LOCUS       NM_001367977            4727 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens signal peptide, CUB domain and EGF like domain
            containing 2 (SCUBE2), transcript variant 4, mRNA.
ACCESSION   NM_001367977 XM_005253032
VERSION     NM_001367977.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4727)
  AUTHORS   Wu,Q., Tian,P., He,D., Jia,Z., He,Y., Luo,W., Lv,X., Wang,Y.,
            Zhang,P., Liang,Y., Zhao,W., Qin,J., Su,P., Jiang,Y.Z., Shao,Z.M.,
            Yang,Q. and Hu,G.
  TITLE     SCUBE2 mediates bone metastasis of luminal breast cancer by
            modulating immune-suppressive osteoblastic niches
  JOURNAL   Cell Res 33 (6), 464-478 (2023)
   PUBMED   37142671
  REMARK    GeneRIF: SCUBE2 mediates bone metastasis of luminal breast cancer
            by modulating immune-suppressive osteoblastic niches.
REFERENCE   2  (bases 1 to 4727)
  AUTHORS   Wang,R., Li,H., Han,Y. and Li,L.
  TITLE     Knockdown of circ_0025908 inhibits proliferation, migration,
            invasion, and inflammation while stimulates apoptosis in
            fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2
  JOURNAL   Autoimmunity 55 (7), 473-484 (2022)
   PUBMED   35904110
  REMARK    GeneRIF: Knockdown of circ_0025908 inhibits proliferation,
            migration, invasion, and inflammation while stimulates apoptosis in
            fibroblast-like synoviocytes by regulating miR-650-dependent
            SCUBE2.
REFERENCE   3  (bases 1 to 4727)
  AUTHORS   Esmaeili,R., Mohammadi,S., Jafarbeik-Iravani,N., Yadegari,F.,
            Olfatbakhsh,A., Mazaheri,M., Kaviani,A., Rezaee,M. and
            Majidzadeh-A,K.
  TITLE     Expression of SCUBE2 and BCL2 Predicts Favorable Response in
            ERalpha Positive Breast Cancer
  JOURNAL   Arch Iran Med 24 (3), 209-217 (2021)
   PUBMED   33878879
  REMARK    GeneRIF: Expression of SCUBE2 and BCL2 Predicts Favorable Response
            in ERalpha Positive Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4727)
  AUTHORS   Wang,J., Kong,X., Hu,H. and Shi,S.
  TITLE     Knockdown of long non-coding RNA PVT1 induces apoptosis of
            fibroblast-like synoviocytes through modulating miR-543-dependent
            SCUBE2 in rheumatoid arthritis
  JOURNAL   J Orthop Surg Res 15 (1), 142 (2020)
   PUBMED   32293498
  REMARK    GeneRIF: Knockdown of long non-coding RNA PVT1 induces apoptosis of
            fibroblast-like synoviocytes through modulating miR-543-dependent
            SCUBE2 in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4727)
  AUTHORS   Gunduz,I., Batmaz,I., Bozan,T., Ekinci,A. and Cevik,R.
  TITLE     The relationship of serum SCUBE-1, -2 and -3 levels with clinical
            findings and ultrasonographic skin thickness in systemic sclerosis
            patients
  JOURNAL   Int J Rheum Dis 23 (4), 526-531 (2020)
   PUBMED   31991528
  REMARK    GeneRIF: The relationship of serum SCUBE-1, -2 and -3 levels with
            clinical findings and ultrasonographic skin thickness in systemic
            sclerosis patients.
REFERENCE   6  (bases 1 to 4727)
  AUTHORS   Lin,Y.C., Chen,C.C., Cheng,C.J. and Yang,R.B.
  TITLE     Domain and functional analysis of a novel breast tumor suppressor
            protein, SCUBE2
  JOURNAL   J Biol Chem 286 (30), 27039-27047 (2011)
   PUBMED   21652720
  REMARK    GeneRIF: Domain and functional analysis of a novel breast tumor
            suppressor protein, SCUBE2.
REFERENCE   7  (bases 1 to 4727)
  AUTHORS   Tsai,M.T., Cheng,C.J., Lin,Y.C., Chen,C.C., Wu,A.R., Wu,M.T.,
            Hsu,C.C. and Yang,R.B.
