LOCUS       NM_021920                526 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens secretin (SCT), mRNA.
ACCESSION   NM_021920
VERSION     NM_021920.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Gilliam-Vigh,H., Jorsal,T., Nielsen,S.W., Forman,J.L., Pedersen,J.,
            Poulsen,S.S., Vilsboll,T. and Knop,F.K.
  TITLE     Expression of Secretin and its Receptor Along the Intestinal Tract
            in Type 2 Diabetes Patients and Healthy Controls
  JOURNAL   J Clin Endocrinol Metab 108 (12), e1597-e1602 (2023)
   PUBMED   37335970
  REMARK    GeneRIF: Expression of Secretin and its Receptor Along the
            Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
REFERENCE   2  (bases 1 to 526)
  AUTHORS   Sun,L., Laurila,S., Lahesmaa,M., Rebelos,E., Virtanen,K.A.,
            Schnabl,K., Klingenspor,M., Nummenmaa,L. and Nuutila,P.
  TITLE     Secretin modulates appetite via brown adipose tissue-brain axis
  JOURNAL   Eur J Nucl Med Mol Imaging 50 (6), 1597-1606 (2023)
   PUBMED   36764966
  REMARK    GeneRIF: Secretin modulates appetite via brown adipose tissue-brain
            axis.
REFERENCE   3  (bases 1 to 526)
  AUTHORS   Chen,L., Wu,N., Kennedy,L., Francis,H., Ceci,L., Zhou,T.,
            Samala,N., Kyritsi,K., Wu,C., Sybenga,A., Ekser,B., Dar,W.,
            Atkins,C., Meadows,V., Glaser,S. and Alpini,G.
  TITLE     Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD
            Phenotypes
  JOURNAL   Hepatology 74 (4), 1845-1863 (2021)
   PUBMED   33928675
  REMARK    GeneRIF: Inhibition of Secretin/Secretin Receptor Axis Ameliorates
            NAFLD Phenotypes.
REFERENCE   4  (bases 1 to 526)
  AUTHORS   Afroze,S., Meng,F., Jensen,K., McDaniel,K., Rahal,K., Onori,P.,
            Gaudio,E., Alpini,G. and Glaser,S.S.
  TITLE     The physiological roles of secretin and its receptor
  JOURNAL   Ann Transl Med 1 (3), 29 (2013)
   PUBMED   25332973
  REMARK    Review article
REFERENCE   5  (bases 1 to 526)
  AUTHORS   Lee,L.T., Tan-Un,K.C. and Chow,B.K.
  TITLE     Retinoic acid-induced human secretin gene expression in neuronal
            cells is mediated by cyclin-dependent kinase 1
  JOURNAL   Ann N Y Acad Sci 1070, 393-398 (2006)
   PUBMED   16888198
  REMARK    GeneRIF: first pathway is by changing the expression levels of
            nuclear factor-I C(NFI-C) and secretin proteins while the second
            pathway is by modifying the phosphorylation status of both NFI-C
            and secretin proteins via cyclin-dependent kinase 1
REFERENCE   6  (bases 1 to 526)
  AUTHORS   Lee,S.M., Yung,W.H., Chen,L. and Chow,B.K.
  TITLE     Expression and spatial distribution of secretin and secretin
            receptor in human cerebellum
  JOURNAL   Neuroreport 16 (3), 219-222 (2005)
   PUBMED   15706223
  REMARK    GeneRIF: Secretin mRNAs are found in Purkinje cells and
            secretin-immunoreactivities are localized in both the soma and
            dendrites of Purkinje cells of human cerebellum.
REFERENCE   7  (bases 1 to 526)
  AUTHORS   Yamagata,T., Aradhya,S., Mori,M., Inoue,K., Momoi,M.Y. and
            Nelson,D.L.
  TITLE     The human secretin gene: fine structure in 11p15.5 and sequence
            variation in patients with autism
  JOURNAL   Genomics 80 (2), 185-194 (2002)
   PUBMED   12160732
  REMARK    GeneRIF: fine structure in 11p15.5 and sequence variation in
            patients with autism
REFERENCE   8  (bases 1 to 526)
  AUTHORS   Chow,B.K.
