LOCUS       NM_002980               1854 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens secretin receptor (SCTR), mRNA.
ACCESSION   NM_002980
VERSION     NM_002980.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Gilliam-Vigh,H., Jorsal,T., Nielsen,S.W., Forman,J.L., Pedersen,J.,
            Poulsen,S.S., Vilsboll,T. and Knop,F.K.
  TITLE     Expression of Secretin and its Receptor Along the Intestinal Tract
            in Type 2 Diabetes Patients and Healthy Controls
  JOURNAL   J Clin Endocrinol Metab 108 (12), e1597-e1602 (2023)
   PUBMED   37335970
  REMARK    GeneRIF: Expression of Secretin and its Receptor Along the
            Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Chen,L., Wu,N., Kennedy,L., Francis,H., Ceci,L., Zhou,T.,
            Samala,N., Kyritsi,K., Wu,C., Sybenga,A., Ekser,B., Dar,W.,
            Atkins,C., Meadows,V., Glaser,S. and Alpini,G.
  TITLE     Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD
            Phenotypes
  JOURNAL   Hepatology 74 (4), 1845-1863 (2021)
   PUBMED   33928675
  REMARK    GeneRIF: Inhibition of Secretin/Secretin Receptor Axis Ameliorates
            NAFLD Phenotypes.
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Fukuhara,S., Kobayashi,K., Kusakizako,T., Iida,W., Kato,M.,
            Shihoya,W. and Nureki,O.
  TITLE     Structure of the human secretin receptor coupled to an engineered
            heterotrimeric G protein
  JOURNAL   Biochem Biophys Res Commun 533 (4), 861-866 (2020)
   PUBMED   33008599
  REMARK    GeneRIF: Structure of the human secretin receptor coupled to an
            engineered heterotrimeric G protein.
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Li,D., Zhang,L., Fu,J., Huang,H., Sun,S., Zhang,D., Zhao,L.,
            Ucheojor Onwuka,J., Zhao,Y. and Cui,B.
  TITLE     SCTR hypermethylation is a diagnostic biomarker in colorectal
            cancer
  JOURNAL   Cancer Sci 111 (12), 4558-4566 (2020)
   PUBMED   32970347
  REMARK    GeneRIF: SCTR hypermethylation is a diagnostic biomarker in
            colorectal cancer.
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Dong,M., Deganutti,G., Piper,S.J., Liang,Y.L., Khoshouei,M.,
            Belousoff,M.J., Harikumar,K.G., Reynolds,C.A., Glukhova,A.,
            Furness,S.G.B., Christopoulos,A., Danev,R., Wootten,D., Sexton,P.M.
            and Miller,L.J.
  TITLE     Structure and dynamics of the active Gs-coupled human secretin
            receptor
  JOURNAL   Nat Commun 11 (1), 4137 (2020)
   PUBMED   32811827
  REMARK    GeneRIF: Structure and dynamics of the active Gs-coupled human
            secretin receptor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Chow,B.K.
  TITLE     Molecular cloning and functional characterization of a human
            secretin receptor
  JOURNAL   Biochem Biophys Res Commun 212 (1), 204-211 (1995)
   PUBMED   7612008
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Patel,D.R., Kong,Y. and Sreedharan,S.P.
  TITLE     Molecular cloning and expression of a human secretin receptor
  JOURNAL   Mol Pharmacol 47 (3), 467-473 (1995)
   PUBMED   7700244
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Felley,C.P., Qian,J.M., Mantey,S., Pradhan,T. and Jensen,R.T.
  TITLE     Chief cells possess a receptor with high affinity for PACAP and VIP
            that stimulates pepsinogen release
  JOURNAL   Am J Physiol 263 (6 Pt 1), G901-G907 (1992)
   PUBMED   1335692
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Ishihara,T., Nakamura,S., Kaziro,Y., Takahashi,T., Takahashi,K. and
            Nagata,S.
  TITLE     Molecular cloning and expression of a cDNA encoding the secretin
            receptor
  JOURNAL   EMBO J 10 (7), 1635-1641 (1991)
   PUBMED   1646711
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Robberecht,P., De Neef,P., Waelbroeck,M., Camus,J.C., Scemama,J.L.,
            Fourmy,D., Pradayrol,L., Vaysse,N. and Christophe,J.
  TITLE     Secretin receptors in human pancreatic membranes
  JOURNAL   Pancreas 3 (5), 529-535 (1988)
   PUBMED   3186683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013275.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 21, 2019 this sequence version replaced NM_002980.2.
            
            Summary: The protein encoded by this gene is a G protein-coupled
            receptor and belongs to the glucagon-VIP-secretin receptor family.