  TITLE     Isolation and characterization of a secreted, cell-surface
            glycoprotein SCUBE2 from humans
  JOURNAL   Biochem J 422 (1), 119-128 (2009)
   PUBMED   19480626
  REMARK    GeneRIF: The full-length cDNA of human SCUBE2 was isolated and the
            role in the hedgehog signalling cascade, was studied.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4727)
  AUTHORS   Cheng,C.J., Lin,Y.C., Tsai,M.T., Chen,C.S., Hsieh,M.C., Chen,C.L.
            and Yang,R.B.
  TITLE     SCUBE2 suppresses breast tumor cell proliferation and confers a
            favorable prognosis in invasive breast cancer
  JOURNAL   Cancer Res 69 (8), 3634-3641 (2009)
   PUBMED   19369267
  REMARK    GeneRIF: Altered SCUBE2 expression is important in breast cancer
            progression and SCUBE2 may serve as a useful prognostic marker.
REFERENCE   9  (bases 1 to 4727)
  AUTHORS   Yang,R.B., Ng,C.K., Wasserman,S.M., Colman,S.D., Shenoy,S.,
            Mehraban,F., Komuves,L.G., Tomlinson,J.E. and Topper,J.N.
  TITLE     Identification of a novel family of cell-surface proteins expressed
            in human vascular endothelium
  JOURNAL   J Biol Chem 277 (48), 46364-46373 (2002)
   PUBMED   12270931
  REMARK    GeneRIF: identification as secreted protein that is expressed in
            vascular endothelium and may play important roles in development,
            inflammation, and thrombosis
REFERENCE   10 (bases 1 to 4727)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079296.5 and KF459545.1.
            
            On Aug 27, 2019 this sequence version replaced NM_001367977.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2577530.1,
                                           SRR14038192.3404599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649792.2/ ENSP00000497523.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC079296.5         89023-89226
            205-327             AC079296.5         90793-90915
            328-453             AC079296.5         101113-101238
            454-588             AC079296.5         106007-106141
            589-714             AC079296.5         111127-111252
            715-831             AC079296.5         113809-113925
            832-921             AC079296.5         114642-114731
            922-1038            AC079296.5         120098-120214
            1039-1161           AC079296.5         121197-121319
            1162-1278           AC079296.5         124713-124829
            1279-1401           AC079296.5         126863-126985
            1402-1518           AC079296.5         127407-127523
            1519-1605           AC079296.5         127790-127876
            1606-1710           AC079296.5         129912-130016
            1711-1866           AC079296.5         132524-132679
            1867-2073           AC079296.5         133060-133266
            2074-2244           AC079296.5         146826-146996
            2245-2412           KF459545.1         66-233              c
            2413-2574           AC079296.5         150577-150738
            2575-2772           AC079296.5         153061-153258
            2773-2925           AC079296.5         154768-154920
            2926-3005           AC079296.5         158667-158746
            3006-4727           AC079296.5         159425-161146
FEATURES             Location/Qualifiers
     source          1..4727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4727
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="signal peptide, CUB domain and EGF like domain
                     containing 2"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
     exon            1..204
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3158
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; signal peptide, CUB and EGF-like
                     domain-containing protein 2"
                     /codon_start=1
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform 4 precursor"
                     /protein_id="NP_001354906.1"
                     /db_xref="CCDS:CCDS91436.1"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
                     /translation="MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQE
                     DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDC
                     LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFL
                     SDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCN
                     HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKR
