LOCUS       NM_001080514            1106 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens scleraxis bHLH transcription factor (SCX), mRNA.
ACCESSION   NM_001080514 XM_926116
VERSION     NM_001080514.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Chattopadhyaya,S., Nagalingam,R.S., Ledingham,D.A., Moffatt,T.L.,
            Al-Hattab,D.S., Narhan,P., Stecy,M.T., O'Hara,K.A. and Czubryt,M.P.
  TITLE     Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis
  JOURNAL   Cells 11 (9), 1471 (2022)
   PUBMED   35563778
  REMARK    GeneRIF: Regulation of Cardiac Fibroblast GLS1 Expression by
            Scleraxis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Paterson,Y.Z., Evans,N., Kan,S., Cribbs,A., Henson,F.M.D. and
            Guest,D.J.
  TITLE     The transcription factor scleraxis differentially regulates gene
            expression in tenocytes isolated at different developmental stages
  JOURNAL   Mech Dev 163, 103635 (2020)
   PUBMED   32795590
  REMARK    GeneRIF: The transcription factor scleraxis differentially
            regulates gene expression in tenocytes isolated at different
            developmental stages.
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Ramirez-Aragon,M., Hernandez-Sanchez,F., Rodriguez-Reyna,T.S.,
            Buendia-Roldan,I., Guitron-Castillo,G., Nunez-Alvarez,C.A.,
            Hernandez-Ramirez,D.F., Benavides-Suarez,S.A.,
            Esquinca-Gonzalez,A., Torres-Machorro,A.L. and Mendoza-Milla,C.
  TITLE     The Transcription Factor SCX is a Potential Serum Biomarker of
            Fibrotic Diseases
  JOURNAL   Int J Mol Sci 21 (14), 5012 (2020)
   PUBMED   32708589
  REMARK    GeneRIF: The Transcription Factor SCX is a Potential Serum
            Biomarker of Fibrotic Diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Strenzke,M., Alberton,P., Aszodi,A., Docheva,D., Haas,E.,
            Kammerlander,C., Bocker,W. and Saller,M.M.
  TITLE     Tenogenic Contribution to Skeletal Muscle Regeneration: The
            Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells
            Enhances Myogenic Differentiation In Vitro
  JOURNAL   Int J Mol Sci 21 (6), 1965 (2020)
   PUBMED   32183051
  REMARK    GeneRIF: Tenogenic Contribution to Skeletal Muscle Regeneration:
            The Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells
            Enhances Myogenic Differentiation In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Schulze-Tanzil,G., Mobasheri,A., Clegg,P.D., Sendzik,J., John,T.
            and Shakibaei,M.
  TITLE     Cultivation of human tenocytes in high-density culture
  JOURNAL   Histochem Cell Biol 122 (3), 219-228 (2004)
   PUBMED   15338228
REFERENCE   7  (bases 1 to 1106)
  AUTHORS   Salingcarnboriboon,R., Yoshitake,H., Tsuji,K., Obinata,M.,
            Amagasa,T., Nifuji,A. and Noda,M.
  TITLE     Establishment of tendon-derived cell lines exhibiting pluripotent
            mesenchymal stem cell-like property
  JOURNAL   Exp Cell Res 287 (2), 289-300 (2003)
   PUBMED   12837285
REFERENCE   8  (bases 1 to 1106)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1106)
  AUTHORS   Schweitzer,R., Chyung,J.H., Murtaugh,L.C., Brent,A.E., Rosen,V.,
            Olson,E.N., Lassar,A. and Tabin,C.J.
  TITLE     Analysis of the tendon cell fate using Scleraxis, a specific marker
            for tendons and ligaments
  JOURNAL   Development 128 (19), 3855-3866 (2001)
   PUBMED   11585810
REFERENCE   10 (bases 1 to 1106)
  AUTHORS   Carlberg,A.L., Tuan,R.S. and Hall,D.J.
