 homolog; nucleolar protein 130; SDA1
                     domain-containing protein 1"
                     /codon_start=1
                     /product="protein SDA1 homolog isoform 1"
                     /protein_id="NP_060585.2"
                     /db_xref="CCDS:CCDS3573.2"
                     /db_xref="GeneID:55153"
                     /db_xref="HGNC:HGNC:25537"
                     /translation="MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEI
                     FKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHTVLDPDLRMTFCK
                     ALILLRNKNLINPSSLLELFFELFRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNVV
                     LQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAAL
                     TFFLGKDEDEKQDSDSESEDDGPTARDLLVQYATGKKSSKNKKKLEKAMKVLKKQKKK
                     KKPEVFNFSAIHLIHDPQDFAEKLLKQLECCKERFEVKMMLMNLISRLVGIHELFLFN
                     FYPFLQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMT
                     VGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKK
                     FRGKPTEASIEARVQEYGELDAKDYIPGAEVLEVEKEENAENDEDGWESTSLSEEEDA
                     DGEWIDVQHSSDEEQQEISKKLNSMPMEERKAKAAAISTSRVLTQEDFQKIRMAQMRK
                     ELDAAPGKSQKRKYIEIDSDEEPRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDR
                     KEFVRKKTKTNPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLALRDALLKK
                     RKRMK"
     exon            195..299
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..398
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..509
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..581
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..682
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..740
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..815
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..917
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..987
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1091
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1149
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1208
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1285
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1383
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1460
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1587
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1682
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1873
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1958
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2120
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..3003
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /note="hexamer: AATAAA"
     polyA_site      3003
                     /gene="SDAD1"
                     /gene_synonym="Sda1"
                     /note="major polyA site"
ORIGIN      
        1 atacccggaa acacgagtcc aagctgcagc tggcagggat tgcggggtgc cggccgtctg
       61 agttttttta aaactgctcg ccgcgaagtc tgtctgcagc caaaatgtcc aacagaaaca
      121 acaacaagct tcccagcaac ctgccgcagt tacagaatct aatcaagcga gacccgccgg
      181 cctacatcga ggagtttcta cagcagtata atcactacaa atccaatgtg gagattttca
      241 aattgcaacc aaataaaccc agcaaagaac tagcagagct ggtgatgttt atggcacaga
      301 ttagtcactg ctacccagag tacctaagta attttcctca agaggtgaaa gatcttctct
      361 cctgcaatca taccgtattg gatccagatc tgcgaatgac attttgcaaa gctttgatct
      421 tgctgagaaa taagaatctc atcaatccat caagcctgct agaactcttc tttgaacttt
      481 ttcgttgcca tgataaactt ctgcgaaaga ctttatacac acatattgtg actgatatca
      541 agaatataaa tgcaaaacac aagaacaata aagtgaatgt agtattgcaa aatttcatgt
      601 acaccatgtt aagagatagc aatgcaaccg cagccaagat gtctttagat gtaatgattg
      661 aactctacag aaggaacatc tggaatgatg caaaaactgt caatgttatc acaactgcat
      721 gtttctctaa ggtcaccaag atattagttg ccgctttgac attctttctt gggaaagatg
      781 aagatgaaaa acaggacagt gactccgaat ctgaggatga tggaccaaca gcaagagacc
      841 tgctagtaca atatgctaca gggaagaaaa gttccaaaaa caagaaaaag ttggaaaagg
      901 caatgaaagt gctcaagaaa caaaaaaaga agaaaaaacc agaggtgttt aacttttcag
      961 ccattcactt gattcatgat ccccaagatt ttgcggaaaa actactaaag cagcttgagt
     1021 gctgtaagga gaggtttgaa gtgaagatga tgctcatgaa ccttatctcc agattggtgg
     1081 gaattcatga gcttttcctc ttcaatttct atcccttttt gcaaaggttt ctgcagcccc
     1141 accaaagaga agtaaccaag atccttctgt ttgctgcaca agcatctcat cacctagtac
     1201 ccccagagat tattcaatca ttgcttatga ctgtggcaaa caattttgtt accgacaaga
     1261 actctggaga agtcatgaca gtaggaatca atgctataaa ggagataaca gctcgatgtc
     1321 ctctggccat gactgaagaa cttctccaag acctggctca gtataaaaca cacaaggata
     1381 agaatgtaat gatgtctgct agaactttga ttcacctctt ccgaacactg aatcctcaga
     1441 tgctgcagaa gaaattccgg ggtaagccta cagaggcctc catagaagca agagtacaag
     1501 aatatggaga attagatgct aaagattaca ttccaggagc agaagttctg gaagttgaga
     1561 aagaagagaa tgctgaaaat gatgaagatg gatgggaaag taccagtctc agtgaggagg
     1621 aggatgctga tggtgaatgg attgatgtgc aacactcttc cgatgaagaa cagcaagaaa
     1681 tctccaagaa gctgaacagc atgcccatgg aggagcggaa ggccaaagct gcagccatca
     1741 gcactagccg agttttaact caggaagact tccagaaaat ccgcatggcc caaatgagaa
     1801 aagaacttga tgctgccccc gggaaatccc agaagaggaa atacattgaa atagacagtg
     1861 atgaagagcc caggggtgaa ttactttctc ttcgggacat tgaacgcctt cataaaaagc
     1921 caaagtctga caaagagaca agactagcaa ctgcaatggc tggaaagaca gaccgaaaag
     1981 aatttgtgag gaagaaaacc aaaacaaatc cattttccag ttcgacaaat aaagagaaga
     2041 aaaaacagaa gaactttatg atgatgcggt atagccagaa tgtccggtca aaaaataagc
     2101 gttccttccg agaaaaacag ttggcactac gagatgcact tttgaaaaag agaaaaagaa
     2161 tgaagtaact tcctggcaag ttttccattc ctagaagaat gctaagtttg tgtccttgct
     2221 ctgaaaattg gtaaatcaag catgtttgtt tacattaaaa agtccagaca cactgtattg
     2281 tgaaaactgc tgaacatgtg gcagcaattt tgtgttttta ttttggagac ggctaatggt
     2341 aggaatgtta atgtaaatag tggtggtaat gtaaaatcat ttcatttatc attcatgcaa
     2401 aaaaaagtat gtattgagtg cctattcatt gtcactgtag atgcaaaacg aatgagctgt
     2461 aaccccttca ctcaaggcat tgacagctta gctgtgaggg tggacacaca tatgtgtatt
     2521 tacagtgcag tgtaaatagt tctgtagtag aggttaactc catatttctg tgaggtcact
     2581 gaggccttat ggactaactc tgtgaggata ggagttatat attcttataa gacaaaacaa
     2641 aacaggacaa tgttacaaga gtaagaggtt cttacttgta cataggcttt cctgctgaaa
     2701 acaggcccct gctgtacaga ttttgggtac ataatttagc tcttttagtc aatccaagag
     2761 atttaagtga cccccccccc cccgtgtttt ttttgttttt gtttttgttt tgaatgccat
     2821 gtaaaggctt tttggttaag acctcacttt taaaactgcc ttaagtataa atagtacctt
     2881 tggaatatat ttagttcatc atttgagctg ccttcatact ggtttcctca gccttccttc
     2941 agcctgtaat attttcagcc cactgtttac cttgtctcaa taaaaggttt ctaatgccaa
     3001 ata
//