            It binds secretin which is the most potent regulator of pancreatic
            bicarbonate, electrolyte and volume secretion. Secretin and its
            receptor are suggested to be involved in pancreatic cancer and
            autism. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035757.1, U28281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000019103.8/ ENSP00000019103.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AC013275.8         117459-117787       c
            330-450             AC013275.8         87732-87852         c
            451-558             AC013275.8         72115-72222         c
            559-662             AC013275.8         66757-66860         c
            663-760             AC013275.8         59093-59190         c
            761-893             AC013275.8         57427-57559         c
            894-1047            AC013275.8         55151-55304         c
            1048-1108           AC013275.8         46591-46651         c
            1109-1178           AC013275.8         45314-45383         c
            1179-1270           AC013275.8         41993-42084         c
            1271-1397           AC013275.8         40063-40189         c
            1398-1439           AC013275.8         34862-34903         c
            1440-1854           AC013275.8         33147-33561         c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..1854
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /note="secretin receptor"
                     /db_xref="GeneID:6344"
                     /db_xref="HGNC:HGNC:10608"
                     /db_xref="MIM:182098"
     exon            1..329
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1580
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /note="pancreatic secretin receptor"
                     /codon_start=1
                     /product="secretin receptor precursor"
                     /protein_id="NP_002971.2"
                     /db_xref="CCDS:CCDS2127.1"
                     /db_xref="GeneID:6344"
                     /db_xref="HGNC:HGNC:10608"
                     /db_xref="MIM:182098"
                     /translation="MRPHLSPPLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQ
                     CLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGS
                     LFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVA
                     LGILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLV
                     MVLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIA
                     RHFLEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEV
                     SHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLN
                     GEVQLEVQKKWQQWHLREFPLHPVASFSNSTKASHLEQSQGTCRTSII"
     exon            330..450
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            451..558
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            559..662
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..760
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            761..893
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1047
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1108
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1178
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1270
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1397
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1439
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1854
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="SCTR"
                     /gene_synonym="SECR; SR"
                     /note="major polyA site"
ORIGIN      
        1 agtccctgcc gggtggagga ggcgcgccgg caaagccgcg tcctgatcaa tggggcgggc
       61 ggcttagcgc gcgcggccac ctggtccgag gaggagcagt cccggggccc gccgcaggtc
      121 gggtggctca gccatggctc ctcggggcgc agcggccggc cggagcccgg gaccctgcgc
      181 ggggcgctga gctcccgagc gggcagaggg cacgggcagg cggacgtcgg ggcgccctcg
      241 gggaacgtgc gggcaccatg cgtccccacc tgtcgccgcc gctgcagcag ctactactgc
      301 cggtgctgct cgcctgcgcc gcgcactcga ctggagccct tccccgacta tgtgacgtgc
      361 tacaagtgct gtgggaagag caagaccagt gcctgcagga actctccaga gagcagacag
      421 gagacctggg cacggagcag ccagtgccag gttgtgaggg gatgtgggac aacataagct
      481 gctggccctc ttctgtgccg ggccggatgg tggaggtgga atgcccgaga ttcctccgga
      541 tgctcaccag cagaaatggt tccttgttcc gaaactgcac acaggatggc tggtcagaaa
      601 ccttccccag gcctaatctg gcctgtggcg ttaatgtgaa cgactcttcc aacgagaagc
      661 ggcactccta cctgctgaag ctgaaagtca tgtacaccgt gggctacagc tcctccctgg
      721 tcatgctcct ggtcgccctt ggcatcctct gtgctttccg gaggctccac tgcactcgca
      781 actacatcca catgcacctg ttcgtgtcct tcatccttcg tgccctgtcc aacttcatca
      841 aggacgccgt gctcttctcc tcagatgatg tcacctactg cgatgcccac agggcgggct
      901 gcaagctggt catggtgctg ttccagtact gcatcatggc caactactcc tggctgctgg
      961 tggaaggcct ctaccttcac acactcctcg ccatctcctt cttctctgaa agaaagtacc
     1021 tccagggatt tgtggcattc ggatggggtt ctccagccat ttttgttgct ttgtgggcta
     1081 ttgccagaca ctttctggaa gatgttgggt gctgggacat caatgccaac gcatccatct
     1141 ggtggatcat tcgtggtcct gtgatcctct ccatcctgat taatttcatc cttttcataa
     1201 acattctaag aatcctgatg agaaaactta gaacccaaga aacaagagga aatgaagtca
     1261 gccattataa gcgcctggcc aggtccactc tcctgctgat ccccctcttt ggcatccact
     1321 acatcgtctt cgccttctcc ccagaggacg ctatggagat ccagctgttt tttgaactag
     1381 cccttggctc attccaggga ctggtggtgg ccgtcctcta ctgcttcctc aatggggagg
     1441 tgcagctgga ggttcagaag aagtggcagc aatggcacct ccgtgagttc ccactgcacc
     1501 ccgtggcctc cttcagcaac agcaccaagg ccagccactt ggagcagagc cagggcacct
     1561 gcaggaccag catcatctga gaggctggag cagggtcacc cacggacaga gaccaagaga
     1621 ggtcctgcga aggctgggca ctgctgtggg acagccagtc ttcccagcag acaccctgtg
     1681 tcctccttca gctgaagatg cccctcccca ggccttggac tcttccgaag ggatgtgagg
     1741 cactgtgggg caggacaagg gcctgggatt tggttcgttt gctcttctgg gaagagaagt
     1801 tcaggggtcc cagaaaggga cagggaaata aatggtgcct gggatgagat tcaa
//