                     VKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC
                     DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRG
                     YTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP
                     TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSGLQGAYSVTCGSSSPLRNKQQKSNDS
                     AFGDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSG
                     KQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKA
                     VHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARER
                     CILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPC
                     QLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIR
                     CPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPG
                     NYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQT
                     YERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASEN
                     HQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK"
     exon            205..327
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            328..453
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            454..588
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            589..714
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            715..831
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            832..921
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1038
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1161
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1278
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1401
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1518
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1605
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1710
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1866
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2073
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2244
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2412
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2574
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2772
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2925
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3005
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..4727
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="hexamer: AATACA"
     polyA_site      3321
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="major polyA site"
     regulatory      3788..3793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="hexamer: AATAAA"
     polyA_site      3817
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
     regulatory      4677..4682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="hexamer: ATTAAA"
     regulatory      4699..4704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /note="hexamer: AACAAG"
     polyA_site      4703
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
     polyA_site      4727
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
ORIGIN      
        1 gcacacctcc ccgcgccgcc gccgccaccg cccgcactcc gccgcctctg cccgcaaccg
       61 ctgagccatc catgggggtc gcgggccgca accgtcccgg ggcggcctgg gcggtgctgc
      121 tgctgctgct gctgctgccg ccactgctgc tgctggcggg ggccgtcccg ccgggtcggg
      181 gccgtgccgc ggggccgcag gaggatgtag atgagtgtgc ccaagggcta gatgactgcc
      241 atgccgacgc cctgtgtcag aacacaccca cctcctacaa gtgctcctgc aagcctggct
      301 accaagggga aggcaggcag tgtgaggaca tcgatgaatg tggaaatgag ctcaatggag
      361 gctgtgtcca tgactgtttg aatattccag gcaattatcg ttgcacttgt tttgatggct
      421 tcatgttggc tcatgacggt cataattgtc ttgatgtgga cgagtgcctg gagaacaatg
      481 gcggctgcca gcatacctgt gtcaacgtca tggggagcta tgagtgctgc tgcaaggagg
      541 ggtttttcct gagtgacaat cagcacacct gcattcaccg ctcggaagag ggcctgagct
      601 gcatgaataa ggatcacggc tgtagtcaca tctgcaagga ggccccaagg ggcagcgtcg
      661 cctgtgagtg caggcctggt tttgagctgg ccaagaacca gagagactgc atcttgacct
      721 gtaaccatgg gaacggtggg tgccagcact cctgtgacga tacagccgat ggcccagagt
      781 gcagctgcca tccacagtac aagatgcaca cagatgggag gagctgcctt gagcgagagg
      841 acactgtcct ggaggtgaca gagagcaaca ccacatcagt ggtggatggg gataaacggg
      901 tgaaacggcg gctgctcatg gaaacgtgtg ctgtcaacaa tggaggctgt gaccgcacct
      961 gtaaggatac ttcgacaggt gtccactgca gttgtcctgt tggattcact ctccagttgg
     1021 atgggaagac atgtaaagat attgatgagt gccagacccg caatggaggt tgtgatcatt
     1081 tctgcaaaaa catcgtgggc agttttgact gcggctgcaa gaaaggattt aaattattaa