  TITLE     Molecular cloning and functional characterization of a human
            secretin receptor
  JOURNAL   Biochem Biophys Res Commun 212 (1), 204-211 (1995)
   PUBMED   7612008
REFERENCE   9  (bases 1 to 526)
  AUTHORS   Holtmann,M.H., Hadac,E.M. and Miller,L.J.
  TITLE     Critical contributions of amino-terminal extracellular domains in
            agonist binding and activation of secretin and vasoactive
            intestinal polypeptide receptors. Studies of chimeric receptors
  JOURNAL   J Biol Chem 270 (24), 14394-14398 (1995)
   PUBMED   7782300
REFERENCE   10 (bases 1 to 526)
  AUTHORS   Kopin,A.S., Wheeler,M.B. and Leiter,A.B.
  TITLE     Secretin: structure of the precursor and tissue distribution of the
            mRNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2299-2303 (1990)
   PUBMED   2315322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY019819.1, HY243621.1 and
            AP006284.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021920.3.
            
            Summary: This gene encodes a member of the glucagon family of
            peptides. The encoded preproprotein is secreted by endocrine S
            cells in the proximal small intestinal mucosa as a prohormone, then
            proteolytically processed to generate the mature peptide hormone.
            The release of this active peptide hormone is stimulated by either
            fatty acids or acidic pH in the duodenum. This hormone stimulates
            the secretion of bile and bicarbonate in the duodenum, pancreatic
            and biliary ducts. [provided by RefSeq, Feb 2016].
            
            CCDS Note: No human mRNA or EST accessions have been deposited in
            public databases to support this CCDS, but the gene, transcript and
            protein have been well-characterized in the literature, e.g.,
            PMIDs:2315322, 12160732, 15706223 and 16888198. Secretin proteins
            in other species also support this CCDS.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY019819.1, HY055530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000176195.4/ ENSP00000176195.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               HY019819.1         60-461
            403-519             HY243621.1         1-117               c
            520-526             AP006284.2         85026-85032         c
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..526
                     /gene="SCT"
                     /note="secretin"
                     /db_xref="GeneID:6343"
                     /db_xref="HGNC:HGNC:10607"
                     /db_xref="MIM:182099"
     exon            1..109
                     /gene="SCT"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..404
                     /gene="SCT"
                     /note="prepro-secretin"
                     /codon_start=1
                     /product="secretin preproprotein"
                     /protein_id="NP_068739.1"
                     /db_xref="CCDS:CCDS7709.1"
                     /db_xref="GeneID:6343"
                     /db_xref="HGNC:HGNC:10607"
                     /db_xref="MIM:182099"
                     /translation="MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGA
                     RLQRLLQGLVGKRSEQDAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPP
                     GPMVSEPAGAAAEGTLRPR"
     exon            110..211
                     /gene="SCT"
                     /inference="alignment:Splign:2.1.0"
     exon            212..304
                     /gene="SCT"
                     /inference="alignment:Splign:2.1.0"
     exon            305..526
                     /gene="SCT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCT"
                     /note="hexamer: AATAAA"
     polyA_site      526
                     /gene="SCT"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgcag cgctcagctc ctgcgccccg accccgccat ggccccccgg cccctcctgc
       61 tgctgctgct gctcctcggg ggctccgccg cgcgccccgc gccccccagg gcccggcgac
      121 actcagacgg gacgttcacc agcgagctca gccgcctgcg ggagggcgcg cggctccagc
      181 ggctgctaca gggcctggtg gggaagcgca gcgagcagga cgcagagaac agcatggcct
      241 ggaccaggct cagcgcgggt ctgctctgcc cgtcagggtc caacatgccc atcctgcagg
      301 cctggatgcc cctggacggg acctggtctc cctggctgcc ccctgggcct atggtttcag
      361 aaccagctgg cgctgctgca gaaggaacct tgcggcccag atgaggaagg aaccccctca
      421 ccacctgccc ggcccaggag cgcagctgca tttggggtgg ggggcaggat gggggagagg
      481 gggaggggtg gtacttggca ccaataaagg aggaatcaga cccaga
//