  TITLE     Regulation of scleraxis function by interaction with the bHLH
            protein E47
  JOURNAL   Mol Cell Biol Res Commun 3 (2), 82-86 (2000)
   PUBMED   10775504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145291.3, CD672767.1, BG230566.1 and CB048390.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001080514.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279857.2849.1,
                                           SRR1163658.174989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567180.3/ ENSP00000476384.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC145291.3         2841-2945           c
            106-601             CD672767.1         1-496
            602-1103            BG230566.1         1-502               c
            1104-1106           CB048390.1         46-48               c
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1106
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /note="scleraxis bHLH transcription factor"
                     /db_xref="GeneID:642658"
                     /db_xref="HGNC:HGNC:32322"
                     /db_xref="MIM:609067"
     exon            1..728
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..767
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /note="class A basic helix-loop-helix protein 41; class A
                     basic helix-loop-helix protein 48; scleraxis homolog A;
                     class II bHLH protein scleraxis; scleraxis homolog B;
                     scleraxis basic helix-loop-helix transcription factor"
                     /codon_start=1
                     /product="basic helix-loop-helix transcription factor
                     scleraxis"
                     /protein_id="NP_001073983.1"
                     /db_xref="CCDS:CCDS43779.1"
                     /db_xref="GeneID:642658"
                     /db_xref="HGNC:HGNC:32322"
                     /db_xref="MIM:609067"
                     /translation="MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHA
                     ARCGLQGARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLI
                     PTEPADRKLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPP
                     PPPPPPARDGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS"
     exon            729..1106
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /note="hexamer: AACAAA"
     polyA_site      1106
                     /gene="SCX"
                     /gene_synonym="bHLHa48; SCXA; SCXB"
                     /note="major polyA site"
ORIGIN      
        1 ggcccgggac gcacatgtgc gcgcgacgcc cggcagctgc caccgcgggg cgcagccgag
       61 accccgcgcc tcgccccggc cggcccgcga ggcccgcggc ggccgcagga ggcggcatga
      121 gcagcgcgcg acagagctga cgccgcgccc ccgccggccc catgtccttc gccacgctgc
      181 gcccggcgcc gccgggccgc tacctgtacc ccgaggtgag cccgctgtcg gaggacgagg
      241 accgcggcag cgacagctcg ggctccgacg agaaaccctg tcgcgtgcac gcggcgcgct
      301 gcggcctcca gggcgcccgg cggagggcgg ggggccggcg ggccgggggc ggggggccag
      361 ggggccggcc aggccgtgag ccccggcagc ggcacacggc gaacgcgcgc gagcgagacc
      421 gcaccaacag cgtgaacacg gccttcacgg cgctgcgcac gctgatcccc accgagcccg
      481 ccgaccgcaa gctctccaag attgagacgc tgcgcctggc ctccagctac atctcgcacc
      541 tgggcaacgt gctgctggcg ggcgaggcct gcggcgacgg acagccctgc cactccgggc
      601 ccgccttctt ccacgcggcg cgcgccggca gccccccgcc gccgcccccg ccgcctcccg
      661 cccgcgacgg cgagaacacc cagcccaaac agatctgcac cttctgcctc agcaaccaga
      721 gaaagttgag caaggaccgc gacagaaaga cagcgattcg cagttaggag gtggccggca
      781 gcagccagga ggcagacgct gctgggggag gtggacgccc ggggtgactg cagacagccc
      841 ccaccttgga cctgagctgg gcaaggccca ccgcaagcat gcccccaggc cagccctggc
      901 tgcgagcggg gccgagggac agacggacgt acagacaggc gccggcagcg ggactctgcg
      961 ctggccccag cacctgcccg ggcccactgg aactttctgc gctggctttt cttccggcca
     1021 ctgtgtgatg gcatcttgtg tttttgatat gataatataa agtctgaaaa ttttgtataa
     1081 ttaaaaacaa aacagtatct tccaaa
//