     1141 cagatgagaa gtcttgccaa gatgtggatg agtgctcttt ggataggacc tgtgaccaca
     1201 gctgcatcaa ccaccctggc acatttgctt gtgcttgcaa ccgagggtac accctgtatg
     1261 gcttcaccca ctgtggagac accaatgagt gcagcatcaa caacggaggc tgtcagcagg
     1321 tctgtgtgaa cacagtgggc agctatgaat gccagtgcca ccctgggtac aagctccact
     1381 ggaataaaaa agactgtgtg gaagtgaagg ggctcctgcc cacaagtgtg tcaccccgtg
     1441 tgtccctgca ctgcggtaag agtggtggag gagacgggtg cttcctcaga tgtcactctg
     1501 gcattcacct ctcttcagga ctgcaagggg cctactctgt cacctgtggc tcttcctctc
     1561 ctctcaggaa caaacaacaa aaatcaaatg actctgcttt tggggatgtc accaccatca
     1621 ggacaagtgt aacctttaag ctaaatgaag gcaagtgtag tttgaaaaat gctgagctgt
     1681 ttcccgaggg tctgcgacca gcactaccag agaagcacag ctcagtaaaa gagagcttcc
     1741 gctacgtaaa ccttacatgc agctctggca agcaagtccc aggagcccct ggccgaccaa
     1801 gcacccctaa ggaaatgttt atcactgttg agtttgagct tgaaactaac caaaaggagg
     1861 tgacagcttc ttgtgacctg agctgcatcg taaagcgaac cgagaagcgg ctccgtaaag
     1921 ccatccgcac gctcagaaag gccgtccaca gggagcagtt tcacctccag ctctcaggca
     1981 tgaacctcga cgtggctaaa aagcctccca gaacatctga acgccaggca gagtcctgtg
     2041 gagtgggcca gggtcatgca gaaaaccaat gtgtcagttg cagggctggg acctattatg
     2101 atggagcacg agaacgctgc attttatgtc caaatggaac cttccaaaat gaggaaggac
     2161 aaatgacttg tgaaccatgc ccaagaccag gaaattctgg ggccctgaag accccagaag
     2221 cttggaatat gtctgaatgt ggaggtctgt gtcaacctgg tgaatattct gcagatggct
     2281 ttgcaccttg ccagctctgt gccctgggca cgttccagcc tgaagctggt cgaacttcct
     2341 gcttcccctg tggaggaggc cttgccacca aacatcaggg agctacttcc tttcaggact
     2401 gtgaaaccag agttcaatgt tcacctggac atttctacaa caccaccact caccgatgta
     2461 ttcgttgccc agtgggaaca taccagcctg aatttggaaa aaataattgt gtttcttgcc
     2521 caggaaatac tacgactgac tttgatggct ccacaaacat aacccagtgt aaaaacagaa
     2581 gatgtggagg ggagctggga gatttcactg ggtacattga atccccaaac tacccaggca
     2641 attacccagc caacaccgag tgtacgtgga ccatcaaccc accccccaag cgccgcatcc
     2701 tgatcgtggt ccctgagatc ttcctgccca tagaggacga ctgtggggac tatctggtga
     2761 tgcggaaaac ctcttcatcc aattctgtga caacatatga aacctgccag acctacgaac
     2821 gccccatcgc cttcacctcc aggtcaaaga agctgtggat tcagttcaag tccaatgaag
     2881 ggaacagcgc tagagggttc caggtcccat acgtgacata tgatgaggac taccaggaac
     2941 tcattgaaga catagttcga gatggcaggc tctatgcatc tgagaaccat caggaaatac
     3001 ttaaggataa gaaacttatc aaggctctgt ttgatgtcct ggcccatccc cagaactatt
     3061 tcaagtacac agcccaggag tcccgagaga tgtttccaag atcgttcatc cgattgctac
     3121 gttccaaagt gtccaggttt ttgagacctt acaaatgact cagcccacgt gccactcaat
     3181 acaaatgttc tgctataggg ttggtgggac agagctgtct tccttctgca tgtcagcaca
     3241 gtcgggtatt gctgcctccc gtatcagtga ctcattagag ttcaattttt atagataata
     3301 cagatatttt ggtaaattga acttggtttt tctttcccag catcgtggat gtagactgag
     3361 aatggctttg agtggcatca gcttctcact gctgtgggcg gatgtcttgg atagatcacg
     3421 ggctggctga gctggacttt ggtcagccta ggtgagactc acctgtcctt ctggggtctt
     3481 actcctcctc aaggagtctg tagtggaaag gaggccacag aataagctgc ttattctgaa
     3541 acttcagctt cctctagccc ggccctctct aagggagccc tctgcactcg tgtgcaggct
     3601 ctgaccaggc agaacaggca agaggggagg gaaggagacc cctgcaggct ccctccaccc
     3661 accttgagac ctgggaggac tcagtttctc cacagccttc tccagcctgt gtgatacaag
     3721 tttgatccca ggaacttgag ttctaagcag tgctcgtgaa aaaaaaaagc agaaagaatt
     3781 agaaataaat aaaaactaag cacttctgga gacataataa tgtacattta ttgccagcct
     3841 tcctcgttgc aagcttccac cctgcagcaa atgcactatg ctgactctcg caccttcagc
     3901 tgtgccctct gacactctgc tggccattgc ctgagggact ggggagttca ggtgaaatgt
     3961 aatttcctca gtggatgaga atcatcaatt gtcatgaaaa ggcgatttca ccaaccctga
     4021 gtcggtattg ccaagggttc tactccccaa gtgggcttcc catcacaagg gatctgaggt
     4081 ccaggtgggt gtggtgaggc ccagcctgtc atgtatgcct tccttcccca gtctcaaatg
     4141 tgagagacgg actctgctcc gtggacatga gcagcccctt gaagggtggt ctcattctct
     4201 aacagtaaca gcactgccag aaacaccccc tgaatgccac acgatcatct cactttgggt
     4261 caggccagca gggcctcacg atcatttctt gaacttgaat tttcagtgtt attgaatctt
     4321 taaacattta aatccccaag caaaaatctc attacagtga ataaaaagga atccaatcaa
     4381 acaagccacc acttccctaa tggatggact acctacaact atagtgtttt gttatttcaa
     4441 taacaattct atgcacagcc aattctccat accaaagtac taaaaaaatg tttaacaagc
     4501 atttttgaag aaaacaaaga gaacttcatt atggttaaac ttgcttttca tctcagtgtt
     4561 gcttttttta acctgttaat aacattgatt cttaaaaagt cctaatcaaa cttctttatt
     4621 tggatgggcc ctaaatattc attttcagat ttctcttcaa aagtttgaac atcatcatta
     4681 aaaaaaaaat agcattaaaa caagcacttg gactttgtta tactgga
//
