LOCUS       NM_033129               3200 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens scratch family transcriptional repressor 2 (SCRT2),
            mRNA.
ACCESSION   NM_033129
VERSION     NM_033129.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Itoh,Y., Moriyama,Y., Hasegawa,T., Endo,T.A., Toyoda,T. and
            Gotoh,Y.
  TITLE     Scratch regulates neuronal migration onset via an
            epithelial-mesenchymal transition-like mechanism
  JOURNAL   Nat Neurosci 16 (4), 416-425 (2013)
   PUBMED   23434913
  REMARK    GeneRIF: Scratch2 and scratch1 are expressed upon neuronal fate
            commitment under the control of proneural genes to promote cell
            migration in the developing neocortex.
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Rodriguez-Aznar,E. and Nieto,M.A.
  TITLE     Repression of Puma by scratch2 is required for neuronal survival
            during embryonic development
  JOURNAL   Cell Death Differ 18 (7), 1196-1207 (2011)
   PUBMED   21252910
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Nakakura,E.K., Watkins,D.N., Schuebel,K.E., Sriuranpong,V.,
            Borges,M.W., Nelkin,B.D. and Ball,D.W.
  TITLE     Mammalian Scratch: a neural-specific Snail family transcriptional
            repressor
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4010-4015 (2001)
   PUBMED   11274425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY129025.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033129.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129025.1, BY796399.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246104.7/ ENSP00000246104.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3200              AY129025.1         384-3583
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3200
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /note="scratch family transcriptional repressor 2"
                     /db_xref="GeneID:85508"
                     /db_xref="HGNC:HGNC:15952"
     exon            1..334
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1125
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /note="scratch 2 protein; scratch family zinc finger 2;
                     scratch homolog 2, zinc finger protein"
                     /codon_start=1
                     /product="transcriptional repressor scratch 2"
                     /protein_id="NP_149120.1"
                     /db_xref="CCDS:CCDS13006.1"
                     /db_xref="GeneID:85508"
                     /db_xref="HGNC:HGNC:15952"
                     /translation="MPRSFLVKKIKGDGFQCSGVPAPTYHPLETAYVLPGARGPPGDN
                     GYAPHRLPPSSYDADQKPGLELAPAEPAYPPAAPEEYSDPESPQSSLSARYFRGEAAV
                     TDSYSMDAFFISDGRSRRRRGGGGGDAGGSGDAGGAGGRAGRAGAQAGGGHRHACAEC
                     GKTYATSSNLSRHKQTHRSLDSQLARKCPTCGKAYVSMPALAMHLLTHNLRHKCGVCG
                     KAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHYRCRQCDKS
                     FALKSYLHKHCEAACAKAAEPPPPTPAGPAS"
     exon            335..3200
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3178..3183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /note="hexamer: ATTAAA"
     polyA_site      3200
                     /gene="SCRT2"
                     /gene_synonym="ZNF898B"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcccg cgatcccctg tctgcgcgcc gccgccgcca agcccgagcc cgagccgggg
       61 ccgccgccac cggtgccggc tccgagcggc ctcccgcgct ccagcccgct gggagctgtc
      121 cagtgctgaa aacccgcgcg gacacagccg atcgcgcccg gccggccgcc tccccgcacc
      181 gagccccgcg ccggccgcgc catgccgcgc tccttcctgg taaagaagat caaaggggac
      241 ggcttccagt gcagcggggt gccggccccc acctaccacc ccttggagac agcctacgtg
      301 ctgcctggcg cccgggggcc tcccggggac aacgggtacg ccccgcaccg cctgcccccg
      361 agcagctacg atgcggacca gaagccgggc ctggagctgg ccccggccga gcccgcgtac
      421 ccgccggcgg cgccggagga gtacagcgac cccgaaagcc cgcagtcgag cctgtcggcg
      481 cgctacttcc gaggggaggc ggcagtgacc gacagctact ccatggacgc cttcttcatc
      541 tcggacgggc gctcgcggcg gcggcggggc gggggcggcg gggacgcggg gggctcggga
      601 gacgcggggg gcgccggggg gcgcgcgggg cgcgcggggg cgcaggcggg cggcgggcac
      661 cggcacgcgt gcgccgagtg cggcaagacc tacgccacgt cgtcgaacct gagccgccac
      721 aagcagacgc accgcagcct ggacagccag ctggcgcgca aatgcccgac gtgcggcaag
      781 gcctacgtgt ccatgcccgc gctcgccatg cacctgctca cgcacaacct gcgccacaag
      841 tgcggcgtct gcggcaaggc cttctcgcgg ccctggctgc tgcagggtca catgcgctcg
      901 cacaccggcg aaaagccgtt cggctgcgcg cactgcggca aggccttcgc cgaccgctcc
      961 aacctgcgcg cgcacatgca gacgcactcg gccttcaagc actaccgctg ccgccagtgc
     1021 gacaagagct tcgcgctcaa gtcctacctc cacaagcact gcgaggcggc ctgcgccaag
     1081 gcggccgagc cacccccgcc gacccccgcc ggcccggcca gctgagcctt ccgcctcgcc
     1141 ctcgcgcccg gaactcgctc tccacgcgcc ccgggccccc tacctgcgcc cgcagcgccc
     1201 tcgcccagcc ccggctgcgt ttccctgccc atgaccctct cgtggggacc cccggcccgg
     1261 cccggaactt ttctccccaa cccccaaacc cacgactcac ttccacaccg tcttccccag
     1321 cgtcccccga cccacttcat cctttccggc catccctcgg accttgaccc ccctgtccgc
     1381 gccttcaagg ctcccaactc aggcaccagg tccgcacctc tcccgcgccc cagagccgga
     1441 aatttctccc tcccagaccc cgcgctgctc ttctaacttc tagatctttt ctctcgcttc
     1501 tcagctgaat ctctctgacc attcctctac tggagccccc aatgaaagcc gcaaacctat
     1561 acccttgacg cccatacctg cctcagtttc cccatccaca cctggacgca ggccctgccg
     1621 ccctgagacc acagtccaac cccagaccat ccctctggcc tctgctgaat ctcccagagt
     1681 gtgtccatct ggggatctaa tcttcaccct tcttgaagtc tccgatctgt ccctgatccc
     1741 atccatgctc aggccttagg tctggccatt cacacacaca cacaccccca caccccactc
     1801 ccacacacag ttcctactgt cttcagtcca tggggatctc atcacccact cccagcccca
     1861 gctccagctg ccctcacctc tctagcagct ctcacccctc tgagtctacc taacctggag
     1921 ggggcttgag gggcacttca gggccctgcc ccctaatgta acccctctct caccccggca
     1981 caacctgggc ttccacagtc tggagctgcc ctacccccag attctctgag cactttcccc
     2041 catccccagg gccacagatc cccttcctta cttgttgggg ggaggtctgg agcacctcgc
     2101 caatgccctt cccccatccg gctgggtcct tccagttatt tatttgtgta tttatttatt
     2161 tatctattta ttattctatt taatctcttg gcctcaccca gggaccgtct ggcttcccca
     2221 gctggactgg gaggtcagga agccaggcaa ggagagggac agcacaggcc acagagggct
     2281 gcccccacca cacacacccc cgcgtctcgg gagaaaccca ccctcttcag agcctgcact
     2341 cgctaaggaa ggggactcga gaatgggggg gcagcttgct gaccctcaac tgggggggtg
     2401 agggagcatc aggaggtcca ggcgtggggc aggtccccac cttcctgaac cttcccctgc
     2461 cactccaggc ggcccggaga gaggagcctc ttcgatttgt ttcctgttta ttcttcttcc
     2521 cgagggaccc caggttccag ggaccgactg agccccggac ccgctggggc ctctggcctg
     2581 ctccccggga ggggcgctct ctcccggcca tgtctatgca actctcccgg acagaggggc
     2641 cgggctgcca gccacccgcc cgttggccgc cactacctcc tccgctgcgc ttttgcatgc
     2701 ccgggcgagg accgaagcac acacctccac gcgcacgggc cctggccccc tccgctttaa
     2761 gcacacgcct ctgccccatt gctctgcagc cagcttgggg gcaggagtcc tggactctca
     2821 gatcctcctc tcccctcctc ttagccacaa aagagggggg agactggagg cacccctgca
     2881 gcaggggcac ttccctaggg ctccagaggg gtgaatgggc ctttgctcag ctccaggccc
     2941 agcgggaagg gaggctgcag ggatggtggg agggagaggg gtagcagaag caattatgga
     3001 ggcgttgacc ctgtaaatag caacttctga cagcaataat tttccatgca tgctaagcct
     3061 tttggccata ttttgtatga gcgcttggcg ctcctcctcc gtcctatccc aactcacccc
     3121 caaaccccca tcccttcccc acctccagca gtattacttg taacgcaatt cagggatatt
     3181 aaagggactt tggccactca
//
